Disclosed a nitric oxide supply system of respiratory failure rescue device belongs to the disease therapy apparatus, which avoids the high concentration NO gas cylinder, the high concentration dry gas cylinder and the nitrogen-oxygen mixed gas cylinder. The invention uses the air as raw material for attaining the NO at any time without the storage and via controlling the electric discharge condition, generates NO gas at most with least NO2 harmful gas to attain the low ratio of NO2/NO. While the concentration of NO ranges from 0-200 ppm in the pulse frequency of 1-90 Hz. The invention comprises an air pump connected in series to the gas passage, a clean-dry air generating device, a flow counter, a pulse generate and control circuit, a arc discharge reactor, a particle filter film, a NO2 catalytic reduction conversion apparatus, a cooler, a particle filter film, a selective absorber and a gas monitor.