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Amnion eye drops for curing cornea alkali burn

A technology for eye drops and alkali burns, applied in the field of medicine, can solve the problems of lack of direct evidence of amniotic membrane, instability of amniotic membrane homogenate, poor appearance, etc., and achieve the goal of relieving ocular discomfort symptoms, increasing bioavailability, and reasonable formula Effect

Active Publication Date: 2010-03-03
HARBIN MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] (3) The postoperative appearance is not good, which affects the appearance;
[0006] (4) Whether the long-term existence of the amniotic membrane after transplantation can become a component of the recipient tissue is still lack of direct evidence
However, due to the instability of amniotic membrane homogenate, it can only be used for a short period of time and has not been used clinically.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Prescription: trehalose 1.5g, sodium hyaluronate 1.0g, heparin sodium 5000 units, sodium chloride 0.6g, benzalkonium bromide 0.002g, vitamin E 0.1g, amniotic membrane homogenate supernatant 2μl, water for injection to 100ml.

[0042] Immerse sodium hyaluronate in an appropriate amount (about 1 / 4 of the total amount) of water for injection, and dissolve it for later use; take about 1 / 2 of the total amount of water for injection, and dissolve heparin sodium, trehalose, sodium chloride, benzene Zalkonium bromide and vitamin E can be heated if necessary, then add sodium hyaluronate solution, then add the prepared amnion homogenate supernatant to the above solution, add water for injection to volume, stir evenly, and adjust the pH to 6.5 with hydrochloric acid -7.5, then filter and sterilize with a 0.22 μm microporous membrane, and obtain the eye drops of the present invention after subpackaging.

Embodiment 2

[0044] Prescription: trehalose 1g, sodium hyaluronate 0.5g, heparin potassium 4000 units, sodium chloride 0.3g, benzalkonium bromide 0.001g, vitamin E 0.05g, amniotic membrane homogenate supernatant 1μl, water for injection to 100ml.

[0045] Soak potassium hyaluronate in an appropriate amount (about 1 / 4 of the total amount) of water for injection, and dissolve it for later use; take about 1 / 2 of the total amount of water for injection, and dissolve heparin potassium, trehalose, sodium chloride, benzene Zonium bromide, vitamins, can be heated if necessary, then add potassium hyaluronate solution, then add the prepared amniotic membrane homogenate supernatant to the above solution, add water for injection to volume, stir evenly, and use phosphoric acid / phosphate buffer Adjust the pH to 5.0-6.5, filter and sterilize with a 0.22 μm microporous membrane, and obtain the eye drops of the present invention after subpackaging.

Embodiment 3

[0047] Prescription: trehalose 2g, sodium hyaluronate 1.5g, heparin sodium 6000 units, sodium chloride 0.9g, benzalkonium bromide 0.003g, vitamin E 0.15g, amniotic membrane homogenate supernatant 3μl, water for injection to 100ml.

[0048] Immerse sodium hyaluronate in an appropriate amount (about 1 / 4 of the total amount) of water for injection, and dissolve it for later use; take about 1 / 2 of the total amount of water for injection, and dissolve heparin sodium, trehalose, sodium chloride, benzene Zonium bromide and vitamins can be heated if necessary, then add sodium hyaluronate solution, then add the amniotic membrane homogenate supernatant to the above solution, add water for injection to volume, stir evenly, adjust the pH to 7.5-9.0 with hydrochloric acid, and then Filter and sterilize with a 0.22 μm microporous membrane, and obtain the eye drops of the present invention after subpackaging.

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PUM

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Abstract

The invention provides amnion eye drops for curing cornea alkali burn and a preparation method thereof. The preparation method comprises the steps of: taking amnion homogenate supernate as main activeconstituent; and adding with trehalose, hyaluronic acid or salt thereof, heparin or salt thereof, sodium chloride, benzalkonium bromide, vitamin, etc. The eye drops belongs to an ophthalmology drug delivery system, has a good lubrication function, and can provide a conglutination-resistant surface; and the drug delivery system is added with the other pharmacological active constituents, thereby being capable of increasing the viscocity of medical liquid, prolonging the residence time of the drug in eye surface, improving the bioavailability of the drug, reducing the side effect of the drug, reducing the drug irritation, and having a slow release effect. The amnion eye drops is an effective ophthalmology new drug, and has good clinic application foreground.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to an ophthalmic medicine for corneal alkali burn, in particular to an amniotic membrane eye drop for treating corneal alkali burn. Background technique [0002] As we all know, amniotic membrane transplantation, as a new technology to reconstruct the ocular surface, has been gradually popularized and applied at home and abroad. Amniotic membrane transplantation has been widely used in corneal alkali burns and achieved good therapeutic effect. However, the amniotic membrane is a temporary biological covering that is deficient in the following ways: [0003] (1) 1-2 weeks after transplantation, the amniotic membrane graft will dissolve, fall off, shift, and become infected by itself; [0004] (2) It is attached to the corneal surface for a long time, and it is slightly cloudy when deposited on the Bowman's membrane, which lasts for three months; [0005] (3) The postoperative appea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K35/50A61K47/36A61P27/02
Inventor 于永斌杨洪滨张明红
Owner HARBIN MEDICAL UNIVERSITY
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