Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material

Abstract

A modified starch material for biocompatible hemostasis, biocompatible adhesion prevention, tissue healing promotion, absorbable surgical wound sealing and tissue bonding, when applied as a biocompatible modified starch to the tissue of animals. The modified starch material produces hemostasis, reduces bleeding of the wound, extravasation of blood and tissue exudation, preserves the wound surface or the wound in relative wetness or dryness, inhibits the growth of bacteria and inflammatory response, minimizes tissue inflammation, and relieves patient pain. Any excess modified starch not involved in hemostatic activity is readily dissolved and rinsed away through saline irrigation during operation. After treatment of surgical wounds, combat wounds, trauma and emergency wounds, the modified starch hemostatic material is rapidly absorbed by the body without the complications associated with gauze and bandage removal.

Description

[0001] This application is a divisional application of the invention patent application with the application number 200810032631.6, the application date is January 14, 2008, and the invention title is "modified starch material with biocompatible hemostasis, anti-adhesion, healing promotion, and shell sealing". technical field [0002] The present invention relates to a kind of modified starch material as biocompatible hemostasis, biocompatible anti-adhesion, promotion of tissue healing, absorbable surgical sealant, and tissue bonding, especially a kind of directly acting on human, breast-feeding Wounds of animals, including bloody wounds or wounds with exudate, are used for hemostasis, anti-adhesion, promotion of tissue healing, sealing of wounded tissue sections, prevention of bleeding and interstitial fluid leakage, and bonding of tissues damaged by trauma and surgery Organs, modified starch materials that help tissue repair, avoid or reduce surgical sutures, and can be absor...

AI Technical Summary

Problems solved by technology

First of all, from the aspect of application, this hemostatic material is mainly limited to the hemostasis of skin or soft tissue wounds, and the hemostasis of tissues and organs in the deep part of the body cavity, especially the hemostasis under endoscopy (such as minimally invasive endoscopy, colonoscopy and laparoscopy). During operation) there is still lack of effective means; the second, from the preparation method, epichlorohydrin is a colorless oily liquid, toxic and anesthetic, so producing this product is unfavorable to the environment, and the production cost is also higher; the third, from In terms of hemostatic effect, because its water absorption is not strong enough, the water absorption rate is low, and the speed of water absorption is slow, the hemostatic effect is not ideal, especially for active bleeding. The viscosity of the gel is poor, so the clot formed after interacting with blood has poor adhesion to the tissue, and cannot effectively block the damaged tissue and blood vessels, thus affecting the effect of hemostasis; fifth, during active bleeding, The hemostatic powder is difficult to adhere to the bleeding site and is easily washed away by the blood flow. If the auxiliary material is pressed on the hemostatic powder, the auxiliary material is easily adhered by the blood clot, causing re-bleeding when the auxiliary material is uncovered

Therefore, it is not effective for active bleeding hemostasis

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