26results about How to "Reduce clearance" patented technology

The invention provides a trimetal nano enzyme as well as a preparation method and application thereof. The ABC trimetal nano-enzyme disclosed by the invention has multi-enzyme activities of glucose oxidase, peroxidase, catalase, glutathione peroxidase, nicotinamide adenine dinucleotide phosphate oxidase and the like, and can be used for enhancing the catalytic treatment on tumors. In a tumor microenvironment, the component A has glucose oxidase-like activity, and can catalyze endogenous glucose to generate hydrogen peroxide to enhance the generation of hydroxyl radicals; the component B has peroxidase-like and glutathione-like peroxidase activity, and can generate hydroxyl radicals and consume glutathione; the component C has peroxidase-like activity and catalase-like activity and can generate hydroxyl radicals, and generated oxygen can improve the glucose oxidase-like activity of the component A. In addition, the component BC has the activity of nicotinamide adenine dinucleotide phosphate oxidase, and oxygen can be catalyzed to generate superoxide anions by utilizing the excellent electron transmission characteristic of the interface of the component BC.

The invention belongs to the field of bone tissue engineering, and particularly relates to a frozen 3D printing stent with synergistic signal molecules and a preparation method and application thereof.The ink composition with the synergistic signal molecules comprises a first porous carrier loaded with CO molecule prodrugs and a second porous carrier loaded with NO molecule prodrugs, the surface of the first porous carrier is coated with a first encapsulation layer, the first encapsulation layer is used for blocking the CO molecule prodrug in pores of the first porous carrier, and the first encapsulation layer can be self-degraded and release CO molecules under the condition of high oxygen activity; the surface of the second porous carrier is coated with a second encapsulation layer, the second encapsulation layer is used for blocking the NO molecule prodrug in pores of the second porous carrier, and the second encapsulation layer can be self-degraded and release NO molecules under an acidic condition. By means of the method, the stent which is complete in structure, capable of achieving timely vascularization and capable of stabilizing osteogenesis can be obtained.

The utility model discloses an angular contact ball bearing which comprises an outer ring, an inner ring and a rolling body arranged between the outer ring and the inner ring in a rolling mode, the outer ring and the inner ring are respectively provided with a roller path for the rolling body to move, the angular contact ball bearing comprises a tolerance ring, the inner ring is matched with the tolerance ring, and the tolerance ring is sleeved with the inner ring. The tolerance ring is provided with an insertion hole which is used for being coaxially aligned with the inner ring shaft hole and allowing an external shaft part to be inserted, a force application part is bent towards the inner ring on the outer circumferential wall of the tolerance ring, and a matching part used for being matched with the force application part is bent towards the rolling body on the side wall of one side of the inner ring. One side of the tolerance ring is provided with a driving part which is used for pushing the tolerance ring to move in the axis direction of the insertion hole after the external shaft part is matched with the tolerance ring and is fixedly matched with the external shaft part after the tolerance ring moves. The automobile steering column bearing solves the problem that an automobile steering column bearing which is zero in bearing clearance, low in axial displacement and large in aligning function is lacked in the prior art.

The present application provides a series of substituted 1,2,4-triazole derivatives and their applications, and specifically provides a compound shown in formula (I) and a pharmaceutically acceptable salt thereof.

The utility model provides a manual lifting frequency conversion control system applied to an ocean platform, which belongs to the field of manual lifting frequency conversion control and comprises a cabinet body, a control loop, a plurality of mounting beams and a plurality of copper bars are arranged in the cabinet body, and an incoming line busbar clamp, an outgoing line busbar clamp, a circuit breaker, a reactor, a frequency converter module and a filter are mounted on each mounting beam. The wire inlet end of the circuit breaker is connected with the wire inlet busbar clamp through a copper bar, the wire outlet end of the circuit breaker is connected with the fast-acting fuse through a copper bar, meanwhile, the fast-acting fuse is installed at the wire inlet end of the electric reactor, and the wire outlet end of the electric reactor is connected with the wire inlet end of the frequency converter module through a copper bar. The wire outlet end of the frequency converter module is connected with the wire inlet end of the filter through a copper bar, and the wire outlet end of the filter is connected with the wire outlet busbar clamp through a copper bar. The device is convenient to maintain, facilitates on-site adjustment and maintenance of a control loop, and can design a harmonic processing scheme in a customized manner according to the characteristics of serious harmonic waves and large harmonic interference of a platform power grid under the working condition of a long cable.

The application discloses a medicine composition for delaying aging and resisting oxidation, and belongs to the technical field of biological medicine and health food. The composition comprises vitamin A, beta-carotene, compound vitamin B, vitamin C, vitamin D, vitamin E, vitamin K, and macroelements calcium, phosphorus, potassium, magnesium and trace elements zinc, selenium, iron, chromium, copper, molybdenum, iodine, fluorine and manganese, traditional Chinese medicines ginseng, astragalus root, medlar, prepared rehmannia root, ganoderma lucidum, conditional essential nutrients nucleic acid, and bioactive ingredients grape seed extract, lycopene, tea polyphenol, taurine, lutein, lutein fat, corn xanthophyll and chlorophyll; the composition is mainly suitable for middle-aged and old people; the composition can eliminate various factors causing aging from multiple systems, multiple links and multiple targets, can significantly delay aging, has the health care and tonifying effects of resisting oxidation and the like, can improve the life quality of the middle-aged and old people while delaying aging, and has no compatibility contraindication and will not produce any toxic and side effects after long-term use.

Provided herein are compounds of formula (I) wherein Ra, Rb, Rc, A and p have the meanings given in the specification, as defined in formula (I), as well as pharmaceutically acceptable salts and solvates thereof, which are useful in the treatment of diseases in which pan-immune proteasome inhibition is desired or desired, and in particular in the treatment of cancer.

The invention relates to a cGAS inhibitor as well as a preparation method and application thereof. Specifically, the compound disclosed by the invention has a structure as shown in a formula I, and the definitions of all groups and substituent groups are described in the specification. The invention also discloses a preparation method of the compound and application of the compound in preventing and / or treating inflammation and autoimmune diseases, neurodegenerative diseases, other diseases and the like. # imgabs0 #

The invention provides a power supply module, which comprises a heat dissipation substrate, a PCB, at least one insulating ceramic substrate, at least one transformer, a plurality of high-voltage devices and a plurality of low-voltage devices, and is characterized in that the bottom surface of the heat dissipation substrate is used for exchanging heat with an external cold source, and the insulating ceramic substrate and the PCB are both mounted on the top surface of the heat dissipation substrate; the transformer comprises a transformer winding and a transformer magnetic core, and the transformer winding is arranged in the PCB and wound on the transformer magnetic core; a plurality of high-voltage devices with high heat dissipation requirements are arranged on the top surface of the insulating ceramic substrate, and other high-voltage devices are arranged on the top surface of the PCB; and the plurality of low-voltage devices are arranged on the top surface of the insulating ceramic substrate, the top surface of the PCB or / and the bottom surface of the PCB. According to the power module, the heat dissipation substrate is adopted to be connected with an external cold source for heat dissipation, electrical insulation is achieved between the PCB and the devices on the top face of the insulating ceramic substrate by coating the electrical insulation paste, compared with a traditional power module, the gap between the devices is small, and then the overall size of the power module is reduced.

The invention discloses an anti-wrinkle and skin-brightening composition containing hydrolyzed ginsenosides and ergothioneine as well as a preparation method and application of the anti-wrinkle and skin-brightening composition, and belongs to the technical field of cosmetics. The composition is prepared from the following components in parts by weight: 5 to 15 parts of ergothioneine, 25 to 40 parts of sphingomonas fermentation product extract, 15 to 30 parts of hydrolyzed ginsenosides and 30 to 40 parts of iris vetiveria root extract. Wherein the hydrolyzed ginsenosides are prepared by enzymolysis of a specific compound enzyme. The four components in the composition synergistically construct an anti-oxidation-anti-inflammation-collagen promotion-collagen degradation inhibition system, the composition has excellent anti-wrinkle, skin brightening, soothing and anti-oxidation effects, and the composition is good in safety, suitable for various skin types, capable of being prepared into essence, emulsion and other cosmetics according to the dosage of 0.01 wt%-30 wt% and wide in application prospect.

The present application belongs to the technical field of chemical drugs, and relates to a compound shown in a general formula (I), or a racemate, or an isomer, or a pharmaceutically acceptable salt thereof, as a complement factor B inhibitor and a method for treating various specific diseases or conditions using the same.

The invention belongs to the technical field of cosmetics, and particularly relates to a natural-source composition with ultraviolet absorption and ultraviolet conversion functions and application of the natural-source composition in cosmetics. The natural source composition provided by the invention comprises a honeysuckle flower extract, a butterflybush flower and leaf extract and a spirulina platensis extract, wherein the mass ratio of the honeysuckle flower extract to the butterflybush flower and leaf extract to the spirulina platensis extract is (5-30): (1-20): (0.01-10). The natural-source composition provided by the invention not only can effectively absorb UVC, UVB and UVA full-wave band ultraviolet light, but also can convert the ultraviolet light into red light beneficial to a human body, so that the effects of resisting inflammation, repairing, fading red light, resisting light damage and resisting light aging are achieved. The natural-source composition provided by the invention is applied to cosmetics and can play a role in sunscreen and synergism. Meanwhile, the composition provided by the invention is natural, green, high in safety, mild and non-irritant, and can be used for children and people with sensitive skin.

This invention relates to the use of peptides as therapeutic agents for degenerative brain diseases. Specifically, it confirms that the peptides of this invention, by targeting microglia, induce microglia in an inflammatory state to an anti-inflammatory state in a disease environment, thereby reducing neuroinflammation and enhancing phagocytic function to clear amyloid-β. Furthermore, in animal models of degenerative brain diseases, the effects of reducing amyloid-β, restoring synaptic plasticity, and improving cognitive impairments related to anxiety, learning, and memory have been confirmed. Therefore, the peptides of this invention can be effectively used as active ingredients in compositions for the prevention or treatment of degenerative brain diseases and the resulting cognitive, learning, or memory impairments.

The present application relates to a method for preparing extracellular vesicles with reduced non-specific binding / endocytosis, which is obtained by knockout and deglycosylation of extracellular vesicle-related adhesion molecules, and the extracellular vesicles with reduced non-specific binding / endocytosis have a prolonged residence time in blood, further, IL12 and antibodies are loaded on the extracellular vesicles with reduced non-specific binding / endocytosis, to achieve the effect of IL12 "multimer" mode enhancement, further, the antibodies achieve targeting, reduce the effective concentration of IL12, improve safety, and also achieve high-efficiency inhibition of tumor growth under certain safety.

The present invention provides antibodies that bind to the human CEACAM5 protein, as well as isolated nucleic acids and host cells comprising sequences encoding the antibodies. The invention also provides immunoconjugates comprising said antibodies linked to a growth inhibitor, and pharmaceutical compositions comprising the antibodies or immunoconjugates of the invention. The invention also provides the use of the antibodies, immunoconjugates and pharmaceutical compositions of the invention for the treatment of cancer or for diagnostic purposes.

The invention discloses a bacterial assembly as well as a preparation method and application thereof. The bacterial assembly is prepared from facultative anaerobic bacteria, double-terminated maleimide polyethylene glycol and cationic albumin, reducing disulfide bonds on the surfaces of bacterial cell walls through a reducing agent so as to expose sulfydryl, carrying out Michael addition reaction on double-terminal maleimide polyethylene glycol and sulfydryl, and connecting a plurality of bacteria with sulfydryl exposed on the surfaces to form the bacterial assembly. According to the reaction system, the cationic albumin is added to increase bacterial adhesion so as to enhance aggregation, meanwhile, bacterial surface antigens are effectively covered, and removal of immune cells is reduced. The bacterial assembly provided by the invention reduces the distribution of bacteria in normal tissues while increasing lung enrichment, has higher lung tumor targeting, and effectively improves the lung tumor treatment effect.

The application discloses a virus-like particle carrier based on a porcine paternal expression gene 10 and application thereof in mRNA delivery, and belongs to the technical field of genetic engineering and biological medicine. The virus-like particle is formed through self-assembly after the nucleocapsid domain of the porcine paternal expression gene 10 (SsPEG10) is deleted and replaced with a lambda phage lambda N peptide segment or an MS2 phage coat protein MCP in situ. The target mRNA is specifically packaged into the VLP interior by using the high-specificity RNA-protein interaction between the lambda N peptide segment and the 12xBoxB RNA stem loop structure or the MCP and the 12xMS2 RNA stem loop structure, and VSV-G is co-expressed during the VLP assembly process, so that the VLP is endowed with the membrane fusion ability mediated by endocytosis. Finally, the recombined VLP carrier capable of efficiently packaging the target mRNA is successfully constructed, the target mRNA can be delivered into target cells, and efficient expression and translation of the target protein are realized.

This invention relates to the field of pharmaceutical preparation technology, specifically to a sulfachlorpyridazine sodium-methotrexate suspension, its preparation method, and its application. The sulfachlorpyridazine sodium-methotrexate suspension of this invention comprises the following components per 100 ml: 20-50 g of sulfachlorpyridazine sodium, 4-10 g of methotrexate, 0.1-0.25 g of suspending agent, 0.05-0.125 g of wetting agent, 0.2-0.5 g of antioxidant, 0.1-0.25 g of disodium edetate, and purified water to a final volume of 100 ml. The suspension prepared by this invention can delay the in vivo clearance of sulfachlorpyridazine sodium, prolong the synergistic effect time, and improve its bioavailability; in the treatment of coccidiosis infection in chickens and sheep, it can significantly improve weight gain, reduce intestinal lesion values, rapidly clear oocysts, and maintain a long-lasting protective effect after drug withdrawal.

The present invention relates to an opioid receptor "biased" ligand, a preparation method thereof and its use in medicine. Specifically, the compound of the present invention has a structure shown in formula (I), wherein the definitions of each group and substituent are as described in the specification. The present invention also discloses a preparation method of the compound and its use in preventing and / or treating pain or pain-related diseases.

The present invention discloses a factory high-temperature waste gas treatment device, which belongs to the technical field of waste gas treatment, and comprises a box body, wherein the inside of the box body is divided into an inner cavity and an outer cavity by an annular plate, the inner cavity is further divided into a cooling chamber and an air suction chamber by an inner partition plate, and the outer cavity is further divided into a solid filter chamber and an adsorption chamber by an outer partition plate, a motor and an air inlet device are installed on the top of the box body, a driving rod is fixed on the bottom of the motor, and the driving rod penetrates to the bottom of the inner cavity of the box body, a scale cleaning device is installed in the cooling chamber, an induced draft fan blade is installed in the air suction chamber, a first filter plate driven by the scale cleaning device and a second filter plate driven by the first filter plate are installed in the solid filter chamber, and the two filter plates can be vibrated and brushed respectively under driving, a transmission structure is connected to the bottom of the driving rod, and an exhaust structure and a push plate driven by the transmission structure are installed in the adsorption chamber. The present invention can reduce the cost and energy consumption of the device, and improve the filtering efficiency by using multi-stage filtration and automatic cleaning.

The utility model provides a shunt protection box and a battery pack. The shunt protection box comprises a box body with an accommodating cavity, a copper bar protection part arranged on the box body and a limiting part arranged in the box body, the accommodating cavity is used for accommodating the shunt main body, and a copper bar is arranged on the shunt main body; the copper bar protection part comprises a protection groove communicated with the containing cavity, one end of the copper bar is located in the protection groove and connected with the shunt body, and the other end of the copper bar extends out of the containing cavity; the limiting part can abut against the diverter body so that the limiting part can limit the diverter body when the diverter body moves in the height direction of the box body. According to the shunt protection box provided by the embodiment of the invention, the risk of high-voltage touch caused by exposure of the copper bar can be avoided, the electrical connection with peripheral conductors can be effectively isolated, the requirements of electrical clearance and creepage distance can be reduced, and meanwhile, the jumping of the shunt main body can be limited, so that the protection effect on the shunt can be improved.

This application relates to a modified chitosan coating for enhancing adhesion to fruit surfaces and resisting fungal spores, and a method for preparing the same. The modified chitosan coating comprises a chitosan-tannic acid-stearic acid copolymer, a plasticizer, and water. The copolymer is modified by grafting tannic acid and stearic acid onto a chitosan backbone. The modified chitosan coating exhibits enhanced adhesion and hydrophobicity to hydrophobic fruit surfaces, improves wettability, reduces swelling under high humidity, enhances gas barrier properties, displays significant antioxidant activity, reduces enzymatic browning and scavenges free radicals, exhibits anti-adhesion against fungi and bacteria, and possesses excellent biocompatibility. It provides a promising, safe, and sustainable solution for extending the shelf life and quality of fresh agricultural products.

The application discloses a series of glutarimide derivatives and application thereof, and specifically discloses a compound shown in formula (VI-1), a stereoisomer or a pharmaceutically acceptable salt thereof.