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571results about How to "Reduce clearance" patented technology
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Compositions and methods for intraocular delivery of fibronectin scaffold domain proteins
InactiveUS20080220049A1Easy to optimizeImprove bioavailabilitySenses disorderPeptide/protein ingredientsMedicineFibronectin
The present disclosure relates to novel sustained-release intraocular drug delivery systems and improvements in the treatment of retinopathies. In particular, fibronectin scaffold domain proteins that selectively inhibit VEGFR-2 are contemplated.
Owner:BRISTOL MYERS SQUIBB CO
Abuse resistant drug formulation
A pharmaceutical composition may include a granulate which may include at least one active pharmaceutical ingredient susceptible to abuse by an individual mixed with at least two materials, a first material that is substantially water insoluble and at least partially alcohol soluble and a second material that is substantially alcohol insoluble and at least partially water soluble, wherein the active pharmaceutical ingredient and the two materials are granulated in the presence of water and alcohol. The composition may also include a coating on the granulate exhibiting crush resistance which may have a material that is deposited on the granulate using an alcohol based solvent. The composition further comprises a second particle comprising a fat / wax. The present invention also includes a coated granulate, various dosage forms of the composition, as well as methods of production and tableting.
Owner:CIMA LABS +1
Gip analog and hybrid polypeptides with selectable properties
InactiveUS20090036364A1Increased insulin secretionDecreasing bone loss boneSenses disorderNervous disorderDyslipidemiaPhysiology
The present invention relates generally to novel GIP analogs and GIP hybrid polypeptides with selectable properties, useful as agents for the treatment and prevention of metabolic diseases and disorders, for example those which can be alleviated by control plasma glucose levels, insulin levels, and / or insulin secretion, positive inotropic effects, reduction of catabolic effects, slowing of gastric emptying. Such conditions and disorders include, but are not limited to, hypertension, dyslipidemia, cardiovascular disease, eating disorders, critical care, insulin-resistance, obesity, and diabetes mellitus of any kind, including type 1, type 2, and gestational diabetes.
Owner:ASTRAZENECA PHARMA LP
Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material
InactiveCN101485897AMaterials that promote healingPromote repairOrganic active ingredientsSurgical adhesivesTissue fluidBandage
The invention relates to a modified starch material for biocompatible hemostasis, biocompatible anti-adhesion, tissue healing promotion, absorbable surgery sealing and tissue adhesion. The invention applies biocompatible modified starch to animal tissues, wherein the modified starch material has the molecular weight of more than 15,000 daltons, and the particle diameter of between 1 and 1,000 mu m. The modified starch hemostatic material has stypticity, reduces hemorrhage, blood oozing and tissue fluid oozing of wounds, maintains relative moistening or drying of wound surfaces or the wounds, inhibits bacterium growth and inflammation reaction, and contributes to locally diminish inflammation of the wounds and relieve pain of patients. Moreover, the modified starch material can wash local parts after operation is over and remove redundant modified starch which does not participate in hemostasis, and can easily remove haemostatic under the condition of debridement treatment after self-help and first-aid treatment of war wounds; and hemostatic materials with a small amount of modified starch can be absorbed by the body, so that the pain of tearing of gauzes and bandages on people is avoided.
Owner:BEIJING UNIVERSAL LIKANG TECH CO LTD
Divided structure of a long plastic component for a vehicle
InactiveUS6948753B2Easy clearance adjustmentEliminate disadvantagesVehicle seatsSuperstructure subunitsEngineeringDivided structure
An improved divided structure of a long plastic component for a vehicle is provided to facilitate an adjustment of a clearance in a joint between constituent parts thereof, thereby setting the clearance at an adequately small dimension. A plurality of constituent parts making up the long plastic component such as a side sill garnish are combined together into one long piece and mounted on a vehicle body. A first garnish is mounted on the vehicle body, and a second garnish is mounted on the first garnish in such a manner as to overlap with the first garnish from a direction substantially perpendicular to a longitudinal direction of the side sill garnish. Accordingly, the first garnish and the second garnish, which have been joined together, can be mounted on the vehicle body.
Owner:HONDA MOTOR CO LTD
Inhibitors of type 2 vascular endothelial growth factor receptors
ActiveUS20070148126A1Improve pharmacokineticsIncrease target binding affinityOrganic active ingredientsSenses disorderVascular Endothelial Growth Factor ReceptorDrug biological activity
The present disclosure relates to novel vascular endothelial growth factor receptor (VEGFR)-binding polypeptides and methods for using these polypeptides to inhibit biological activities mediated by vascular endothelial growth factors (VEGFs). The present disclosure also provides various improvements relating to single domain binding polypeptides.
Owner:BRISTOL MYERS SQUIBB CO
Short peptides from the 'A-region' of protein kinases which selectively modulate protein kinase activity
InactiveUS20020137141A1Improve propertiesImprove permeabilityPeptide/protein ingredientsMetabolism disorderProtein kinase domainProtein kinase C
Owner:CHILDRENS MEDICAL CENT CORP
System and method for gas purge control
ActiveUS20140318514A1Reduce trafficAmount of vacuum in the intake manifold mayElectrical controlInternal combustion piston enginesControl systemEngineering
Systems and methods for providing vacuum to one or more of a crankcase ventilation system, an emission control system, and an exhaust gas recirculation (EGR) system included in a turbocharged engine system are provided. In one example, approach, a method comprises drawing vacuum from a vacuum source located in an intake of the engine downstream of a pre-compressor throttle and upstream of an intake throttle, and applying the drawn vacuum to a discharge outlet of a uni-directional crankcase ventilation system, where an inlet of the crankcase ventilation system is coupled to the intake of the engine upstream of the pre-compressor throttle.
Owner:FORD GLOBAL TECH LLC
Light Guiding Device
ActiveUS20160341393A1Reduce clearanceUniform distributionOptical signallingVehicle lighting systemsWing mirrorLacquer
A light guiding device for an illumination device, especially for a motor vehicle or an indicator device in a rearview device of a motor vehicle includes a light coupling side for incoupling light from a light source, a reflection side having a reflection layer; and a light outcoupling side, which is disposed generally opposite the reflection side. A clearance between the reflection side and the light outcoupling side generally decreases as the distance from the light incoupling side increases. The reflection side having the reflection layer is configured so that light arriving from the light incoupling side is deflected to the light outcoupling side. The reflection layer may be a paint or lacquer layer that is imprinted or evaporation-coated on the reflection side; and the having a white sheet on or next to the rejection side.
Owner:SMR PATENTS S A R L
Pharmacokinetic modulation and compositions for modified Fn3 polypeptides
ActiveUS20070160533A1Improve continuityReduce the differenceSenses disorderPeptide/protein ingredientsVascular Endothelial Growth Factor ReceptorDrug biological activity
Owner:BRISTOL MYERS SQUIBB CO
Modified starch absorbable hemostasia material and preparation method thereof
ActiveCN101361986AHigh viscosityImprove water absorption speedSurgical adhesivesPharmaceutical delivery mechanismWound healingBiomedical engineering
Owner:BEIJING UNIVERSAL LIKANG TECH CO LTD
Composite hydrogel drug delivery systems
ActiveUS20080279944A1Reduce molecular weightEasy to processPowder deliveryIn-vivo radioactive preparationsMedicineWater soluble
Owner:INCEPT LLC
Polyethylene glycol-modified integrin blocking agent HM-3 and application thereof
InactiveCN102417540AExtended half-lifeDoes not affect the activity in vivo and in vitroConnective tissue peptidesPeptide/protein ingredientsTumor angiogenesisPolyethylene glycol
The invention relates to the field of medicaments, in particular to an integrin blocking agent HM-3 which has the function of inhibiting tumor angiogenesis, integrin affinity and a bonding capacity and application thereof. The blocking agent is a polypeptide modified with polyethylene glycol, and the modified integrin blocking agent polypeptide can be applied to treatment of solid tumors. During application of the integrin blocking agent to preparation of a tumor treatment medicament, the sequence and structure of the integrin blocking agent is mPEG-SC20k-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp. The integrin blocking agent polypeptide designed in the invention is scientific, reasonable, practical and effective, can be used for preparing a treatment medicament for treating human solid tumors, and has remarkable social value and market value; and the treatment spectrum of the integrin blocking agent is expanded greatly, and novel thought and prospect are provided for future development of medicaments.
Owner:CHINA PHARM UNIV
Modified enzyme and treatment method
InactiveUS20090041741A1Extended half-lifeConvenient treatmentPeptide/protein ingredientsTransferasesLysosomeCompound (substance)
There is disclosed an isolated, modified recombinant β-glucuronidase wherein the modification is having its carbohydrate moeties chemically modified so as to reduce its activity with respect to mannose and mannose 6-phosphate cellular delivery system while retaining enzymatic activity Also disclosed are methods for the treatment of lysosomal storage disease in mammals wherein the mammal is administered a therapeutically effective amount of isolated, modified recombinant β-glucuronidase whereby said storage diseased is relieved in the brain and visceral organs of the mammal. Also disclosed are other lysosomal enzymes within the scope of the invention.
Owner:SAINT LOUIS UNIVERSITY
Measuring unit for measuring characteristics of a sample liquid, in particular viscoelastic characteristics of a blood sample
ActiveUS20100184201A1Firmly connectedEasy to disassembleBioreactor/fermenter combinationsBiological substance pretreatmentsCouplingEngineering
The present invention is directed to a measuring unit, for measuring characteristics of a sample liquid, comprising a support member, having at least one upper bearing arm, with an upper bearing unit, at least one lower bearing arm, with a lower bearing unit, and a base, for being attachable to a respective measuring system; a shaft, having shaft toes and being rotatably supported about a rotation axis, by said upper bearing unit, and said lower bearing unit, wherein said upper bearing unit, said lower bearing unit, and said shaft toes form toe bearings, respectively; an interface member, having a detecting element, and a drive element, said interface member, being fixed on said shaft, and being connected to a coupling shaft, with a probe connector section, for measuring characteristics of said sample liquid; wherein said interface member, and the coupling shaft, are coaxially aligned with said shaft.
Owner:C A CASYSO
Cryogenic coupling device
ActiveUS6945477B2Prevent overflowSmall sizeVessel mounting detailsSpray nozzlesThermal breakCoupling
A cryogenic coupling device includes a valved receptacle and a valved nozzle. Rollers in an outer collar of the receptacle are received in helical channels along a collar of the nozzle. A notch or detent in each of the channels provides a vent position to vent fluid before the nozzle is fully disconnected from the receptacle. Interface seals on the nozzle include first and second annular seals that function as ice and containment scrapers, as well as fluid seals. The nozzle has a rotatable handle assembly, isolated from the fluid path, which provides easy connect and disconnect of the nozzle from the receptacle. The handle assembly includes a thermal break, and is easily removable from the nozzle, along with other parts of the nozzle and receptacle, for service and maintenance.
Owner:PARKER INTANGIBLES LLC
Measuring unit for measuring characteristics of a sample liquid, in particular viscoelastic characteristics of a blood sample
ActiveUS8383045B2Avoid large gapsReduce clearanceBioreactor/fermenter combinationsBiological substance pretreatmentsCouplingEngineering
The present invention is directed to a measuring unit, for measuring characteristics of a sample liquid, comprising a support member, having at least one upper bearing arm, with an upper bearing unit, at least one lower bearing arm, with a lower bearing unit, and a base, for being attachable to a respective measuring system; a shaft, having shaft toes and being rotatably supported about a rotation axis, by said upper bearing unit, and said lower bearing unit, wherein said upper bearing unit, said lower bearing unit, and said shaft toes form toe bearings, respectively; an interface member, having a detecting element, and a drive element, said interface member, being fixed on said shaft, and being connected to a coupling shaft, with a probe connector section, for measuring characteristics of said sample liquid; wherein said interface member, and the coupling shaft, are coaxially aligned with said shaft.
Owner:C A CASYSO
Rubber composition for a colored tire
InactiveUS6344506B2Assess the hardness of the compositionsReduce clearanceOrganic chemistrySpecial tyresElastomerPolymer science
The invention concerns a white, light-colored tire rubber composition, devoid of carbon black, comprising at least a diene elastomer, a reinforcing white or colored filler, and an anti-photo-oxidizing system, wherein said protective system comprises (A) a 2,2'-methylene-bis-[4-alkyl (C1-C10)-6-alkyl(C1-C12)phenol]; (B) a dialkylthiodipropionate, the alkyl radicals thereof, which may be identical or different, are (C1-C20), radicals; (C) a 2-(2-hydroxyphenyl) benzotriazole; and (D) a "HALS" amine derived from 2,2,6,6-tetramethylpiperidine.
Owner:MICHELIN & CO CIE GEN DES ESTAB MICHELIN
Pegylated exenatide ramification and use thereof
InactiveCN102827270AReduce clearanceExtended half-lifeHormone peptidesPeptide/protein ingredientsClearance rateMotility
The invention provides a pegylated exenatide ramification (Exendin-4-Cys-PEG (polyethylene glycol)) and the use of the pegylated exenatide ramification, belonging to the technical field of the preparation and the application of a polypeptide drug. A preparation method of the pegylated exenatide ramification provided by the invention comprises the following steps of: introducing a cysteine at the C-end of exenatide, and coupling maleic acylamino polyethylene glycol, so that the pegylated exenatide ramification can be formed. The pegylated exenatide ramification provided by the invention has slow clearance rate in the blood circulation and prolonged half-life period, and can be used for preparing the related illness treatment drugs for reducing the blood sugar, reducing the ingestion, reducing the gastrointestinal emptying, increasing the beta cell quantity or reducing the gastrointestinal motility.
Owner:无锡和邦生物科技有限公司
Inducible binding proteins and methods of use
InactiveUS20180134789A1Specific activityImprove pharmacokineticsAntibody mimetics/scaffoldsAntiviralsDiseaseProteinase activity
Provided herein are conditionally activated polypeptide constructs comprising a protease-activated domain binding to CD3, at least one half-life extension domain, and two or more domains binding to one or more target antigens. Also provided are pharmaceutical compositions thereof, as well as nucleic acids, recombinant expression vectors and host cells for making such polypeptide constructs. Also disclosed are methods of using the disclosed polypeptide constructs in the prevention, and / or treatment diseases, conditions and disorders.
Owner:TAKEDA PHARMACEUTICALS CO LTD
Compliant brush shroud assembly for gas turbine engine compressors
InactiveUS6880829B1Inexpensive and easy to manufactureLight weightEngine sealsPump componentsBristleEngineering
A brush shroud assembly for reducing the tip clearance between a rotating blade and an engine casing is disclosed. The assembly includes a plurality of bristle packs supported within a housing such that the bristle distribution at the inner diameter of the bristle packs is substantially continuous. The continuous surface is created by mounting the bristles packs within a housing such that the packs are flared, i.e. width at the outer diameter of the bristle pack is smaller than that at the inner diameter. Various embodiments are disclosed for mounting the flared bristle packs to form a substantially continuous inner diameter. The bristle strips may be mounted in one or more annular rings, may be secured within one or more channels in the housing, the bristle packs may be formed into a tufted ring, or any of these may be utilized in combination with a backplate supporting an abradable seal, i.e. a hybrid design.
Owner:ADVANCED COMPONENTS & MATERIALS
Compounds as dynamic organ function monitoring agents
InactiveUS6887854B2Simple and efficient and effective monitoring of organ functionRapid liver uptakeUltrasonic/sonic/infrasonic diagnosticsBiocideDiseaseFluorescence
Highly hydrophilic indole and benzoindole derivatives that absorb and fluoresce in the visible region of light are disclosed. These compounds are useful for physiological and organ function monitoring. Particularly, the molecules of the invention are useful for optical diagnosis of renal and cardiac diseases and for estimation of blood volume in vivo.
Owner:MALLINCKRODT INC
Biocompatibility pre-gelatinized modified starch and preparation thereof
InactiveCN101497670AAbsorbentSpeed up absorptionSurgical adhesivesFibre treatmentBiocompatibility TestingHigh pressure
The invention relates to a biocompatible pre-gelatinized modified starch. The water absorbency is not less than one time, and the biocompatible pre-gelatinized modified starch is taken as biocompatible hemostatic material, biocompatible anti-blocking material, biocompatible tissue-healing promoting material, biocompatible surgical sealant or biocompatible wound closure tissue glue. The invention has the advantages that the biocompatible pre-gelatinized modified starch is directly acted on the wounded area with blood for immediately stopping bleeding, has obviously increased water absorbency and speed of water absorption and greater viscosity and stickiness and further plays the role in preventing the tissue and the blood vessel from being damaged during the process of stopping bleeding; the modified starch is easy to swell or dissolve in water, and is washed by normal saline after the bleeding stopping so as to reduce the residual in the body, to be favorable for wound healing and to avoid the pain due to tearing the gauze and the bandage out; the pre-gelatinized modified starch has the actions of bacterial resistance and anti-inflammatory; and the pre-gelatinized modified starch is stable, not easy to decompose, long in guarantee period, convenient for storage, resistant at high pressure and low pressure, resistant at high temperature and low temperature and not easy to change the physicochemical characteristics.
Owner:纪欣
Composite hydrogel drug delivery systems
InactiveUS7413752B2Reduce molecular weightEasy to processPowder deliveryIn-vivo radioactive preparationsMedicineMicroparticle
Compositions and methods are provided to control the release of relatively low molecular weight therapeutic species through hydrogels by first dispersing or dissolving such therapeutic species within relatively hydrophobic rate modifying agents to form a mixture. The mixture is formed into microparticles that are dispersed within bioabsorbable hydrogels, so as to release the water soluble therapeutic agents in a controlled fashion. Methods of using the compositions of the present invention in therapeutic systems are also provided.
Owner:INCEPT LLC
Compounds for fluorescence imaging
InactiveUS20100278745A1Improved propertyReduce diffuseUltrasonic/sonic/infrasonic diagnosticsMicrobiological testing/measurementIonSolid phases
Methods and compositions involving enzyme-activatable fluorophore polymer imaging agents for photodetection of specific tissues and / or human diseases and disorders are provided. In certain embodiments, the imaging agent comprises a hydrophilic polymer backbone (e.g., poly(L)lysine), a hydrophobic fluorophore, and a hydrophilic solubilizing agent. The solubilizing agent may comprise a quarternary ammonium group (e.g., a 1-methylnicotinic group) to enhance self-quenching of the fluorophore. Various methods for the generation and purification of imaging agents are also provided, including methods involving solid phase probe extraction or ion exchange purification.
Owner:UNIVERSITY OF GENEVA
Multifunctional assistant plating additive for hot dip plating process, preparation and use method thereof
ActiveCN101328568AReduce lossImprove stabilityHot-dipping/immersion processesDissolutionLiquid metal
The invention relates to a multifunctional plating assisting additive for a hot dipping metallization process and a preparation and application method thereof, and belongs to the metal material anticorrosive technical field for providing multiple plating assisting efficacy. The technical proposal of the invention comprises that: a plurality of cations or an amphoteric surfactant ( an equivalent concentration of a quaternary ammonium group is between 0.1 and 2 mol / L) and nonionics (an equivalent concentration of a polyoxyethylene group is between 0.5 and 5 mol / L) are dissolved in deionized water. The method can improve the wetting quality between a liquid-state metal and a workpiece, and the adhesive uniformity and continuity of the plating assisting additive, reduces the drying time, prevents the liquid-state metal from falling and splashing, shortens the dipping and plating time, saves raw materials, improves a residue form, reduces an ash content, increases an ash discharge speed, isolates air, stops oxidation, disperses residual dirt and is suitable for a plurality of processes of hot galvanizing, hot plating zinc-aluminum alloy, hot plating aluminum, etc. The preparation steps comprise dissolution, cubage determination, cooling, keeping stand and filling; when the multifunctional plating assisting additive is used, the multifunctional plating assisting additive is directly added into a plating assisting additive solution and is evenly stirred.
Owner:JIANGSU FEITUO INTERFACE ENG TECH CO LTD
Compressor flowpath
InactiveUS20130192198A1Reduce clearanceReduced flow separationPump componentsEngine fuctionsSlope angleEngineering
A core flowpath through a low pressure compressor section of a gas turbine engine includes an outer diameter, which has a slope angle relative to an axis defined by the core flowpath. The slope angle is a slope angle that is operable to prevent flow separation of a fluid passing through the core flowpath.
Owner:RAYTHEON TECH CORP
Scroll device integrating a feed pump
InactiveUS20100254835A1Prevent thermal deformationMaximum flexibilityRoller bearingsEngine of arcuate-engagement typeWorking fluidEngineering
A scroll device including two coupled stages on a rotary shaft, at both ends of an intermediate electric power device, wherein the first stage is formed by a first pressure variation device of an operating fluid, comprising a scroll case containing a fixed scroll and a mobile scroll relatively to the case, and with admission and outlet ports, and wherein the second stage is a feed pump which pumps the operating liquid and provides it in return.
Owner:ENEFTECH INNOVATION
Radioiodinated phospholipid ether analogs and methods of using the same
InactiveUS6255519B1Reduce accumulationReduce the amount requiredRadioactive preparation carriersIsotope introduction to organic compoundsHalf-lifePhospholipid Ethers
Improved radioiodinated phospholipid ether analogs are described which exhibit significant tumor avidity and longer plasma half-life relative to shorter chain analogs. Use of these compounds results in superior imaging and visualization of neoplastic lesions and tumor-specific cytotoxic cancer therapy.
Owner:MICHIGAN RGT UNIV
Split-cycle engine with disc valve
InactiveUS7481190B2Lower the volumeImprove efficiencyCombustion enginesRotary slide valveEngineeringValve seat
A split-cycle engine with disc valve includes a crankshaft, a power cylinder and a compression cylinder. A gas crossover passage interconnects the compression cylinder and the power cylinder. An air intake port circumscribes a periphery of the compression cylinder and defines an outer valve seat. An annular ring having a generally central opening is disposed between the compression cylinder and the air intake port and forms a washer valve for opening and closing the air intake port. A disc valve member is concentrically mounted over the central opening of the annular ring. The disc valve member includes a piston portion having a sidewall biased into engagement with the outer valve seat for controlling flow between the compression cylinder and the gas crossover passage.
Owner:SKADERI GRUP LLC
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