Modified starch absorbable hemostasia material and preparation method thereof

Abstract

The invention discloses an absorbable haemostatic material of a modified starch and a preparation method thereof. The haemostatic material is etherified modified starch or a composition which is formed by one or two or more than two of the etherified modified starch, cross-linked and composite modified starch, with a molecular weight of 15,000 to 2,000,000, a grain diameter of 10-1000Mu m and a water absorbency of 1 time to 100 times. The modified starch absorbable haemostatic material has the advantages that: the haemostatic material with biocompatibility is directly applied to bloody surface of wound to stop bleeding immediately, obviously increase the water absorbency and the water absorbing speed and have more viscosity and viscidity, thereby simultaneously blocking up damaged tissues and blood vessels while stopping bleeding. The haemostatic material is easy to swell or dissolve in water and after stopping bleeding, normal saline is used for washing to eliminate the haemostatic material not participating in stopping bleeding, thus reducing residues in the body, being beneficial to wound healing, and avoiding pains caused by unclosing pledget and bandage. The haemostatic material has the physical and chemical properties of stability, difficult decomposition, long guarantee period, convenient storage, high pressure resistance, low pressure resistance, high temperature resistance, low temperature resistance and difficult change.

Description

Technical field [0001] The invention relates to a modified starch absorbable hemostatic material and a preparation method thereof, in particular to a modified starch hemostatic material that is directly sprayed on blood wounds of humans, mammals, etc. for hemostasis and can be absorbed by the human body. The modified starch absorbable hemostatic material has biocompatibility, and can be further used as one of surgical anti-adhesion materials, tissue healing promoting materials, surgical sealants, and non-seam-free tissue glues for wounds. Background technique [0002] Surgery and trauma usually cause bloody wounds and cause a large amount of blood loss. It is necessary to use hemostatic methods in time. Here are several commonly used surgical absorbable hemostatic materials. [0003] 1. Absorbable gelatin sponge and collagen sponge [0004] Gelatin sponge is derived from animal tissue extracts, and its main component is animal collagen. Its hydrophilicity and porous structure can...

AI Technical Summary

Problems solved by technology

First of all, from the aspect of application, this hemostatic material is mainly limited to the hemostasis of skin or soft tissue wounds, and the hemostasis of tissues and organs in the deep part of the body cavity, especially the hemostasis under endoscopy (such as minimally invasive endoscopy, colonoscopy and laparoscopy). During operation) still lack effective means; The 2nd, from preparation method, epichlorohydrin is colorless oily liquid, has irritating smell like ether and chloroform, has toxicity and anesthesia, therefore unfavorable to environmental protection, production cost Thirdly, in terms of hemostatic effect, its water absorption is not strong enough, the water absorption multiple is low, and the speed of water absorption is slow, especially for active bleeding.

Fourth, its viscosity is low, and the gel formed after absorbing water has poor viscosity. Therefore, the clot formed after interacting with blood has poor adhesion to tissues, and cannot effectively block damaged tissues and blood vessels, thus affecting hemostasis. Effect

[0020] The natural native starch is in the form of powder. Because of its small and light particles, it often floats on the surface of the bleeding blood when it is sprayed on the bleeding wound. When encountering blood, the denatured starch often coalesces by itself, and it is difficult to penetrate into the bleeding site, especially for active patients. Bleeding, difficult to stop bleeding

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