Modified starch absorbable hemostasia material and preparation method thereof

A technology of modified starch and hemostatic materials, applied in the direction of absorbent pads, pharmaceutical formulations, applications, etc., can solve the problems of affecting the hemostatic effect, low viscosity, difficult to achieve hemostasis, etc., to promote wound tissue healing, good biocompatibility, The effect of improving the hemostatic effect

A technology of modified starch and hemostatic materials, applied in the direction of absorbent pads, pharmaceutical formulations, applications, etc., can solve the problems of affecting the hemostatic effect, low viscosity, difficult to achieve hemostasis, etc., to promote wound tissue healing, good biocompatibility, The effect of improving the hemostatic effect

CN101361986AActive Publication Date: 2009-02-11BEIJING UNIVERSAL LIKANG TECH CO LTD
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  • Modified starch absorbable hemostasia material and preparation method thereof
  • Modified starch absorbable hemostasia material and preparation method thereof
  • Modified starch absorbable hemostasia material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0103] A modified starch absorbable hemostatic material, including carboxymethyl starch, which is made from native starch (potato starch) through etherification and denaturation to make carboxymethyl starch. The carboxymethyl starch raw material is placed in a boiling machine at 40-50°C , Adding distilled water, coagulating, pelletizing, and sieving to prepare hemostatic material 66# (manufacturer Starch Medical Inc. batch number 070717, degree of substitution is 2 to 4). The molecular weight of the carboxymethyl starch 66# product is 15,000-2,000,000, and the particle size is 10-1000μm. Among them, starch particles with a particle size of 30-500μm account for not less than 95% of the total starch particles. More preferably, the particle size is less than 95%. The viscosity of the 6.67% starch solution at 50~250μm at 37℃ is 557.9mPa·s, and the viscosity work of the modified starch when water is saturated at room temperature is 68.1g·mm.

Embodiment 2

[0105] A modified starch absorbable hemostatic material, including hydroxyethyl starch, which is prepared from native starch (potato starch) through etherification and denaturation to produce hydroxyethyl starch. The raw material of hydroxyethyl starch is placed in a boiling machine at 40-50°C. Distilled water was added, polymerized, pelletized, and sieved to prepare hemostatic material 88# (manufacturer Starch Medical Inc. batch number 071122). The molecular weight of the hydroxyethyl starch 88# product is 15,000-2,000,000, and the particle size is 10-1000μm. Among them, starch particles with a particle size of 50-500μm account for not less than 95% of the total starch particles. More preferably, the particle size is less than 95%. The viscosity of the 6.67% starch solution at 50~250μm at 37℃ is 30.6mPa·s, and the viscosity work of the modified starch when water is saturated at room temperature is 75.2g·mm.

[0106] The water absorption performance of the invention is measured by...

Embodiment 3

[0136] A biocompatible modified starch used for hemostasis, including cross-linked carboxymethyl starch, which is made from original starch (potato starch) through etherification and cross-linking and denaturation to make cross-linked carboxymethyl starch, raw material of cross-linked carboxymethyl starch Place it in a boiling machine at 40-50°C, add distilled water, polymerize, pelletize, and sieve to make cross-linked carboxymethyl starch hemostatic material 66#+ (manufacturer StarchMedical Inc. batch number 071108). The cross-linked carboxymethyl starch 66#+ product has a molecular weight of 15,000-2,000,000 and a particle size of 10-1000μm. Among them, starch particles with a particle size of 50-500μm account for not less than 95% of the total starch particles.

[0137] For each modified starch and Arista in Examples 1, 2, and 3 of the present invention TM Hemostatic powder (medafor, USA) was subjected to centrifugal method to determine the water absorption rate, and the resul...

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Abstract

The invention discloses an absorbable haemostatic material of a modified starch and a preparation method thereof. The haemostatic material is etherified modified starch or a composition which is formed by one or two or more than two of the etherified modified starch, cross-linked and composite modified starch, with a molecular weight of 15,000 to 2,000,000, a grain diameter of 10-1000Mu m and a water absorbency of 1 time to 100 times. The modified starch absorbable haemostatic material has the advantages that: the haemostatic material with biocompatibility is directly applied to bloody surface of wound to stop bleeding immediately, obviously increase the water absorbency and the water absorbing speed and have more viscosity and viscidity, thereby simultaneously blocking up damaged tissues and blood vessels while stopping bleeding. The haemostatic material is easy to swell or dissolve in water and after stopping bleeding, normal saline is used for washing to eliminate the haemostatic material not participating in stopping bleeding, thus reducing residues in the body, being beneficial to wound healing, and avoiding pains caused by unclosing pledget and bandage. The haemostatic material has the physical and chemical properties of stability, difficult decomposition, long guarantee period, convenient storage, high pressure resistance, low pressure resistance, high temperature resistance, low temperature resistance and difficult change.

Description

Technical field [0001] The invention relates to a modified starch absorbable hemostatic material and a preparation method thereof, in particular to a modified starch hemostatic material that is directly sprayed on blood wounds of humans, mammals, etc. for hemostasis and can be absorbed by the human body. The modified starch absorbable hemostatic material has biocompatibility, and can be further used as one of surgical anti-adhesion materials, tissue healing promoting materials, surgical sealants, and non-seam-free tissue glues for wounds. Background technique [0002] Surgery and trauma usually cause bloody wounds and cause a large amount of blood loss. It is necessary to use hemostatic methods in time. Here are several commonly used surgical absorbable hemostatic materials. [0003] 1. Absorbable gelatin sponge and collagen sponge [0004] Gelatin sponge is derived from animal tissue extracts, and its main component is animal collagen. Its hydrophilicity and porous structure can...

Claims

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Application Information

Patent Timeline
11 Feb 2009
Publication
CN101361986A
IPC
A61L15/28; A61L15/58; A61L15/64; A61L24/08; A61L31/04
CPC
A61L2400/04; C08L3/04; C08L3/08; A61L24/08; C08L2205/02
Inventors
纪欣; 邢程