Vitamin E selenium microcapsule tablet and preparation method and application thereof

A technology of vitamins and microcapsules, which can be used in applications, anti-toxins, and pill delivery. It can solve the problems of cell membrane and cell wall peroxidation damage, activity reduction, etc., and achieve the effects of preventing human cell damage, easy absorption, and improving immunity.

Inactive Publication Date: 2018-11-27
济源希健生物医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When selenium is deficient, the activity of this enzyme decreases, and it cannot fully catalyze peroxides to cause the accumulation of lipid free radicals and peroxides, resulting in peroxidative damage to cell membranes and cell walls

Method used

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  • Vitamin E selenium microcapsule tablet and preparation method and application thereof
  • Vitamin E selenium microcapsule tablet and preparation method and application thereof
  • Vitamin E selenium microcapsule tablet and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Grind L-selenium-methylselenocysteine, vitamin E microcapsules (50% content), microcrystalline cellulose, dextrin, and sugar powder in advance, and pass through a 60-mesh sieve; Selenocysteine, vitamin E microcapsules (50% content) are mixed according to the mass ratio of 0.035:15, then add microcrystalline cellulose that mass ratio is 5:5:10: dextrin: powdered sugar mixes, and then Add 7.5% PVP aqueous solution with a mass ratio of 1 and stir evenly to prepare a soft material (the degree to which the prepared soft material can be held tightly with hands can be formed into agglomerates, and can be cracked by pressing with fingers); the prepared soft material is passed through a 14-mesh sieve Net granulation, and then drying in a vacuum oven at 40°C, the moisture content is controlled at 2%, and then passing through a 18-mesh sieve to remove broken parts. The granules that will make, add the magnesium stearate that mass ratio is 0.1:0.1: Talcum powder, fully mix, then be...

Embodiment 2

[0025] Grind L-selenium-methylselenocysteine, vitamin E microcapsules (50% content), microcrystalline cellulose, dextrin, and sugar powder in advance, and pass through a 100-mesh sieve; L-selenium-methylselenocysteine Selenocysteine, vitamin E microcapsules (50% content) are mixed according to the mass ratio of 0.005:5, then add microcrystalline cellulose that mass ratio is 15:25:25: dextrin: powdered sugar mixes, and then Add a 7.5% PVP aqueous solution with a mass ratio of 3 and stir evenly to prepare a soft material (the degree to which the prepared soft material reaches is that it can form agglomerates when held tightly by hand, and can be split by pressing with fingers); the prepared soft material is passed through a 20-mesh sieve Net granulation, then drying in a vacuum drying oven at 65°C, the moisture content is controlled at 8%, and then passing through a 24-mesh sieve to remove broken parts. The granules that will make, add the magnesium stearate that mass ratio is 1...

Embodiment 3

[0027] Grind L-selenium-methylselenocysteine, vitamin E microcapsules (50% content), microcrystalline cellulose, dextrin, and sugar powder in advance, and pass through an 80-mesh sieve; L-selenium-methylselenocysteine Selenocysteine, vitamin E microcapsules (50% content) are mixed according to the mass ratio of 0.010:10, then add microcrystalline cellulose that mass ratio is 10:20:20: dextrin: powdered sugar mixes, and then Add a 7.5% PVP aqueous solution with a mass ratio of 2 and stir evenly to prepare a soft material (the degree to which the prepared soft material reaches is that it can form agglomerates when held tightly by hand, and can be split by pressing with fingers); the prepared soft material is passed through a 18-mesh sieve Net granulation, then drying in a vacuum drying oven at 50°C, the moisture content is controlled at 6%, and then passing through a 20-mesh sieve to remove broken parts. The granules that will make, add the magnesium stearate that mass ratio is ...

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Abstract

The invention belongs to the field of functional foods and discloses a vitamin E selenium microcapsule tablet and a preparation method and application thereof. The vitamin E selenium microcapsule tablet comprises L-selenium-methyl selenocysteine, vitamin E microcapsules (50% in content), microcrystalline cellulose, powdered sugar, dextrin, magnesium stearate and talcum powder. The preparation method includes that main functional components including L-selenium-methyl selenocysteine and vitamin E microcapsules (50% in content) and other auxiliary materials are prepared proportionally and subjected to pretreatment, mixing, soft material making, granulating, drying, shaping, tabletting and the like to obtain the vitamin E selenium microcapsule tablet. The vitamin E selenium microcapsule tablet has evident in-vivo and in-vitro oxyradical resistance activity.

Description

technical field [0001] The invention belongs to the technical field of functional food, and in particular relates to a vitamin E selenium microcapsule tablet, a preparation method and an application thereof. Background technique [0002] Organic selenium L-selenomethylselenocysteine ​​(L-Se-methylselenocysteine, L-SeMC) is a methylated selenocysteine, a new type of selenium enhancer, with similar glutathione Peptide peroxidase (GSH-Px) activity, play an antioxidant role. Vitamin E (Vitamin E, VE), also known as tocopherol, is a group of biologically active phenolic compounds with similar chemical structures, which are necessary for maintaining normal reproductive function of animals, promoting body metabolism, maintaining muscle health and antioxidation substance. Both L-SeMC and VE have certain antioxidant capacity. [0003] Selenium is an essential trace element for human growth and development. Selenium is a component of GSH-Px. GSH-Px has anti-oxidation function, whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/198A61K31/355A61K47/38A61P3/02A61P39/06A23L33/15A23L33/175
CPCA23L33/15A23L33/175A23V2002/00A61K9/2054A61K9/2081A61K31/198A61K31/355A61P3/02A61P39/06A61K2300/00A23V2200/302
Inventor 姚一姚永强冯书晓范江伟姚品李金
Owner 济源希健生物医药科技发展有限公司
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