Whitening and freckle-removing cosmetic composition containing lipidosome and application thereof
A cosmetic composition and a whitening and freckle-removing technology are applied in the field of whitening and freckle-removing cosmetics, which can solve the problems of easily causing dependence, human injury, toxic and side effects, and achieve the effects of improving body immunity, lightening pigmentation, and being easy to absorb.
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Embodiment 1
[0033] Preparation of phosphate buffered saline (PBS): Weigh disodium hydrogen phosphate (Na 2 HPO 4 12H 2 O) 0.37g and sodium dihydrogen phosphate (NaH 2 PO 4 2H 2 O) 2.0g, add an appropriate amount of purified water, dissolve and dilute to 1000mL (pH is about 5.7).
[0034] Preparation of phospholipid film: Weigh 400mg of lecithin and 80mg of cholesterol, place them in a 100mL flask, add absolute ethanol to dissolve, place the flask in a water bath at 60-65°C, and spin on a rotary evaporator to remove the organic solvent under reduced pressure to make the phospholipids The ethanol solution forms a film on the wall, and the ethanol is removed under reduced pressure to prepare a phospholipid film.
[0035] (1) Ascorbic acid liposome preparation
[0036] Add 40 mL of PBS containing 160 mg of ascorbic acid and 320 mg of Tween-80, spin the membrane for 30 minutes under reduced pressure to form a milky white suspension; transfer the milky white suspension to a brown volumetr...
Embodiment 2
[0042] Embodiment 2 skin use effect experiment
[0043] Mix 1.5% hyaluronic acid, 1% ascorbic acid, 0.05% L-selenium-methylselenocysteine, 1% Tween-80, and the rest with purified water to make an emulsion. Volunteers used the emulsion prepared in Example 1 and compared the emulsion prepared by direct mixing. The trial period was 1 month. After the liposome-containing emulsion of the present invention was continuously used for 1 month, the freckle removal effect was obviously better than that of the simple mixture of materials. Lotion products. See the results of the trial Figure 1 ~ Figure 4 .
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