126 results about "Selenium Compound" patented technology

The invention relates to the technical field of nutrient element extraction, and discloses a step-by-step extraction method of organic selenium in natural selenium-rich agricultural products, which comprises the following steps: cleaning, drying and crushing the natural selenium-rich agricultural products into fine powder; then sequentially using an aqueous solution containing a buffer agent, low-concentration ethanol and a high-concentration organic solvent for ultrasonic-assisted extraction to respectively obtain water-soluble, hydrophilic, hydrophobic and fat-soluble organic selenium compounds; and finally, combining the extracting solutions in the steps, and carrying out rotary evaporation concentration and purification treatment to obtain the high-purity organic selenium compound. Through a step-by-step extraction method, different types of organic selenium compounds in natural selenium-rich agricultural products are efficiently extracted by using the aqueous solution, the low-concentration ethanol and the high-concentration organic solvent respectively under low-temperature and mild conditions, so that high purity and biological activity are kept, meanwhile, the process flow is simplified, and the production cost is reduced. The energy consumption and the use of organic solvents are reduced, the environmental pollution is reduced, and the method is suitable for large-scale industrial production.

The invention relates to the technical field of heavy metal wastewater treatment, in particular to an electrochemical device and an extraction method for extracting copper from copper-containing wastewater, an anode material of the electrochemical device is one of activated carbon, graphite, lead dioxide, BDD and CumX1-a-bYaZb, a cathode material of the electrochemical device is one of CunX1-c-dYcZd and a carbon-selenium compound, and after a cathode and an anode are connected with a power supply, the copper is extracted from the copper-containing wastewater. The device is used for treating copper-containing wastewater. Wherein 1 < m < = 2, 1 < = n < 2, and m > n; 0 < = a < = 1, 0 < = b < = 1, and 0 < = a + b < = 1; 0 < = c < = 1, 0 < = d < = 1, and 0 < = c + d < = 1; x, Y and Z are selected from one of S, Se and Te. The copper-based chalcogenide is used as an electrode material and forms an electrochemical device with other electrodes, the device is an electro-catalysis coupling deionization system with electrochemical oxidation complex breaking performance, and the selective removal effect on Cu < 2 + > in organic complex copper-containing wastewater, strong acid wastewater and wastewater interfered by high-concentration salt ions and heavy metal ions is good; by means of the device, the complexing breaking effect on an organic complexing pollutant Cu-EDTA can be effectively achieved, and then Cu < 2 + > extraction is completed.

The invention provides a novel organic selenium compound and a synthesis method thereof, and application of the compound in preparation of drugs for preventing and / or treating cancers. According to the organic selenium compound provided by the invention, the natural active compound and the selenium element are combined, so that the anticancer activities of the natural active compound and the selenium element generate a synergistic effect, the safety and the anticancer effect of the organic selenium compound are improved, and the organic selenium compound has huge potential in the aspects of preventing and treating cancers. # imgabs0 #

The invention relates to a small molecular boron-10 carrying agent, a preparation method and application. The structural formula of the small molecule boron-10 carrying agent is shown as a formula (I). The invention also provides a preparation method of the small molecular boron-10 carrying agent, which comprises the following steps: carrying out condensation connection on a phenylboronic acid derivative and N-(2-aminoethyl) maleimide hydrochloride, and covalently coupling a boron drug to obtain a first intermediate; n < 2 >-(((9H-fluorene-9-yl) methoxy) carbonyl)-N < 6 >-(tert-butoxycarbonyl)-L-lysine, N-(2-aminoethyl) maleimide hydrochloride and a phenylboronic acid derivative are subjected to condensation connection, and a second intermediate is obtained; carrying out esterification connection on a selenium-containing compound and a DNA repair inhibiting compound to obtain a third intermediate; and carrying out condensation connection on the second intermediate and the third intermediate, and connecting the first intermediate to obtain the small molecule boron-10 carrying agent. The invention solves the problems of limited treatment effect and difficulty in inhibiting DNA damage repair in the existing BNCT. # imgabs0 # (I)

The invention belongs to the technical field of battery materials, and particularly relates to a sodium ion battery positive electrode material and a preparation method and application thereof. The preparation method of the sodium ion battery positive electrode material provided by the invention comprises the following steps: 1) mixing a sodium source, a precursor and a hexavalent tellurium source, and carrying out first calcination to obtain a first calcined material; and 2) mixing the first calcined material obtained in the step 1), a metal selenium compound and an organic solvent, and performing second calcination to obtain the sodium-ion battery positive electrode material. The structure and interface stability of the material are effectively enhanced through a three-in-one modification strategy of doping the high-valence element Te6 + coating the metal selenium compound and adjusting the microstructure, and the obtained sodium ion battery positive electrode material is stable in structure, stable in interface and good in redox reversibility and has good rate capability and cycle performance.

The invention relates to a method for preparing small-particle-size red nano-selenium particles and application of the small-particle-size red nano-selenium particles, and belongs to the technical field of selenium compounds. The nano-selenium particles contain nano-selenium and a lipoic acid oligomer. The preparation method comprises the following steps: respectively preparing nano-selenium and a lipoic acid oligomer, and uniformly mixing the nano-selenium and the lipoic acid oligomer to obtain the nano-selenium particles. The nano-selenium particles have good stability; the content of total protein and fat in highland barley grains to which the nano-selenium particles are applied is remarkably increased through detection, the nano-selenium particles become an effective means for selenium enrichment of crops, the nano-selenium particles are well applied to selenium-enriched planting of highland barley, and the application of the nano-selenium particles to the highland barley grains is developed by combining development of new selenium-enriched crop varieties and research of a new selenium fertilizer application technology. And a powerful promotion effect is achieved on the development of selenium-enriched ecological agriculture.

The invention relates to the technical field of biological materials, in particular to a biocompatible method for synthesizing quantum dots from living cells, which comprises the following steps: in the living cell culture process, adding an organic selenium compound containing Se-Se or Se-S bonds into a culture medium, and incubating to obtain selenized cells; further culturing by using a culture medium containing a metal ion-glutathione complex to obtain quantum dots containing metal elements and Se elements; according to the method, the generation of an active selenium precursor with cytotoxicity, such as hydrogen selenide, is effectively avoided, and meanwhile, the outbreak of active oxygen species in cells is also avoided, so that high quantum dot synthesis efficiency is shown. In-vitro cell experiment results show that the cells are endowed with a fluorescent function and still maintain good cell viability, and the cell viability is maintained at 80% or above; in-vivo experiment results show that the fluorescent cells with the synthesized quantum dots have good proliferation, tumor formation, invasion and metastasis capabilities in vivo.

The present invention relates to a method for determining the IC50 value of the toxicity of a selenium compound to cancer cells based on gene expression. Specifically, the method comprises the steps of: (1) performing dimensionality reduction processing on cancer cell gene expression data using an FCBF algorithm to obtain a cancer cell gene expression dataset F' after dimensionality reduction; (2) dividing the cancer cell gene expression dataset F' after dimensionality reduction obtained in step (1) into an F' training sample subset and an F' test sample subset; (3) performing a Gauss-Newton iterative algorithm on the F' training sample subset and the IC50 values ​​of the toxicity of selenium compounds to different cancer cells to obtain a determination model for determining the IC50 value of the toxicity of selenium compounds to cancer cells based on cancer cell gene expression; using the determination model, determining the IC50 value of the toxicity of selenium compounds to cancer cells according to the gene expression of cancer cells. The method of the present invention can quickly and accurately determine the IC50 value of the toxicity of selenium compounds to cancer cells based on gene expression data.

The application belongs to the technical fields of functional material preparation, catalysis and transition metal complex material, and discloses a selenium compound heterojunction catalyst coupled with hydrogen evolution, a method and application. In preparation, a cobalt source, urea, a foamed nickel and an ammonium fluoride mixed solution are mixed in a reaction, and after being hydrothermally synthesized and cooled to room temperature, the precursor Co(OH)2 / NF is obtained by washing with ethanol and water and drying. Then, selenium powder and a strong base are added into a reaction kettle, and heating is performed to obtain the heterojunction catalyst NiSe@CoSe2 / NF with high density. The obtained heterojunction material can be used for electrocatalysis of 5-hydroxymethylfurfural. When the current density is 10 mAcm ‑2 , the potential is 1.29 V, and the optimal conversion rate is more than 98%, and the catalyst has excellent catalytic activity for electrocatalysis of 5-hydroxymethylfurfural oxidation.

Selenium-containing capsule structure (1), comprising: - a shell (10) containing a selenium compound, a selenium-containing composition or a combination thereof; and - a recording room (20) located in the shell (10).

The application provides a preparation method of high-selenium compound powder for postoperative and radiotherapy rehabilitation immune repair, and belongs to the technical field of functional food or special medical use formula food processing technology.The application realizes sufficient wall breaking by respectively pre-wetting and low-temperature complex enzymolysis of hard plant wall and fungal wall raw materials, and then prevents active loss by using endogenous substances of the raw materials for in-situ anchoring without adding, after drying and crushing, adding postbiotic powder, active peptide, whey protein, yeast beta-glucan, EGCG and other heat-sensitive components into low-temperature sterile dry mixing, while maximizing the release of organic selenium and immune active substances, the heat-sensitive functional components are completely protected from degradation and inactivation, and finally the technical target of sufficient wall breaking, complete activity and stable immune repair effect is achieved.The product prepared by the application can improve the immune organ damage and immune homeostasis imbalance caused by radiotherapy, and is suitable for the immune repair of postoperative and radiotherapy rehabilitation population.

The application belongs to the technical field of biological medicine, and particularly relates to a nano selenium compound with liver fibrosis prevention and treatment integration function and a preparation and application thereof. The preparation method is as follows: bovine serum albumin is mixed with sodium selenite, and under the reduction of glutathione, elemental selenium is generated, BSA-Se is obtained through dialysis ultrafiltration, and then the BSA-Se is reacted with dopamine hydrochloride in a Tris-HCl buffer solution in the dark to obtain a nano drug BSA-Se@PDA (BSP). The synthesis method is simple in process, convenient in operation and good in repeatability; the BSP is high in stability, good in biocompatibility, can effectively eliminate active oxygen, inhibit the activation of liver stellate cells, and thus significantly relieve liver fibrosis; meanwhile, the BSP also shows good protection in alcoholic liver injury in the fibrosis stage, realizes the dual treatment effects of'source intervention' and 'pathological process regulation' of liver fibrosis, and provides a new nano preparation and intervention strategy for the treatment of alcoholic liver disease and liver fibrosis.

A compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof is disclosed. The invention also discloses a selenium-containing polymer, injectable selenium-containing hydrogel prepared from the selenium-containing polymer, and a preparation method and application of the injectable selenium-containing hydrogel. # imgabs0 #

The invention discloses an optimized formula of plant organic nano-selenium for activating an immune system, inhibiting cancer cell proliferation, preventing cancers, preventing tumors, resisting oxidation and resisting aging, and belongs to the technical field of functional food formulas. According to the formula, selenium-enriched yeast and dl-alpha-tocopheryl acetate are used as main materials, L-ascorbic acid can be selectively added, auxiliary materials such as microcrystalline cellulose and starch sodium octenylsuccinate are matched to prepare a capsule preparation, and the content of functional components in a single preparation is precisely controlled as follows: 90-100 micrograms of selenium and 40-50 mg of vitamin E, or 90-100 micrograms of selenium, 40-50 mg of vitamin E and 40 mg of vitamin C. According to the invention, synergistic interaction is realized through scientific proportioning of functional components, a fat-soluble and water-soluble dual anti-oxidation system is constructed, an organism immune system can be effectively activated, cancer cell proliferation can be inhibited, and meanwhile, the composition has multiple effects of preventing cancers, preventing tumors, resisting oxidation and resisting aging; the preparation method is simple and convenient in process, easy in parameter control and suitable for industrial large-scale production, the prepared preparation is high in active ingredient stability, excellent in bioavailability, high in safety and capable of being widely applied to preparation of related functional foods, and all raw materials are food-grade. The technical problems that an existing selenium compound formula is unreasonable in proportion, poor in efficacy synergy and poor in preparation performance are solved.

Provided herein are novel sulfur or selenium-containing compound, compositions containing the compounds, and preparation methods and uses thereof. The sulfur or selenium-containing compounds are compounds represented by Formulae (I) to (II), or tautomers, stereoisomers, prodrugs, crystal forms, isotopically labeled forms, pharmaceutically acceptable salts, hydrates or solvates thereof. The compounds and compositions of the present disclosure can be used to treat diseases or disorders mediated by po1θ, in particular, cancer. (I) (II)

The invention belongs to the field of selenium compounds, and particularly relates to a layered Cu2Se material and a preparation method and application thereof. The layered Cu2Se material comprises two layers of selenium and a Se-Cu-Se repeating layer unit formed by copper located between the two layers of selenium, wherein the atomic ratio of Cu to Se in the Se-Cu-Se repeating layer unit is 2: 1; and the Se-Cu-Se repeating layer units are repeatedly arranged in the thickness direction. According to the layered Cu2Se material, Se-Cu-Se is taken as a repeated layer unit, and layers are combined together by Van der Waals force, so that a layered quasi-two-dimensional structure with crystal preferred orientation is formed. The lamellar quasi-two-dimensional structure is relatively low in stripping energy and is about easy to strip, and Se becomes unstable after stripping, so that two-dimensional copper can be prepared.

This invention relates to the field of feed, specifically disclosing a method for preparing selenium- and strontium-enriched amino acid chelated feed; including the preparation of selenium / strontium-enriched amino acid fermentation products, the preparation steps of which are as follows: S1: Inoculating activated microalgae and yeast strains into a culture medium supplemented with selenium and strontium compounds, the pH of the culture medium is 6.5-7.5, the culture temperature is 25-35℃, and the culture is carried out under light and aeration conditions for 5-7 days; S2: Collecting selenium / strontium-enriched algal biomass using a flocculant, and ultrasonically treating the selenium / strontium-enriched algal biomass for 10-20 minutes, then adding soybean meal and rapeseed cake to the selenium / strontium-enriched algal biomass and stirring; S3: Adding cellulase, papain, alkaline protease, and pectinase for enzymatic hydrolysis to obtain selenium / strontium-enriched amino acid fermentation products. The selenium- and strontium-enriched amino acid chelated feed and its preparation method of this invention can improve the intestinal health of animals, increase the absorption and utilization rate of nutrients, and enhance animal immunity.

The invention discloses a preparation method and application of vitamin E hydrogel with an oxidation-reduction characteristic. The vitamin E hydrogel with the oxidation-reduction characteristic is prepared from the following components in percentage by weight: 10.0 to 30.0 percent of TPGS-SH, 0 to 10.0 percent of TPGS-SeSe-TPGS and 60 to 90.0 percent of solvent. Redox dynamic response regulation and control of the hydrogel are achieved through molecular structure design, in an oxidation environment, sulfydryl in TPGS-SH molecules is subjected to a bimolecular oxidation reaction to form a disulfide bond cross-linked dimer, a selenium-containing compound TPGS-SeSe-TPGS is introduced to cooperate with a catalytic oxidation process, the gelation rate is remarkably increased, and in a physiological reduction environment, the selenium-containing compound TPGS-SeSe-TPGS can be used for preparing the hydrogel. The disulfide bond can be reduced and broken by glutathione and other reducing agents, so that the controllable degradation of the gel network is realized. In-vitro experiments show that the hydrogel can maintain the structural stability for more than 100 hours in simulated body fluid, and can be completely degraded within 84 hours under the condition of 10mM glutathione. According to the invention, an intelligent gel system with vitamin E biological activity and redox dynamic response is constructed for the first time, and a potential treatment platform is provided for local administration of oxidative stress related diseases.

The invention belongs to the field of organic synthesis, and particularly relates to a synthesis method for constructing a beta-amino-organic selenium compound through copper catalysis. The structural formula of the compound is shown as a general formula X, and the compound with the general formula X is prepared from aryl olefin, aryl selenide, a copper catalyst, an oxidizing agent and a solvent through a one-pot method. Research finds that under the action of an oxidizing agent, aryl selenide is oxidized into selenium positive ions by the oxidizing agent, then aryl olefin is attacked to form a carbocation intermediate, then nitrile nucleophilic attacks carbocation under the catalysis of copper, and then the target beta-amino-organic selenium compound is formed. The synthesis method is low in cost, green, efficient and wide in substrate application range.

The invention discloses a selenium compound and its application, belongs to the technical field of pesticide compounding, and solves the problem that the control method of rapeseed sclerotinia in the prior art is not environmentally friendly and safe. The active ingredients of the selenium compound are composed of sodium selenite and cuminic acid, and the mass ratio of sodium selenite to cuminic acid is 1:2-3. The compounding of sodium selenite and cuminic acid in the invention shows a synergistic effect, and has a good effect in the control of sclerotinia of rapeseed detached leaves and growing rapeseed plants, which effectively solves the problem of reduced efficacy of existing fungicides and damage to the ecological environment.

The invention relates to application of lipidosome nano-selenium in preparation of a nutritional feed additive, and belongs to the field of poultry feed. The invention provides an application of lipidosome nano-selenium in preparation of a nutritional feed additive. Experiments prove that the selenium content in serum of the broiler fed with the phospholipid bilayer-coated nano-selenium is remarkably higher than that of the broiler fed with a selenium compound not coated with the phospholipid bilayer, the phospholipid bilayer can promote the broiler to absorb the nano-selenium, the utilization rate of selenium in the broiler is further increased, and the yield of the broiler is increased. The chicken quality is improved. Meanwhile, the lipidosome nano-selenium can improve the immune performance of the intestinal mucosa of the poultry, optimize the intestinal flora structure, promote the generation of beneficial metabolites, namely short-chain fatty acids, of the intestinal tract, improve the health level of the intestinal tract of the poultry, reduce the addition of antibiotics and promote the green, healthy and sustainable development of the livestock and poultry industry.

The invention relates to a medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises dissolved oxygen (DO), preferably 0.5 ppm to 8 ppm DO.

The invention belongs to the field of meat product processing, and particularly relates to a selenium-rich meat product and a processing method thereof. The invention provides a selenium-rich meat product, the selenium-rich meat product comprises selenium-rich pork and seasonings, and the seasonings comprise edible salt, chilli powder, Chinese prickly ash powder, dark soy sauce and oyster sauce. According to the method disclosed by the invention, the selenium-enriched pork is thermally processed on the basis of a low-temperature vacuum slow cooking technology, and volatilization and liquefaction of selenium compounds in the processing process of the selenium-enriched pork are reduced by reducing the processing temperature, so that the problems of low oxidation resistance and low bioavailability of the selenium-enriched pork are solved, and the quality of a final selenium-enriched pork product is improved.

The invention relates to, among others, a dispersion electrolyte for galvanically depositing particle-containing nickel or nickel alloy layers. The dispersion electrolyte comprises 2 to 200 g / L of nickel ions, in total 1 to 200 g / L of at least one type of particle, selected from inorganic piezoelectric particles, electrically conductive ceramic particles, and combinations thereof, an anionic and / or non-ionic dispersant, and water. In the case of a nickel alloy, the dispersion electrolyte contains ions of at least one other metal, selected from transition metals, noble metals, and combinations thereof, in a total concentration of up to 40 g / L and / or at least one non-metal compound, selected from phosphor compounds, sulfur compounds, selenium compounds, tellurium compounds, carbon compounds, and combinations thereof, in a total concentration of up to 50 g / L. The pH value equals 2.0 to 7.0. By virtue of the dispersion electrolyte, a particle-containing nickel or nickel alloy layer can be galvanically deposited onto a metal or metallized substrate.

The present invention provides a method for synthesizing a selenium-containing compound and its application. The provided method for synthesizing a selenium-containing compound uses a multi-enzyme catalytic system to introduce selenium element into a substrate to form a selenium-containing compound. The multi-enzyme catalytic system includes a sulfur transfer protein, a sulfur carrier protein, and a sulfur carrier protein kinase. The present invention utilizes a multi-enzyme catalytic system derived from microorganisms, including a sulfur transfer protein, a sulfur carrier protein, and a sulfur carrier protein kinase, to achieve the introduction of selenium element into the structure of organic small molecule compounds. The biological enzymes used in the present invention can be directly obtained by microbial fermentation. The process of introducing selenium element has the characteristics of being green and efficient, and is an important solution strategy for the synthesis strategy of selenium-containing compounds. The catalytic system mediated by the sulfur carrier protein is typically representative. According to the substrate selectivity and difference of the sulfur carrier protein system, selenium element can be introduced into different small molecule compounds, thereby different selenium-containing compounds can be obtained.

The present invention includes compositions and method of treating a textile with an antimicrobial agent, the method comprising contacting the textile with an antimicrobial agent that comprises a reactive dye or crosslinking agent comprising an organo-selenium compound in a treatment solution.

To provide a climacteric disorder improver, a climacteric disorder prevention agent, a food composition for improving climacteric disorder, a food composition for preventing climacteric disorder, a method for determining crisis of climacteric disorder, and a method for predicting crisis of climacteric disorder.SOLUTION: The invention provides, a climacteric disorder improver containing selenium compounds as an active ingredient, a climacteric disorder prevention agent containing selenium compounds as an active ingredient, a food composition for improving climacteric disorders containing selenium compounds as an active ingredient, a food composition for preventing climacteric disorders containing selenium compounds as an active ingredient, a method for determining the onset of climacteric disorders that includes a step of measuring the selenium concentration in the subject's sample, and a method for predicting the onset of climacteric disorders that includes a step of measuring the selenium concentration in the subject's sample.SELECTED DRAWING: None

The present invention provides novel organoselenium compounds and methods for their synthesis, as well as their use in the preparation of drugs for the prevention and / or treatment of cancer. The compounds provided by the present invention combine naturally occurring active compounds with selenium, creating a synergistic anticancer effect and enhancing their safety and anticancer efficacy, showing great potential for the prevention and treatment of cancer.

The invention discloses an application of a nutritional composition in preparation of an immunoregulation product. The nutritional composition comprises a lactoferrin gastrointestinal digest and a selenium gastrointestinal digest, wherein in the nutritional composition, the content of the lactoferrin gastrointestinal digests is 80 to 180 [mu] g / mL; in terms of selenium element, the content of selenium gastrointestinal digests is 12-28 ng / mL. The nutritional composition provided by the invention contains digestive juice compounded by lactoferrin and selenium, and compared with single lactoferrin and selenium, the nutritional composition has a better synergistic anti-inflammatory effect.

The present application belongs to the field of gas detection, and relates to a combined detection tube for detecting carbon monoxide concentration in blood. The device of the present application is composed of a sample adding tube and a detection tube. The filler section arranged in the sample adding tube can effectively destroy red blood cells to release CO gas under the action of Cr(VI) / Cr(III) redox system, and at the same time, the reducing substances such as glutathione (GSH) and ascorbic acid in blood are removed through the interference removal section, thereby significantly improving the specificity and accuracy of detection. The indicating glue section in the detection tube adopts a platinum-selenium compound and a potassium iodate system, which occurs a color reaction in the presence of CO: I2O5+5CO→I2+5CO2, and the generated iodine element presents a brown color development band, the length of which is positively correlated with the concentration of HbCO, so as to realize the visual quantitative analysis of the content of carboxyhemoglobin in blood.