49 results about "Selenium Compound" patented technology

The application belongs to the technical field of biological medicine, and particularly relates to a nano selenium compound with liver fibrosis prevention and treatment integration function and a preparation and application thereof. The preparation method is as follows: bovine serum albumin is mixed with sodium selenite, and under the reduction of glutathione, elemental selenium is generated, BSA-Se is obtained through dialysis ultrafiltration, and then the BSA-Se is reacted with dopamine hydrochloride in a Tris-HCl buffer solution in the dark to obtain a nano drug BSA-Se@PDA (BSP). The synthesis method is simple in process, convenient in operation and good in repeatability; the BSP is high in stability, good in biocompatibility, can effectively eliminate active oxygen, inhibit the activation of liver stellate cells, and thus significantly relieve liver fibrosis; meanwhile, the BSP also shows good protection in alcoholic liver injury in the fibrosis stage, realizes the dual treatment effects of'source intervention' and 'pathological process regulation' of liver fibrosis, and provides a new nano preparation and intervention strategy for the treatment of alcoholic liver disease and liver fibrosis.

The invention discloses an optimized formula of plant organic nano-selenium for activating an immune system, inhibiting cancer cell proliferation, preventing cancers, preventing tumors, resisting oxidation and resisting aging, and belongs to the technical field of functional food formulas. According to the formula, selenium-enriched yeast and dl-alpha-tocopheryl acetate are used as main materials, L-ascorbic acid can be selectively added, auxiliary materials such as microcrystalline cellulose and starch sodium octenylsuccinate are matched to prepare a capsule preparation, and the content of functional components in a single preparation is precisely controlled as follows: 90-100 micrograms of selenium and 40-50 mg of vitamin E, or 90-100 micrograms of selenium, 40-50 mg of vitamin E and 40 mg of vitamin C. According to the invention, synergistic interaction is realized through scientific proportioning of functional components, a fat-soluble and water-soluble dual anti-oxidation system is constructed, an organism immune system can be effectively activated, cancer cell proliferation can be inhibited, and meanwhile, the composition has multiple effects of preventing cancers, preventing tumors, resisting oxidation and resisting aging; the preparation method is simple and convenient in process, easy in parameter control and suitable for industrial large-scale production, the prepared preparation is high in active ingredient stability, excellent in bioavailability, high in safety and capable of being widely applied to preparation of related functional foods, and all raw materials are food-grade. The technical problems that an existing selenium compound formula is unreasonable in proportion, poor in efficacy synergy and poor in preparation performance are solved.

Provided herein are novel sulfur or selenium-containing compound, compositions containing the compounds, and preparation methods and uses thereof. The sulfur or selenium-containing compounds are compounds represented by Formulae (I) to (II), or tautomers, stereoisomers, prodrugs, crystal forms, isotopically labeled forms, pharmaceutically acceptable salts, hydrates or solvates thereof. The compounds and compositions of the present disclosure can be used to treat diseases or disorders mediated by po1θ, in particular, cancer. (I) (II)

This invention relates to the field of feed, specifically disclosing a method for preparing selenium- and strontium-enriched amino acid chelated feed; including the preparation of selenium / strontium-enriched amino acid fermentation products, the preparation steps of which are as follows: S1: Inoculating activated microalgae and yeast strains into a culture medium supplemented with selenium and strontium compounds, the pH of the culture medium is 6.5-7.5, the culture temperature is 25-35℃, and the culture is carried out under light and aeration conditions for 5-7 days; S2: Collecting selenium / strontium-enriched algal biomass using a flocculant, and ultrasonically treating the selenium / strontium-enriched algal biomass for 10-20 minutes, then adding soybean meal and rapeseed cake to the selenium / strontium-enriched algal biomass and stirring; S3: Adding cellulase, papain, alkaline protease, and pectinase for enzymatic hydrolysis to obtain selenium / strontium-enriched amino acid fermentation products. The selenium- and strontium-enriched amino acid chelated feed and its preparation method of this invention can improve the intestinal health of animals, increase the absorption and utilization rate of nutrients, and enhance animal immunity.

The invention relates to a medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises dissolved oxygen (DO), preferably 0.5 ppm to 8 ppm DO.

The invention discloses an application of a nutritional composition in preparation of an immunoregulation product. The nutritional composition comprises a lactoferrin gastrointestinal digest and a selenium gastrointestinal digest, wherein in the nutritional composition, the content of the lactoferrin gastrointestinal digests is 80 to 180 [mu] g / mL; in terms of selenium element, the content of selenium gastrointestinal digests is 12-28 ng / mL. The nutritional composition provided by the invention contains digestive juice compounded by lactoferrin and selenium, and compared with single lactoferrin and selenium, the nutritional composition has a better synergistic anti-inflammatory effect.

The present application belongs to the field of gas detection, and relates to a combined detection tube for detecting carbon monoxide concentration in blood. The device of the present application is composed of a sample adding tube and a detection tube. The filler section arranged in the sample adding tube can effectively destroy red blood cells to release CO gas under the action of Cr(VI) / Cr(III) redox system, and at the same time, the reducing substances such as glutathione (GSH) and ascorbic acid in blood are removed through the interference removal section, thereby significantly improving the specificity and accuracy of detection. The indicating glue section in the detection tube adopts a platinum-selenium compound and a potassium iodate system, which occurs a color reaction in the presence of CO: I2O5+5CO→I2+5CO2, and the generated iodine element presents a brown color development band, the length of which is positively correlated with the concentration of HbCO, so as to realize the visual quantitative analysis of the content of carboxyhemoglobin in blood.

The invention discloses an MXene-SnO2 composite material, a preparation method and application. The composite material comprises a semiconductor substrate material and a tin-containing compound, the material of the semiconductor substrate is MXene; the MXene is at least one of Ti2C3 and TiMoC2, and the MXene is at least one of Ti2C3 and TiMoC2; the selenide is SnO2 (stannic oxide). According to the invention, MXene is taken as a substrate, in-situ construction of the oxide nanosheet on MXene is realized by adopting a one-pot method, the nanosheet has a loose structure and relatively large porosity, and a rapid dynamic process in an NH3 sensing process can be realized. Besides, by regulating and controlling the oxygen vacancies on the surface of SnO2, the construction of more Lewis acid sites can be realized, so that the affinity of the material to NH3 molecules is enhanced, and efficient sensing detection is realized.

The present application relates to the technical field of chemical synthesis, in particular to a double selenium compound, a selenium-containing film and a preparation method thereof.The double selenium compound has a structure of formula (I).The preparation method comprises the following steps: mixing a compound of formula (II) and an inorganic diselenide to obtain the compound of formula (I).The present application takes the double selenium compound as a core raw material, and combines a substrate and optional reagents such as a reducing agent, a base, a melanin precursor and an oxidizing agent to prepare a selenium-containing film under mild conditions.The present application solves the synthesis problem of integrating catechol and diselenide bond and the application bottleneck of uneven distribution of selenium components and weak binding force in the selenium-containing film, and the product has good adhesion and stability, and has a wide application prospect.

The invention discloses a method for recovering Se and TeO2 from tellurium-containing crude selenium refining slag, which comprises the following steps of: crushing the tellurium-containing crude selenium refining slag, performing temperature-controlled roasting, decomposing nitrate, and oxidizing tellurium into a high valence state; the roasting slag and a reducing agent are mixed and heated under the vacuum condition, so that the selenium compound is reduced into elemental Se and volatilized, and meanwhile high-valence tellurium is reduced into tetravalent tellurium salt residues; crushing the reduced product, performing water-soluble leaching, and filtering to obtain a solution containing selenite and tellurite and TeO2 precipitate; adding acid into the leaching filtrate to hydrolyze the tellurite salt into TeO2 precipitate, and filtering and separating to obtain TeO2 and selenium-containing filtrate; finally, acid and a reducing agent are added into the selenium-containing filtrate, and selenite is reduced into elemental Se precipitate. The method realizes efficient separation and recovery of selenium and tellurium, is reasonable in process flow and high in recovery rate, and has a good application prospect.

The invention provides a method for recovering germanium-selenium-arsenic and arsenic-selenium-chalcogenide glass cold working mixed chips, which utilizes the physicochemical properties of all components in the germanium-selenium-arsenic and arsenic-selenium-chalcogenide glass cold working mixed chips, introduces a segmented vacuum fractionation process, and enables water, oil and other low-boiling-point pollutants in raw materials to be recycled at different heating and condensing temperatures, so as to obtain the germanium-selenium-arsenic and arsenic-selenium-chalcogenide glass cold working mixed chips. The arsenic-selenium compound and the elementary substance enter a gas phase in sequence, and separation from the Ge-Se binary compound and the high-boiling-point impurities is achieved; the fractionation residue Ge-Se binary compound is subjected to oxidizing roasting, germanium concentrate and coarse selenium dioxide are obtained, the direct recovery rate of germanium reaches 96.5%, and the comprehensive direct recovery rate of selenium reaches 97.8%. The method effectively solves the problem of difficult recovery of germanium-selenium-arsenic and arsenic-selenium chalcogenide glass cold processing mixed chips, realizes green and efficient cyclic utilization of rare and precious metal elements in the material, is simple in process and environment-friendly, and provides support for benign development of the chalcogenide glass industry in China.

The invention provides an organic selenide. The organic selenide has a structure shown as the following I. The natural active compound sinapic acid is combined with the selenium element to synthesize the novel organic selenium compound, so that the blank of drug combination of a traditional Chinese medicine antioxidant activity structure and the selenium element is filled up, the antioxidant activity of the traditional Chinese medicine antioxidant activity structure and the selenium element generates a synergistic effect, and the safety and the antioxidant effect are improved; and the compound has huge potential in the aspects of preparing antioxidants, medicines for preventing and / or treating diseases caused by oxidative damage and the like.

The invention discloses an environment-friendly crude selenium fire refining process which comprises the following steps: heating and melting a crude selenium raw material in a closed reactor, adding a molten oxidant, and stirring for reaction to generate tellurium slag, refined selenium liquid and nitrogen oxide tail gas; standing and separating to obtain purified selenium liquid and tellurium-containing waste residues; the method comprises the following steps: crushing tellurium-containing waste residues, carrying out temperature-controlled roasting, oxidizing tellurium into high-valence tellurium, mixing the tellurium with a reducing agent, heating in a vacuum reduction furnace, reducing a selenium compound into elemental selenium, volatilizing, returning to a refining process, and keeping tellurium in the residues; finally, nitrogen oxide tail gas is introduced into a tail gas treatment device to be reduced into nitrogen and carbon dioxide. The method realizes efficient separation and comprehensive recovery of selenium and tellurium, realizes harmless treatment of tail gas, and has the advantages of reasonable process flow, high resource utilization rate, environmental friendliness and the like.

The application discloses a preparation method of a lysozyme-nano selenium compound and application of the lysozyme-nano selenium compound in ROS removal. To mix sodium selenite solution and lysozyme uniformly, a lysozyme-sodium selenite solution is obtained, then vitamin C is added, and the mixture is uniformly mixed under the condition of light shielding and at room temperature, the pH value is adjusted to 6.5-7.5, a red solution is obtained, and dialysis is performed, so that the lysozyme-nano selenium compound is obtained. The lysozyme-nano selenium compound has the advantages of simple process, mild preparation condition, higher stability, biological safety, efficient ROS removal in egg white, and no influence on the regulation ability of the functional property, edible quality and other characteristics of the egg white, so that the deterioration problem of the egg white in the storage process is solved. The lysozyme-nano selenium compound has good application prospect in ROS removal, and can be applied to the fields of biomedical science and material science.

The application discloses a kind of sulfur selenium co-doped carbon fluoride materials, preparation method and application thereof, belong to carbon fluoride material field, a kind of sulfur selenium co-doped carbon fluoride material, including carbon fluoride, carbon fluoride surface doped with sulfur selenium compound, the mass fraction of sulfur selenium compound is 9.99%-30%.The sulfur selenium co-doped carbon fluoride material of the application, preparation method and application thereof synthesize a kind of sulfur selenium co-doped carbon fluoride material by simple heating treatment, can improve the discharge voltage and rate capability of carbon fluoride material under large rate.

The invention discloses a preparation method and application of a nickel-selenium compound with an inverse opal structure, and belongs to the technical field of material preparation. The method comprises the following steps: assembling a polystyrene nanosphere template on a conductive substrate through a vertical pulling method, filling pores of the template with a nickel-selenium compound precursor through constant potential electrodeposition, removing the template, and carrying out inert atmosphere heat treatment to obtain the three-dimensional ordered macroporous network inverse opal structure nickel-selenium compound. The invention also provides application of the material as a working electrode in non-enzymatic glucose electrochemical detection. The nickel-selenium compound with the inverse opal structure has a highly-ordered and communicated pore channel network, a large number of active sites can be exposed, diffusion mass transfer can be accelerated, and therefore the conductivity and the electrocatalytic activity are improved. Through the synergistic effect of structural design and element composition, the sensitivity, the linear range and the selectivity of glucose detection are further improved, and the application potential of the sensor in a non-enzymatic glucose sensor is highlighted.

The utility model relates to the technical field of selenium detection devices, and particularly discloses a liquid sample atomization device applied to direct mass spectrometry of selenium compounds, which is characterized in that a first one-way valve is fixedly mounted in one end, close to a small air compressor, of a first conveying pipe, and a second conveying pipe is fixedly mounted at the top of the first conveying pipe; a second one-way valve is fixedly installed in the end, away from the first conveying pipe, of the second conveying pipe, a third conveying pipe is fixedly installed on the side wall of the second conveying pipe, a third one-way valve is fixedly installed in the end, close to the second conveying pipe, of the third conveying pipe, and a fourth conveying pipe is fixedly installed at the top of the third one-way valve. The first one-way valve controls the flow direction of the selenium-containing solution in the first conveying pipe and prevents the selenium-containing solution from flowing back, so that the accurate solution transfer and control ensure that the selenium-containing solution can stably and accurately enter the reaction cavity for detection, solution leakage or wrong transfer is avoided, the detection accuracy and stability are improved, the detection error is reduced, and the detection efficiency is improved. And reliable sample conveying guarantee is provided for selenium detection.

The invention belongs to the technical field of medicinal chemistry, and particularly relates to a selenium-containing gentiopicroside nitroxide free radical derivative as well as a preparation method and application thereof. A series of selenium-containing gentiopicroside nitroxide free radical derivatives with a specific structure are prepared and synthesized through a chemical process, and the selenium-containing compound derivatives obtained by adding a selenium-containing structure on the basis of the gentiopicroside nitroxide free radical derivatives show good in-vitro ROS scavenging activity and anti-inflammatory activity; the expression level of an inflammatory medium iNOS is effectively reduced, and the compound has a wide application prospect in preparation of medicines with the effects of preventing, relieving or treating inflammation.

The invention discloses application of an organic selenium compound in preparation of anti-tumor angiogenesis drugs. The anti-tumor angiogenesis activity of selenium compounds (inorganic selenium, organic selenium and selenium nanoparticles) in different forms is compared by the system, the effect of organic selenium is most prominent, and the organic selenium can effectively induce active oxygen mediated apoptosis and cell cycle arrest of human umbilical vein endothelial cells (HUVECs). The organic selenium is used as a lead compound for drug design, and a good reference is provided for developing novel high-efficiency and low-toxicity anti-tumor angiogenesis drugs.

This invention belongs to the field of biomedical technology, specifically relating to an organic selenium composition for inhibiting tumor cells and its preparation method. The organic selenium composition comprises the following components in parts by weight: 7-12 parts selenobenzonitrile-glycyrrhizinamide, 2-5 parts trazastilbene, and 0.5-1 part selenized carrageenan. This invention utilizes the reaction of the carbonyl α,β-unsaturated olefin bond in methyl glycyrrhizinic acid with 4-mercaptobenzonitrile to introduce a benzonitrile structure to enhance targeting while retaining the core active structure of methyl glycyrrhizinic acid. Simultaneously, a selenium compound is introduced onto the carboxyl group of methyl glycyrrhizinic acid, thereby preparing selenobenzonitrile-glycyrrhizinamide. When selenobenzonitrile-glycyrrhizinamide is used in combination with trazastilbene and selenized carrageenan, the prepared organic selenium composition exhibits significant inhibitory effects on the proliferation of various tumor cells, while showing no significant toxicity to normal human liver cells (L02).

The application belongs to the field of electrochemical energy storage, and discloses a nickel-sulfur-selenium compound / nitrogen-doped carbon composite material, a preparation method thereof and an energy storage device. The preparation method comprises the following steps: dissolving nickel ammonium sulfate, citric acid and sodium chloride in water to obtain a mixed solution, and then evaporating the mixed solution to obtain a solid precursor; the mass ratio of nickel ammonium sulfate, citric acid and sodium chloride is 1:(0.8-1.2):(8-15); the solid precursor is placed in a reducing atmosphere, calcined at 500-800 DEG C for 2-4 h to obtain a triniickel disulfide / nickel / nitrogen-doped carbon composite material; the triniickel disulfide / nickel / nitrogen-doped carbon composite material is uniformly mixed with selenium powder, and then placed in an inert atmosphere, calcined at 400-500 DEG C for 2-4 h to obtain the final nickel-sulfur-selenium compound / nitrogen-doped carbon composite material; the mass ratio of the triniickel disulfide / nickel / nitrogen-doped carbon composite material and the selenium powder is 1:(2-5). The application can improve the stability of the potassium ion hybrid capacitor electrode material.

The invention discloses stable polyfunctional selenol and a preparation method thereof. The method can solve the problems that selenol is poor in stability and extremely easy to oxidize in air, and high-purity selenol cannot be prepared. The selenium-containing compound has good dynamic characteristics, optical activity and biological activity, and has a wide application prospect. Although selenol has reactivity similar to that of hydroxyl and sulfydryl, the selenol is extremely unstable and is extremely easy to oxidize in air, high-purity selenol cannot be prepared, and polymerization reaction and the like needing quantitative functional group ratio cannot be carried out. The polyfunctional selenol disclosed by the invention is stable in structure, simple in preparation method and high in product purity, and can be stored for a long time; besides, stable selenol with different chemical structures and different functional group numbers can be obtained by replacing different reactants, polyfunctional selenol with different properties such as flexibility and rigidity can be prepared according to requirements, and a new thought is provided for development of organic selenium chemistry by means of the stability and high purity of the polyfunctional selenol.

The application discloses a lead-free copper-based self-lubricating composite material and a preparation method thereof, and relates to the technical field of self-lubricating bearing materials.According to the weight percentage, the lead-free copper-based self-lubricating composite material comprises the following components: Sn 5% to 10%, Si 0.5% to 5%, selenium compound 1% to 6%, and the balance of Cu, wherein the selenium compound is selected from one or a combination of two of molybdenum diselenide and niobium diselenide.The application realizes significant improvement of the comprehensive performance of the lead-free copper-based self-lubricating composite material through material system design, and is outstanding in mechanical properties and service reliability, can effectively prolong the service cycle of the copper-based sliding bearing, has higher performance and environmental friendliness compared with traditional lead-containing materials, and is suitable for bearing application under extreme working conditions.

The invention belongs to the technical field of nutritional food, and particularly relates to vitamin A, D and E zinc-selenium composite nutritional powder for resisting oxidation and regulating the immune function. Comprising the following components: 4.0 to 4.6 g of retinyl acetate, 35.8 to 6.3 g of vitamin D, 380 to 420 g of zinc sulfate, 29 to 33 g of sodium selenite, 57 to 61 g of dl-alpha-tocopheryl acetate, 9300 to 9400 g of maltodextrin, 95 to 105 g of silicon dioxide, 8 to 12 g of stevioside, 18 to 22 g of ethyl vanillin and 18 to 22 g of citric acid. Through scientific proportioning of vitamin A, vitamin D3, vitamin E, zinc, selenium and other active components and matching of appropriate auxiliary materials, the multi-effect health-care food achieves multiple effects of enhancing immunity, promoting calcium absorption and bone health, protecting eyesight, resisting oxidation, delaying senescence and promoting growth and development, and meets health requirements of different crowds.

The invention relates to a composite active material and a preparation method thereof, a solid-state battery monomer, a battery device and a power utilization device. The solid-state battery monomer comprises a current collector and a film layer arranged on the surface of at least one side of the current collector, and the film layer comprises a composite active material and sulfide solid-state electrolyte; the composite active material comprises an inner core and a coating layer, wherein the coating layer coats at least part of the surface of the inner core; the coating layer comprises a selenium-containing compound, the chemical formula of the selenium-containing compound is SeaMb, M comprises at least one of Li, Na, K, Mg, Ca, S, Mo, Cr, Zn, In, Ga, Co and Mn, a is greater than 0 and less than or equal to 5, and b is greater than 0 and less than or equal to 20. According to the embodiment of the invention, the cycling stability and the first coulombic efficiency of the solid-state battery monomer can be improved.

The invention discloses a zero-addition selenium-rich milk production mode based on yeast selenium feeding and milk selenium regulation and control. The method is realized through two stages of precise regulation and control: in the first stage, a specific dose of yeast selenium is added into daily ration of cows in the lactation period, and the content of natural organic selenium in raw milk is increased through biotransformation; in the second stage, the fresh milk is subjected to low-temperature milk selenium stability regulation and control, under the condition that no exogenous selenium compound is added, the stability and bioavailability of the selenium form in the milk are kept, the problems that in traditional selenium-rich milk production, selenium additive residues exist, the selenium form is unstable, and product safety is low are solved, and the selenium-rich milk is suitable for large-scale production. The invention provides the production method of the selenium-enriched milk which is free of chemical addition in the whole process, stable and controllable in selenium content, and high-bioavailability selenomethionine is taken as the main selenium form. The obtained product accords with the development trend of natural and safe functional dairy products, and is suitable for large-scale dairy product processing.

The invention relates to the technical field of aluminum secondary battery positive electrode materials, in particular to a transition metal sulfur-selenium compound and a preparation method and application thereof.The transition metal sulfur-selenium compound is in a crystalline state and has the chemical formula of MxQ1-xSySe3-y, x is larger than or equal to 0 and smaller than or equal to 1, y is larger than 0 and smaller than 3, M is selected from at least one of Sc, Ti, Mo, Nb, Zr, Y, W and Ta, and Q is selected from at least one of Cu, Ni, Fe, Co, Mn, V, Cr, Tc, Ru, Rh, Ag, Pd, Re, Ir, Pt and Au; the preparation method comprises a high-temperature solid phase method, a solvent method and a high-energy ball milling method. The composition of the transition metal sulfur-selenium-rich compound is designed by regulating and controlling overlapping of the transition metal element orbital energy level and the sulfur-selenium anion non-bonding orbital energy level and introducing a sulfur anion pair [S-S] 2-and a selenium anion pair [Se-Se] 2-to generate a ligand-vacancy, and the problems that the aluminum secondary battery positive electrode material is low in capacity and poor in stability are solved.

The invention relates to a composite active material and a preparation method thereof, a solid-state battery monomer, a battery device and a power utilization device. The solid-state battery monomer comprises a current collector and a film layer arranged on the surface of at least one side of the current collector, and the film layer comprises a composite active material and sulfide solid-state electrolyte; the composite active material comprises an inner core, at least one first coating layer and a second coating layer, at least part of the surface of the inner core is coated with the at least one first coating layer, and at least part of the surface of the outermost first coating layer is coated with the second coating layer; the second coating layer comprises a selenium-containing compound, the chemical formula of the selenium-containing compound is SeaMb, M comprises at least one of Li, Na, K, Mg, Ca, S, Mo, Cr, Zn, In, Ga, Co and Mn, a is greater than 0 and less than or equal to 5, and b is greater than 0 and less than or equal to 20. According to the embodiment of the invention, the cycling stability and the first coulombic efficiency of the solid-state battery monomer can be improved.

The invention provides preparation of a selenium-water-soluble high-molecular polysaccharide hydrogel and use thereof. The preparation method includes: (1) water solution of polysaccharide and seleno-compound was prepared by heating the mixture with stirring; and (2) the solution was cooled with standing within shaped container to obtain the selenium-polysaccharide composite hydrogel. Plant seeds are sown on the surface of the composite hydrogel and cultivated to obtain selenium-rich plants. Shape-controllable hydrogel could be prepared by recycled hydrogel through high-temperature dissolution followed with cooling to realize the effective utilization of selenium in the hydrogel. Compared with the traditional selenium enrichment method, current method showed advances in prevent of selenium pollution, which normally caused by the application of selenium fertilizers.

The present application relates to a composite active material and a preparation method therefor, a solid-state battery cell, a battery device, and an electric device. The solid-state battery cell comprises a current collector and a film layer arranged on at least one side surface of the current collector, wherein the film layer comprises a composite active material and a sulfide solid electrolyte. The composite active material comprises an inner core, at least one first coating layer and a second coating layer, wherein the at least one first coating layer is coated on at least part of the surface of the inner core, and the second coating layer is coated on at least part of the surface of the outermost first coating layer. The second coating layer comprises a selenium-containing compound, and the chemical formula of the selenium-containing compound is SeaMb, wherein M comprises at least one of Li, Na, K, Mg, Ca, S, Mo, Cr, Zn, In, Ga, Co, and Mn, 0<a≤5, and 0<b≤20. The embodiments of the present application can improve the cycle stability and initial coulombic efficiency of the solid-state battery cell.