27 results about "Sodium Hydroselenite" patented technology

The invention discloses an immunomodulatory composition based on a cordycepin-selenium nano chelate and a preparation method thereof, and belongs to the technical field of biological medicines.The immunomodulatory composition is characterized in that 15-25 nm zero-valent selenium nano particles are chelated through hydroxyl of cordycepin and N7 site bidentate coordination, and a stable five-membered ring structure with the molar ratio is formed; the preparation method comprises the following steps: reducing sodium selenite in an inert atmosphere to generate selenium colloid, chelating the selenium colloid with a cordycepin ethanol solution, and carrying out ultrafiltration and freeze-drying to obtain the product. The invention aims to solve the problems of fuzzy structure, inconsistent batch, uncontrollable immunomodulatory function and the like caused by non-specific mixing in the prior art, and the composition can bidirectionally regulate and control IRF3 pathways, promote polarization of M2 type macrophages and proliferation of Treg cells, and has a clear immunomodulatory mechanism and excellent stability.

The invention discloses a composition for improving sexual life and / or prostate symptoms and a preparation method thereof. The composition is prepared from the following components in parts by weight: 30 to 50 parts of algal polysaccharides, 15 to 25 parts of phospholipid, 8 to 12 parts of euphausia superba oil, 8 to 12 parts of magnesium oxide, 8 to 12 parts of lycopene, 2 to 4 parts of zinc gluconate, 1 to 3 parts of radix ginseng extract, 0.8 to 1.2 parts of flos sophorae immaturus extract, 0.8 to 1.2 parts of fructus rubi extract, 0.8 to 1.2 parts of mulberry fruit extract, 0.8 to 1.2 parts of fructus lycii extract and 0.8 to 1.2 parts of sodium selenite. By limiting the raw materials and the dosage, under the combined action of the raw materials, the prepared composition can improve erectile, ejaculation and anterior lacrimal gland symptoms, can improve the quality of sexual life, and has no side effect on the body.

The invention relates to a medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises dissolved oxygen (DO), preferably 0.5 ppm to 8 ppm DO.

The invention discloses a Fe-doped Bi2SeO5 nano material as well as a preparation method and application of the Fe-doped Bi2SeO5 nano material. The preparation method comprises the following steps: dissolving ferric chloride hexahydrate, bismuth nitrate pentahydrate and sodium selenite according to a specific ratio by using a hydrothermal synthesis technology and taking pure water as a solvent, and stirring at the room temperature of 25 DEG C until a system is uniform, so as to obtain a precursor mixed solution of the Fe-doped Bi2SeO5 nano material; the mixed solution is subjected to a hydrothermal reaction and then is subjected to heat treatment in an air atmosphere, and the target Fe-doped Bi2SeO5 nano material is finally obtained by regulating and controlling parameters such as a precursor ratio, a hydrothermal reaction temperature, heat preservation time and heat treatment conditions through a system. The nano material is used for catalytic degradation of antibiotics in a PMS system, and has the characteristics of strong anti-interference capability, good tolerance to acid and alkali environments, remarkable catalytic effect, high stability and the like.

This invention provides a nano-selenium, its preparation method, and its applications, relating to the field of nano-selenium fertilizer technology. Using sodium selenate or sodium selenite as raw material A and thiol-functionalized graphene as raw material B, raw material A and raw material B are mixed and reacted for a certain period to obtain nano-selenium, which can be used in fertilizers, food anti-oxidation and preservation, industrial catalysis, or chemical analysis. This invention uses inorganic selenium and thiol-functionalized graphene as raw materials. Through a simple solution mixing, reaction, and settling process, the in-situ reduction of selenite by thiol-functionalized graphene and the stable loading of nano-selenium are achieved, completing the conversion from inorganic selenium to nano-selenium in one step without the need for reducing agents.

This invention belongs to the technical field of functional personal care products, and specifically relates to a highly efficient and stable natural sulfur hot spring bath concentrate formula and its preparation process. The bath concentrate formula, by mass percentage, comprises the following components: 35.0-65.0% sulfur hot spring active concentrate, 0.001-0.01% sodium selenite, 0.1-1.0% sodium thiosulfate, 0.05-0.2% disodium EDTA, 0.5-3.0% cationic liposomes, 0.2-0.8% carrageenan, 0.5-3.0% calcium source, 0.3-2.0% magnesium source, 0.1-0.5% bisabolol, 0.1-0.5% dipotassium glycyrrhizate, 0.2-1.5% citrate-sodium citrate buffer pair, 3.0-8.0% polyol, 0.1-0.3% β-cyclodextrin-encapsulated fragrance, and deionized water to 100%. A liquid bath concentrate was obtained using natural sulfur hot spring water as the water source, which fully retains its active sulfide spectrum and characteristic mineral ions, and can be stored for a long time at normal temperature and pressure. It has the advantages of high stability, high polysulfide content, slow release, and no irritation.

The application discloses a preparation method of a lysozyme-nano selenium compound and application of the lysozyme-nano selenium compound in ROS removal. To mix sodium selenite solution and lysozyme uniformly, a lysozyme-sodium selenite solution is obtained, then vitamin C is added, and the mixture is uniformly mixed under the condition of light shielding and at room temperature, the pH value is adjusted to 6.5-7.5, a red solution is obtained, and dialysis is performed, so that the lysozyme-nano selenium compound is obtained. The lysozyme-nano selenium compound has the advantages of simple process, mild preparation condition, higher stability, biological safety, efficient ROS removal in egg white, and no influence on the regulation ability of the functional property, edible quality and other characteristics of the egg white, so that the deterioration problem of the egg white in the storage process is solved. The lysozyme-nano selenium compound has good application prospect in ROS removal, and can be applied to the fields of biomedical science and material science.

This invention relates to a rare-earth-selenium tungsten oxide nanocluster material functionalized with mixed organic ligands, the chemical formula of which is [HDMEA]. 9 Na 12 H3[Ce6(DMEA)3(H2O)9W9(HTA)6O 18 (SeW9O 33 [6]ˑ81H2O, where DMEA = N,N-dimethylethanolamine and H3TA = hydroxymalonic acid. This material is prepared by a one-step self-assembly reaction of sodium tungstate dihydrate, N,N-dimethylethanolamine, sodium selenite, hydroxymalonic acid, and cerium nitrate hexahydrate in aqueous solution. The experimental operation is simple and the cost is low. This material can be used as a polyanionic polymer to form a thin film material by layer-by-layer assembly with positively charged chitosan. This multilayer film can be used as a sensitizing material to combine with polypyrrole containing template molecules (2,4-dichlorophenol) to form a molecularly imprinted polymer. This polymer can be used to construct an electrochemical sensor for detecting 2,4-dichlorophenol. Experimental results show that this electrochemical sensor has high sensitivity, strong stability, a wide detection range (1 μM–1 mM), and a low detection limit (0.125 μM).

The application discloses a kind of stabilized hot spring sulfide active ingredients and its preparation method and application, belong to natural product processing and daily chemical technology field, including hot spring water or concentrated liquid rich in sulfide, sodium selenite, cationic polymer, hydrophobic silicone oil or natural oil, metal ion chelating agent, cyclodextrin inclusion zinc salt, natural aromatic oil and antioxidant.The application builds the dual stabilization and slow-release system of "electrostatic adsorption+physical barrier" by the in-situ synergistic effect of cationic polymer and oil, solves the contradiction between storage stability and service life.The final product of the application is extremely high in stability, has no bad smell, low irritability, and has smooth skin feel, completely overcomes the traditional obstacles of sulfur component in daily chemicals.

The invention provides selenium-rich chlorella powder and a preparation method and application thereof, the preparation method comprises the following steps: preparation of nano-selenium: uniformly mixing a sodium selenite solution with a carboxymethyl cellulose solution, then adding a vitamin C solution, reacting at room temperature in a dark place, and dialyzing to obtain red transparent nano-selenium sol; culturing the selenium-rich chlorella: inoculating the chlorella into a culture medium containing nano-selenium sol, and carrying out aerobic culture under an illumination condition; and collection of selenium-rich chlorella powder: filtering to remove precipitated large selenium particles, centrifugally collecting algae, washing, drying and crushing to obtain the selenium-rich chlorella powder. The obtained product is high in selenium content, strong in biological activity and good in safety, and can be used as a raw material of a functional selenium supplement.

The invention provides a sustained-release bar for repairing mammary glands in the early stage of dry milk of dairy cows and a preparation method thereof, and belongs to the technical field of veterinary pharmaceutical preparations. The breast repair slow-release bar for the dairy cow in the early stage of dry milk is prepared from the following raw materials in parts by weight: 6 to 10 parts of compound plant extract, 10 to 15 parts of ferroferric oxide, 8 to 12 parts of magnesium oxide, 6 to 10 parts of zinc sulfate, 1 to 5 parts of hordenine hydrochloride, 1 to 5 parts of manganese sulfate, 0.05 to 0.15 part of calcium iodate, 0.05 to 0.15 part of sodium selenite, 0.5 to 2 parts of calcium stearate and 3 to 10 parts of vegetable oil. The breast repair slow-release bar for the dairy cow in the initial dry period can effectively promote emptying and involution of breasts of the dairy cow in the dry period, the involution period is remarkably shortened, the risk of mastitis infection in the dry period is reduced, and the repair effect of the breast repair slow-release bar is better than that of natural milk stop.

The invention discloses selenium-doped ruthenium dioxide and a preparation method and application thereof.Ruthenium trichloride and sodium selenite are dissolved in an alcohol solvent and then placed in an oil bath pan to react, a reacted sample is washed, loaded, dried and calcined, and finally selenium-doped ruthenium dioxide is successfully prepared. The prepared ruthenium dioxide is in a porous cluster shape, more active sites can be exposed, the activity and stability of the ruthenium dioxide are improved by regulating electron transfer through selenium doping and inducing reaction mechanism transformation, and the ruthenium dioxide shows excellent oxygen evolution performance when serving as a catalyst to be used for hydrogen production through water electrolysis and has application prospects in the field of electrocatalysis.

The application provides a precipitant for precipitating a silver base body, a preparation method and application, and the precipitant comprises potassium thiocyanate, an auxiliary complexing agent, trace rare earth elements, a synergist and trace selenium compounds; wherein the auxiliary complexing agent is at least one of pyrrolidone, N-ethyl-N-methyl aminoacetic acid or a combination thereof; the trace selenium compounds are sodium selenite or sodium selenate, the addition amount of the trace selenium compounds is 0.001%-0.05% of the total mass of the precipitant; and the mass ratio of the auxiliary complexing agent to the trace selenium compounds is 20:1-60:1. Through optimization of component allocation and auxiliary additives, rapid precipitation of silver elements is realized, and the application is suitable for various scenes such as element content analysis of silver alloy products and harmful element migration amount detection of silver tableware.

The invention discloses a culture medium composition for promoting maturing of masson pine somatic embryos, which is a maturing culture medium based on maturing culture of masson pine somatic embryos and comprises the following components: a GST activator, a GR activator and an antioxidant stress enhancer, the GST activator is quercetin, the GR activator is sodium selenite, and the antioxidant stress enhancer is melatonin. According to the method, quercetin, sodium selenite and melatonin are combined for regulating and controlling maturing of masson pine somatic embryos, so that the purpose of regulating and controlling the redox state of cells to an optimal'window 'is accurately achieved, the total GSH level in the cells is effectively maintained in a relatively low range (about 300-400 mu g / g FW), and meanwhile, the GSH / GSSG ratio is larger than or equal to 7.

The invention provides an application of selenium-rich probiotics in preparation of a preparation for treating fluoxetine-induced liver injury, and relates to the technical field of biological medicine, the application is characterized in that Se-BL is obtained by reducing sodium selenite through ascorbic acid and modifying the surface of bifidobacterium longum, and nano-scale selenium dots are formed. The preparation plays a role through dual mechanisms: active oxygen (ROS) is directly removed, an Nrf2 pathway is activated, and the liver oxidation resistance (GSH, SOD) is improved; the traditional Chinese medicine composition is capable of inhibiting NF-kappa B inflammation signal channels, reducing proinflammatory factors (TNF-alpha and IL-6) and synchronously regulating intestinal flora so as to enhance the intestinal barrier function. Experiments prove that the traditional Chinese medicine composition can remarkably reduce the level of serum transaminase (ALT / AST / ALP) and relieve liver tissue necrosis and lipid peroxidation damage (MDA), the dosage form of the traditional Chinese medicine composition is an oral preparation, and each dose of the traditional Chinese medicine composition contains 1 * 10 <-1 > * 10 <-1 > CFU of Se-BL viable bacteria. The selenium-modified probiotics are used for antagonizing hepatotoxicity of mental drugs for the first time, and an innovative therapy is provided for fluoxetine-induced drug-induced liver injury (DILI) and acute hepatic failure (ALF).

The invention relates to the technical field of nano-selenium materials, in particular to a nano-selenium material based on glutathione driving and a preparation method and application thereof.The nano-selenium material is prepared from glutathione and sodium selenite through a one-pot hydrothermal method, the preparation method is simple and easy to implement, and the nano-selenium material is suitable for industrial production. The prepared GSH-Se nanoparticles comprise a nano-selenium core and a glutathione modified shell, and a solution of the GSH-Se nanoparticles has excellent colloidal stability and broad-spectrum free radical scavenging characteristics. Meanwhile, the GSH-Se nanoparticles provided by the invention have the effects of improving Parkinson's disease, promoting mitochondrial homeostasis, relieving neuroinflammation, improving dopaminergic neuron function and motor behavior disorder and the like, and have great clinical application value.

The invention relates to the technical field of selenium nano materials, in particular to selenium nano particles and a preparation method thereof. According to the method, selenourea is used as a selenium source, selenium simple substance is prepared through oxidation reaction, deoxysodium cholate is used as a stabilizer to prepare micelles, and selenium nanoparticles with uniform size and diameter and good dispersity can be simply prepared. Compared with a traditional method, the method has the advantages that a reducing agent is not needed, the high toxicity risk caused by selenium salt such as sodium selenite is avoided, meanwhile, oxygen serves as a green oxidizing agent, natural biomolecular bile salt with biocompatibility serves as a stabilizer, only one-step reaction is needed, complex reaction conditions are not needed, and therefore the method is more suitable for preparing the selenium nano material in batches; the method is safe in raw materials, green in process, excellent in product performance, easy to industrialize and wide in application prospect.

The invention belongs to the technical field of methylation experimental methods, and particularly relates to a methylation experimental method for microbiological treatment of selenium in various environments, which comprises the following steps: adopting aeromonas hydrophila D15 with the preservation number of CCTCC M 20251975; dissolving LB powder in ultrapure water, sub-packaging into brown high borosilicate glass bottles, sterilizing at 121 DEG C for 30 minutes, and cooling for later use; inoculating the strain liquid into the cooled culture medium according to the inoculation amount of 1% in a clean bench, sealing with a sterile breathable film of 0.22 [mu] m, and culturing for 24 h at 30 DEG C and 120 rpm; adding a sodium selenite solution into the pre-cultured mature bacterial liquid, adjusting the concentration of Se (IV) in the system, sealing, and culturing for 3-7 days under the conditions of set temperature and 120rpm; collecting liquid formed by mixing H2O2 and HNO3 is connected with a culture device through a polytetrafluoroethylene gas path pipe, and enrichment is carried out for 1 hour at the gas flow rate; and after the trapping liquid is filtered by 0.45 mu m, measuring the selenium form and the yield of dimethyl diselenide in the trapping liquid by adopting LC-ICP-MS (Liquid Chromatography-Inductively Coupled Plasma Mass Spectrometry).

This invention discloses a highly stable inulin-selenium nanoparticle and its preparation method, belonging to the field of nanomaterials technology. The preparation method aims to address the problems of existing nano-selenium preparation methods, which rely on external chemical reducing agents, pose a risk of toxic residues, and have insufficient colloidal stability. Using natural inulin simultaneously as a reducing agent, stabilizer, and structure-directing agent, sodium selenite is reduced to nano-selenium particles in a one-step process under alkaline conditions and with the assistance of ultrasonic or magnetic stirring. The resulting solid powder is obtained after ethanol precipitation and freeze-drying. The product contains no external chemical reducing agents, exhibits excellent colloidal stability, and combines the prebiotic activity of inulin with the antioxidant function of nano-selenium, making it applicable to biomedicine, functional foods, and green agriculture.

The utility model relates to a sodium selenite solution stirring tank. The lower end of a tank body is communicated with a water inlet of a water pump through a first through pipe, a water outlet of the water pump is communicated with the lower end of a three-way valve through a second through pipe, the left end of the three-way valve is communicated with the side face of the tank body through a third through pipe, and the axis of the third through pipe and the axis of the tank body are not intersected. The joint of the third through pipe and the inner cavity of the tank body is tangent to the inner side wall of the inner cavity of the tank body, and the upper end of the three-way valve is communicated with the flowmeter through a fourth through pipe. The three-way valve is arranged, water at the bottom of the tank body is pumped upwards through the water pump, enters the three-way valve and then blocks the channel at the upper end, and water flow enters the tank body from the side face of the tank body, so that the water flow obliquely enters the inner cavity of the tank body under the pumping pressurization condition, vortex-shaped water flow is formed in the tank body, and the circulating mixing effect is achieved in a single-water-pump mode. And after mixing is completed, the left end channel is blocked, the upper end channel is opened, and then water flow enters the flow meter and then enters the next procedure.

The invention relates to a production method of alfalfa health-care eggs, and belongs to the technical field of laying hen breeding and functional feed processing, and the production method comprises the following steps: S1, preparing a selenium-rich alfalfa polypeptide chelating additive: selecting alfalfa hay, carrying out physical impurity removal, and then carrying out airflow superfine grinding treatment to obtain alfalfa micro powder; mixing the alfalfa micro powder with water according to a mass ratio of (1: 10)-(1: 15), carrying out ultrasonic dispersion pretreatment, then adding a compound enzyme preparation, and carrying out gradient enzymolysis reaction under a constant-temperature condition, so as to prepare enzymatic hydrolysate; according to the scheme, through specific airflow superfine grinding, ultrasonic dispersion pretreatment and gradient enzymolysis reaction of a compound enzyme preparation, alfalfa macromolecular protein is sheared into short-chain polypeptide with rich chelation sites. In the subsequent constant-temperature mechanical stirring chelation reaction, sodium selenite and polypeptide form stable organic chelated selenium, and the selenium deposition amount is increased by more than one time.

The invention discloses a nano-selenium-phellinus igniarius polysaccharide composite carrier and a preparation method and application thereof.The composite carrier takes nano-selenium particles as a core and phellinus igniarius polysaccharide as a coating layer, the phellinus igniarius polysaccharide coats the surface of nano-selenium through electrostatic interaction and / or chemical bonding, the nano-selenium particles are spherical particles of 20-100 nm, a characteristic ultraviolet absorption peak exists at 250 nm, the coating rate is not lower than 80%, and the nano-selenium particles are spherical particles of 20-100 nm. The phellinus igniarius polysaccharide is prepared by adopting a chemical reduction method, taking phellinus igniarius polysaccharide, sodium selenite and ascorbic acid as raw materials, and performing liquid-phase reduction and process optimization. The composite carrier induces iron overload and lipid peroxidation by excessively activating a colorectal cancer cell ROS / Nrf2 / HO-1 pathway, specifically induces ferroptosis, can bypass a chemotherapy drug resistance mechanism, and is high in targeting property and low in toxicity. The preparation method is simple, convenient and controllable, the composite carrier is high in stability and bioavailability and remarkable in tumor inhibition effect, various dosage forms can be prepared, a novel efficient and low-toxicity strategy is provided for treatment of colorectal cancer, especially chemotherapy drug-resistant colorectal cancer, and the clinical transformation prospect is good.

The invention relates to a method for preparing sodium selenite from crude selenium recovered from copper anode slime. The method comprises the following steps: S1, oxidizing: oxidizing the crude selenium recovered from the copper anode slime under the conditions that the temperature is 500-550 DEG C and the oxygen flow is 0.9-1.0 L / min; after the selenium is completely burnt, stopping heating, continuing to introduce O2, and then cooling to room temperature in air to obtain an oxidation product SeO2; s2, separation and purification: fully dissolving the oxidation product SeO2 with deionized water, filtering, heating, evaporating and crystallizing, condensing, re-dissolving, boiling and cooling to obtain a seleninic acid solution; s3, neutralization and crystallization: adding a NaOH solution into the seleninic acid solution for reaction, and performing vacuum drying, standing, cooling and crystallization to obtain crystalline sodium selenite; and S4, heating and dehydrating: heating and dehydrating the crystallized sodium selenite to obtain an anhydrous sodium selenite product. The process is simple in production process, stable and reliable in quality, low in cost and high in economic benefit.

The invention discloses an ochrobactrum strain capable of efficiently tolerating selenate and biologically synthesizing nano-selenium and application of the ochrobactrum strain, and belongs to the technical field of microbial fermentation and nano-biology. The screened ochrobactrum strain which is efficient, selenium-resistant and capable of biologically synthesizing nano-selenium is classified and named as Ochrobactrum sp. RS1 and is preserved in the China Center for Type Culture Collection on December 15, 2025, the preservation date is December 15, 2025, and the preservation number is CCTCC NO: M20252876. After the strain is subjected to selenium-resistant domestication, the highest tolerance concentration of the strain to sodium selenite can reach 300 nM, the sodium selenite can be reduced into uniform spherical nano-selenium particles in a liquid culture medium, and the average particle size is 190.0-282.5 nm. By optimizing fermentation conditions (PH, temperature and culture time), the conversion rate of the domesticated ochrobactrum anthropi RS1 to sodium selenite reaches 70.20% + / -0.39%. Compared with a traditional chemical and physical nano-selenium synthesis method, the production efficiency of nano-selenium is improved by fermenting sodium selenite with ochrobactrum anthropi RS1, the production cost is reduced, and the method has the advantages of being environmentally friendly, easy and convenient to operate and the like.

The invention provides a method for controlling solubility of ultra-long chain alkyl trimethyl ammonium bromide by using pH-mediated iodide, which comprises the following steps: mixing sodium octyl selenite and iodide as an auxiliary agent with eicosyl trimethyl ammonium bromide, adding water for dissolving, adding alkali to adjust the pH value, reducing the Krafft temperature of eicosyl trimethyl ammonium bromide to 25 DEG C or below, and reacting to obtain the ultra-long chain alkyl trimethyl ammonium bromide. And adding acid to reduce the pH value, so that the sodium octyl selenite is converted into octyl diselenide, and meanwhile, the KT of eicosyl trimethyl ammonium bromide is increased to 25 DEG C or above. The method does not involve the use of an oxidizing agent H2O2, and only involves the regulation and control of the pH value in an extremely small range, so that the technical risk caused by the use of H2O2 can be effectively avoided. More importantly, crystals separated out from the aqueous solution of the ultra-long-chain alkyl trimethyl ammonium bromide can be separated and recycled only through filtering operation, operation is simple, and the good effect that the recovery rate is not lower than 96% is achieved.

This invention provides a copper-containing lentinan nano-selenium, its application, and preparation method, comprising the following steps: (1) Preparation of stock solutions: Prepare ascorbic acid solution, sodium selenite solution, copper sulfate solution, and lentinan solution respectively; then, according to c(CuSO4):c(Na2SeO3) = 1%-100%, take a concentration value within this concentration range and dilute the copper sulfate solution with water to obtain a dilute copper sulfate solution; (2) Stir the sodium selenite solution, dilute copper sulfate solution, and lentinan solution in a reaction flask, then add ultrapure water and stir, then add ascorbic acid solution and stir, then place the reaction flask at low temperature for a certain time, and then stir the reaction at room temperature for a certain time; (3) After the reaction is completed, load the reaction solution into a dialysis belt and dialyze for a certain time; after dialysis, transfer the reaction solution, centrifuge, take the supernatant, and obtain the target product, copper-containing lentinan nano-selenium. This invention aims to explore the application of copper-containing nano-selenium drugs in the treatment of tumors.