48 results about "Sodium Hydroselenite" patented technology

The preparation method comprises the following steps: S1, raw material preparation: selecting sodium selenite as a selenium source, and preparing konjac glucomannan and vitamin C as reducing agents at the same time; the molar ratio of the selected sodium selenite to the selected konjac glucomannan to the selected vitamin C is 1: (0.5-2): (2-5); s2, solution preparation: dissolving sodium selenite in deionized water to prepare a sodium selenite solution with the concentration of 0.1-0.5 mol / L; according to the preparation method of the nano-selenium fertilizer, through the nano-selenium fertilizer prepared through the steps S1 to S6, the particle size of nano-selenium particles can be distributed between 30 nm and 80 nm, so that the nano-selenium fertilizer has good dispersity and stability and is conveniently and efficiently applied to agricultural production, and the effect of improving the selenium absorption and utilization efficiency of crops is achieved; and the preparation method is simple and easy to implement, low in cost, green and environmentally friendly.

The invention provides a preparation method and application of red nano-selenium particles, and relates to the technical field of nano-medicines.The preparation method comprises the steps that sodium selenite is dissolved in ultrapure water, silicate microspheres containing copper, zinc and aluminum are added, the pH value is 4.8, 1.5 M of ascorbic acid solution is dropwise added while stirring, the temperature is increased till solid ascorbic acid is added, the pH value is adjusted through NaOH, and nano-selenium suspension liquid is obtained through stirring reaction; the preparation method comprises the following steps: mixing and stirring a nano-selenium suspension, a sodium alginate sulfydryl graphene oxide mixture and a chitosan oligosaccharide citric acid buffer solution, centrifugally washing, and freeze-drying to obtain red nano-selenium particles, and preparing the copper-zinc-containing aluminosilicate microspheres through mesoporous template calcination and copper-zinc co-doping. The red nano-selenium particles prepared by the method have a core-shell structure, uniform particle size, high oxidation resistance and remarkable interface bonding strength.

The invention relates to the technical field of biological medicine, and discloses a culture medium for human metapneumovirus and application, the culture medium comprises the following components by mass: 850-920 parts of a basic culture medium; the metabolism reprogramming module is prepared from the following components in parts by weight: 0.05 to 0.15 part of 5-methyltetrahydrofolic acid, 0.3 to 0.7 part of N-acetyl-D-mannosamine and 1.0 to 3.0 parts of sodium dichloroacetate; the immune regulation and control module is prepared from 0.005 to 0.015 part of an RIG-I / MAVS pathway inhibitor; the receptor induction module is prepared from 0.5 to 1.5 parts of all-trans retinoic acid; the redox balance module is prepared from the following components in parts by weight: 0.1 to 0.5 part of pegylated superoxide dismutase and 0.002 to 0.008 part of sodium selenite. According to the method, the proportion of infectious virus particles can be remarkably increased, the generation of defective particles is reduced, meanwhile, the production cycle of host cells is prolonged, large-scale continuous culture is supported, and a high-quality and high-efficiency solution is provided for industrial production of gene therapy vectors and virus vaccines.

The invention belongs to the technical field of soil conditioners, and particularly relates to a soil biological conditioner and a preparation method thereof. The biological soil improver comprises the following raw materials in parts by weight: 30-50 parts of soybean meal, 10-15 parts of modified diatomite, 1-5 parts of a microbial agent, 6-12 parts of urea, 0.5-3 parts of a Zostera marina extract and 0.01-0.03 part of sodium selenite. A preparation process of the modified diatomite comprises the following steps: adding pretreated diatomite into water, then adding sodium dodecyl benzene sulfonate, adjusting the pH value of a system, and stirring to obtain diatomite with the surface modified by sodium dodecyl benzene sulfonate; adding magnesium nitrate and ferric nitrate into deionized water to obtain a mixed solution A; under the stirring condition, the mixed solution A is added into a sodium hydroxide solution, then diatomite with the surface modified by sodium dodecyl benzene sulfonate is added, heating reaction is conducted, and the modified diatomite is obtained. The obtained soil biological improver can improve the property of acid soil and promote the growth of crops.

The invention discloses an immunomodulatory composition based on a cordycepin-selenium nano chelate and a preparation method thereof, and belongs to the technical field of biological medicines.The immunomodulatory composition is characterized in that 15-25 nm zero-valent selenium nano particles are chelated through hydroxyl of cordycepin and N7 site bidentate coordination, and a stable five-membered ring structure with the molar ratio is formed; the preparation method comprises the following steps: reducing sodium selenite in an inert atmosphere to generate selenium colloid, chelating the selenium colloid with a cordycepin ethanol solution, and carrying out ultrafiltration and freeze-drying to obtain the product. The invention aims to solve the problems of fuzzy structure, inconsistent batch, uncontrollable immunomodulatory function and the like caused by non-specific mixing in the prior art, and the composition can bidirectionally regulate and control IRF3 pathways, promote polarization of M2 type macrophages and proliferation of Treg cells, and has a clear immunomodulatory mechanism and excellent stability.

According to the red nano-selenium and the preparation method thereof, sodium selenite is used as a selenium source, and ascorbic acid is used as a reducing agent. The reaction medium is impacted by mechanical force in the high-speed crusher and refined, so that the surface area is increased, the reaction is accelerated to achieve a nano effect, and a red nano-selenium mixture is formed. The molar ratio of sodium selenite to ascorbic acid serving as reaction media is increased, the particle size of the nano-selenium is controlled to be 10-50nm, the agglomeration phenomenon of the nano-selenium is reduced, and the stability of the nano-selenium is improved. Ascorbic acid is used as a reducing agent to completely replace traditional toxic reagents such as hydrazine hydrate and thiourea, so that harmful substance residues are avoided. The product can be directly applied without washing, and agglomeration of the nano-selenium material in washing and drying is avoided. Solid-phase mechanochemical reduction is achieved through high-speed smashing equipment, and the strict dependence of a traditional liquid phase on the temperature and the pH value is broken through. The preparation method is low in investment, simple to operate, free of emission of three wastes and suitable for small-batch and industrial production.

The invention discloses a composition for improving sexual life and / or prostate symptoms and a preparation method thereof. The composition is prepared from the following components in parts by weight: 30 to 50 parts of algal polysaccharides, 15 to 25 parts of phospholipid, 8 to 12 parts of euphausia superba oil, 8 to 12 parts of magnesium oxide, 8 to 12 parts of lycopene, 2 to 4 parts of zinc gluconate, 1 to 3 parts of radix ginseng extract, 0.8 to 1.2 parts of flos sophorae immaturus extract, 0.8 to 1.2 parts of fructus rubi extract, 0.8 to 1.2 parts of mulberry fruit extract, 0.8 to 1.2 parts of fructus lycii extract and 0.8 to 1.2 parts of sodium selenite. By limiting the raw materials and the dosage, under the combined action of the raw materials, the prepared composition can improve erectile, ejaculation and anterior lacrimal gland symptoms, can improve the quality of sexual life, and has no side effect on the body.

The invention discloses a selenium-rich dendrobium polysaccharide and a preparation method thereof, wherein the preparation method comprises the following steps: 1) taking a dendrobium officinale extract and adding a nitric acid solution to dissolve it; 2) taking the solution obtained in step 1), adding sodium selenite and barium chloride to react for 6 to 10 hours, cooling and filtering, taking the filtrate to adjust the pH value to 4 to 7, dialyzing, taking the dialyzate and drying, and obtaining the selenium-rich dendrobium polysaccharide. The preparation method of the selenium-rich dendrobium polysaccharide of the invention, through specific synthesis process parameters and a concentration and purification method, the total polysaccharide content in the selenium-rich dendrobium polysaccharide is greater than 90%, and the selenium content is greater than 1.2 mg / g. Experiments have proved that it has significant antioxidant and anti-wrinkle activities.

The invention provides a nano-selenium preparation for targeted regulation of GPx3 expression, a preparation method of the nano-selenium preparation and application of the nano-selenium preparation in anti-tumor drugs, especially application of the nano-selenium preparation in anti-prostatic cancer drugs. The preparation method comprises the following steps: respectively mixing a sodium selenite solution with an LET (lentinan) solution, water and a VC (vitamin C) solution for reaction, then separating and purifying the reaction solution, and filtering to obtain the nano-selenium preparation for targeted regulation of GPx3 expression. The invention aims to provide a novel nano-selenium preparation which has higher anti-tumor activity and lower toxicity on prostatic cancer.

The invention relates to a medical product for preventing or correcting selenium deficiency in a patient comprising a solution provided in a flexible container comprising at least one selenium compound in the form of Se(IV), which is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide, characterized in that the solution comprises dissolved oxygen (DO), preferably 0.5 ppm to 8 ppm DO.

The invention relates to a flexible container / multi-chamber container with selective dissolved gas content for stabilizing at least one compound of a medical product having a selective gas requirement for remaining stable, comprising a solution comprising the at least one compound and a fil material from which the container is made that provides for high gas-barrier for the said gas. The at least one compound may be selenium in the form of Se(IV) and is preferably selected from the group consisting of sodium selenite, selenous acid and selenium dioxide. The selective gas may be oxygen, and the headspace of the oxygen maintains the solution to comprise dissolved oxygen (DO) at a level of 0.5 ppm to 8 ppm.

The invention discloses a Fe-doped Bi2SeO5 nano material as well as a preparation method and application of the Fe-doped Bi2SeO5 nano material. The preparation method comprises the following steps: dissolving ferric chloride hexahydrate, bismuth nitrate pentahydrate and sodium selenite according to a specific ratio by using a hydrothermal synthesis technology and taking pure water as a solvent, and stirring at the room temperature of 25 DEG C until a system is uniform, so as to obtain a precursor mixed solution of the Fe-doped Bi2SeO5 nano material; the mixed solution is subjected to a hydrothermal reaction and then is subjected to heat treatment in an air atmosphere, and the target Fe-doped Bi2SeO5 nano material is finally obtained by regulating and controlling parameters such as a precursor ratio, a hydrothermal reaction temperature, heat preservation time and heat treatment conditions through a system. The nano material is used for catalytic degradation of antibiotics in a PMS system, and has the characteristics of strong anti-interference capability, good tolerance to acid and alkali environments, remarkable catalytic effect, high stability and the like.

The invention belongs to the technical field of nano-selenium material preparation, and particularly discloses needle-like nano-selenium and a preparation method thereof. According to the method, a sodium selenite solution and an ascorbic acid solution are subjected to an oxidation-reduction reaction under the ultrasonic condition, the needle-like nano-selenium can be obtained, and the diameter of the needle-like nano-selenium is 20-100 nm. The preparation steps disclosed by the invention are simple and convenient to operate, the reaction can be carried out under the conditions of normal temperature and normal pressure, complicated equipment is not needed, and excessive auxiliaries such as a surfactant are not needed; and the shape and size of the needle-shaped nano-selenium can be effectively controlled through an ultrasonic-assisted technology, so that the needle-shaped nano-selenium can meet the requirements of various applications. By introducing ultrasonic waves, the speed of the reduction reaction is remarkably increased, the generation rate of nano-selenium is increased, and the preparation process is more efficient. The method is suitable for large-scale industrial production and has a wide application prospect.

The invention relates to the technical field of biological nano-materials, in particular to a preparation method and application of sodium alginate functionalized nano-selenium, and the preparation method comprises the following steps: step 1, uniformly mixing sodium selenite and a sodium alginate solution, and then slowly adding an ascorbic acid solution to form a reaction system; stirring with a magnetic stirrer at a constant temperature and a constant speed at regular time, and reacting for a period of time to obtain an alginic acid nano-selenium solution; 2, optimizing experimental reaction conditions in the step 1 by adopting a dual-wavelength method, and determining optimal reaction conditions by changing the solubility of a sodium alginate solution, the concentration ratio of ascorbic acid to sodium selenite and reaction time to obtain a reaction solution; and step 3, performing dialysis treatment on the reaction solution in the step 2, and performing freeze drying to obtain the alginic acid nano-selenium. According to the invention, a dual-wavelength method is adopted to optimize reaction conditions, the synthesis method is simple, the raw material source is rich, and the prepared polysaccharide nano-selenium has the characteristics of good stability, strong oxidation resistance, high selenium content and good dispersibility.

The invention belongs to the technical field of nano materials and nano medicine, and particularly relates to bismuth selenide nano particles and a preparation method and application thereof.The bismuth selenide nano particles are prepared from sodium selenite, bismuth nitrate (III) pentahydrate, polyvinylpyrrolidone and hydrazine hydrate, polyvinylpyrrolidone is adsorbed on the surface of bismuth selenide generated by reaction of sodium selenite and bismuth (III) nitrate pentahydrate. After photo-thermal treatment is finished, ROS can be eliminated through the bismuth selenide nano-particles so as to reduce aseptic inflammation caused by postoperative infection, side effects caused by PTT are further reduced, and the bismuth selenide nano-particles are ideal materials for treating peritumoral infection caused by tumors.

This invention provides a nano-selenium, its preparation method, and its applications, relating to the field of nano-selenium fertilizer technology. Using sodium selenate or sodium selenite as raw material A and thiol-functionalized graphene as raw material B, raw material A and raw material B are mixed and reacted for a certain period to obtain nano-selenium, which can be used in fertilizers, food anti-oxidation and preservation, industrial catalysis, or chemical analysis. This invention uses inorganic selenium and thiol-functionalized graphene as raw materials. Through a simple solution mixing, reaction, and settling process, the in-situ reduction of selenite by thiol-functionalized graphene and the stable loading of nano-selenium are achieved, completing the conversion from inorganic selenium to nano-selenium in one step without the need for reducing agents.

This invention belongs to the technical field of functional personal care products, and specifically relates to a highly efficient and stable natural sulfur hot spring bath concentrate formula and its preparation process. The bath concentrate formula, by mass percentage, comprises the following components: 35.0-65.0% sulfur hot spring active concentrate, 0.001-0.01% sodium selenite, 0.1-1.0% sodium thiosulfate, 0.05-0.2% disodium EDTA, 0.5-3.0% cationic liposomes, 0.2-0.8% carrageenan, 0.5-3.0% calcium source, 0.3-2.0% magnesium source, 0.1-0.5% bisabolol, 0.1-0.5% dipotassium glycyrrhizate, 0.2-1.5% citrate-sodium citrate buffer pair, 3.0-8.0% polyol, 0.1-0.3% β-cyclodextrin-encapsulated fragrance, and deionized water to 100%. A liquid bath concentrate was obtained using natural sulfur hot spring water as the water source, which fully retains its active sulfide spectrum and characteristic mineral ions, and can be stored for a long time at normal temperature and pressure. It has the advantages of high stability, high polysulfide content, slow release, and no irritation.

The present invention relates to a method for synthesizing and screening Bi2O2Se twisted molar superlattices, belonging to the technical field of material synthesis. In the present invention, under an ice-water bath and stirring conditions, ammonium bismuth citrate and sodium selenite are successively added to a KOH solution, mixed evenly and stirred for 0.8 - 1.2 h to obtain a precursor solution A; the precursor solution A is hydrothermally reacted at a temperature of 180 - 185 °C for 24 - 36 h to obtain a mixed solution B; the mixed solution B is successively washed with deionized water and ethanol, and centrifuged to remove the bottom solid impurities to obtain a supernatant; the supernatant is evenly dispersed on a silicon substrate and dried to obtain a sample, and the sample is observed with a visible light microscope, and the sample showing a color different from that of the intrinsic Bi2O2Se sample under the visible light microscope is located; the located sample is placed under a scanning electron microscope for observation, and the sample with orange wrinkles is selected, then the sample showing a color different from that of the intrinsic Bi2O2Se sample under the visible light microscope and having orange wrinkles under the scanning electron microscope is the Bi2O2Se twisted molar superlattice.

The application discloses a preparation method of a lysozyme-nano selenium compound and application of the lysozyme-nano selenium compound in ROS removal. To mix sodium selenite solution and lysozyme uniformly, a lysozyme-sodium selenite solution is obtained, then vitamin C is added, and the mixture is uniformly mixed under the condition of light shielding and at room temperature, the pH value is adjusted to 6.5-7.5, a red solution is obtained, and dialysis is performed, so that the lysozyme-nano selenium compound is obtained. The lysozyme-nano selenium compound has the advantages of simple process, mild preparation condition, higher stability, biological safety, efficient ROS removal in egg white, and no influence on the regulation ability of the functional property, edible quality and other characteristics of the egg white, so that the deterioration problem of the egg white in the storage process is solved. The lysozyme-nano selenium compound has good application prospect in ROS removal, and can be applied to the fields of biomedical science and material science.

This invention relates to a rare-earth-selenium tungsten oxide nanocluster material functionalized with mixed organic ligands, the chemical formula of which is [HDMEA]. 9 Na 12 H3[Ce6(DMEA)3(H2O)9W9(HTA)6O 18 (SeW9O 33 [6]ˑ81H2O, where DMEA = N,N-dimethylethanolamine and H3TA = hydroxymalonic acid. This material is prepared by a one-step self-assembly reaction of sodium tungstate dihydrate, N,N-dimethylethanolamine, sodium selenite, hydroxymalonic acid, and cerium nitrate hexahydrate in aqueous solution. The experimental operation is simple and the cost is low. This material can be used as a polyanionic polymer to form a thin film material by layer-by-layer assembly with positively charged chitosan. This multilayer film can be used as a sensitizing material to combine with polypyrrole containing template molecules (2,4-dichlorophenol) to form a molecularly imprinted polymer. This polymer can be used to construct an electrochemical sensor for detecting 2,4-dichlorophenol. Experimental results show that this electrochemical sensor has high sensitivity, strong stability, a wide detection range (1 μM–1 mM), and a low detection limit (0.125 μM).

The application discloses a kind of stabilized hot spring sulfide active ingredients and its preparation method and application, belong to natural product processing and daily chemical technology field, including hot spring water or concentrated liquid rich in sulfide, sodium selenite, cationic polymer, hydrophobic silicone oil or natural oil, metal ion chelating agent, cyclodextrin inclusion zinc salt, natural aromatic oil and antioxidant.The application builds the dual stabilization and slow-release system of "electrostatic adsorption+physical barrier" by the in-situ synergistic effect of cationic polymer and oil, solves the contradiction between storage stability and service life.The final product of the application is extremely high in stability, has no bad smell, low irritability, and has smooth skin feel, completely overcomes the traditional obstacles of sulfur component in daily chemicals.

The invention belongs to the technical field of electrocatalytic oxygen evolution reaction, and particularly relates to a method for preparing a cobalt diselenide reduced graphene oxide electrocatalyst by taking ZIF-67 as a precursor. The invention solves the problems of poor conductivity and easy agglomeration of cobalt diselenide, and develops an electro-catalytic oxygen evolution reaction catalyst with low cost and high catalytic performance. The electrocatalyst provided by the invention adopts foamed nickel to bear cobalt diselenide and graphene oxide. The preparation method comprises the following steps: step 1, mixing a 2-methylimidazole solution with a cobalt nitrate hexahydrate solution to obtain a ZIF-67 precursor; 2, the foamed nickel is sequentially cleaned with ethyl alcohol and deionized water in an ultrasonic cleaner and then dried; and 3, dispersing the ZIF-67 precursor in water, adding graphene oxide, sodium hydroxide, ethylenediamine tetraacetic acid, sodium borohydride and sodium selenite into the solution, mixing, carrying out a hydrothermal reaction with foamed nickel, washing the product after the reaction, and drying.

The invention provides selenium-rich chlorella powder and a preparation method and application thereof, the preparation method comprises the following steps: preparation of nano-selenium: uniformly mixing a sodium selenite solution with a carboxymethyl cellulose solution, then adding a vitamin C solution, reacting at room temperature in a dark place, and dialyzing to obtain red transparent nano-selenium sol; culturing the selenium-rich chlorella: inoculating the chlorella into a culture medium containing nano-selenium sol, and carrying out aerobic culture under an illumination condition; and collection of selenium-rich chlorella powder: filtering to remove precipitated large selenium particles, centrifugally collecting algae, washing, drying and crushing to obtain the selenium-rich chlorella powder. The obtained product is high in selenium content, strong in biological activity and good in safety, and can be used as a raw material of a functional selenium supplement.

The invention provides a sustained-release bar for repairing mammary glands in the early stage of dry milk of dairy cows and a preparation method thereof, and belongs to the technical field of veterinary pharmaceutical preparations. The breast repair slow-release bar for the dairy cow in the early stage of dry milk is prepared from the following raw materials in parts by weight: 6 to 10 parts of compound plant extract, 10 to 15 parts of ferroferric oxide, 8 to 12 parts of magnesium oxide, 6 to 10 parts of zinc sulfate, 1 to 5 parts of hordenine hydrochloride, 1 to 5 parts of manganese sulfate, 0.05 to 0.15 part of calcium iodate, 0.05 to 0.15 part of sodium selenite, 0.5 to 2 parts of calcium stearate and 3 to 10 parts of vegetable oil. The breast repair slow-release bar for the dairy cow in the initial dry period can effectively promote emptying and involution of breasts of the dairy cow in the dry period, the involution period is remarkably shortened, the risk of mastitis infection in the dry period is reduced, and the repair effect of the breast repair slow-release bar is better than that of natural milk stop.

The invention discloses selenium-doped ruthenium dioxide and a preparation method and application thereof.Ruthenium trichloride and sodium selenite are dissolved in an alcohol solvent and then placed in an oil bath pan to react, a reacted sample is washed, loaded, dried and calcined, and finally selenium-doped ruthenium dioxide is successfully prepared. The prepared ruthenium dioxide is in a porous cluster shape, more active sites can be exposed, the activity and stability of the ruthenium dioxide are improved by regulating electron transfer through selenium doping and inducing reaction mechanism transformation, and the ruthenium dioxide shows excellent oxygen evolution performance when serving as a catalyst to be used for hydrogen production through water electrolysis and has application prospects in the field of electrocatalysis.

The present invention first discloses a method for preparing a lectin-modified nano-selenium composite material, including the steps of mixing AANL with sodium selenite for the first incubation, mixing with ascorbic acid for the second incubation, coating, centrifuging and discarding the supernatant, resuspending, washing, etc. The present invention also discloses the application of the composite material in sugar binding, especially cell agglutination and / or in anti-oxidation and / or in the preparation of drugs for inhibiting lung cancer cell proliferation. The method of the present invention has low cost, environmental protection, high efficiency, simple preparation method, simple required equipment, and is easy to promote. The composite material provided has good dispersibility, is more stable, has good biocompatibility and solubility, and has significant application effect. It can be better used in the field of glycobiology as a sugar tool; it has better biological activity, strong antioxidant activity and ability to inhibit lung cancer cell proliferation, and has good application prospects in the field of biomedicine.

The application provides a precipitant for precipitating a silver base body, a preparation method and application, and the precipitant comprises potassium thiocyanate, an auxiliary complexing agent, trace rare earth elements, a synergist and trace selenium compounds; wherein the auxiliary complexing agent is at least one of pyrrolidone, N-ethyl-N-methyl aminoacetic acid or a combination thereof; the trace selenium compounds are sodium selenite or sodium selenate, the addition amount of the trace selenium compounds is 0.001%-0.05% of the total mass of the precipitant; and the mass ratio of the auxiliary complexing agent to the trace selenium compounds is 20:1-60:1. Through optimization of component allocation and auxiliary additives, rapid precipitation of silver elements is realized, and the application is suitable for various scenes such as element content analysis of silver alloy products and harmful element migration amount detection of silver tableware.

The invention provides a preparation method and application of a quantum dot composite fluorescent microsphere solution, and the preparation method comprises the following steps: dissolving sodium selenite and sodium sulfite in purified water, stirring, heating and refluxing to obtain a Na2SeSO3 solution; dissolving cadmium acetate in purified water to adjust the pH value, and injecting a stabilizer and a Na2SeSO3 solution to obtain a CdSe quantum dot solution; znSO4. 7H2O is dissolved in purified water, MPA is added, the pH value is adjusted, NaHS powder is added, and a ZnS shell layer precursor solution is prepared; adding the ZnS shell layer precursor solution into the CdSe quantum dot solution, performing heating reflux, and performing centrifugal drying to obtain CdSe / ZnS quantum dots; the preparation method comprises the following steps: coating CdSe / ZnS quantum dots in carboxylated polystyrene microspheres, and carrying out oscillation, swelling equilibrium, centrifugation, washing and drying to obtain a CdSe / ZnS (at) PS-COOH quantum dot fluorescent microsphere solution. The stability and fluorescence efficiency of a quantum dot solution can be effectively improved, and meanwhile, the dog and cat helicobacter pylori antigen detection test strip prepared from the quantum dot fluorescent microspheres combines the advantages of quick reading detection and high sensitivity, and is suitable for on-site quick screening or quantitative detection.

The invention discloses schizophyllum commune and a method for synthesizing nano-selenium by using the schizophyllum commune. According to the invention, a Schizophyllum commune FLM1 strain is separated and identified in dalbergia odorifera, the strain is preserved in Guangdong Microbial Culture Collection Center on April 6, 2023, and the preservation number is GDMCC No: 63328. Research shows that the FLM1 strain has the capacity of efficiently converting sodium selenite to generate nano-selenium, schizophyllum commune mycelium is adopted as a biological material, a sodium selenite solution is added into a fermentation medium, and red elementary substance nano-selenium is prepared after fermentation; according to the method, tetravalent inorganic selenium salt can be converted to produce nano-selenium, the conversion rate of selenium reaches up to 91.44% under the high sodium selenite concentration, and the selenium content of mycelia is high. The invention provides a simple, convenient, safe and efficient nano-selenium biosynthesis method with mild conditions, and reference is provided for development and utilization of selenium resources.