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Bioactive artificial joint capable of slowly releasing trace element selenium

An artificial joint, biological activity technology, applied in medical science, prosthesis, coating and other directions, to achieve the effect of improving the body's immunity

Inactive Publication Date: 2010-06-16
江苏广达医材集团有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Technical problem: The object of the present invention is to address the above-mentioned shortcomings of artificial joints, and propose an artificial joint that has the function of slow-release of trace element selenium, and can significantly improve the ability of artificial joint surface to induce osteogenesis at the initial stage of implantation and its preparation method

Method used

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  • Bioactive artificial joint capable of slowly releasing trace element selenium
  • Bioactive artificial joint capable of slowly releasing trace element selenium
  • Bioactive artificial joint capable of slowly releasing trace element selenium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0025] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial joint;

[0026] (3) Centrifugal loading treatment of trace amounts of sodium selenite and BMP: fix the artificial joint of the sodium titanate bioactive coating with microporous structure on the surface in the centrifugal cylinder, pour 5 × 10 -3 mol / L sodium selenite, 0.1-50 mg / L bone morphogenetic protein and 0.1 mol / L phosphate-buffered saline solution, and submerge more than twice the height, and work at a centrifuga...

Embodiment 2

[0029] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0030] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 120 degrees Celsius. The time is 6 hours, and a sodium titanate bioactive coating with a microporous structure is obtained on the surface of the artificial joint;

[0031] (3) Centrifugal loading treatment of trace amounts of sodium selenite and BMP: fix the artificial joint of the sodium titanate bioactive coating with microporous structure on the surface in the centrifugal cylinder, pour 5 × 10 -3 mol / L sodium selenite, 0.1-50 mg / L bone morphogenetic protein and 0.1 mol / L phosphate-buffered saline solution, and submerge more than twice the height, and work at a centrifuga...

Embodiment 3

[0034] (1) First choose Ti6Al4V alloy to process the artificial joint;

[0035] (2) Hydrothermal treatment of the artificial joint surface: the artificial joint is ground and polished, then ultrasonically cleaned with acetone, 70% alcohol, and distilled water, and the hydrothermal reaction is carried out with a sodium hydroxide aqueous solution with a concentration of 10mol / L, and the working temperature is 150 degrees Celsius. The time is 72 hours, and a sodium titanate bioactive coating with microporous structure is obtained on the surface of the artificial joint, and its SEM photos and XRD spectra are shown in figure 1 and figure 2 ;

[0036] (3) Centrifugal loading treatment of trace amounts of sodium selenite and BMP: fix the artificial joint of the sodium titanate bioactive coating with microporous structure on the surface in the centrifugal cylinder, pour 5 × 10 -3 mol / L sodium selenite, 0.1-50 mg / L bone morphogenetic protein and 0.1 mol / L phosphate-buffered saline sol...

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Abstract

The invention relates to a bioactive artificial joint capable of slowly releasing trace element selenium. The artificial joint consists of a pure titanium or titanium alloy artificial joint matrix and a microporous sodium titanate surface layer loaded with trace sodium selenite and bone morphogenetic protein (BMP), wherein the sodium titanate bioactive layer with microporous structures is combined with the surface of the metal matrix and formed by mutually and alternately stacking the sodium titanate microporous structures generated by carrying out a hydrothermal reaction on the surface of the titanium or titanium alloy matrix and a sodium hydroxide solution, and the trace sodium selenite and the BMP are compounded in the microporous structures through centrifugal force and the effect of capillaries. A preparation method of the bioactive artificial joint comprises the following steps of: firstly, selecting a processed pure titanium or titanium alloy artificial joint; then obtaining the sodium titanate layer with the microporous structures on the surface of the titanium artificial joint by adopting an alkali liquor hydrothermal synthesis technology; and finally, loading the sodium selenite and the BMP in the microporous sodium titanate layer by adopting a centrifugal loading technology.

Description

technical field [0001] The invention relates to a biologically active artificial joint capable of slow release of trace element selenium, in particular to a microporous sodium titanate surface layer composed of pure titanium or titanium alloy artificial joint matrix and loaded with trace element selenium and bone morphogenetic protein The composed artificial joint and its preparation method belong to the technical field of artificial joint materials. Background technique [0002] Every year, about 1.5 million patients with joint loss due to degenerative and inflammatory arthritis need artificial joint replacement. Among them, the application of metal materials in the manufacture of artificial joints is the earliest, and it is still the most widely used in clinical practice. Over time and clinical studies have shown that artificial joints made of metal materials commonly loosen, sink or break, causing bone resorption, which is one of the main complications affecting the long...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/30A61L27/06A61L27/56A61L27/54
Inventor 储成林盛晓波
Owner 江苏广达医材集团有限公司
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