Nano-selenium-zein composite nano-particle and preparation method thereof

A technology of zein and composite nanoparticles, which is applied in the direction of drug combination, active ingredients of sulfur/selenium/tellurium, non-active ingredients of polymer compounds, etc., can solve the problem of stable nano-selenium and achieve controllable particle size Effect

Active Publication Date: 2020-10-13
GUANGZHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In summary, there is no related research on the use of zein to stabilize nano-selenium in existing reports

Method used

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  • Nano-selenium-zein composite nano-particle and preparation method thereof
  • Nano-selenium-zein composite nano-particle and preparation method thereof
  • Nano-selenium-zein composite nano-particle and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] A nano-selenium-zein composite nanoparticle, the preparation method of which comprises the following steps:

[0035] (1) Weigh 0.1295g of sodium selenite and dissolve it in 250mL of 1% acetic acid to obtain a 3mmol / L sodium selenite solution.

[0036] (2) According to the weight ratio of sodium selenite to zein of 1:4, zein was weighed and dissolved in 8 mL of 85% ethanol solution to obtain a zein solution.

[0037] (3) Pour 50 mL of the sodium selenite solution in step (1) into the zein solution in step (2) under magnetic stirring at one time, stir for 1 minute to make it fully mixed, and then transfer it to the rotary evaporator bottle, 55°C rotary evaporation for 13 minutes, and dilute to 50mL.

[0038] (4) Add ascorbic acid according to the ratio of selenous acid to ascorbic acid molar ratio of 1:4. The nano-selenium-zein composite nanoparticles were prepared by magnetic stirring for 20 minutes.

Embodiment 2

[0040] A nano-selenium-zein composite nanoparticle, the preparation method of which comprises the following steps:

[0041] (1) Weigh 0.2595g of sodium selenite and dissolve it in 250mL of distilled water to obtain a 6mmol / L sodium selenite solution.

[0042] (2) According to the weight ratio of sodium selenite to zein of 1:0.5, zein was weighed and dissolved in 8 mL of 85% ethanol solution to obtain a zein solution.

[0043] (3) Pour 50 mL of the sodium selenite solution in step (1) into the zein solution in step (2) under magnetic stirring at one time, stir for 1 min to make it fully mixed, and then transfer it to a rotary steamer , 55°C rotary evaporation for 13min, and dilute to 50mL.

[0044] (4) Add ascorbic acid according to the ratio of selenous acid to ascorbic acid molar ratio of 1:4. The nano-selenium-zein composite nanoparticles were prepared by magnetic stirring for 20 minutes.

Embodiment 3

[0046] A nano-selenium-zein composite nanoparticle, the preparation method of which comprises the following steps:

[0047] (1) Weigh 0.2595g of sodium selenite and dissolve it in 250mL of distilled water to obtain a 6mmol / L sodium selenite solution.

[0048] (2) According to the weight ratio of sodium selenite to zein of 1:1, zein was weighed and dissolved in 8 mL of 85% ethanol solution to obtain a zein solution.

[0049] (3) Pour 50 mL of the sodium selenite solution in step (1) into the zein solution in step (2) under magnetic stirring at one time, stir for 1 min to make it fully mixed, and then transfer it to a rotary steamer , 55°C rotary evaporation for 13min, and dilute to 50mL.

[0050] (4) Add ascorbic acid according to the ratio of selenous acid to ascorbic acid molar ratio of 1:4. The nano-selenium-zein composite nanoparticles were prepared by magnetic stirring for 20 minutes.

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Abstract

The invention relates to nano-selenium-zein composite nano-particle and a preparation method thereof, and belongs to the field of modern healthy food processing. The nano-selenium-zein composite nano-particle disclosed by the invention comprises elemental selenium and zein coating the elemental selenium. The preparation method comprises the following steps: (1) pouring a sodium selenite solution into a zein solution, and performing uniform mixing; and (2) adding ascorbic acid into the solution obtained in the step (1), and performing stirring or ultrasonic treatment to obtain the nano-selenium-zein composite nano-particle. The invention discloses the preparation of the nano-selenium particle by using zein for the first time, the prepared nano-selenium composite particle has the advantagesof good pH responsiveness and controllable particle size, and the problems of single nano-selenium particles and limited application scenarios in the prior art are solved.

Description

technical field [0001] The invention belongs to the technical field of modern food processing, and in particular relates to a nanometer selenium-zein composite nanoparticle and a preparation method thereof. Background technique [0002] Selenium is an essential trace element in human nutrition and has important physiological functions. It cannot be synthesized by the human body and can only be supplemented externally. In 2017, China’s health industry standard WS / T 578.3-2017, Part 3 of Chinese Residents’ Dietary Nutrient Reference Intakes stipulates that the daily selenium intake for adults is 50 μg, the recommended amount is 60 μg, and the maximum intake is 400 μg. In nature, the main forms of selenium are insoluble elemental selenium and soluble selenite and selenate. However, due to its narrow range of toxicity and safety, how to supplement selenium has become a difficult point. With the advancement of science and technology, the form of selenium supplements has graduall...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/42A61K33/04A61P3/02A23L33/16A23L33/185A23L29/00A23L5/30A23P10/30
CPCA61K9/5169A61K9/5192A61K33/04A61P3/02A23L33/16A23L33/185A23L29/015A23L29/045A23L5/32A23P10/30A23V2002/00A23V2200/30A23V2250/1626A23V2250/548A23V2250/082A23V2250/708A23V2250/1614A23V2250/06A23V2300/48Y02A40/90
Inventor 袁杨王号
Owner GUANGZHOU UNIVERSITY
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