230results about How to "Improved controlled release" patented technology

The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B₁ of at least 500 N in direction of extension E₁ and having a breaking strength B₂ of less than 500 N in direction of extension E₂.

The invention discloses a controlled release fertilizer coated by vegetable oil based polyurethane and a preparation method thereof. The preparation method of the controlled release fertilizer coated by vegetable oil based polyurethane comprises the following steps of: 1) preheating the granular fertilizer; 2) heating plant oil polyhydric alcohol containing 2-6 hydroxys and isocyanate containing at least two isocyanate groups, and uniformly mixing the ingredients to form a vegetable oil based polyurethane coating liquid; 3) spray coating the vegetable oil based polyurethane coating liquid on the surfaces of the preheated fertilizer granules, repeatedly spray coating the vegetable oil based polyurethane coating liquid for 2-10 times after the vegetable oil based polyurethane coating liquid solid is solidified to obtain the controlled release fertilizer coated by vegetable oil based polyurethane. According to the controlled release fertilizer coated by vegetable oil based polyurethane and the preparation method thereof provided by the invention, the adopted coating material is extensive in resource, cheap and liable to obtain, non-toxic, harmless, simple in production process and good in controlled release effect of fertilizer.

A sustained release composition comprising expanded thermoplastic microspheres, an active agent, and an optional release retardant is disclosed. The composition has an improved ability to stabilize and release the active agent over an extended time period.

The invention belongs to the field of biomedical engineering materials and discloses a nitric oxide loaded cationic polymer, a preparation method therefor and an application of the nitric oxide loaded cationic polymer in the field of biomedicine. A cationic polymer which is used for loading nitric oxide and containing a dendritic polyamide element specifically is a polyethyleneimine grafted dendritic polyamide polymer and has a molecular formula shown in the description. The invention further provides the nitric oxide loaded cationic polymer based on the polymer. The nitric oxide loaded cationic polymer disclosed by the invention can be applied to the field of biomedicine as a nitric oxide donor material through loading NO, is used as a biomedical material and particularly is applied to the preparation of antibacterials; and the nitric oxide loaded cationic polymer has the effects of effectively inhibiting the growth and reproduction of bacteria and fungi, has remarkable inhibitory effects on common oral cavity pathogenic bacteria, dermatophyte, wound infection bacteria and the like, has the functions of promoting wound healing, diminishing inflammation and the like and provides a support for the application of the nitric oxide loaded cationic polymer in preparation of the biomedical engineering materials.

A multilayer structure with improved permeation for atmospheric diffusion of aromatic products wherein the structure comprises: a permeable membrane wherein said permeable membrane comprises at least two polymeric layers wherein the polymer of each layer is independently selected from the group consisting of polyethylene, very low density polyethylene, low density polyethylene, ethylene methylacrylate copolymer; a release layer wherein said release layer comprises a nylon polymer or a ethylene vinyl alcohol copolymer wherein the release layer is adhered to most inner polymeric layer of the permeable member which comprises the permeable membrane and wherein the adhesion between release layer and the adjacent layer of the polymeric permeable membrane is a relatively weak bond compared to the bond between the layers of the polymeric permeable membrane; and an impermeable membrane wherein said impermeable membrane comprises one or more layers wherein the materials which comprise the individual layers of the impermeable membrane are independently selected from metal or foil and wherein said impermeable portion is laminated to said release layer.

A vacuum cleaner comprises a rigid dirt receptacle 14 having an outlet at one end, through which the collected dirt and dust can be emptied, a flap 16 for closing the outlet, and an actuator 58 for moving the flap 16 between a closed position and an open position, the actuator 58 being operable to control the position of the flap 16 between the open and closed positions.

A location is provided at a partially opened position of the flap 16, at which position fine dirt and dust can be emptied through the restricted outlet in a controlled manner. The restricted size of the outlet retains any coarse and fibrous dirt inside the receptacle 14. Once the fine dirt has been emptied, the flap 16 can be moved to its fully open position to allow the coarse dirt and fibrous matter to be emptied from the receptacle 14 separately from the fine dust.

The invention relates to an alkyd resin emulsion-wax compound coated controlled release fertilizer and a preparation method thereof. The coated controlled release fertilizer consists of a fertilizer core and a capsule which is outside the fertilizer core, wherein, the capsule comprises a wax capsule, the exterior of the wax capsule has a polymer film that contains an alkyd resin emulsion coated agent and an inorganic layer that is arbitrarily arranged on the polymer film and contains inorganic powders.

The invention provides a special controlled-release fertilizer for fast-growing eucalyptus and a preparation method thereof, belonging to the field of mixed fertilizers. The fertilizer comprises an outer wrapping layer consisting of rumen protected fat and inner fertilizer particles. The fertilizer particles are prepared by mixing the following components: urea, monoammonium phosphate, potassium chloride, calcium-magnesium phosphate powder, borax, copper sulfate, zinc sulfate, compound sodium nitrophenolate, polyglutamic acid, humic acid and an adhesive. The fertilizer has abundant and comprehensive nutritional ingredients, can satisfy the demands of eucalyptus on various nutrients in the normal growing process to accelerate the eucalyptus to grow fast, and has a good controlled-release effect, so that the loss of nutrients of the fertilizer is effectively reduced, and the utilization ratio of the fertilizer is improved.

The invention discloses a method for preparing mineral organic fertilizer by using surplus sludge in municipal sewage plants. The method mainly comprises the following three steps: firstly reducing sludge in a sludge thickening tank, dehydrating the reduced sludge by adopting a catalytic ozonation method, carrying out subcritical water reaction on the dehydrated sludge, and discharging solids subjected to harmless treatment; finally mixing modified attapulgite clay with the sludge subjected to harmless treatment, chicken manure and microorganism beneficial microbial agents, and fermenting the mixture to obtain the mineral ecological organic fertilizer. The method is green and environment-friendly and realizes the harmless and resourceful treatment of the sludge; the obtained mineral organic fertilizer is capable of obviously improving the structure of soil, enabling the volume-weight of soil to be reduced, the holes of soil to be increased and the ventilation and water permeability of the soil to become good and adjusting the uniform growth of crops and has a good controlled release effect, thus the quality of the crops is improved.

A fuser and receiver release system and method are provided for improving the release of receivers in high speed of printing systems. This system controls the release of a receiver in conjunction with a fuser in a printing system, and specifically the efficiency and accuracy of the release system. One embodiment of this method includes a belt fuser that allows the separating of the heat transfer and release functions of the fuser such that fuser roller could be made of hard metal core that can be heated to high temperatures without the fear of delaminating elastomeric coatings which are common in roller fusing.

The invention discloses a swelling-type hollow silk fibroin micro-needle drug delivery system and a preparation method thereof. According to the technical scheme of the preparation method, a swelling modified silk fibroin solution is casted in a PDMS mold to be vacuumized, dried and molded as a hollow needle-type housing. After that, a silk fibroin micro-needle array provided with cavities in the hollow needle-type housing is filled with powder-like or solution-like drugs, vacuumizing and drying are carried out to form a drug part. Finally, a layer of modified silk fibroin solution is cast, dried and molded as a cladded coating. The cladded coating is removed to obtain the swelling-type hollow silk fibroin micro-needle drug delivery system. The drugs are wrapped inside the cavities of the silk fibroin micro-needle arrays, so that the system is high in drug loading ratio and low in skin allergenicity and stimulation. The system facilitates the sustained release and the controlled release of micro-needle drugs. Meanwhile, according to the preparation method, since the swelling modified silk fibroin solution is cast, dried and molded in a mild processing condition, the system is low in processing cost and suitable for large-scale production. Drugs are directly wrapped in the cavities of the swelling hollow micro-needles, so that controlled-release drugs are swelled in the micro-needle base material. In this way, the biological activities of the controlled-release drugs are maintained, while the structure of the hollow silk fibroin micro-needle drug delivery system is greatly simplified. The system is better in practicality.

The invention relates to an antibacterial functionalized artificial joint with a silver-loaded nanotube array surface. The surface of a metal substrate of the artificial joint is provided with a silver-doped sodium titanate nanotube array layer with a tubular structure. The inside of the silver-doped sodium titanate nanotube array layer is further loaded with bone morphogenetic protein (BMP). A preparation method of the antibacterial functionalized artificial joint with the silver-loaded nanotube array surface comprises the following steps: firstly selecting pure titanium or titanium alloy to process the artificial joint; then adopting the two-step anodizing technology to obtain a titanium dioxide nanotube array layer with a tubular structure on the surface of the pure titanium or titanium alloy artificial joint; adopting the alkaline hydrothermal synthesis technology to convert the titanium dioxide nanotube array layer into the sodium titanate nanotube array layer; doping trace silver in the sodium titanate nanotube array layer by solution impregnation iron exchange; and finally adopting the centrifugal load technology to load the bone morphogenetic protein in the silver-doped sodium titanate nanotube array layer.

The invention relates to a method for preparing W/O/W type compound emulsion embedding an chlorogenic acid, belonging to the field of compound emulsion preparation and comprising the following steps: mixing 1 part of aqueous chlorogenic acid solution by weight, 2 parts of oil phases by weight and 0.2-0.4 part of lipophilic emulsifier by weight to be stirred for 4-10 minutes under the speed of 6,000-15,000 turns/minute so as to obtain W/O type colostrums; and then mixing 2-3 parts of the W/O type colostrums and 2-3 parts of external water phrases to be stirred for 2-10 minutes under the speed of 1000-6000 turns/minute so as to obtain the W/O/W type compound emulsion. The method for preparing the W/O/W type compound emulsion can not only play roles of protection and storage on the chlorogenic acid, but also realize the uniform and effective release of the chlorogenic acid in human bodies, and also promotes the slow release, the controlled release and the target effect of absorption and sufficiently plays a role of the chlorogenic acid by embedding the hlorogenic acid with the W/O/W type compound emulsion.