233results about How to "Improved controlled release" patented technology

The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.

Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.

The invention relates to an enveloped controlled release fertilizer and method for preparation which consists of, preheating the urea particles to a predetermined temperature, spraying the molten liquid state sulfur to the urea particles, forming a layer of smooth and compact sulfur-coated urea, charging hot-curing resin component on the sulfur-coated urea for even distribution onto the urea particle surface and fast formation.

The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.

The invention relates to an enveloped controlled release fertilizer and method for preparation which consists of, preheating the urea particles to a predetermined temperature, spraying the molten liquid state sulfur to the urea particles, forming a layer of smooth and compact sulfur-coated urea, charging hot-curing resin component on the sulfur-coated urea for even distribution onto the urea particle surface and fast formation.

The invention discloses a controlled release fertilizer coated by vegetable oil based polyurethane and a preparation method thereof. The preparation method of the controlled release fertilizer coated by vegetable oil based polyurethane comprises the following steps of: 1) preheating the granular fertilizer; 2) heating plant oil polyhydric alcohol containing 2-6 hydroxys and isocyanate containing at least two isocyanate groups, and uniformly mixing the ingredients to form a vegetable oil based polyurethane coating liquid; 3) spray coating the vegetable oil based polyurethane coating liquid on the surfaces of the preheated fertilizer granules, repeatedly spray coating the vegetable oil based polyurethane coating liquid for 2-10 times after the vegetable oil based polyurethane coating liquid solid is solidified to obtain the controlled release fertilizer coated by vegetable oil based polyurethane. According to the controlled release fertilizer coated by vegetable oil based polyurethane and the preparation method thereof provided by the invention, the adopted coating material is extensive in resource, cheap and liable to obtain, non-toxic, harmless, simple in production process and good in controlled release effect of fertilizer.

A fuser and receiver release system and method are provided for improving the release of receivers in high speed of printing systems. This system controls the release of a receiver in conjunction with a fuser in a printing system, and specifically the efficiency and accuracy of the release system. One embodiment of this method includes a belt fuser that allows the separating of the heat transfer and release functions of the fuser such that fuser roller could be made of hard metal core that can be heated to high temperatures without the fear of delaminating elastomeric coatings which are common in roller fusing.

A sustained release composition comprising expanded thermoplastic microspheres, an active agent, and an optional release retardant is disclosed. The composition has an improved ability to stabilize and release the active agent over an extended time period.

The invention discloses a polymer-coated controlled release pesticide granule and a preparation method thereof. The polymer-coated controlled release pesticide granule comprises a pesticide granule and a polymer layer, wherein the pesticide granule is coated by the polymer layer; the pesticide granule contains one or more effective pesticide components; the polymer layer is a hydrophobic membrane layer and comprises a water-based polyacrylate membrane material or a polyurethane membrane material; the mass of the polymer layer accounts for 3%-15% of the weight of the polymer-coated controlled release pesticide granule. The effective pesticide components are acted on the peripheries of crop roots after the polymer-coated controlled release pesticide granule disclosed by the invention is applied along with a base fertilizer. The polymer-coated controlled release pesticide granule has good prevention and control effects on farmland weeds, soil insects and soil-borne diseases, and the coating material synthesis and preparation process is advanced and the polymer-coated controlled release pesticide granule has good controlled release property. The polymer-coated controlled release pesticide granule provided by the invention has the advantages of pesticide utilization ratio improvement, environment pollution reduction, sustainable development and wide application prospect.

The invention discloses a water-based polymer coated film and a preparation method of a film-coated controlled release fertilizer thereof, which belongs to the agricultural controlled release fertilizer preparation technical field and relates to using a novel water-emulsion type polymer. The polymer film-coated controlled release fertilizer is coating a layer of novel degradable latex polymer film layer on the surface of granular fertilizer. The granular fertilizer with the diameter of 2 to 5mm is packed inside a film coating device of a rotating drum or a fluidized bed, and the granular fertilizer flows inside the film coating device to be heated to 80 DEG C to 100 DEG C. Organic matter is sprayed on the surface of the granular fertilizer, then complex polymer latex is sprayed on the facial surface of the organic matter film layer of the granular fertilizer to be dried continuously, the water of the film layer is removed by complete drying, and the polymer latex film-coated controlled release fertilizer is obtained. The invention conquers the problem that organic solvent leaks to cause the environmental pollution during the process of the production and avoids the problems of solvent recycling; the manufacturing process is easy for realizing the large scale chemical industry production; the investment cost is low; the production cost is reduced greatly.

Compositions for wound healing, use of the compositions, and kits and methods of using thereof are described herein. In a preferred aspect, the compositions are suitable for use in a method for forming a fibrin matrix or foam that can be applied or injected at the site of need. In another preferred aspect, the compositions are also suitable for use in methods for forming enhanced controlled delivery fibrin matrices that can be administered as gels or foams.

The invention belongs to the field of biomedical engineering materials and discloses a nitric oxide loaded cationic polymer, a preparation method therefor and an application of the nitric oxide loaded cationic polymer in the field of biomedicine. A cationic polymer which is used for loading nitric oxide and containing a dendritic polyamide element specifically is a polyethyleneimine grafted dendritic polyamide polymer and has a molecular formula shown in the description. The invention further provides the nitric oxide loaded cationic polymer based on the polymer. The nitric oxide loaded cationic polymer disclosed by the invention can be applied to the field of biomedicine as a nitric oxide donor material through loading NO, is used as a biomedical material and particularly is applied to the preparation of antibacterials; and the nitric oxide loaded cationic polymer has the effects of effectively inhibiting the growth and reproduction of bacteria and fungi, has remarkable inhibitory effects on common oral cavity pathogenic bacteria, dermatophyte, wound infection bacteria and the like, has the functions of promoting wound healing, diminishing inflammation and the like and provides a support for the application of the nitric oxide loaded cationic polymer in preparation of the biomedical engineering materials.

The invention provides a polymer coated controlled release fertilizer based on water-based reaction for forming films and a preparation method thereof. The polymer coated controlled release fertilizer comprises fertilizers and high polymer coating. The fertilizer is characterized in that the high polymer coating comprises the following raw materials in parts by mass: 100 parts of acrylic monomers, 10-16 parts of emulsifiers, 0.5-1.2 parts of initiators, 50-200 parts of water, 0-30 parts of organosilicon and 0-5 parts of crosslinking agents; and the raw materials of the high polymer coating account for 5-15% of the fertilizer by mass. The preparation process comprises preparation of coating mother liquid, preparation of coating liquid and preparation of the coated fertilizer. Release of the fertilizer nutrients is effectively controlled and the fertilizer nutrients can be continuously released for more than 30 days in the water at 25 DEG C. In the invention, the acrylic substance is used as the coated polymer body, water-based reaction for forming films is adopted to produce the polymer coating and secondary pollution caused by organic solvents does not exist in the production process. In addition, the hydrophobicity of the coated materials is effectively controlled and the controlled release effect is good.

A multilayer structure with improved permeation for atmospheric diffusion of aromatic products wherein the structure comprises: a permeable membrane wherein said permeable membrane comprises at least two polymeric layers wherein the polymer of each layer is independently selected from the group consisting of polyethylene, very low density polyethylene, low density polyethylene, ethylene methylacrylate copolymer; a release layer wherein said release layer comprises a nylon polymer or a ethylene vinyl alcohol copolymer wherein the release layer is adhered to most inner polymeric layer of the permeable member which comprises the permeable membrane and wherein the adhesion between release layer and the adjacent layer of the polymeric permeable membrane is a relatively weak bond compared to the bond between the layers of the polymeric permeable membrane; and an impermeable membrane wherein said impermeable membrane comprises one or more layers wherein the materials which comprise the individual layers of the impermeable membrane are independently selected from metal or foil and wherein said impermeable portion is laminated to said release layer.

A vacuum cleaner comprises a rigid dirt receptacle 14 having an outlet at one end, through which the collected dirt and dust can be emptied, a flap 16 for closing the outlet, and an actuator 58 for moving the flap 16 between a closed position and an open position, the actuator 58 being operable to control the position of the flap 16 between the open and closed positions. A location is provided at a partially opened position of the flap 16, at which position fine dirt and dust can be emptied through the restricted outlet in a controlled manner. The restricted size of the outlet retains any coarse and fibrous dirt inside the receptacle 14. Once the fine dirt has been emptied, the flap 16 can be moved to its fully open position to allow the coarse dirt and fibrous matter to be emptied from the receptacle 14 separately from the fine dust.

The invention discloses an anti-tumor nano medicine based on cross-linking biodegradable polymer vesicae and a preparation method of the anti-tumor nano medicine. The anti-tumor nano medicine is prepared by loading a medicine on reversible cross-linking biodegradable polymer vesicae of asymmetric membrane structures; the medicine is a protein medicine, a polypeptide drug or a small molecule medicine; the reversible cross-linking biodegradable polymer vesicae of the asymmetric membrane structures are prepared from a polymer in a manner of self-assembling and cross-linking in sequence; the molecular chain of the polymer comprises a hydrophilic chain segment, a hydrophobic chain segment and PEI molecules which are connected in sequence; the hydrophobic chain segment comprises a polycarbonate chain segment and / or polyester chain segment; the medicine can be compounded and loaded under the electrostatic interaction of PEI; a membrane is reversible cross-linking biodegradable polyester / polycarbonate which is good in compatibility; dithiolane of a side chain is similar to a human body natural antioxidant lipoic acid; a shell takes PEG as a background and can target to cancer cells; the anti-tumor nano medicine has the potential to be a nano medicine system with advantages of simplicity, stability, multifunction and the like.

The invention relates to an aqueous polymer-paraffin wax twolayer coating controlled release fertilizer and a preparation method thereof. The coated controlled release fertilizer consists of a fertilizer core and a coating outside the fertilizer core, wherein the coating comprises a paraffin wax film and a polymer film which is arranged on the paraffin wax film and is formed by a composite coating agent containing aqueous polymer emulsion and biodegradable natural macromolecules.

The invention discloses a complex coacervation multicore plant essential oil slow-release microcapsule which is formed by coating a core material of plant essential oil with natural alkaline polysaccharide-chitosan and natural plant gum-Arabic gum which are taken as compound wall materials; the complex coacervation multicore plant essential oil slow-release microcapsule adopts a regular spherical multicore structure, and a plurality of cores are uniformly dispersed; the average particle size of the complex coacervation multicore plant essential oil slow-release microcapsule is 95 microns; the loading amount of the plant essential oil exceeds the volume of the cavity used for loading the plant essential oil in the complex coacervation multicore plant essential oil slow-release microcapsule by 65%; the complex coacervation multicore plant essential oil slow-release microcapsule can be added into edible essence, daily chemical essence or cosmetics for use; the complex coacervation multicore plant essential oil slow-release microcapsule has good controlled-release and slow-release functions due to the spherical multicore structure; the complex coacervation multicore plant essential oil slow-release microcapsule not only can be separately used in the edible or daily essence but also can be used in the cosmetics to generate aromas or effects.

The invention relates to an alkyd resin emulsion-wax compound coated controlled release fertilizer and a preparation method thereof. The coated controlled release fertilizer consists of a fertilizer core and a capsule which is outside the fertilizer core, wherein, the capsule comprises a wax capsule, the exterior of the wax capsule has a polymer film that contains an alkyd resin emulsion coated agent and an inorganic layer that is arbitrarily arranged on the polymer film and contains inorganic powders.

The invention provides a special controlled-release fertilizer for fast-growing eucalyptus and a preparation method thereof, belonging to the field of mixed fertilizers. The fertilizer comprises an outer wrapping layer consisting of rumen protected fat and inner fertilizer particles. The fertilizer particles are prepared by mixing the following components: urea, monoammonium phosphate, potassium chloride, calcium-magnesium phosphate powder, borax, copper sulfate, zinc sulfate, compound sodium nitrophenolate, polyglutamic acid, humic acid and an adhesive. The fertilizer has abundant and comprehensive nutritional ingredients, can satisfy the demands of eucalyptus on various nutrients in the normal growing process to accelerate the eucalyptus to grow fast, and has a good controlled-release effect, so that the loss of nutrients of the fertilizer is effectively reduced, and the utilization ratio of the fertilizer is improved.

The invention discloses a method for preparing mineral organic fertilizer by using surplus sludge in municipal sewage plants. The method mainly comprises the following three steps: firstly reducing sludge in a sludge thickening tank, dehydrating the reduced sludge by adopting a catalytic ozonation method, carrying out subcritical water reaction on the dehydrated sludge, and discharging solids subjected to harmless treatment; finally mixing modified attapulgite clay with the sludge subjected to harmless treatment, chicken manure and microorganism beneficial microbial agents, and fermenting the mixture to obtain the mineral ecological organic fertilizer. The method is green and environment-friendly and realizes the harmless and resourceful treatment of the sludge; the obtained mineral organic fertilizer is capable of obviously improving the structure of soil, enabling the volume-weight of soil to be reduced, the holes of soil to be increased and the ventilation and water permeability of the soil to become good and adjusting the uniform growth of crops and has a good controlled release effect, thus the quality of the crops is improved.

The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.

A fuser and receiver release system and method are provided for improving the release of receivers in high speed of printing systems. This system controls the release of a receiver in conjunction with a fuser in a printing system, and specifically the efficiency and accuracy of the release system. One embodiment of this method includes a belt fuser that allows the separating of the heat transfer and release functions of the fuser such that fuser roller could be made of hard metal core that can be heated to high temperatures without the fear of delaminating elastomeric coatings which are common in roller fusing.

The invention discloses a reversible crosslinked biodegradable polymer vesicle having positive charges on an inner membrane, a preparation method thereof and application in preparation of antineoplastic drugs. The biodegradable polymer vesicle based on tumor targeting of a block polymer PEG-P (TMC-DTC)-SP or PEG-P (LA-DTC)-SP, having the positively charged membrane, reversibly crosslinked in reduction sensitivity and intracellularly solvable and crosslinked can effectively support and protect biological macromolecules such as proteins, DNA and siRNA and micromolecular drugs with negative charges in a physical environment and can be delivered to intravital tumor cells to induce apoptosis. The system has lots of unique advantages including simple and easy controllability of preparation, excellent biocompatibility, excellent controlled drug release property, super-strong in-vivo circulation stability, superior cancerous cell targeting and remarkable cancer cell apoptosis capability and the like. Therefore, the reversible crosslinked biodegradable polymer vesicle is expected to become a simple, stable, multifunctional nano system platform integrating multiple advantages and is used for efficient, active and targeted delivery from nucleic acids to in-situ tumors.

The invention discloses a swelling-type hollow silk fibroin micro-needle drug delivery system and a preparation method thereof. According to the technical scheme of the preparation method, a swelling modified silk fibroin solution is casted in a PDMS mold to be vacuumized, dried and molded as a hollow needle-type housing. After that, a silk fibroin micro-needle array provided with cavities in the hollow needle-type housing is filled with powder-like or solution-like drugs, vacuumizing and drying are carried out to form a drug part. Finally, a layer of modified silk fibroin solution is cast, dried and molded as a cladded coating. The cladded coating is removed to obtain the swelling-type hollow silk fibroin micro-needle drug delivery system. The drugs are wrapped inside the cavities of the silk fibroin micro-needle arrays, so that the system is high in drug loading ratio and low in skin allergenicity and stimulation. The system facilitates the sustained release and the controlled release of micro-needle drugs. Meanwhile, according to the preparation method, since the swelling modified silk fibroin solution is cast, dried and molded in a mild processing condition, the system is low in processing cost and suitable for large-scale production. Drugs are directly wrapped in the cavities of the swelling hollow micro-needles, so that controlled-release drugs are swelled in the micro-needle base material. In this way, the biological activities of the controlled-release drugs are maintained, while the structure of the hollow silk fibroin micro-needle drug delivery system is greatly simplified. The system is better in practicality.

The invention provides an embedding system based on a eutectic solvent and using the eutectic solvent as a solvent. The embedding system comprises an embedding material, a carrier and the eutectic solvent, and the eutectic solvent is formed by a hydrogen bond donor and a hydrogen bond acceptor through hydrogen bond association; the hydrogen bond acceptor includes quaternary ammonium salt, and thehydrogen bond donor includes one or more of urea, polyol, monosaccharide and carboxylic acid. The embedding system uses the eutectic solvent to serve as the solvent, and the eutectic solvent can increase the embedding rate of medicine, is low in toxicity and degradable, can reduce the side effects of the medicine in a controlled release and medicine delivery process and can improve the permeability and controllable release performance of cell membranes.

Porous calcium phosphate implant compositions that approximate the chemical composition of natural bone mineral are provided. In addition to calcium phosphate, the compositions include an effervescent agent to promote the formation of interconnected pores and a cohesiveness agent to maintain the shape and hardness of the hardened composition. When introduced at an implant site, the calcium phosphate compositions are remodeled into bone. Methods for using the calcium phosphate compositions, e.g., to repair or replace bone, are also provided.

The invention relates to an antibacterial functionalized artificial joint with a silver-loaded nanotube array surface. The surface of a metal substrate of the artificial joint is provided with a silver-doped sodium titanate nanotube array layer with a tubular structure. The inside of the silver-doped sodium titanate nanotube array layer is further loaded with bone morphogenetic protein (BMP). A preparation method of the antibacterial functionalized artificial joint with the silver-loaded nanotube array surface comprises the following steps: firstly selecting pure titanium or titanium alloy to process the artificial joint; then adopting the two-step anodizing technology to obtain a titanium dioxide nanotube array layer with a tubular structure on the surface of the pure titanium or titanium alloy artificial joint; adopting the alkaline hydrothermal synthesis technology to convert the titanium dioxide nanotube array layer into the sodium titanate nanotube array layer; doping trace silver in the sodium titanate nanotube array layer by solution impregnation iron exchange; and finally adopting the centrifugal load technology to load the bone morphogenetic protein in the silver-doped sodium titanate nanotube array layer.

The invention relates to a method for preparing a cyclodextrin porous nanocapsule through ultrasonically initiated soap-free emulsion polymerization. The preparation method is characterized in that the cyclodextrin porous nanocapsule with regular morphology and uniform distribution is prepared by cross-linking cyclodextrin or its derivatives by a highly biocompatible cross-linking agent through using an ultrasonically initiated soap-free emulsion polymerization technology. The preparation method has the advantages of simplicity, easy implementation, one step reaction and environmental protection. The cyclodextrin porous nanocapsule prepared in the invention has good biocompatibility, inclusion ability, controlled release performance, identification ability, stability and chemical adjustability, so the cyclodextrin porous nanocapsule has potential industrial production and application values in many fields, such as a drug delivery system, pollutant adsorption, gas storage, food processing, cosmetics, and chemical separation and analysis. The invention also relates to an application of the cyclodextrin porous nanocapsule prepared through the method in the drug delivery system.

The invention relates to a method for preparing W / O / W type compound emulsion embedding an chlorogenic acid, belonging to the field of compound emulsion preparation and comprising the following steps: mixing 1 part of aqueous chlorogenic acid solution by weight, 2 parts of oil phases by weight and 0.2-0.4 part of lipophilic emulsifier by weight to be stirred for 4-10 minutes under the speed of 6,000-15,000 turns / minute so as to obtain W / O type colostrums; and then mixing 2-3 parts of the W / O type colostrums and 2-3 parts of external water phrases to be stirred for 2-10 minutes under the speed of 1000-6000 turns / minute so as to obtain the W / O / W type compound emulsion. The method for preparing the W / O / W type compound emulsion can not only play roles of protection and storage on the chlorogenic acid, but also realize the uniform and effective release of the chlorogenic acid in human bodies, and also promotes the slow release, the controlled release and the target effect of absorption and sufficiently plays a role of the chlorogenic acid by embedding the hlorogenic acid with the W / O / W type compound emulsion.