Preparation method for eucheuma gelatinae polysaccharide selenide and application

Abstract

The invention discloses a novel preparation method of eucheuma gelatinae polysaccharide selenide. The selenylation of the eucheuma gelatinae polysaccharide is processed by sodium selenite being catalyzed by dilute nitric acid. The preparation method is simple, environment protecting, convenient and economic. The production shows higher biological activity, which can be applied widely in preparing the drug for inhibiting cancer cells, and has wide application prospect.

Description

technical field [0001] The invention relates to a chemical synthesis method, in particular to a preparation method and application of selenized Eucheuma agaricus polysaccharide. Background technique [0002] Selenium is closely related to the body's immune function and antioxidant capacity. Appropriately increasing the intake of selenium has obvious effects on improving the body's immune function, enhancing the ability to fight cancer, maintaining health and preventing the occurrence of certain diseases. In our country, the incidence areas of Keshan disease and Kaschin-Beck disease are in low-selenium areas, and selenium supplementation has become an effective measure for the prevention and treatment of Keshan disease and Kaschin-Beck disease. Selenium is also a basic component of some enzyme active sites. It participates in the formation of various proteins such as glutathione peroxidase and iodothyronine deiodinase in the form of selenocysteine ​​in the body, and can effe...

AI Technical Summary

Problems solved by technology

At present, there are two main methods for the preparation of selenium polysaccharides, namely biological enrichment method and chemical synthesis method. The disadvantages of the biological enrichment method are that the preparation cycle is long, the conditions are not easy to control, and the feasibility of mass production is difficult.

The chemical synthesis method has the patent CN 1014522B "The preparation method of selenized carrageenan", dissolves selenium powder with concentrated nitric acid and then reacts with carrageenan to obtain a kind of organic selenium polysaccharide-selenized carrageenan, and its disadvantage is that Elemental selenium powder and concentrated nitric acid can generate toxic hydrogen selenide, also produce the decomposition product of concentrated nitric acid simultaneously, have bigger pollution to environment, and selenium content is lower; Another is patent CN 1121414C " selenized polysaccharide compound and its Preparation method", the polysaccharide and selenous acid or its salt are catalyzed by barium ions in an acidic solution, and the selenium polysaccharide is obtained after heating for several hours, and then the barium ions in the reaction solution are removed with dilute sulfuric acid, and the filtered solution is added with chlorine Ferric chloride solution, NH 3 -NH 4 Cl adjusts the pH value, removes unreacted selenite ions for purification, and has disadvantages such as the use of toxic barium ions, cumbersome post-treatment, and inability to fully utilize selenite.

Images