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Preparation method and application of nano-selenium

A technology of nano-selenium and sodium selenite, applied in the field of nano-selenium, can solve the problems of increased free radical content and harmful protein, and achieve the effects of good crystallinity, short reaction time, good water solubility and biocompatibility

Pending Publication Date: 2020-06-09
GUANGDONG PHARMA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At the same time, oxidative stress often causes elevated levels of free radicals in the body, which can have deleterious effects on proteins, lipids, and DNA

Method used

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  • Preparation method and application of nano-selenium
  • Preparation method and application of nano-selenium

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Preparation and characterization of embodiment 1 nano-selenium

[0030] 1. Preparation of nano-selenium

[0031] 1.1 Preparation of solution

[0032] 1.1.1 0.1M sodium selenite solution

[0033] Accurately weigh 1.729g of sodium selenite, use deionized water as solvent, dissolve it in a beaker with an appropriate amount of deionized water, transfer it to a 100mL volumetric flask, and add deionized water to make it up to the mark.

[0034] 1.1.2 0.1M ascorbic acid solution

[0035] Accurately weigh 0.440 g of ascorbic acid, use deionized water as solvent, dissolve in a beaker with an appropriate amount of deionized water, transfer it to a 25mL volumetric flask, and add deionized water to make it up to the mark.

[0036] 1.1.3 0.5% polyvinyl alcohol solution

[0037] Precisely weigh 0.500g of polyvinyl alcohol, use deionized water as the solvent, dissolve it in a beaker with an appropriate amount of deionized water, transfer it to a 100mL volumetric flask, and add dei...

Embodiment 2

[0043] Embodiment 2 nano-selenium antioxidant test

[0044] 2.1 DPPH free radical scavenging experiment

[0045] 2.1.1 Solution preparation

[0046](1) Accurately weigh 0.0025g of 1,1-diphenyl-2-trinitrophenylhydrazine (DPPH), dissolve it with a small amount of 70% ethanol, transfer it to a 50ml brown volumetric flask, and dilute to volume with 70% ethanol to obtain 0.05mg / mLDPPH test solution, stored in the refrigerator, ready for immediate use;

[0047] (2) Take the above-mentioned nano-selenium solution and prepare solutions with concentrations of 0.5, 1.0, 1.5, 2.0 and 2.5 mg / mL.

[0048] 2.1.2 Determination of clearance rate

[0049] Accurately draw 5.00mL of sample solution, add 5.00mL of DPPH solution (0.05mg / mL), shake fully, and stand in the dark for 30min. Measure the absorbance value A of the test solution at 517nm i . After fully mixing 5.00mL of sample solution with 5.00mL of solvent, the absorbance at 517nm is A j . After fully mixing 5.00mL of DPPH solut...

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Abstract

The invention discloses a preparation method and an application of nano-selenium, and belongs to the technical field of nano-selenium. The method comprises the following steps: mixing a polyvinyl alcohol solution with a sodium selenite solution, dropwise adding an ascorbic acid solution into the mixed solution, and carrying out ultrasonic reaction to obtain nano-selenium. The preparation conditionis normal pressure, the reaction temperature is low, the reaction time is short, the whole preparation process is safe and stable, the method is convenient to master and control and easy to implement, the raw materials are low in cost, non-toxic and harmless, the obtained product is uniform in particle size, small in particle size, good in crystallinity and good in water solubility and biocompatibility, the oxidation resistance of the nano-selenium is verified through experiments, and a good foundation can be provided for research and application of the oxidation resistance of the nano-selenium in the future.

Description

technical field [0001] The invention relates to the technical field of nano-selenium, in particular to a preparation method and application of nano-selenium. Background technique [0002] Selenium belongs to group VIA and is a metalloid element. The early research on selenium was mainly on its properties and uses. For example, the thin layer of gray selenium is widely used in photovoltaic cells, rectifiers, copying technology, etc., because it has excellent photoelectric properties and unidirectional conductivity; selenium is also widely used in the manufacture of railway and navigation mark lights, as well as coatings and ceramics industries. Because it has good red light transmission. Selenium is also an essential trace element for the human body. Selenium deficiency can cause a variety of diseases, and an appropriate amount of selenium supplementation can effectively prevent and treat a variety of diseases. And single crystal selenium is an important elemental semicondu...

Claims

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Application Information

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IPC IPC(8): C01B19/02A61K8/23A61Q19/08
CPCC01B19/02A61K8/23A61Q19/08C01P2004/03
Inventor 贲永光曹碧琅吴艳波杨月玲
Owner GUANGDONG PHARMA UNIV
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