The invention relates to a fruit and vegetable yogurt drink and a preparation method thereof. The method comprises the following steps: selecting excellent apples, cucumbers, carrots, radishes, aloes, mango, pineapple, yangtao, sweet potatoes, tomatoes and milk; cleaning and processing the raw materials; preparing fruit and vegetable juice, and homogenizing and degassing the fruit and vegetable juice; mixing the fruit and vegetable juice with the milk; fermenting, homogenizing and sterilizing; cooling and bulking; checking and warehousing. The fruit and vegetable yogurt drink disclosed by the invention achieves micro-molecularization after being juiced, can be absorbed by a human body more easily, has the characteristics of being pleasant in sweetness and sourness, comprehensive and abundant in nutrition, and appetizing, contains a plurality of natural mineral substances such as dietary fibers, protein, vitamin B2, vitamin C, vitamin E, superoxide dismutase (SOD), carotene, nicotinic acid, calcium, phosphorus, ferrum, potassium, copper and selenium, is an excellent yogurt drink, and also has the effects of stimulating a digestive system and an inner circulation system, reducing blood pressure, preventing cancers, clearing away heat and toxic materials, inducing saliva and slaking thirst, tonifying spleen and reinforcing the stomach, eliminating toxin and beautifying skin, and preventing blurring of image.