An three-dimensional intensive culture technique of shrimps, crabs and shellfish in a seawater pond comprises the following steps: the pond is cleaned up before stocking, the bottom of the pond is solarized, a central canal and a circular canal are excavated, and feed water is disinfected and sterilized with medicines; fresh seawater is fed, the water quality culture, fertilization and algae culture are carried out, a lifting device for a swimming crab breeding cage is prepared, and lines are parallel set up at the two ends of the culture pond with each line spaced 50cm; and 30cm higher than the surface of the water, the cage is suspended every 50cm, the inside of the cage is provided with fine sand, the outside of the cage is sheathed with a plastic netting, benthonic seashells are put into the cage for the first, and the stocking density is 30 benthonic seashells per mu, then the stocking of prawns is carried out, and the stocking density is 5000 prawns per mu. By adopting the three-dimensional multi-species hybrid culture technique of shrimps, crabs and shellfish in a seawater pond, the water layers of the stocking ponds can be fully utilized, the utilization rates of each water layer of the stocking ponds, stocking devices and manpower are further improved, the water purification capacity of the seashell can be fully utilized, and the swimming crabs are suspended in a cage, thus avoiding cannibalism and catching and killing the shrimps and seashells in the same pound; Furthermore, the three-dimensional intensive culture technique provides adhesion and sheltering objects for prawns, and achieves the purposes of improving yield and increasing economic benefits.