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114 results about "Disease prognosis" patented technology
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A prognosis is made on the basis of the normal course of the diagnosed disease, the individual's physical and mental condition, the available treatments, and additional factors. A complete prognosis includes the expected duration, function, and description of the course of the disease, such as progressive decline, intermittent crisis,...
Method and system for predicting cardiovascular and cerebrovascular disease risk
InactiveCN106874663AGood prognosis riskPrognosis risk prediction is goodHealth-index calculationEpidemiological alert systemsPersonalizationDisease risk
The invention provides a method and a system for predicting cardiovascular and cerebrovascular disease risks. The method comprises the following steps: step 1, defining problems of cardiovascular and cerebrovascular disease prognosis risk prediction, step 2, collecting health medical data of cardiovascular and cerebrovascular disease patients; step 3, preprocessing data, including data integration, data cleaning, and processing missing data; step 4, constructing features and selecting features, identifying potential risk factors; step 5, the identified risk factors and rehabilitation outcomes forming an input-output sample set, inputting the input-output sample set to a random forest algorithm for model training, and evaluating prediction performance of a model. The method and the system can obtain health medical data of cardiovascular and cerebrovascular disease patients, the data being required by a clinician input model, and a predicted rehabilitation outcome of a patient in a certain time period in future is obtained through the model. The method and the system can preferably predict prognosis risks, so as to realize personalized accurate rehabilitation treatment.
Owner:中电科数字科技(集团)有限公司
Patient follow-up system for clinical medicine and scientific research
The invention relates to a patient follow-up system for clinical medicine and scientific research, which consist of a patient management module, a follow-up list module, a short message module, an incoming call module, a medical personnel management module, a super administrator module, a follow-up question type management module, a questionnaire management module, a data import and export module, a scanning image management module, a department message management module, a senior query module, a disease classification management module, a batch print module and a statistical analysis module; and a function module is developed based on a Microsoft WINNT4.0 Server operating platform and runs on a server, is externally connected with a modulator-demodulator, contains GSM (Global System for Mobile Communication) / GPRS (General Packet Radio Service) / CDMA (Code Division Multiple Access) double-frequency communication chips and a GSM Modem for supporting EGDM900 / 1800 Mhz double-frequency communication and is simultaneously connected with a telephone set, a printer and a medical image film scanner. The patient follow-up system has the beneficial effects that patient resources and disease prognosis data are ensured to be saved; and by means of a network and communication technology, a patient is periodically visited and managed, and the results are tidied and analyzed.
Owner:王斌全 +7
System and method for dynamic determination of disease prognosis
InactiveUS20060289020A1Predictive powerImprove predictive performanceSurgeryMedical automated diagnosisPredictor variablePatient data
A method of obtaining and processing patient data and patient treatment data to provide a prognosis parameter related to a patient's disease state is provided. The method identifies and calculates coefficients related to appropriate predictor variables which are then used by the prediction model to calculate the prognosis parameter. The prediction model may be a logistic regression model. The method may also be used to assess the level of care being provided to patients, as well as providing a way of assessing the outcome of the patient's condition as a function of treatment. A method of calculating a harm index reflective of the risk of treatment is also provided.
Owner:CAREFUSION 303 INC
Extracellular histones as biomarkers for prognosis and molecular targets for therapy
Hyper-inflammatory responses can lead to a variety of diseases including sepsis. It is now shown that extracellular histones released in response to inflammatory challenge are mediators contributing to endothelial dysfunction, organ failure and death during sepsis. As such, they can be targeted pharmacologically by inhibitors, as well as used as biomarkers for prognosis of sepsis and other diseases.
Owner:OKLAHOMA MEDICAL RES FOUND
Telemedical stethoscope
The present invention relates to a telemedical stethoscope, which automatically diagnoses a disease, and records visually and auditorily, and stores the stethoscope data on a screen. The present invention enhances primary diagnosis and treatment effect for a patient by transmitting / receiving the data to / from a doctor at a medical center and by receiving a telemedicine service. In addition, the present invention transmits the data to a health management program so as to be used for personal healthcare and disease prognosis decision of a patient.
Owner:LEE BYUNG HOON +1
Analysis of HIV-1 coreceptor use in the clinical care of HIV-1-infected patients
InactiveUS6727060B2Accurate predictionMore effectivenessMicrobiological testing/measurementArtificial cell constructsImmunodeficiency virusHIV positives
A change in viral tropism occurs in many HIV positive individuals over time and can be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus can be shifted back to CCR5-mediated entry after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CXCR4 specific strains. The diagnostic methods can be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time.
Owner:HEALTH RES INC
Skin Sampling Kit Which Stores Nucleic Acids In Stable Status, Genetic Test Methods By Using The Kit And Their Practical Application
InactiveUS20110033842A1Easily and stably acquiredAccurate conditionBioreactor/fermenter combinationsBiological substance pretreatmentsGenomicsSkin test results
The present invention relates to a new skin gene card for genetic test, a method for acquiring DNA and RNA and performing various genetic tests using the same, and practical applications thereof. More specifically, the inventors of the present invention have developed a skin gene card capable of acquiring samples from human skin, hair or mucosa simply, safely and quickly and enabling stable long-term storage and transport of DNA and RNA included in the acquired sample at room temperature. Various genetic tests may performed using the acquired DNA and RNA, including polymerase chain reaction (PCR), reverse transcription (RT)-PCR, real-time PCR, sequencing, hybridization, DNA chip analysis, single-nucleotide polymorphism (SNP) assay, gene mutation assay, promoter methylation assay, gene expression assay, etc. The genetic skin test result may be utilized for disease prognosis, nutrigenomic test, pharmacogenomic test, forensic test such as personal identification, diagnosis of genetic diseases, diagnosis of skin diseases, or the like. In addition, through an objective evaluation of the skin or hair condition, a personalized cosmetic and skin care system may be established for practical application in beauty care, cosmetology, dermatology, and clinical practice.
Owner:GOODGENE
Method and apparatus for acquiring an image biomarker and prognosing a blood related disease
A method of acquiring an image biomarker suitable for prognosis of a blood-related disease, such as acute myeloid leukemia, includes the steps of: (a) acquiring physical parameter sets, each including at least two physical parameters, respectively from time-signal intensity curves, the time-signal intensity curves being respectively obtained from magnetic resonance image sets of different subjects that are diagnosed as having the blood-related disease, each of the image sets being acquired through MRI scanning using one of first and second configuration parameter sets; (b) analyzing the physical parameter sets thus acquired with reference to prognoses of the different subjects so as to obtain weight values corresponding to the physical parameters; and (c) establishing a risk score function that is a sum of products of each of the physical parameters and the corresponding weight value, wherein a risk score obtained using the risk score function serves as the image biomarker suitable for prognosis of the blood-related disease.
Owner:NAT TAIWAN UNIV
Epigenetic modification of mammalian genomes using targeted endonucleases
The present disclosure provides genetically engineered cell lines comprising chromosomally integrated synthetic sequences having predetermined epigenetic modifications, wherein a predetermined epigenetic modification is correlated with a known diagnosis, prognosis or level of sensitivity to a disease treatment. Also provided are kits comprising said epigenetically modified synthetic nucleic acids or cells comprising said epigenetically modified synthetic nucleic acids that can be used as reference standards for predicting responsiveness to therapeutic treatments, diagnosing diseases, or predicting disease prognosis.
Owner:SIGMA ALDRICH CO LLC
Heteroduplex tracking assay
InactiveUS20060194227A1Accurately predict disease prognosis over timeGood treatment effectMicrobiological testing/measurementVertebrate cellsHeterologousHeteroduplex
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus may be shifted back to CCR5-mediated entry after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment and clinical management of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CCR5- or CXCR4-specific strains. The diagnostic methods may be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. The methods of the invention include cell-based methods, including cell fusion assays, and molecular-based methods, including heteroduplex tracking assay, to both quantitatively and qualitatively analyze patient-derived HIV for coreceptor usage.
Medical tracheal catheter with safe and effective antibacterial performance
ActiveCN103948973AReduce infection complicationsImprove disease outcomesAntifouling/underwater paintsPaints with biocidesCritically illSilanes
The invention discloses a medical tracheal catheter with safe and effective antibacterial performance. The organic silicon silver-loaded antibacterial coating tracheal intubation catheter is prepared by using tetraethoxysilane (TEOS) as a silicon source, gamma-methacryloxy propyl trimethoxyl silane (KH570) and methyl triethoxysilane (MTES) as organic-phase precursors and inorganic nano-silver as an antibacterial agent, adopting a sol-gel method, taking a tracheal intubation catheter as a base material and applying a surface antibacterial coating. The organic silicon silver-loaded antibacterial coating tracheal intubation catheter can be used for reducing related infectious complications in the tracheal catheter staying process, reducing the state of a patient, prolonging the catheter staying time to win precious time to successfully rescue of critically ill patients, and reducing economic burden of medical care, treatment risks and physical and psychological torture of patients, so that the disease prognosis of a tracheal intubated patient can be improved.
Owner:蒋旭宏
Prognostic method for the determination of the suitability of biopharmaceutical treatment
InactiveUS20100311052A1Microbiological testing/measurementSkeletal disorderPolymorphism analysisDisease cause
The invention refers to a method for the prognosis of a disease in a subject by the administration of a biopharmaceutical treatment in a subject suffering from, or likely to suffer from the disease, the method involving the analysis of SNP polymorphisms in the subjects pattern recognition receptor genes (PRRs), eg the analysis of polymorphisms' with the purpose of predicting the response of anti-TNFx antibody therapy in rheumatoid arthritis patients. Also the response to Beta-interferon in multiple sclerosis patients may be predicted. The genes whose polymorphisms are analysed may be TLRs, NOD-like receptors or retinoic acid-inducible gene I-like receptors (RLR).
Owner:BIOMONITOR
Medical Imaging System Providing Disease Prognosis
ActiveUS20160073969A1Add dimensionReduce the numberMedical data miningComputing modelsData setHigh dimensionality
A medical imaging system that processes input data (imaging and / or non imaging) having high dimensionality and few samples to learn from, by using multiple ranks of machine learning modules each dealing with a separate portion of the clinical data. The outputs of the individual machine learning modules are the combined to provide a result reflective of the complete image data set.
Owner:WISCONSIN ALUMNI RES FOUND
Sense-antisense gene pairs for patient stratification, prognosis, and therapeutic biomarkers identification
InactiveUS20160259883A1Quality improvementHighly prognostically significantMicrobiological testing/measurementLibrary screeningPrognostic signaturePatient stratification
The present invention relates to a method of identification of clinically and genetically distinct sub-groups of patients subject to a medical condition, particularly breast, lung, and colon cancer patients using a composition of respective gene expression values for certain gene pairs. Sense-antisense gene pairs (SAGPs) which are relevant for a medical condition and the disease prognosis are used by the method to generate statistical models based on the expression values of the SAGPs. SAGPs for which the statistical models are found to have high value in prognosis of the variation of medical condition and the diseases are selected and integrated in the prognostic signature including specified parameters (e.g. cut-off values) of the prognostic model. It further relates to using respective gene expression values for these genes to predict patient′ risk groups (in context of patient's survival or / and disease progression) and to using the predicted groups for identification of patient risk, and specific and robust prognostic biomarkers with mechanistic interpretations of biological changes (associated with the gene signatures) appropriating for an implementation of therapeutic targeting.
Owner:AGENCY FOR SCI TECH & RES
New skin sampling kit which stores nucleic acids in stable status, genetic test methods by using the kit and their practical application
InactiveCN101990578AEx situ and stable acquisitionAccurate evaluationMicrobiological testing/measurementSurgical needlesStable statusSkin test results
Owner:GOODGENE
Medical image processing method based on dictionary studying upsampling
InactiveCN101968851AImprove recognition rateOvercome learning problemsImage analysisCharacter and pattern recognitionPattern recognitionDictionary learning
The invention discloses a medical image processing method based on dictionary studying upsampling, and belongs to the technical field of image processing. The medical image processing method is realized by the following steps of: inputting an original medical image; cutting and reinforcing the original medical image; extracting the characteristics of the cut and reinforced medical image to obtain a training sample set and a testing sample set according the extracted characteristics; finding out boundary points of weakness samples from the training sample set to obtain the number of new samples to be generated according to the situation of the neighborhoods of the boundary points; generating required new samples by utilizing a sparse ligature and point getting method; adding the new samples into the training sample set to form a new training sample set; carrying out classifying diagnosis to the new training sample set to get a classifier; and diagnosing the testing sample set by adopting the classifier to get a final diagnosis result. The medical image processing method has the advantages of high recognition rate and strong generalization capability on medical image diagnosis, and can be used for medical workers to evaluate disease prognosis and therapeutic effect.
Owner:XIDIAN UNIV
Method and kit for in vitro diagnosis of atherosclerosis
A method for in vitro diagnosis of atherosclerosis, comprising: (a) obtaining a sample from a subject; (b) determining expression levels of one or more microRNAs (miRNAs) as atherosclerotic biomarkers and an internal control RNA; (c) computing the relative expression levels of the one or more miRNAs as atherosclerotic biomarkers; (d) computing a prediction model with one or more variables, wherein the variable includes one or more relative expression levels of the one or more miRNAs as atherosclerotic biomarkers and one or more risk factors of atherosclerosis; and (e) computing a prediction probability by the prediction model, wherein the subject is diagnosed with atherosclerosis if the probability is more than 0.5 is presented. A kit for in vitro diagnosis of atherosclerosis or prognosis of atherosclerosis-inducing diseases is also presented.
Owner:KAOHSIUNG MEDICAL UNIVERSITY
Heteroduplex tracking assay
Owner:HEALTH RES INC
A processing system of unbalanced medical image and processing method thereof
InactiveCN101551854AImprove diagnostic recognition rateReduce computationCharacter and pattern recognitionComputerised tomographsPersonalizationTherapeutic effect
The invention discloses a processing system of unbalanced medical image and a processing method thereof, belonging to the technical field of image processing. The whole system comprises an image preprocessing module, an image individuation splitting module, an image feature extracting module and an image kernel matching / tracing / integrating / classifying diagnosing module. The image preprocessing module implements the elimination of redundancy and histogram equalization enhancement processing, further implements uniform splitting, uneven splitting or sliding window splitting to the processed image, conducts feature extraction of gray-level co-occurrence matrix and Hu matrix to obtain labeled training sample set, part of the samples are taken out to train the single classifier so as to obtain each training classifier, each training classifier is used for classifying the unlabelled test samples to obtain the classified labels, and then final diagnosis results of the unlabelled test samples are obtained according to a decision function. The invention has the advantages of high discrimination of medical image diagnosis and short processing time and can be used by medical personnels for evaluating disease prognosis and treatment effect.
Owner:XIDIAN UNIV
Kit and process for PCR amplification detecting type 2 pig streptococcus virulence gene
InactiveCN101020929AEasy diagnosisConvenient researchMicrobiological testing/measurementDNA/RNA fragmentationVirulent characteristicsStreptococcus infection
The (Streptococcus suis Serotype 2 (SS2) virulence gene PCR amplification kit includes a SS2DNA contrast template, a PCR amplification detecting reagent, an agarose gel electrophoresis reagent and a DNA gradient standard. The PCR amplification detecting process includes the measurement of 7 important SS2 genes, diagnosing Streptococcus infection and SS2 infection based on whether to amplify specific Streptococcus gene, specific SS2 gene and 5 relevant important SS2 virulence genes, and predicting the virulence, invasiveness trend and disease prognosis fast and early. The present invention is favorable to the clinical diagnosis of borderline case and early warning, and is hopeful to be applied in emergency detection of human SS2 infection, etc.
Owner:ZHEJIANG CENT FOR DISEASE CONTROL & PREVENTION
Disease prognosis prediction system based on deep semi-supervised multi-task learning survival analysis
InactiveCN111640510AGood explanatoryAchieve sharingMedical data miningMedical practises/guidelinesSupervised learningNeural network nn
The invention discloses a disease prognosis prediction system based on deep semi-supervised multi-task learning survival analysis. The disease prognosis prediction system comprises a data acquisitionmodule, a data preprocessing module, a prediction model construction module and the like. On the basis of a deep neural network model, a survival analysis problem is converted into a multi-task learning model composed of a semi-supervised learning problem of multi-time-sequence-point survival probability prediction; the model directly models the survival probability, does not depend on proportional risk hypothesis, can fit a time-dependent effect, and has better interpretability; a semi-supervised loss function and a sorting loss function are utilized to fit the data, complete data and deleteddata are fully utilized, and a traditional survival analysis problem and a survival analysis problem considering competition risks can be solved; according to the model, through multi-task learning of multiple time sequence points, data sharing among multiple prediction tasks is achieved, mutual constraint among the multiple prediction tasks is achieved, and the generalization ability of the model is improved.
Owner:ZHEJIANG LAB
System for detecting multiple quantitative and virulent genes of H.pylori as well as kits and applications of system
ActiveCN105506160AThe test result has no impurityHigh sensitivityMicrobiological testing/measurementDNA/RNA fragmentationBeta globinVirulent characteristics
The invention relates to a system for detecting multiple quantitative and virulent genes of H.pylori as well as kits and applications of the system. The system for detecting multiple quantitative and virulent genes of H.pylori comprises multiple pairs of primers, each for strain identification genes (16S rRNA), quantitative analysis genes ureCand Beta-globin, as well as virulent genes (cagA, vacA-s1, vacA-s2, vacA-m1, vacA-m2, iceA1, iceA2, dupA, oipA and luxS). The system for detecting multiple quantitative and virulent genes of H.pylori and the kits of the system can directly perform synchronous detection and analysis on the strain identification, quantification and virulence of a tissue sample in a same reaction system without adopting a conventional culture step or other steps, remedy defects that a conventional detection method is low in throughput, time-consuming and low in detection rate, obviously improve the accuracy of detection results, immediately provide a comprehensive, accurate and low-cost etiological diagnosis for clinic, and provide an important reference for the accurate diagnosis, differential diagnosis and disease prognosis of H.pylori infection.
Owner:HUADONG HOSPITAL +1
Methods for Classifying Samples Based on Network Modularity
Owner:MOUNT SINAI HOSPITAL
Method of Preparing Disease Prognosis Model, Disease Prognosis Prediction Method using this Model, Prognosis Prediction Device Based on this Model, and Program for Performing the Device and Storage Medium Wherein Said Program is Stored
InactiveUS20070208514A1Add supportAccurate analysisMedical simulationMedical data miningPrognosis predictionDisease cause
The present invention relates to a disease prognosis prediction modeling method for preparing a model for predicting the prognosis of a specified disease from clinical laboratory test values for the disease by means of a computer, the method comprising the steps of: inputting a plurality of actually measured clinical laboratory test values for the disease and actual measured values of the prognoses into the computer; processing these values by a data mining method to determine one or a plurality of clinical laboratory test items which have an influence on the prognosis of the disease; determining a priority of the items with respect to the prognosis in a case where there are a plurality of the items; and establishing a judgment routine in which correlation of the plurality of clinical laboratory test items and the clinical laboratory test value ranges of the test items with the predicted value of the prognosis is stipulated on the basis of the priority, wherein the judgment routine is used as the model.
Owner:EISIA R&D MANAGEMENT CO LTD
Medical imaging system providing disease prognosis
ActiveUS9687199B2Add dimensionReduce the numberMedical data miningCharacter and pattern recognitionData setHigh dimensionality
Owner:WISCONSIN ALUMNI RES FOUND
Detection kit for detecting MDS/MPN (myelodysplastic syndrome/myeloproliferative neoplasms) related gene group
InactiveCN107868823AImprove detection efficiencyImprove the detection rateMicrobiological testing/measurementFlow cytometryRelated gene
The invention relates to a detection kit for detecting an MDS / MPN (myelodysplastic syndrome / myeloproliferative neoplasms) related gene group. According to the technical scheme, firstly, a gene group used for screening MDS / MPN related gene mutation is determined, and 17 genes with high directivity are screened out. On the basis, a high-throughput sequencing technology is combined, auxiliary diagnosis of the MDS / MPN beyond the morphology and the flow cytometry can be realized, and particularly, the detection kit has special advantages in evaluation of disease prognosis and anticipation of actioneffects on related target medicines. The provided detection kit of the gene group for used for screening MDS / MPN related gene mutation has the advantages of high detection efficiency, high detectionrate and the like.
Owner:天津见康华美医学诊断技术有限公司
Heteroduplex tracking assay
A change in viral tropism occurs in many HIV positive individuals over time and may be indicated by a shift in coreceptor use from CCR5 to CXCR4. The shift in coreceptor use to CXCR4 has been shown to correlate with increased disease progression. In patients undergoing HAART, the predominant populations of virus may be shifted back to CCR5-mediated entry soon after the CXCR4-specific strains have emerged. The present invention relates to a diagnostic method to monitor coreceptor use in the treatment and clinical management of human immunodeficiency virus (HIV) infection. The present invention further relates to a diagnostic method applied to HIV-positive individuals undergoing HAART to monitor the suppression of CCR5- or CXCR4-specific strains. The diagnostic methods may be used to assist in selecting antiretroviral therapy and to improve predictions of disease prognosis over time. The methods of the invention include cell-based methods, including cell fusion assays, and molecular-based methods, including heteroduplex tracking assay, to both quantitatively and qualitatively analyze patient-derived HIV for coreceptor usage.
Owner:HEALTH RES INC
Disease gene animal model of primary open angle glaucoma and construction method thereof
InactiveCN102229959AShort reproductive cyclePromote growthVector-based foreign material introductionAnimal husbandryOpen angle glaucomaClone human
The invention discloses a disease gene animal model of primary open angle glaucoma and a construction method thereof. The method comprises the following steps: (1) cloning human an OPTN (optineurin, E50K) mutant gene to an expression vector with a retinal specific promoter c-kit to construct a recombinant mammal expression vector; and (2) introducing the recombinant mammal expression vector into the bodies of mice and screening and identifying to obtain transgenic mice. In consideration of the difference between the mouse OPTN (E50K) and the human gene, the human OPTN (E50K) is introduced into the retinal specific promoter so that the human OPTN (E50K) gene is specifically expressed in the retina of the mouse. The model of primary open angle glaucoma due to the mutation of OPTN (E50K) is constructed, and the laboratory animals are provided for the systemic researches on pathogenic mechanism, development trend and disease prognosis and treatment of primary open angle glaucoma (POAG) due to the mutation of OPTN (E50K) in human beings.
Owner:HARBIN MEDICAL UNIVERSITY
Methods for identification and modification of lncrna associated with target genotypes and phenotypes
ActiveUS20200248184A1Increase productionIncreased abiotic stress toleranceMicrobiological testing/measurementDisease diagnosisMelanomaDrug resistance
The application relates to methods for compositions for identifying IncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.
Owner:THE BROAD INST INC +2
Telemedical stethoscope
Owner:LEE BYUNG HOON +1
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