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Medical tracheal catheter with safe and effective antibacterial performance

A technology of tracheal tube and tracheal intubation, which is applied in the medical field to achieve the effect of prolonging the indwelling time of the tube, relieving the disease, and high-efficiency antibacterial performance

Active Publication Date: 2014-07-30
蒋旭宏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] This patent is just to overcome the deficiencies of the existing clinically used PVC tracheal intubation catheter and the currently developed antibacterial tracheal intubation catheter, and to provide a method that can reduce infection complications after tracheal intubation, and does not have biological Adverse reactions, endotracheal intubation catheters with silicone silver-loaded antibacterial coating suitable for human use

Method used

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  • Medical tracheal catheter with safe and effective antibacterial performance
  • Medical tracheal catheter with safe and effective antibacterial performance
  • Medical tracheal catheter with safe and effective antibacterial performance

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Using orthoethyl silicate (TEOS) as the silicon source, γ-methacryloxypropyltrimethoxysilane (KH570) and methyltriethoxysilane (MTES) as the organic phase precursor , with the ratio of TEOS / KH570 / MTES=15 / 6 / 1, the TEOS / KH570 / MTES organosilicon sol with multifunctional molecular compound was prepared by sol-gel process at room temperature. The preparation route of organosilicon composite sol is as follows: figure 1 : First mix TEOS, absolute ethanol and deionized water under a magnetic stirrer, add acetic acid to hydrolyze TEOS to obtain silica sol, then add KH570 and MTES mixed solution, continue stirring for hydrolysis and condensation reaction, Obtain organosilicon composite sol. The Si-OH, R1-COO-R, and Si-O-Si groups contained in organosilica sol can show good film-forming properties, and Si-CH 3 、-CH 3 Can reduce the surface energy of the coating, thereby preventing protein tissue cell adhesion.

[0044] (2) Add the inorganic nano-silver antibacterial agent ...

Embodiment 2

[0069] We prepare TEOS / KH570 / MTES / Ag-SiO by the same method as Example 1 2 The endotracheal intubation catheter with silicone silver-loaded antibacterial coating of the quaternary system, wherein TEOS / KH570 / MTES=14 / 7 / 3, and the concentration of inorganic nano-silver antibacterial agent is 1.3%. Using a thermal curing process, drying and curing at a temperature of 90° C. for 50 minutes, the thickness of the obtained coating is controlled at 400 nm.

[0070] With the same detection method detection result of embodiment 1 as follows:

[0071] (1) Antibacterial properties

[0072] TEOS / KH570 / MTES / Ag-SiO 2 The bacterial growth of the silicone-coated PVC tracheal intubation tube sample almost disappeared, and the bactericidal rate was over 99.8%.

[0073] (2) Coating mechanical properties

[0074] TEOS / KH570 / MTES / Ag-SiO 2 The test results of the silicone silver-loaded coating are: coating hardness 4H, adhesion level 1, emulsion stability without precipitation or gel.

[0075] ...

Embodiment 3

[0094] We prepare TEOS / KH570 / MTES / Ag-SiO by the same method as Example 1 2 Quaternary system silicone silver-loaded antibacterial coating tracheal intubation catheter, in which TEOS / KH570 / MTES=16 / 5 / 1, the concentration of inorganic nano-silver antibacterial agent is 0.8%, adopts heat curing process, and dries at 80 ℃ After curing for 60 minutes, the coating thickness was controlled at 200nm.

[0095] With the same detection method detection result of embodiment 1 as follows:

[0096] (1) Antibacterial properties

[0097] TEOS / KH570 / MTES / Ag-SiO 2 The growth of bacteria in the PVC tracheal intubation tube samples coated with silicone silver was significantly reduced or even disappeared, and the bactericidal rate reached 96.3%.

[0098] (2) Coating mechanical properties

[0099] TEOS / KH570 / MTES / Ag-SiO 2 The test results of the silicone silver-loaded coating are: coating hardness 5H, adhesion level 0, emulsion stability without precipitation or gel.

[0100] (3) Morphology o...

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Abstract

The invention discloses a medical tracheal catheter with safe and effective antibacterial performance. The organic silicon silver-loaded antibacterial coating tracheal intubation catheter is prepared by using tetraethoxysilane (TEOS) as a silicon source, gamma-methacryloxy propyl trimethoxyl silane (KH570) and methyl triethoxysilane (MTES) as organic-phase precursors and inorganic nano-silver as an antibacterial agent, adopting a sol-gel method, taking a tracheal intubation catheter as a base material and applying a surface antibacterial coating. The organic silicon silver-loaded antibacterial coating tracheal intubation catheter can be used for reducing related infectious complications in the tracheal catheter staying process, reducing the state of a patient, prolonging the catheter staying time to win precious time to successfully rescue of critically ill patients, and reducing economic burden of medical care, treatment risks and physical and psychological torture of patients, so that the disease prognosis of a tracheal intubated patient can be improved.

Description

technical field [0001] This patent relates to the medical field, specifically, a medical endotracheal intubation catheter with silver-loaded antibacterial coating on organic silicon. Background technique [0002] Endotracheal intubation is a simple and effective method to establish an unobstructed airway in critically ill patients. In addition to general anesthesia patients, in the rescue process of many critically ill patients, in order to effectively carry out mechanical ventilation, remove sputum or blood in the trachea, prevent vomiting and suffocation, and relieve respiratory obstruction, tracheal intubation is often required. The artificial airway established by tracheal intubation has become the most important "lifeline" for patients. Once the patient is intubated, the indwelling time of the endotracheal tube is generally: oral intubation generally does not exceed 72 hours; nasal intubation generally does not exceed 1 week, and prolonged intubation is very likely to ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L29/16A61L29/08A61L29/04C09D5/14C09D183/06C08J7/04
Inventor 蒋旭宏
Owner 蒋旭宏
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