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Traditional Chinese medicine composition for treating leukemia by adjusting BCL family and preparation method thereof

A technology of leukemia and composition, applied in the field of traditional Chinese medicine composition and preparation for treating leukemia

Pending Publication Date: 2022-04-15
XIAMEN MIAOJIU TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] Although there are a variety of traditional Chinese medicine composition formulas for the treatment of leukemia, they are basically formulated from the perspective of traditional Chinese medicine, and none of them are formulated from the perspective of adjusting the BCL family

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] A traditional Chinese medicine composition for treating leukemia by adjusting the BCL family, made of the following raw materials in parts by weight:

[0038] 28 parts of astragalus, 18 parts of heterophylla, 13 parts of Polygonatum, 18 parts of raw land, 16 parts of Ophiopogon japonicus, 16 parts of Eclipta chinensis, 16 parts of Ligustrum lucidum, 28 parts of Hedyotis diffusa, 28 parts of Scutellaria barbata, 8 parts of Magnolia officinalis 8 parts of turmeric, 13 parts of honeysuckle, 13 parts of forsythia, 4 parts of safflower.

[0039] The preparation method of the above-mentioned traditional Chinese medicine composition for treating leukemia by adjusting the BCL family comprises the following steps:

[0040]S1. Take 15 kinds of raw materials by weight, mix after rinsing, and extract with purified water in the traditional Chinese medicine extraction production line, the extraction method is as follows:

[0041] a) For the first extraction, add 6 times the amount o...

Embodiment 2

[0047] Referring to Example 1, the difference from Example 1 is that a traditional Chinese medicine composition for treating leukemia by adjusting the BCL family in this example is made of the following raw materials in parts by weight:

[0048] 30 parts of astragalus, 20 parts of heterophylla, 15 parts of sealwort, 20 parts of raw land, 20 parts of Ophiopogon japonicus, 18 parts of eclipse, 18 parts of Ligustrum lucidum, 30 parts of Hedyotis diffusa, 30 parts of Scutellaria barbata, 10 parts of Magnolia officinalis 10 parts of turmeric, 15 parts of honeysuckle, 15 parts of forsythia, 5 parts of safflower.

Embodiment 3

[0050] Referring to Example 1, the difference from Example 1 is that a traditional Chinese medicine composition for treating leukemia by adjusting the BCL family in this example is made of the following raw materials in parts by weight:

[0051] 32 parts of astragalus, 22 parts of heterophylla, 17 parts of sealwort, 22 parts of raw land, 24 parts of Ophiopogon japonicus, 20 parts of eclipse, 20 parts of Ligustrum lucidum, 32 parts of Hedyotis diffusa, 32 parts of Scutellaria barbata, 12 parts of Magnolia officinalis 12 parts of turmeric, 17 parts of honeysuckle, 17 parts of forsythia, 6 parts of safflower.

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PUM

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Abstract

The invention discloses a traditional Chinese medicine composition for treating leukemia by adjusting a BCL family and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 26-34 parts of astragalus membranaceus, 16-24 parts of radix pseudostellariae, 11-19 parts of rhizoma polygonati, 16-24 parts of radix rehmanniae, 14-26 parts of radix ophiopogonis, 14-22 parts of eclipta alba, 14-22 parts of glossy privet fruit, 26-34 parts of oldenlandia diffusa, 26-34 parts of sculellaria barbata and 6-14 parts of mangnolia officinalis. , 6-14 parts of turmeric, 11-19 parts of honeysuckle, 11-19 parts of fructus forsythiae, and 2-8 parts of safflower. The traditional Chinese medicine composition can inhibit expression of MCL-1, increase chemotherapy sensitivity, reverse drug resistance and enable leukemia cells to recover sensitivity to chemotherapy drugs.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition and a preparation method for treating leukemia by adjusting the BCL family. Background technique [0002] Leukemia is a malignant disease of hematopoietic tissue, also known as "blood cancer". A certain series of hematopoietic cells, mainly the precursor cells of a certain white blood cell series, lose their ability to differentiate and mature, and show malignant clonal hyperplasia in the bone marrow and other hematopoietic tissues, accumulate and invade the liver, spleen, and lymph nodes, and finally infiltrate and destroy the tissues of the whole body , organs, so that the normal hematopoietic function is inhibited. Leukemia cells are malignant in bone marrow and other hematopoietic tissues, proliferate without restriction, infiltrate various tissues and organs of the whole body, and produce different symptoms; blood cells ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/02
Inventor 卢喜
Owner XIAMEN MIAOJIU TECH DEV CO LTD
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