128 results about "Oldenlandia diffusa" patented technology

The invention belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating triple negative breast cancer and application thereof. The traditional Chinese medicine composition is prepared from the following main active ingredients in parts by mass: 20 to 40 parts of radix astragali seu hedysari, 10 to 20 parts of rhizoma curcumae, 10 to 20 parts of herba hedyotidis diffusae, 5 to 15 parts of fructus aurantii immaturus, 5 to 15 parts of radix bupleuri, 5 to 15 parts of radix paeoniae alba and 5 to 15 parts of liquorice root. Animal experiments show that the traditional Chinese medicine composition can significantly inhibit tumor growth and pulmonary metastasis of triple-negative breast cancer tumor-bearing mice, increase the proportion of CD8 + T lymphocytes in blood, reduce the proportion of MDSCs, significantly down-regulate the expression of pro-inflammatory cytokines such as IL-6, IL-1alpha, CXCL1 and GM-CSF in serum, and cooperate with PD-L1 immunotherapy to achieve a synergistic effect. And the whole blood and liver and kidney function indexes are in a normal range. Therefore, the traditional Chinese medicine composition disclosed by the invention can be used for effectively inhibiting the tumor growth and pulmonary metastasis of the triple negative breast cancer, remodeling the immune state of an organism and reducing the release of proinflammatory factors, and is safe, reliable, free of obvious liver and kidney toxicity and blood toxicity and small in side effect.

The invention relates to a traditional Chinese medicine composition for preventing and treating liver rupture syndrome of broiler breeders and application thereof, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 50-200 parts of silybum marianum, 50-200 parts of schisandra chinensis, 50-200 parts of gentiana macrophylla, 50-200 parts of andrographis paniculata, 50-200 parts of radix paeoniae alba, 50-200 parts of oldenlandia diffusa, 50-200 parts of folium isatidis and 50-200 parts of patrinia. The traditional Chinese medicine composition has the effects of resisting endotoxin, inflammation, allergy and liver injury and the like, and effectively prevents and treats the liver rupture syndrome of the broiler breeders.

The invention discloses a traditional Chinese medicine compound exosome for treating ovarian cancer and a preparation method and application thereof. The preparation method of the traditional Chinese medicine compound exosome comprises the following steps: (1) soaking the raw material medicines in the traditional Chinese medicine compound in deionized water, boiling with big fire, and decocting for 35-45 minutes; then adjusting to slow fire, and continuously decocting for 30-35 minutes to obtain the traditional Chinese medicine compound water decoction. (2) preparing the traditional Chinese medicine compound exosome from the traditional Chinese medicine compound water decoction by an ultracentrifugation method; wherein the traditional Chinese medicine compound comprises the following raw material medicines: astragalus membranaceus, bighead atractylodes rhizome, cinnamon, curcuma zedoary, fructus lycii, seaweed, pericarpium citri reticulatae viride, lindera aggregata, turtle shell, oldenlandia diffusa, scorpio, artemisia apiacea, arisaema cum bile, edible tulip and radix ranunculi ternati. The prepared traditional Chinese medicine compound exosome can be used for treating ovarian cancer, and the curative effect of the exosome is superior to that of a traditional traditional Chinese medicine compound administration mode.

The invention discloses a production process of a tumor swelling and pain relieving cataplasm patch, and belongs to the technical field of traditional Chinese medicine preparations. According to the process, rheum officinale, golden cypress, turmeric and tripterygium wilfordii stir-fried with vinegar are taken as monarch drugs and are matched with sculellaria barbata and oldenlandia diffusa to enhance the antitumor activity, pseudo-ginseng synergistically improves the transdermal efficiency, and the preparation is optimized through a segmented extraction and nano-targeting technology: 1) adopting supercritical COextraction to extract angelica dahurica and cinnamon volatile oil (20-25MPa and 40-50 DEG C), and carrying out beta-cyclodextrin inclusion; the preparation method comprises the following steps of (1) performing dynamic countercurrent extraction on non-volatile components (70% ethanol at a flow rate of 2.0 mL / min) of other medicinal materials, and coating triptolide (with a particle size of 80-150 nm) in combination with PLGA nanoparticles, and (3) mixing the extract and a composite matrix (sodium polyacrylate-sodium carboxymethyl cellulose-azone), and coating a pH response type chitosan-sodium alginate sustained release layer with the mixture to form the breathable patch.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a more low-irritation analgesic ancient prescription microemulsion gel and application thereof in anti-arthritis drugs. The application finds that after water-soluble and fat-soluble components of black plaster prepared from raw frankincense, myrrh, eaglewood, dragon's blood, Strychnos nux-vomica, Panax notoginseng, Oldenlandia diffusa, Venenum Bufonis, bovine bezoar, Stachys jamaicensis, Platycodon grandiflorum, Hirudo nipponia, Tinea, Solenopsis geminata, Scorpio, scorpio, red lead and sesame oil are extracted, a more low-irritation analgesic ancient prescription microemulsion gel is prepared; compared with the black plaster itself, the analgesic effect of the microemulsion gel is significantly improved, and the microemulsion gel has good anti-inflammatory effect and can be used for preparing anti-arthritis drugs; and the microemulsion gel has reduced toxicity and is more convenient to use.

The invention provides a broad-spectrum combined medicine for treating colorectal cancer. The broad-spectrum combined medicine is prepared from the following components in parts by weight: 100 parts of purified water, 38 to 90 parts of tripterygium wilfordii alkaloid, 38 to 90 parts of tripterygium hypoglaucum alkaloid, 28 to 85 parts of chamaejasmine, 28 to 85 parts of gelsmium elegans alkaloid and 28 to 85 parts of xanthoxylin. The medicine is prepared from the following raw materials in parts by weight: 16 to 80 parts of ganoderan, 16 to 80 parts of pinellia ternate sitosterol, 16 to 80 parts of radix rehmanniae praeparata, 16 to 80 parts of astragaloside, 16 to 80 parts of oldenlandia diffusa alkaloid, 16 to 80 parts of sculellaria barbata alkaloid, 16 to 80 parts of tanshinone, 16 to 80 parts of carthamin, 16 to 80 parts of honeysuckle chlorogenic acid and 16 to 80 parts of pericarpium citri reticulatae flavone. By integrating anti-tumor components with multiple action mechanisms, tripterygium wilfordii alkaloid, tripterygium hypoglaucum alkaloid and the like, tumor cell proliferation can be directly inhibited, and apoptosis can be induced; tanshinone, emodin and the like can inhibit tumor angiogenesis; ganoderma lucidum polysaccharides, astragaloside and the like can activate the immune system of the body, enhance the activity of T cells and NK cells, and form double strikes of direct killing and immune surveillance.

The composition is composed of a herbal medicine alcohol extract and an alcohol solvent, the herbal medicine comprises Jinfo grass, radix angelicae, solidago decurrens, oldenlandia diffusa, fructus kochiae, fructus cnidii, bletilla striata, radix clematidis, cortex dictamni, portulaca grandiflora and gallnut, and the herbal medicine is scientifically proportioned according to the principle of monarch, minister and guide. The preparation method comprises the following steps: processing medicinal materials such as fructus cnidii, crushing, soaking with high-concentration alcohol according to a specific ratio, extracting, and finally filling into a spray bottle. The traditional Chinese medicine composition integrates multiple functions of disinfection, hemostasis, detumescence, pain relieving, itching relieving and the like, is suitable for multiple skin problems such as traumatic bleeding, burns and scalds, eczema and mosquito bites, and can be used for skin disinfection during epidemic situations so as to reduce epidemic risks. The product takes effect quickly, is convenient to use and is safe and effective, and the preparation process integrates tradition and efficiency.

The invention belongs to the technical field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine preparation for treating pleural effusion and peritoneal effusion and a preparation method thereof.The traditional Chinese medicine preparation is prepared from, by weight, 10-50 parts of traditional Chinese medicine extract, 30-70 parts of filler, 5-20 parts of enteric coating material, 5-15 parts of HPMC, 0.5-2 parts of triethyl citrate and 0.25-1.5 parts of magnesium stearate; poria cocos, polyporus umbellatus, rhizoma alismatis, astragalus membranaceus, curcuma zedoary, cassia twig, oldenlandia diffusa, sculellaria barbata, semen coicis and traditional Chinese medicine extracts are used as cores, the stability of volatile drugs is improved through an inclusion technology, and the volatile drugs are entrapped in a pH intelligent response type enteric coating material composed of aromatic ring-containing vinyl monomers, ethyl acrylate, DMAEMA and MAA. The traditional Chinese medicine preparation has the synergistic effect of efficiently inducing diuresis, activating blood circulation and eliminating tumors and enteric-coated long-acting directional delivery, and is suitable for patients with pleural effusion and peritoneal effusion, especially malignant effusion.

The present application relates to a kind of anti-non-small cell lung cancer for strengthening healthy qi and resolving stasis and preparation method thereof, strengthening healthy qi and resolving stasis is made from the following weight proportion of raw medicinal materials: Ficus pumila 2g~50g / portion, radix pseudostellariae 2g~50g / portion, poria cocos 2g~50g / portion, atractylodes 2g~50g / portion, radix scutellariae 2g~50g / portion, oldenlandia 2g~50g / portion, cat's paw grass 2g~50g / portion, giant knotweed 2g~50g / portion, curcuma zedoary 2g~50g / portion, oyster 2g~50g / portion, platycodon 2g~50g / portion, mountain bitterling 2g~50g / portion, half branch orchid 2g~50g / portion. By cell test and the construction NSCLC osimertin drug resistance animal model prove, strengthening healthy qi and resolving stasis of the present application can adjust tumor microenvironment (TME) and inhibit non-small cell lung cancer cell growth of osimertin drug resistance. Not only this, strengthening healthy qi and resolving stasis of the present application can also inhibit common non-small cell lung cancer cell growth. While clinical observation finds, strengthening healthy qi and resolving stasis of the present application can improve insomnia, skin rash, diarrhea and other symptoms of lung accumulation (lung cancer, lung nodule) patient, improve its quality of life.

The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 to 20 parts of radix codonopsis, 10 to 20 parts of rhizoma atractylodis macrocephalae, 10 to 15 parts of poria cocos, 10 to 12 parts of pericarpium citri reticulatae, 6 to 10 parts of rhizoma pinellinae praeparata, 10 to 12 parts of radix aucklandiae, 10 to 12 parts of rhizoma corydalis, 3 to 6 parts of radix notoginseng, 10 to 12 parts of fructus aurantii immaturus, 10 to 20 parts of radix ginseng rubra, 15 to 30 parts of herba hedyotidis diffusae, 15 to 30 parts of semen coicis, 10 to 15 parts of rhizoma curcumae, 10 to 20 parts of radix salviae miltiorrhizae, 10 to 20 parts of radix astragali seu hedysari and 3 to 6 parts of liquorice root. The invention further discloses a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition aims at chronic atrophic gastritis with pathological characteristics of gastric mucosa dysplasia and intestinal metaplasia, and is remarkable in curative effect and small in side effect through reasonable medicine compatibility.

This invention discloses a pharmaceutical composition and its preparation method for treating atrophic gastritis, precancerous lesions of the stomach, and stomach cancer, belonging to the field of traditional Chinese medicine preparation technology. The pharmaceutical composition is prepared by a specific two-step microbial fermentation process using Astragalus membranaceus, Hericium erinaceus, Curcuma zedoaria, Actinidia chinensis root, Camptotheca acuminata fruit, Hedyotis diffusa, Coptis chinensis, Taraxacum mongolicum, Viola yedoensis, Corydalis yanhusuo (processed with vinegar), Phellodendron chinense, Solanum nigrum, Scutellaria baicalensis, Panax notoginseng, Zingiber officinale, Piper cubeba, Cuttlebone, Fritillaria thunbergii, roasted soybean, and red yeast rice. This invention significantly improves the bioavailability of the active pharmaceutical ingredients through the synergistic effect of the multifunctional groups of traditional Chinese medicine and the enhanced effect of microbial fermentation. It can systematically reverse gastric mucosal atrophy and intestinal metaplasia, effectively improve microcirculation, and inhibit Helicobacter pylori, while also exhibiting good safety. This provides a novel and effective treatment for the aforementioned gastric diseases.

This invention provides a traditional Chinese medicine composition for treating ectopic pregnancy, its enema preparation, and its application. A traditional Chinese medicine enema composition for ectopic pregnancy comprises the following raw materials in parts by weight: 28-35 parts of *Ilex pubescens*, 18-23 parts of rhubarb, 18-23 parts of *Hedyotis diffusa*, 18-23 parts of *Liquidambar formosana*, and 18-23 parts of safflower. This invention also provides a traditional Chinese medicine enema preparation for ectopic pregnancy, comprising the traditional Chinese medicine composition described in any one of the present invention, preferably an enema preparation. This invention targets ectopic pregnancy, using *Ilex pubescens* as the principal herb, and safflower and *Liquidambar formosana* as assistant herbs to enhance the blood-activating and stasis-removing effects of *Ilex pubescens*; rhubarb as the adjuvant herb; and *Hedyotis diffusa* as the guiding herb. The precise combination of these herbs effectively activates blood circulation, clears the meridians, removes stasis, and eliminates masses, resulting in a good therapeutic effect for ectopic pregnancy. This invention uses *Ilex pubescens*, rhubarb, *Hedyotis diffusa*, *Liquidambar formosana*, and safflower in a certain proportion, which has a synergistic effect, resulting in a high cure rate for ectopic pregnancy and good safety.

The invention relates to the technical field of medicines for treating intestinal ischemia-reperfusion injury, and discloses a medicine for treating intestinal ischemia-reperfusion injury and a preparation method thereof. Comprising 10 to 25 parts of rosmarinic acid, 5 to 15 parts of betaine, 3 to 10 parts of glutamine, 10 to 25 parts of salvianolic acid B, 5 to 15 parts of astragaloside, 3 to 10 parts of ginsenoside Rg1, 2 to 8 parts of curcumin, 5 to 12 parts of ophiopogon japonicus polysaccharide, 2 to 6 parts of notoginsenoside R1, 3 to 7 parts of total flavonoids of oldenlandia diffusa and 4 to 9 parts of angelica sinensis polysaccharide. The medicine disclosed by the invention can be used for relieving intestinal edema, repairing oxidative injury, clearing excessive ROS, improving SOD activity, blocking oxidative stress injury, inhibiting epithelial cell apoptosis, reducing intestinal permeability and maintaining mucous membrane integrity, and has an excellent treatment effect on intestinal ischemia reperfusion injury.

The invention patent is titled "Dragon and Cypress Gel," belonging to the pharmaceutical category. The main components of Dragon and Cypress Gel are: Phellodendron bark, earthworm, dragon's blood, Oldenlandia diffusa, Sophora flavescens, and Bletilla striata. In recent years, research on cervicitis and cervical lesions has shown good results using external treatments of traditional Chinese medicine. Vaginal cervical medications are characterized by high local drug concentration, low dosage, and safety and effectiveness, receiving high clinical evaluation. The vagina and cervix have abundant capillaries and lymphatic vessels, and lack clearly defined nerve endings, resulting in minimal pain stimulation for patients during administration. This makes it an effective drug release site for specific diseases such as cervicitis and vaginitis. Traditional Chinese medicine gels are a novel type of external preparation of traditional Chinese medicine. They are made by dissolving or uniformly dispersing traditional Chinese medicine in a gel. These gels adhere tightly to the treatment site for a relatively long time, exhibiting good bioadhesion, and are simple to prepare. It is suitable for use on skin, mucous membranes and cavities. It not only avoids the first-pass effect of enzymes and acids in the gastrointestinal tract that exists in oral administration, but also reduces the adverse reactions of drugs. It has the characteristics of good spreadability, non-greasy feeling, easy to wash off, good transdermal absorption, and comfortable use.

The invention provides a traditional Chinese medicine composition for treating pulmonary nodules and a preparation method thereof. The traditional Chinese medicine composition is prepared by extracting the following traditional Chinese medicine decoction pieces in parts by weight: 25-35 parts of raw coix seeds, 8-12 parts of platycodon grandiflorum, 8-12 parts of curcuma zedoary, 8-12 parts of radix curcumae, 8-12 parts of salvia chinensis, 8-12 parts of astragalus membranaceus, 8-12 parts of radix pseudostellariae, 8-12 parts of akebia fruits, 10-20 parts of oldenlandia diffusa, 10-20 parts of rabdosia rubescens, 3-7 parts of radix ranunculi ternati and 8-12 parts of glossy privet fruits. The traditional Chinese medicine can be used for treating the phlegm stasis and toxin stagnation syndrome type pulmonary nodule, and fully embodies the treatment principle of clearing damp and reducing phlegm, promoting blood circulation to remove blood stasis, promoting qi circulation to relieve pain, tonifying qi and lifting yang, replenishing qi and strengthening spleen, promoting salivation and moistening lung, promoting qi circulation to diuresis, promoting qi circulation to relieve pain, strengthening spleen to promote digestion, clearing away heat and toxic materials, promoting diuresis and eliminating carbuncle, promoting blood circulation to relieve pain, nourishing liver and kidney, and preventing blood-activating drugs from consuming blood and injuring yin; the traditional Chinese medicine is an effective prescription for treating the phlegm stasis and toxin stagnation syndrome type pulmonary nodule.

The invention relates to the technical field of traditional Chinese medicine compositions, in particular to an external traditional Chinese medicine composition for promoting wound healing after perineotomy as well as a preparation method and application of the external traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components in parts by mass: 15 to 60 parts of spreading hedyotis herb, 10 to 15 parts of honeysuckle flower, 6 to 15 parts of fructus forsythiae, 10 to 30 parts of herba taraxaci, 5 to 15 parts of radix angelicae sinensis, 10 to 15 parts of radix rubiae, 10 to 30 parts of herba leonuri, 0.3 to 1 part of pearl powder, 3 to 10 parts of rhizoma bletillae, 10 to 15 parts of carbonized sanguisorba root, 10 to 60 parts of radix astragali seu hedysari, 2 to 10 parts of catechu, 10 to 30 parts of calcined dragon bone, 5 to 15 parts of rhizoma atractylodis macrocephalae, 2 to 10 parts of liquorice root and 10 to 20 parts of red halloysite. By the adoption of the components, wound detumescence, inflammation diminishing, tissue regeneration promoting and healing accelerating processes can be remarkably promoted, two preparation processes of liquid medicine and freeze-dried powder are provided, and the liquid medicine preparation can be used immediately after being unsealed and is convenient to use; the freeze-dried powder preparation retains heat-sensitive components and is long in shelf life.

The invention discloses a traditional Chinese medicine external nursing medicine for treating burns and scalds. The traditional Chinese medicine external nursing medicine comprises the following raw material medicines and auxiliary materials in parts by weight, raw material medicines: 8-12 parts of dandelion, 6-8 parts of oldenlandia diffusa, 8-10 parts of purpleflower holly leaf, 8-10 parts of Chinese elm bark, 10-12 parts of calcined dragon bone, 6-8 parts of aloe, 8-10 parts of safflower, 8-10 parts of radix angelicae, 8-10 parts of astragalus membranaceus, 3-5 parts of borneol, 2-4 parts of pearl powder, 1-3 parts of a salvia miltiorrhiza extract, 8-10 parts of golden cypress, 6-8 parts of sanguisorba officinalis and 4-6 parts of rheum officinale; auxiliary materials: 5-10 parts of chitosan, 3-6 parts of hyaluronic acid, 10-20 parts of olive oil and 1-2 parts of nano titanium dioxide; the pearl powder, the radix salviae miltiorrhizae extract, the cortex phellodendri, the radix sanguisorbae and the radix et rhizoma rhei are added to construct an anti-infection-healing promoting-scar inhibiting triple-effect synergistic system, and pharmacodynamic experiments prove that the deep II-degree wound healing time can be shortened by 3-5 days, and the scar hyperplasia degree can be reduced by 40%; the temperature-sensitive hydrogel realizes'gelation when being contacted with skin ', is uniformly coated and is not easy to fall off.

The invention discloses a compound traditional Chinese medicine preparation for improving tumor immunity and resisting tumors, belongs to the technical field of anti-tumor traditional Chinese medicines, and discloses a compound traditional Chinese medicine preparation for improving tumor immunity and resisting tumors. The traditional Chinese medicine composition comprises the following components in parts by weight: 10-25 parts of ginseng, 15-18 parts of selfheal, 12-18 parts of seaweed, 12-19 parts of astragalus membranaceus, 10-16 parts of angelica sinensis, 18-30 parts of oldenlandia diffusa, 10-15 parts of fleece-flower root, 10-14 parts of poria cocos, 10-16 parts of thunberg fritillary bulb, 8-14 parts of pseudobulbus cremastrae seu pleiones and 8-17 parts of curcuma zedoary. Through the specific pharmacological action, growth and proliferation of thyroid tumor cells are inhibited, the development speed of tumors can be slowed down, the malignancy degree of the tumors can be reduced, apoptosis of the thyroid tumor cells can be induced, and the number of the tumor cells can be effectively reduced by inducing apoptosis of the tumor cells, so that the anti-tumor purpose is achieved.

The invention discloses a traditional Chinese medicine composition for treating constipation as well as a preparation method and application thereof, and belongs to the technical field of traditional Chinese medicines. The composition comprises the following components in parts by weight: 45 to 85 parts of Chinese pulsatilla root, 45 to 85 parts of oldenlandia diffusa, 45 to 85 parts of sculellaria barbata, 80 to 140 parts of Chinese actinidia root, 45 to 85 parts of trogopterus dung, 80 to 140 parts of coix seed, 80 to 140 parts of poria cocos, 80 to 140 parts of rhizoma pinellinae praeparata, 45 to 85 parts of pericarpium citri reticulatae, 60 to 100 parts of bighead atractylodes rhizome, 45 to 85 parts of endothelium corneum gigeriae galli, 60 to 100 parts of white hyacinth bean, 60 to 100 parts of dried ginger and 45 to 85 parts of liquorice. The traditional Chinese medicine composition has a good treatment effect on constipation caused by gastrointestinal tumors, is mild in medicine property, and is specially developed for patients with constipation caused by tumors.

The invention provides a traditional Chinese medicine composition for treating chronic atrophic gastritis and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 280-320 parts of red ginseng; the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 580 to 620 parts of rhizoma atractylodis macrocephalae, 280 to 320 parts of rhizoma zingiberis, 80 to 120 parts of sandalwood, 280 to 320 parts of edible tulip, 580 to 620 parts of concha arcae, 580 to 620 parts of oldenlandia diffusa, 180 to 220 parts of notholirion bulbuliferum and 280 to 320 parts of sea buckthron oil. The total effective rate of the traditional Chinese medicine composition for treating chronic atrophic gastritis with intestinal metaplasia is 93%, and the traditional Chinese medicine composition has a remarkable clinical effect on treating chronic atrophic gastritis with intestinal metaplasia clinically.

The present invention belongs to the technical field of research, development and utilization of traditional Chinese medicine, and relates to a traditional Chinese medicine compound for treating acne-causing mastitis, a preparation method and application thereof, which comprises the following raw materials in parts by weight: 10-15 parts of bupleurum, 15-25 parts of thunbergii, 25-35 parts of salvia miltiorrhiza, 5-10 parts of red peony root, 25-35 parts of millettia reticulata, 5-10 parts of dried tangerine peel, 25-35 parts of dandelion, 15-20 parts of selfheal, 10- 15 parts, 5-10 parts of roasted liquorice root, 5-10 parts of chuanxiong, 5-10 parts of angelica, 25-35 parts of white peony root, 15-25 parts of honeysuckle, 5-10 parts of angelica dahurica, 25-35 parts of astragalus, 5-10 parts of platycodon, 5-10 parts of licorice root, 10-20 parts of codonopsis pilosula, 10-20 parts of poria, 10-15 parts of atractylodes macrocephala, 15-20 parts of knotweed, 25-35 parts of raw hawthorn, and 15-20 parts of oldenlandia diffusa. It has good clinical efficacy in treating comedonal mastitis.

The application provides a traditional Chinese medicine composition for treating brain tumors and a preparation method and application thereof, and the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 3-5 parts of tianlong, 3-5 parts of centipede, 6-12 parts of sanleng, 6-12 parts of zedoary, 15-60 parts of belamcanda chinensis, 9-12 parts of acorus gramineus, 10-20 parts of dandelion, 9-12 parts of poria cocos and 9-12 parts of atractylodes. The composition is prepared through the strict combination of monarch, minister, assistant and messenger and the synergistic effect of specific medicinal ingredients, nine drugs are combined, warm and cool are in order, and elimination and tonification are combined and cancelled, so that the effects of removing blood stasis and resolving masses, dispelling wind and calming are realized; the unique combination mechanism effectively restrains the toxic and side effects of insect drugs while enhancing the treatment intensity of removing blood stasis and resolving masses, and ensures the safety of the medicine; in addition, based on the syndrome differentiation strategy of flexible adjustment of the amount of monarch drug, the composition can be widely used for various types of brain tumor patients, and significant progress is achieved in the aspects of efficacy, safety and clinical applicability.

The invention provides a traditional Chinese medicine composition with an anti-inflammatory effect and a preparation method and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following functional components: oldenlandia diffusa, rhizoma smilacis glabrae, astragalus membranaceus, radix aconiti carmichaeli, sargentgloryvine stem, madder, centipede and liquorice. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 30-45 parts of oldenlandia diffusa, 30-45 parts of rhizoma smilacis glabrae, 30-45 parts of astragalus membranaceus, 10-15 parts of radix aconiti carmichaeli, 10-20 parts of sargentgloryvine stem, 10-15 parts of madder, 2-4 parts of centipede and 6-9 parts of liquorice through mixing and water extraction, and the components have a synergistic effect, so that the traditional Chinese medicine composition has the effects of detoxifying, expelling toxins and diminishing swelling, has a remarkable effect of treating rheumatoid arthritis and is free of toxic and side effects. The methotrexate pharmaceutical composition has the advantages that the methotrexate pharmaceutical composition has an obvious curative effect on treating joint swelling of a patient, especially has an obvious curative effect on improving joint swelling of a patient, can better reduce inflammation indexes ESR and CRP, has more advantages in long-term curative effects on improving joint pressing pain and joint swelling, and can effectively improve the drug effect of methotrexate and reduce toxic / side effects of methotrexate.

The application belongs to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating lung cancer bone metastasis and application thereof. The main active ingredients of the traditional Chinese medicine composition include, in mass parts, 20-40 parts of radix codonopsis, 20-40 parts of poria, 20-40 parts of astragalus, 10-30 parts of atractylodes, 10-20 parts of licorice, 10-30 parts of curcuma, 10-20 parts of pinellia, 5-10 parts of dried tangerine or orange peel, 20-40 parts of oldenlandia, 10-30 parts of psoralea, 10-30 parts of drynaria, 10-30 parts of epimedium, and 10-20 parts of jackinthepulp. Animal experiments show that the traditional Chinese medicine composition can not only inhibit primary tumor growth, but also slow down tumor progression of bone metastasis. When combined with a chemotherapy drug, the traditional Chinese medicine composition can not only significantly enhance the tumor inhibition effect of the chemotherapy drug, but also significantly prolong the survival time of mice, relieve weight loss and organ toxic side effects caused by the chemotherapy drug.

The invention discloses a traditional Chinese medicine composition for treating multiple myeloma as well as a preparation method and application thereof, and the traditional Chinese medicine composition is prepared from herba taxilli, eucommia ulmoides, herba epimedii, roasted rhizoma atractylodis macrocephalae, radix scrophulariae, processed rhizoma pinelliae, selfheal, semen brassicae, thunberg fritillary bulb, oyster, oldenlandia diffusa, sculellaria barbata, duchesnea indica, Chinese polyphaga, honey-fried stiff silkworm and honey-fried licorice root. On the basis of the traditional Chinese medicine theory that kidney deficiency serves as the root and phlegm stasis serves as the symptom, a compatibility system with kidney tonifying, bone strengthening, phlegm reducing, stasis removing and detoxification as the treatment rule is built, the core pathogenesis of deficiency, phlegm, stasis and toxicity of multiple myeloma can be covered in an all-round mode, the traditional Chinese medicine composition can be subjected to compatibility addition and reduction according to different traditional Chinese medicine syndromes, various clinical dosage forms can be prepared, and the traditional Chinese medicine composition is suitable for clinical application. Clinical practice shows that the composition can remarkably relieve core symptoms of patients, improve life quality and reduce adverse reactions of western medicine treatment, provides a traditional Chinese medicine solution which treats both symptoms and root causes and is low in side effect for multiple myeloma, and has great popularization value.

The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for preventing recurrence and metastasis of triple negative breast cancer and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 5-10 parts of pericarpium citri reticulatae, 5-10 parts of rhizoma atractylodis macrocephalae, 5-10 parts of pinellia ternate, 15-20 parts of oldenlandia diffusa, 5-10 parts of radix paeoniae alba, 15-20 parts of radix pseudostellariae, 10-15 parts of angelica sinensis, 5-10 parts of curcuma zedoary, 15-20 parts of poria cocos and 3-8 parts of liquorice. The traditional Chinese medicine composition for preventing recurrence and metastasis of the triple-negative breast cancer is successfully prepared by starting from the traditional Chinese medicine theory and adhering to the prescription principle of supporting healthy qi and removing cancer evil, and the traditional Chinese medicine composition is named as the six-monarch yin prescription. The traditional Chinese medicine composition can tonify qi and blood, quickly recover human immune functions and prevent recurrence and metastasis of triple negative breast cancer diseases, thereby having good practical application value.

The application belongs to the field of traditional Chinese medicine, and particularly relates to a traditional Chinese medicine composition for treating liver cancer and a preparation method thereof. The traditional Chinese medicine composition is composed of the following raw materials: green calyx plum 10 parts, Chinese scholartree flower 10 parts, privet fruit 15 parts, eclipta 15 parts, yellow ginseng 30 parts, Chinese wolfberry root 30 parts, white atractylodes 15 parts, poria 15 parts, fried licorice 10 parts, dried ginger 6 parts, angelica 10 parts, red sage root 30 parts, Szechuan lovage 10 parts, half branch lotus 30 parts, and white flower snake tongue grass 30 parts. The half branch lotus and the white flower snake tongue grass are the monarch drugs, which clear heat and detoxify and resolve stasis and promote diuresis; the yellow ginseng, the Chinese wolfberry root, the white atractylodes, the poria, the privet fruit, the eclipta, the angelica, the red sage root, the Szechuan lovage, and the dried ginger are the ministerial drugs, which tonify qi and nourish blood, invigorate the spleen and tonify the liver and kidney, and the dried ginger is used for warming the middle, which can prevent the half branch lotus and the white flower snake tongue grass from being too hot to hurt the stomach and intestines; the green calyx plum and the Chinese scholartree flower are the auxiliary drugs, which soothe the liver, relieve stagnation, and calm the mind; and the fried licorice is the ministerial drug, which invigorates the spleen and tonifies qi and harmonizes all the drugs. The traditional Chinese medicine composition can effectively inhibit the growth of liver cancer cells and has no side effects.

The invention discloses a traditional Chinese medicine formula for treating atrophic gastritis with intestinal metaplasia and atypical hyperplasia and a preparation method thereof, and belongs to the technical field of traditional Chinese medicine formulas. The traditional Chinese medicine composition comprises the following components in parts by weight: 16-20 parts of Zhejiang radix ophiopogonis, 15-20 parts of moutan bark, 28-32 parts of salvia miltiorrhiza, 10-14 parts of pseudo-ginseng slices, 15-18 parts of curcuma zedoary, 18-22 parts of codonopsis pilosula, 28-32 parts of astragalus membranaceus and 28-32 parts of oldenlandia diffusa. The preparation method comprises the following steps: (1) cleaning the medicinal materials, and then cutting into small blocks to obtain a mixed medicinal material; (3) boiling with big fire after soaking, continuing to decoct with small fire, and filtering to obtain first medicine liquid and medicine residues; and (4) adding water again, boiling with big fire, continuously decocting with small fire, filtering to obtain a second liquid medicine, and mixing the first liquid medicine and the second liquid medicine. The traditional Chinese medicine composition can obviously improve inflammation and atrophic lesion of gastric mucosa, and has a remarkable effect on treating atrophic gastritis with intestinal metaplasia and atypical hyperplasia.

The invention provides a pharmaceutical composition and application thereof in preparation of medicines for treating ovarian cancer, and the pharmaceutical composition is prepared from the following components in parts by weight: 5-20 parts of cortex phellodendri, 5-20 parts of rhizoma atractylodis, 5-20 parts of radix achyranthis bidentatae, 5-20 parts of oldenlandia diffusa, 5-20 parts of radix trichosanthis, 5-20 parts of cassia twig, 20-40 parts of radix astragali and 20-40 parts of semen coicis. The pharmaceutical composition provided by the invention is suitable for ovarian cancer postoperative combined chemotherapy, and can significantly reduce the incidence rate of adverse reactions of chemotherapy, improve the chemotherapy effect and compliance, and reduce the toxic and side effects of chemotherapy drugs.

The invention discloses a traditional Chinese medicine lotion for treating intractable psoriasis. The traditional Chinese medicine lotion is prepared from 22 raw material medicines, namely wrinkled gianthyssop herb, rhizoma acori graminei, fineleaf schizonepeta herb, divaricate saposhnikovia root, cicada slough, snake slough, nidus vespae, dahurian angelica root, pricklyash peel, rehmannia root, common cnidium fruit, belvedere fruit, dandelion, bunge corydalis herb, spreading hedyotis herb, Chinese gall, densefruit pittany root-bark, tree peony bark, red paeony root, clove, eclipta alba and liquorice. According to the traditional Chinese medicine lotion, a dredging method is adopted, the moist, closed and airtight environment of the skin is improved, the skin environment is effectively treated, stagnation on the surface of the skin is relieved, the environment on which fungi live is lost, and psoriasis can be thoroughly cured. Clinical statistics show that when the lotion is used for treating psoriasis, the effective rate of the lotion is 100%, and the cure rate can be up to 98% when the lotion is used for persistently treating the psoriasis.