59 results about "Tripterygium hypoglaucum" patented technology

The invention has brought to light a kind of antirheumatic and its preparation, which was made from Tripterygium hypoglaucum (Levl.) Hutch, Epimedium brevicornum Maxim, Lycium barbarum L, and Cuscuta chinensis Lam. The invented medicine has the merits of prominent effect, mild side reaction and convenient administration.

The invention relates to a triptophenolide preparation method, in particular to a method for extracting and purifying triptophenolide by means of the supercritical CO2 extraction technology. The method includes: using triperygium hypoglaucum as raw materials, extracting by means of supercritical CO2, using 90% ethanol as entrainer, collecting extract liquor, using ethyl acetate for extracting after ethanol is recovered, subjecting ethyl acetate extractum obtained by condensing ethyl acetate extract liquor to magnesium oxide short-range column chromatography, using n-hexane-acetone for gradient elution, and crystallizing. The triptophenolide preparation method is mild in condition, reasonable in process, capable of realizing quick extraction and separative purification, and easy for industrialization.

The invention relates to a medicine for treating rheumatic arthritis and rheumatoid arthritis and a method for preparing the medicine. The medicine is mainly prepared from pharmaceuticals of polyrhachis vicina roger, zaocys dhumnades, radix aconiti preparata, radix rehmanniae, tripterygium wilfordii, radix clematidis, paniculate swallowwort root, suberect spatholobus stem, herba epimedii, anemarrhena asphodeloides, cornu cervi, buthus martensi karsch, centipede and earthworm, pseudo-ginseng, astragalus, pawpaw, herba taxilli, eucommia ulmoides, radix achyranthis bidentatae, ligusticum chuanxiong and the like. The medicine is used for treating the rheumatoid arthritis and the rheumatic arthritis of finger morning stiffness, muscle and join pain, inhibited bending and stretching, muscle emaciation and anchylosis and malformation, and has the functions of tonifying kidney and strengthening bones, activating blood and relieving wind, dispelling cold and clearing dampness, an exact curative effect and no toxic and side effects.

The invention belongs to the field of medicines and discloses a pharmaceutical composition of a triptolide-containing medicine and bracken and preparation and application thereof. The triptolide-containing medicine comprises triptolide, tripterygium glycosides, thunder god vine, tripterygium hypoglaucum hutch and tripterygium regelii. The pharmaceutical composition comprises the following raw materials in parts by weight: 1 part of triptolide and 100-107 parts of bracken or 1 part of tripterygium glycosides and 1-105 parts of bracken or 1 part of thunder god vine and 0.01-1000 parts of bracken or 1 part of tripterygium hypoglaucum hutch and 0.01-1000 parts of bracken or 1 part of tripterygium regelii and 0.01-1000 parts of bracken. Compared with the original medicine containing triptolide, the pharmaceutical composition has the advantages of immunological suppression, anti-inflammatory, treatment of rheumatoid arthritis, comparative antineoplastic activity and small toxicity, enhances the medication security and can be used as a medicine for immunological suppression, anti-inflammatory, rheumatoid arthritis and antitumor.

To solve the problem of an obvious side effect existing in the traditional Tripterygium Hypoglaucum Hutch root tablet, the invention provides a bi-layer extended release tablet which can reduce medicine peak plasma concentration. A Tripterygium Hypoglaucum Hutch root extract is any one extract of the whole Tripterygium Hypoglaucum Hutch root, Tripterygium Hypoglaucum Hutch root bark, or Tripterygium Hypoglaucum Hutch root core with the bark removed. The Tripterygium Hypoglaucum Hutch extract bi-layer extended release tablet has the characteristics of little untoward effect, and is convenient and safe to use. At the same time, a medicine-time curve is stable, the plasma concentration has small fluctuations, and the half life is prolonged. The Tripterygium Hypoglaucum Hutch root extract extended release bi-layer tablet using the root core with the bark removed has good therapeutic effects on asthma, lupus erythematosus, nephritis, and rheumatoid arthritis.

The invention discloses film coated tablets of tripterygium hypoglaucum tablets and a preparation method thereof. The film coated tablets are characterized in that: oblate or elliptic tripterygium hypoglaucum tablets with the diameter of 0.8 to 1.2 centimeters are used as tablet bases, and a film coating with the thickness of 0.1 to 0.3 millimeter is sprayed and coated on the tablet surface; and the tripterygium hypoglaucum tablet cores comprise the following components in part by weight: 40 to 80 parts of tripterygium hypoglaucum, 10 to 40 parts of starch, 0 to 30 parts of microcrystalline cellulose, 10 to 30 parts of 1 to 10 percent hydroxypropyl methyl cellulose methanol solution, 0.5 to 5 parts of magnesium stearate and 1 to 5 parts of carboxymethyl starch sodium. The preparation method for the tripterygium hypoglaucum film coated tablets has the advantages of simple preparation, easy operation, easy mastery, low equipment investment and short production period; and the prepared tablets have stable main medicinal property, are favorable for improving the medicinal quality, and ensure the effect of the tablets.

A pharmaceutical composition for the treatment of rheumatism and a method of preparing it are provided. The composition consists of an alcoholic extract of 1-4 parts by weight Tripterygium hypoglaucum (Levl.) Hutch.; 1-4 parts by weight Epimedium brevicornum Maxim.; 1-4 parts by weight Lycium barbarum L.; and 1-4 parts by weight Cuscuta chinensis Lam., or Cuscuta australis R. Br. The composition has substantial therapeutic efficacy, with mild side effects, and is easy to administer.

The invention provides a Tripterygium hypoglaucum seed propagation method. The method includes the steps of low-temperature storage of seeds, vernalization of the seeds, seed sowing, intertillage management, etc. The step of vernalization of the seeds is as follows: storing the Tripterygium hypoglaucum seeds that have been stored at a low temperature in sand at room temperature in a moisturizing and ventilating condition for one month; and after soaking of the Tripterygium hypoglaucum seeds stored in sand in gibberellin, placing the seeds in a condition with temperature ranging from 7+/-2 DEG C, and maintaining illumination and humidity for one month. Through exploring and researching, a low-temperature treatment method and a hormone regulation method are adopted to overcome a factor of instability of a seed germination rate. Therefore, the seed germination rate is increased. Moreover, a systematic method is employed to lay a foundation for artificial cultivation in future.

The invention discloses a sesterterpene compound 1-34 and a medicinal composition taking the compound as an active ingredient. A preparation method of the sesterterpene compound 1-34 comprises the following steps of: performing direct cold soaking or thermal reflux extraction on leaves or flowers or stems of labiatae tripterygium hypoglaucum plant with an organic solvent, i.e., petroleum ether or n-hexane or cyclohexane or chloroform or acetone or methanol or ethanol; or performing cold soaking or thermal reflux extraction on the organic solvent, and extracting with ethyl acetate to obtain a total extract; and repeatedly performing column chromatography on the total extract to obtain the compound. The compound is applied to preparation of an anti-angiogenesis agent, an anti-prolyl endopeptidase agent, an antibacterial agent, an anti-feedant and a flavor: the compound has high antibiotic activity when being applied to a substrate or a group in an amount of 10-1,000muM and being optionally combined with a carrier and/or a medium; the compound has high antifeedant activity when being applied to a substrate or a group in an amount of 0.005-10muM/cm<2> and being optionally combined with a carrier and/or a medium; and the compound has clear flavor and high hair permeability, can be used for improving the hair flavor when used for blending, has the characteristic of unique flavor, is clear and pure, can be used for covering bad flavors of surfactant substrate raw materials, and is safe for a long time.

The invention discloses a Chinese medicine composition for treating knee arthritis and a preparation method thereof, and belongs to the field of traditional Chinese medicine. According to the Chinese medicine composition, active components are prepared from the following traditional Chinese medicinal materials: honeysuckle stem, hematoxylon, lanceolate jasmine root, rhizoma bolbostemmae, galeola faberi, tripterygium hypoglaucum, pilea plataniflora and mallow leaves as raw materials in combination; the active components and auxiliary materials of a common pharmaceutic preparation are prepared into Chinese medicine tablets, granules and capsules. The Chinese medicine composition has an accurate therapeutical effect on the knee arthritis.

The invention discloses 3-carbonyl hyperin as well as an extraction method and application thereof in the preparation of antitumor drugs. The structure of 3-carbonyl hyperin is shown as (I). The extraction method of 3-carbonyl hyperin comprises the following steps: 1) crushing roots and stems of tripterygium hypoglaucum, extracting with ethanol, and carrying out reduced pressure concentration to obtain a concentrate; 2) extracting the concentrate with petroleum ether and dichloromethane in sequence, collecting the dichloromethane extract, and concentrating the dichloromethane extract to a small volume to obtain a sample concentrate; 3) separating the sample concentrate in a high-speed counter-current chromatograph, collecting a main component, concentrating the main component under reducedpressure to a small volume, and purifying by gel column chromatography Sephadex-LH20. The compound has remarkable inhibition activity on solid tumors such as lung cancer, can promote apoptosis of tumor cells, inhibits angiogenesis, remarkably inhibits growth and metastasis of tumors in lung cancer tumor-bearing mice, and prolongs the lifetime of the mice. The invention also provides an application of 3-carbonyl hyperin in the preparation of antitumor drugs.

The invention discloses a traditional Chinese medicine formula for treating eczematous dermatitis and a preparing method of traditional Chinese medicine. The traditional Chinese medicine comprises, by weight, the raw materials of 8g of Gynura pseudochina, 4 g of Flueggea virosa, 15 g of cajeput, 8 g of garden erphorbia herb, 6 g of nauclea officinalis pierre ex petard, 12 g of mottle leaves, 9 g of radix tinosporae, 9 g of tripterygium hypoglaucum hutch, 6 g of clamshell powder, 12 g of herba leucatis molloissimae, 8 g of sweet broomwort herb, 4 g of Sedum sarmentosum, 12 g of Polygonum posumbu, 15 g of Vitis flexuosa Thunb. leaves, 8 g of cynanchum amplexicaule, 10 g of Senecio dianthus Franch, 5 g of herb of three-leaved pronephrium and 8 g of Securidaca inapfondiculata Hassk. The cajeput is cajeput leaves. The traditional Chinese medicine formula for treating eczematous dermatitis is obvious in medicine effect, convenient to use, low in recurrence rate, free from side effect and low in price.

The invention provides a tripterygium hypoglaucum (level) hutch root external preparation for relieving swelling and pain as well as a preparation method and application thereof. The active ingredient of the external preparation is an ethanol extract of peeled root cores of tripterygium hypoglaucum (level) hutch root. The invention provides the external preparation extracted from the tripterygium hypoglaucum (level) hutch root, and the external preparation can effectively reduce cytotoxicity of the tripterygium hypoglaucum (level) hutch root extract. Moreover, the root cores of the tripterygium hypoglaucum (level) hutch root are used as a medicine, and a low-alcohol-concentration impurity removal method is adopted, so that the toxicity of the tripterygium hypoglaucum (level) hutch root external preparation is further reduced.

The invention relates to a medicine for treating a cold-heat jumble symptom of rheumatoid arthritis. The medicine is prepared from, by weight, 10 parts of rhizoma et radix notopterygii, 6 parts of carthamus tinctorius, 15 parts of hypericum beanii, 15 parts of ludwigia octovalvis, 8 parts of beautiful sweetgum fruit, 9 parts of tripterygium hypoglaucum, 8 parts of herba euonymi and 18 parts of vitis coignetiae. The rhizoma et radix notopterygii has efficacies of exterior cold dispelling, wind-damp expelling, joint tonifying and pain relieving; the carthamus tinctorius has efficacies of blood circulation promoting, meridian activating, stasis removing and pain relieving; the hypericum beanii and the ludwigia octovalvis have efficacies of heat clearing and diuresis promoting; the beautiful sweetgum fruit has the efficacy of meridian activating; the tripterygium hypoglaucum has efficacies of Qi regulating and meridian activating; the herba euonymi has efficacies of stasis removing, bleeding stopping, muscle relaxing and meridian activating; the vitis coignetiae has efficacies of heat clearing, deficiency tonifying, stasis removing and meridian activating. By joint application of the raw herbal materials, efficiencies of channel warming, cold expelling, heat clearing, damp removing, blood circulation promoting and meridian activating are realized, and the cold-heat jumble symptom of rheumatoid arthritis can be treated effectively. According to clinical trials, the medicine is capable of safely and effectively treating the cold-heat jumble symptom of rheumatoid arthritis.

The invention discloses a traditional Chinese medicament for treating hernia and a preparation method thereof. The traditional Chinese medicament is prepared from the following main raw materials in percentage by weight: 13 to 18 percent of clerodendrum fortunatum, 9 to 13 percent of shoot of omei mountain bamboo, 10 to 15 percent of melastoma dodecandrum, 8 to 17 percent of euphorbia kansui, 11 to 15 percent of fortunella hindsii, 7 to 10 percent of mandarin orange seed, 12 to 18 percent of angelica citriodora hance, 10 to 13 percent of tripterygium hypoglaucum, 9 to 17 percent of euonymus alatus, 11 to 16 percent of polygonum orientale, 12 to 16 percent of tree peony root bark, 9 to 16 percent of cortex acanthopanacis giraldii, 11 to 14 percent of smallflower microtis, 10 to 17 percent of rhizoma corydalis, 8 to 13 percent of olivary nucleus, 12 to 18 percent of root of marigold and 9 to 14 percent of smilax china. The traditional Chinese medicament disclosed by the invention has the advantages of no risk, no pains, short cure time, low treatment cost, capability of treating both manifestation and root cause of disease, low possibility of relapse, obvious therapeutic effect, safety and no toxic or side effect.

The invention discloses a preparation method for external-use styptic powder based on a traditional Chinese medicine composition. The styptic powder comprises the following constituents in part by mass: 1-3 parts of ageratum conyzoides, 1-3 parts of marsdenia longipes, 1-3 parts of cinnamomum burmanni, 1-3 parts of aristolochia kwangsiensis (Guan Nan Xiang), 1-3 parts of Weiyu (winged euonymus twig), 1-3 parts of tripterygium hypoglaucum, 1-3 parts of boenninghausenia albiflora, 1-3 parts of radix zanthoxyli, 1-3 parts of carpet bugle, 1-3 parts of butterfly bush, 1-3 parts of boea hygrometrica, 1-3 parts of asystasiella neesiana and 1-3 parts of normal saline. The preparation method comprises the following steps: A, selecting 1 part of high-quality and clean ageratum conyzoides, 1 part of high-quality and clean marsdenia longipes, 1 part of high-quality and clean cinnamomum burmamnni, 1 part of high-quality and clean aristolochia kwangsiensis (Guan Nan Xiang), 1 part of high-quality and clean Weiyu (winged euonymus twig), 1 part of high-quality and clean tripterygium hypoglaucum, 1 part of high-quality and clean boenninghausenia albiflora, 1 part of high-quality and clean radix zanthoxyli, 1 part of high-quality and clean carpet bugle, 1 part of high-quality and clean butterfly bush, 1 part of high-quality and clean boea hygrometrica and 1 part of high-quality and clean asystasiella neesiana for air drying and stir-frying, and carrying out smashing and grinding respectively to obtain medicine powder; B, filtering the grinded medicine powder with a 80-mesh sieve, putting the filtered medicine powder into a container of a special bag packing machine in a sterile room, and then carrying out sealed packing to obtain the external-use styptic powder. The external-use styptic powder takes common Chinese herbal medicines as raw materials, and has the advantages of stopping bleeding, invigorating blood circulation, eliminating inflammation, easing pain, promoting blood circulation to remove blood stasis, promoting reunion of fractured tendons and bones, and promoting fast wound healing.

A traditional Chinese medicine preparation for external use for treating inflammation of superior clunial nerves comprises schizonepeta spike, a notopterygium root, radix angelicae pubescentis, herba asari cum radice, tripterygium hypoglaucum, olibanum, myrrh, lycopodium clavatum, tuberculate speranskia herb, a short-pedicel aconite root, caulis sinomenii, folium photiniae, fructus evodiae, rhizome of decumbent corydalis, turmeric, aromatic, resina liquidamberis, achyranthes bidentata, rhizoma drynariae, sangusis draconis, rhizoma corydalis and a himalayan teasel root. A compatibility rule of the twenty-two traditional Chinese medicines of a prescription is based on basic theories of traditional Chinese medicine; a formula hits the point of traditional Chinese medicine pathogeny and pathogenesis of wind-cold-damp retention supraspinatus tenositis; the prescription takes treatment of a primary symptom, an accompanied symptom and an altered symptom into consideration; compared with the existing treatment means such as traditional Chinese medicine massage, a manner of the traditional Chinese medicine preparation is softer; a treatment process is comfortable; no secondary injury is caused to an affected part; each preparation is used for a single person; and the traditional Chinese medicine preparation is safe, convenient and quick.

The invention provides a tripterygium hypoglaucum hutch active-components detection method based on ionic liquid-ultrasonic assistance-HPLC. The key technology is that a preparation sample 1-butyl-3-methylimidazolehexafluorophosphate solution is used as an extracting solution to extract a tripterygium hypoglaucum hutch medicinal material. Detection efficiency of the method provided by the invention is obviously higher than detection efficiency of a traditional single-component detection method. The more important is that transfer rate of active components in the process is obviously higher than transfer rate of a traditional methanol extraction method. And detection errors are effectively avoided.

The invention belongs to the field of traditional Chinese medicine preparations and aims to provide traditional Chinese medicine composition for treating herniated disk on the basis of the know mechanism of Chinese traditional treatment on herniated disk. The traditional Chinese medicine composition is prepared from components by mass as follows: 4-10 g of semen strychni, 6-15 g of radix angelicaesinensis, 3-18 g of Chinese alangium root, 6-18 g of herb or root-bark of tripterygium hypoglaucum, 6-18 g of caulis piperis kadsurae, 15-38 g of radix rehmanniae preparata, 6-10 g of radix clematidis, 15-28 g of common threewingnut root, 3-10 g of pyritum, 10-35 g of pubescent holly root, 15-35 g of herba gendarussae, 3-8 g of caulis akebiae, 6-15 g of herba agrimoniae, 3-15 g of ramulus cinnamomi, 9-35 g of herba sarcandrae, 3-10 g of radix aconiti, 3-15 g of radix aconiti kusnezoffii, 6-20 g of radix paeoniae alba, 3-10 g of radix notoginseng, 5-15 g of radix gentianae macrophyllae, 9-16 gof herba speranskiae tuberculatae, 3-10 g of spina gleditsiae, 5-15 g of stellaria saxatilis herb, 3-15 g of herba lycopodii, 3-16 g of rhizoma homalomenae and 9-20 g of semen cuscutae (stir-fried with salt). The drug adopts a good traditional Chinese medicine formula.

The invention discloses a navel externally-applied plaster for adjuvant therapy of cancer and a preparation method thereof. The navel externally-applied plaster is prepared from the following components of musk, natural calculus bovis, radix euphorbiae lantu, airpotato yam rhizome, tripterygium hypoglaucum, medical stone, bee pollen, pine pollen, semen momordicae, cortex cinnamomi, realgar, arsenic, processed semen strychni, bulb of edible tulip, dried lacquer, raw rhizoma pinelliae, garden balsam seeds, venenum bufonis, euphorbia kansui, euphorbia pekinensis roots, roots and leaves of wikstroemia indica, moleplant seed, rhizoma anemarrhenae, muskmelon pedicel, chalcanthite, gamboge, borneol, pseudobulbus cremastrae seu pleiones, semen pharbitidis, seaweed, kelp, roasted pangolin, white muscardine silkworm, sea clam powder, dragon bone and conch shell. The application amount is determined, and during preparation, the medicines of all the components are ground into fine powder, are prepared into plaster through an excipient, and are put into a patch. The externally-applied navel patch is used for treating cancers in an auxiliary manner, and a good treatment effect is also achieved clinically.

Compound tripterygium hypoglaucum gum confection relate to traditional Chinese medicine products and can effectively prevent or assist treatment of recurrent oral ulcers. The compound tripterygium hypoglaucum gum confection comprises, by mass parts, 1-5 parts of tripterygium hypoglaucum total alkaloid, 200-400 parts of ligustrum purpurascens micropowder, 2500-3000 parts of edible gum base, 5000-5500 parts of sweetener, 30-50 parts of mint essence, 1000-2000 parts of edible softener and 200-400 parts of filler. The tripterygium hypoglaucum gum confection can be used for treating and preventingacute attack of the recurrent oral ulcers. In the early stage, 36 cases of recurrent oral ulcers are treated with traditional Chinese medicine syndrome differentiation supplemented with the tripterygium hypoglaucum gum confection. Among them, 26 cases are cured after 4 days, another 8 cases are cured on the 5th day, 1 case is cured on the 6th day, and 1 case is cured on the 7th day.

The invention provides a formation process and vacuum drying equipment for direct powder of Tripterygium hypoglaucum roots, and the process comprises the following steps: (1) crushing: taking a certain amount of Tripterygium hypoglaucum roots, putting the Tripterygium hypoglaucum roots into a crusher, and crushing the Tripterygium hypoglaucum roots into small blocks; (2) extracting a decoction: introducing the decoction into a centrifugal machine, controlling the environment temperature to rise to 80-100 DEG C, then performing ultrasonic vibration on the decoction, and repeating the process for a plurality of times; (3) decoction concentrating: combining the decoction of each time, and concentrating the filtrate into clear paste with the relative density of 1.05-1.07 at the temperature of 50-70 DEG C; (4) standing and filtering: adding ethanol into the clear paste to enable the alcohol content of the clear paste to reach 70-80%, and conducting standing for 12 hours under a low-temperature condition to obtain a second filtrate; and (5) direct powder tabletting: adding the second filtrate into vacuum drying equipment for drying, taking out the dried Tripterygium hypoglaucum root powder, adding starch, pregelatinized starch, talcum powder and magnesium stearate according to the weight ratios of the starch, the pregelatinized starch, the talcum powder and the magnesium stearate to the Tripterygium hypoglaucum root tablets being 0.104-0.109, 0.02-0.05, 0.01-0.02 and 0.003-0.005 respectively, and uniformly conducting mixing.