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Tripterygium hypoglaucum (level) hutch root external preparation for relieving swelling and pain as well as preparation method and application thereof

An external preparation, swelling and pain relief technology, applied in the direction of non-central analgesics, medical preparations containing active ingredients, anti-inflammatory agents, etc., can solve the problem of severe toxicity, and achieve the effect of reducing cytotoxicity and toxicity

Active Publication Date: 2016-01-20
CHONGQING ACAD OF CHINESE MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, Kunming mountain crabapple is a poisonous traditional Chinese medicine, which is considered "very poisonous" by traditional Chinese medicine. The total alkaloids contained in it are its main toxic components, and it shows certain cytotoxicity.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The investigation of embodiment 1 Huobahua root extraction method method

[0015] 1. Peel the torch flower root, keep the root core, weigh 10kg of the peeled torch flower root core, and crush the root core to obtain the extracted raw material; use 50-60% of the extracted raw material to extract the raw material Extract with ethanol more than 3 times to obtain an ethanol extract; stand at a temperature lower than 10°C for more than 12 hours, filter the supernatant, concentrate the supernatant, and obtain Huobahuagen root core extract 1.

[0016] 2. Peel the torch flower root, keep the root core, weigh 10kg of the peeled torch flower root core, crush the root core to obtain the extracted raw material; use 50-60% of the extracted raw material for the extracted raw material Extract with ethanol more than 3 times to obtain the ethanol extract; recover the ethanol in the ethanol extract, and reduce the ethanol concentration of the ethanol extract to 5-10%; under the condition...

Embodiment 2

[0026] The preparation of embodiment 2 Huobahua root external preparation

[0027] With the four kinds of extracts in Example 1, weigh 0.93g Huobahuagen root core extract respectively, add 20mL distilled water, stir continuously to make it dissolve, and make the drug-containing matrix; slowly add 5mL1,2 to the drug-containing matrix -Propylene glycol, 0.3g sodium benzoate, 0.5g Tween-80, 0.3g borneol, after stirring and mixing, dilute to 100mL with 80% ethanol. Filtrate, sub-package, and fill into spray bottles to prepare Huobahua root spray 1, Huobahua root spray 2, Huobahua root spray 3, and Huobahua root spray 4.

[0028] Comparing comprehensively the four preparations of Huobahua root spray 1, Huobahua root spray 2, Huobahua root spray 3, and Huobahua root spray 4, it was found that the preparations of Huobahua root spray 1 and Huobahua root spray 4 were viscous , the color is darker, and the skin of the human body has a greasy feeling when it is sprayed.

Embodiment 3

[0029] Example 3 Effect of Huobahuagen External Preparation on Pain in Mice Caused by Hot Plate Method

[0030] Get 60 female mice and divide them into 6 groups at random, namely blank control group, positive control group (Faston gel), Huobahua root spray 1, Huobahua root spray 2, Huobahua root spray 3 and Huobahua root spray 4 groups of root spray, the abdomen of mice in each group was shaved about 2×2.5cm2, the blank group was externally coated with carbomer matrix 0.1g / mouse, the positive control group was externally coated with Farstone gel 0.1g / mouse, and the rest were administered Apply Huobahuagen Spray 0.3ml / mouse to the outside of the group, and apply the medicine once a day on the shaved skin for 7 consecutive days. 30, 60, and 90 minutes after the last application, put the mice in a smart room preheated to 50°C. On the hot plate apparatus, the latency period of the mouse hind paw licking reaction was used as the index of pain closure, and the differences among the ...

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Abstract

The invention provides a tripterygium hypoglaucum (level) hutch root external preparation for relieving swelling and pain as well as a preparation method and application thereof. The active ingredient of the external preparation is an ethanol extract of peeled root cores of tripterygium hypoglaucum (level) hutch root. The invention provides the external preparation extracted from the tripterygium hypoglaucum (level) hutch root, and the external preparation can effectively reduce cytotoxicity of the tripterygium hypoglaucum (level) hutch root extract. Moreover, the root cores of the tripterygium hypoglaucum (level) hutch root are used as a medicine, and a low-alcohol-concentration impurity removal method is adopted, so that the toxicity of the tripterygium hypoglaucum (level) hutch root external preparation is further reduced.

Description

technical field [0001] The invention provides an external preparation of traditional Chinese medicine, and more specifically relates to an external preparation of Huobahua root for reducing swelling and relieving pain, a preparation method and application thereof. technical background [0002] Kunming Mountain Begonia [Tripterygium hypoglaucum (Level) Hutch, referred to as THH], also known as Tripterygium hypoglaucum (Level) Hutch, is also known as Tripterygium hypoglaucum (Level) Hutch, and King Kongteng. Produced in Qiandongnan Prefecture, especially in the area of ​​Leigong Mountain in Leishan County, the medicinal part is mainly the root; therefore, it is also called torch flower root. Kunming Mountain Begonia and Tripterygium wilfordii belong to the Euonymus family Tripterygium genus. They are similar in chemical structure and pharmacological effects, and have anti-inflammatory, immune-regulating, and anti-tumor effects. However, Kunming mountain crabapple is a poisono...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61K9/12A61P29/00A61K125/00
Inventor 励娜梁旭明杨大坚姚媛媛陈一龙张小梅廖系晗阳勇秦伟瀚
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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