Medicinal composition for treating early-stage diabetic foot and preparation method thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of complicated active ingredients

Active Publication Date: 2012-07-04
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although local treatment such as topical ointment can be considered in the early stage of diabetic foot, since most of the traditional Chinese medicines for external use are compound prescriptions with complex active ingredients, the preparation of topical Chinese medicine preparations for external use faces more challenges than chemical pharmaceutical preparations with simple ingredients. Complexity and Uncertainty

Method used

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  • Medicinal composition for treating early-stage diabetic foot and preparation method thereof
  • Medicinal composition for treating early-stage diabetic foot and preparation method thereof
  • Medicinal composition for treating early-stage diabetic foot and preparation method thereof

Examples

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Effect test

preparation example 1

[0100] Preparation Example 1: Preparation of the medicinal material extract used in the composition of the present invention

[0101] Ratio of medicinal materials: 300g of Kunming Begonia, 120g of Radix Paeoniae Rubra, 180g of Duhuo, 60g of Angelica dahurica, 90g of Shichangpu.

[0102] Preparation:

[0103] Step 1: Kunming Begonia was extracted by heating and refluxing with 7 times the amount of 50% ethanol for 3 times, each time for 1 hour, and the extract was concentrated and dried to obtain 19 g of Kunming Begonia extract.

[0104] Step 2: decoct Radix Paeoniae Rubra with 10 times the amount of water for 2 times, each time for 2 hours, add ethanol to 54% of the combined water extract to precipitate, concentrate the supernatant, and dry to obtain 23 grams of Radix Paeoniae Rubra extract .

[0105] Step 3: The three medicines of lovage, angelica, and calamus are extracted by percolation with 70% ethanol, the percolation liquid is concentrated under reduced pressure, allowe...

preparation example 2

[0107] Preparation Example 2: Preparation of medicinal material extracts used in the composition of the present invention

[0108] Ratio of medicinal materials: 600g of Kunming Begonia, 60g of Radix Paeoniae Rubra, 360g of Duhuo, 30g of Angelica dahurica, 180g of Shichangpu.

[0109] Referring to the preparation method of Preparation Example 1, the difference is that in step 1, 85% ethanol is used for extraction once for 1 hour, in step 2, water decoction is used twice for 0.5 hours each time, and in step 3, 90% ethanol is used. Three extracts were obtained.

preparation example 3

[0110] Preparation Example 3: Preparation of medicinal material extracts for the composition of the present invention

[0111] Ratio of medicinal materials: 150g of Kunming Begonia, 240g of Radix Paeoniae Rubra, 90g of Duhuo, 120g of Angelica dahurica, 40g of Shichangpu.

[0112] Referring to the preparation method of Preparation Example 1, the difference is that in step 1, 30% ethanol is used for extraction once for 1 hour, in step 2, water decoction is used for 3 times for 3 hours each time, and in step 3, 50% ethanol is used. Three extracts were obtained.

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Abstract

The invention relates to a medicinal composition for treating an early-stage diabetic foot and a preparation method thereof. Particularly, the medicinal composition is prepared from medicinal materials serving as active components and optional pharmaceutically acceptable auxiliary materials, wherein the medicinal materials comprise tripterygium hypoglaucum, red peony root, radix angelicae pubescentis, angelica root and grassleaf sweelflag rhizome. The invention also relates to a gel prepared from the medical composition, application of the medicinal composition in preparation of a medical product for treating or preventing the diabetic foot, and the like. The medical composition can be used for treating the diabetic foot, such as early-stage diabetic foot.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition for treating early diabetic foot and a preparation method. Background technique [0002] Diabetic Foot (DF), also known as diabetic acral gangrene, refers to insufficient blood supply to the extremities, sensory disturbance, and infection of the extremities caused by diabetic patients with neuropathy and various degrees of peripheral vascular lesions. A group of diseases characterized by the formation and / or destruction of deep tissues. Diabetic foot is one of the common chronic complications of diabetes, and it is also an important cause of amputation, disability, death and disability in diabetic patients. [0003] With the increasing incidence of diabetes, the incidence of diabetic foot is also increasing year by year. 2.8-14.5% of people with diabetes develop diabetic foot every year. About 5-10% of patients need...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/888A61P3/10A61P9/14A61P17/02
Inventor 张德芹刘虹王亚静高秀梅胡利民刘二伟李天祥皮佳鑫
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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