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Tripterygium Hypoglaucum Hutch root extract, and bi-layer extended release tablet and application thereof

A technology of extracts and sustained-release tablets, which is applied in the field of traditional Chinese medicine extract tablets, can solve problems such as toxic and side effects, and achieve the effects of prolonged half-life, small adverse reactions, and small fluctuations in blood drug concentration

Inactive Publication Date: 2012-10-17
CHONGQING ACAD OF CHINESE MATERIA MEDICA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But Kunming Begonia medicine also has certain toxic and side effects. According to reports, after Kunming Begonia Tablets (produced by Kunming Pharmaceutical Company Pharmaceutical Factory), gastrointestinal side effects such as chest tightness and discomfort, nausea and vomiting

Method used

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  • Tripterygium Hypoglaucum Hutch root extract, and bi-layer extended release tablet and application thereof
  • Tripterygium Hypoglaucum Hutch root extract, and bi-layer extended release tablet and application thereof
  • Tripterygium Hypoglaucum Hutch root extract, and bi-layer extended release tablet and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Example 1 Preparation method of torch flower root extract double-layer sustained-release tablet

[0019] Cut the torch flower root medicinal material into slices, add water to decocting for 2 to 5 times, combine the filtrate, heat and concentrate to a clear ointment with a density of 1.05 ~ 1.07; add ethanol to the clear ointment to adjust the ethanol concentration to 50 ~ 80%; let stand, and filter for precipitation ; The temperature is 40-60 ℃ under reduced pressure recovery, the recovery of ethanol until no alcohol taste, the density of the thick paste is 1.30 to 1.35. Get torch flower root extract. Peel the torch flower root medicinal material, slice it, and obtain the peeled torch flower root extract according to the above method.

[0020] Pre-selection of the auxiliary materials for the sustained-release layer uses HPMC K4M (hypromellose K4M) as the skeleton material, and the torch flower root extract and PEG (polyethylene glycol), cyclodextrin, HPMC K4M and other aux...

Embodiment 2

[0035] Example 2 Preparation of double-layer sustained-release tablets of Torchilla extract

[0036] Weigh 15 g of torch flower root extract provided in Example 1, appropriate amount of starch, and 10 g of calcium carbonate; sustained-release part: 35 g of torch flower root extract, 17.5 g of PEG 6000, 52.5 g of cyclodextrin, and 10.5 g of HPMC K4M.

[0037] According to the preferred sustained-release part of the prescription of Example 1, take 10.5g of Torchilla root extract, add proper amount of ethanol and heat to dissolve, add PEG 6000, cyclodextrin and HPMC K4M alcohol solution in turn, mix well, evaporate the solvent, dry and crush , Sieved, granulated with water, dried, granulated, and set aside. According to the preferred immediate-release part of the prescription of Example 1, take 4.5 g of Torchilla root extract, add appropriate amount of ethanol to dissolve, add medicinal starch, calcium carbonate in sequence, mix, dry, crush, sieving, and prepare with 3% HPC wet method...

Embodiment 3

[0039] Example 3 Investigation on the activity of extracts from the root of Torchilla on asthma

[0040] Forty-five healthy male guinea pigs, weighing 390-500g, were randomly divided into 5 groups. Purchasing the torch flower root tablets from the pharmaceutical factory of Chongqing Academy of Chinese Materia Medica as the torch flower ordinary tablets (Kunming Shanhaitang tablets) group. Experimental method: 45 guinea pigs were randomly divided into 5 groups, group A: experimental group I administration group, group B: experimental group II administration group, group C: Huobahua ordinary tablet group, group D: dexamethasone Methasone administration group, E group: as the asthma control group.

[0041] The guinea pig asthma model was established by intraperitoneal injection of 1ml of 10% ovalbumin saline per mouse for sensitization. On the 14th day, the guinea pigs were inhaled in a nebulizer box to inhale 1% ovalbumin atomized by human ultrasound for 5 minutes to trigger an asth...

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Abstract

To solve the problem of an obvious side effect existing in the traditional Tripterygium Hypoglaucum Hutch root tablet, the invention provides a bi-layer extended release tablet which can reduce medicine peak plasma concentration. A Tripterygium Hypoglaucum Hutch root extract is any one extract of the whole Tripterygium Hypoglaucum Hutch root, Tripterygium Hypoglaucum Hutch root bark, or Tripterygium Hypoglaucum Hutch root core with the bark removed. The Tripterygium Hypoglaucum Hutch extract bi-layer extended release tablet has the characteristics of little untoward effect, and is convenient and safe to use. At the same time, a medicine-time curve is stable, the plasma concentration has small fluctuations, and the half life is prolonged. The Tripterygium Hypoglaucum Hutch root extract extended release bi-layer tablet using the root core with the bark removed has good therapeutic effects on asthma, lupus erythematosus, nephritis, and rheumatoid arthritis.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine extract tablet, more specifically to a torch flower root extract, a double-layer sustained-release tablet and applications thereof. technical background [0002] The scientific name of torch flower is Kunming Mountain Begonia (Tripterygium Hypoglaucum Hutch, THH), also known as powder-backed torch flower, diamond vine, etc. It is a deciduous or vine-like shrub of Tripterygium genus in the family Eucalyptus family. my country's Kunming Mountain is rich in resources of crabapple, mostly concentrated in Yunnan Chuhong, Honghe, Yuxi, Kunming and other places. The name of torch flower was first published in "Compendium of Materia Medica", Li Shizhen's collection of explanations: "Those born in southern Yunnan are red, and they are called torch flowers." There are still many controversies about the medicinal parts of torches, but the Shanghai Institute for Drug Control in 1990 The survey showed that the mai...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61K9/24A61P11/06A61P37/02A61P19/04A61P13/12A61P19/02A61P29/00A61K125/00
Inventor 杨大坚陈新滋陈国庆陈士林徐宏喜
Owner CHONGQING ACAD OF CHINESE MATERIA MEDICA
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