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Method of preparing tripterygium hypoglaucum (Levl) hutch alkaloids

A technology of alkaloids and Begonias, applied in the field of plant extraction technology and drug research, can solve problems affecting patients' drug compliance, toxic and side effects, and affect treatment effects, etc., achieve good market prospects and social benefits, small toxic and side effects, and high-tech easy effect

Active Publication Date: 2007-09-26
KUNMING FENGSHANJIAN MEDICINE RES
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  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0005] Kunming Shanhaitang Tablet is an effective drug for treating rheumatoid arthritis and lupus erythematosus selected in clinical application, but it is also found in long-term clinical application observation that this drug has serious toxic and side effects, which often affect patients' medication due to toxic and side effects. compliance, which affects the efficacy of the treatment

Method used

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  • Method of preparing tripterygium hypoglaucum (Levl) hutch alkaloids

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Effect test

Embodiment 1

[0053] Get 5kg of Kunming Begonia extract extract powder, add 5 times the amount (W / V) of ethyl acetate, reflux extraction 3 times, each time for 1 hour, combine the extracts, filter; ethyl acetate solution with (phosphoric acid) acid water (PH=2~3) wash 6 times, add 10L of acid water each time, shake fully, and combine the acid water; add NaOH solution to the acid water, stir constantly, adjust the pH value of the solution to 10, add ethyl acetate to extract 3 times, 5 L each time, combined the ethyl acetate solution; concentrated the solvent under reduced pressure to obtain 40.5 g of the Kunming Begonia alkaloid composition; took 8 g of the composition, added 142 g of starch, mixed, granulated, dried, granulated, Fill capsules to make 1000 capsules.

Embodiment 2

[0055] Get 5 kg of Kunming Begonia extract extract powder, add 2 times the amount (W / V) butanol cold soaking 5 times, each 8 hours, combine the extract, filter; 2~3) Wash 5 times, add 10L of acid water each time, shake fully, and combine the acid water; add KOH (potassium hydroxide) to the acid water, stir continuously, adjust the pH value of the solution to 10, and extract with butanol 4 times, 10 L each time, the butanol solution was combined, and the solvent was concentrated under reduced pressure to obtain 42.8 g of the Kunming Begonia alkaloid composition. Get 8g of the composition, dissolve it in vegetable oil, fill it into soft capsules, and make 1000 capsules.

Embodiment 3

[0057] Take 5kg of extract powder of Kunming Begonia extract, add 15kg of 80-100 mesh silica gel, and mix to obtain the gel; Percolation, until the percolation liquid does not show alkaloid reaction, the percolation liquid is concentrated under reduced pressure to about 30L, and filtered; the filtrate is washed with (sulfuric acid) acid water (PH=2) 3 times, 10L each time, fully shaken, Combine the acid water solution; add ammonia water to the acid water solution, keep stirring, adjust the solution to PH=13, add ethyl acetate for extraction 3 times, 10 L each time, combine the ethyl acetate solution; concentrate the solvent under reduced pressure to obtain the Kunming Begonia alkaloid Composition 38.7g. Take 10g of the composition, dissolve it in 500ml water for injection, stir well, continuously add 10% hydrochloric acid solution dropwise until it is completely dissolved, add water for injection to 1000ml, adjust the pH of the solution to 3~6 with 5% NaOH solution, filter, po...

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Abstract

The invention relates to a method for preparing Malus spectabilis alkaloid, and relative application, comprising that using Malus spectabilis extractive to immerge paste powder, adding acetic acid ethyl ester, chloroform or butanol to reflux or immerge for several times, until the extractive has not alkaloid reaction, extracting via acetic acid ethyl ester, chloroform or butanol for several times, until the water phase has not alkaloid reacton, taking the organic extractive liquid, concentrating and recycling solvent, to obtain the Malus spectabilis alkaloid compound, or using Malus spectabilis extractive to immerge paste powder, adding silica gel to be mixed uniformly to obtain material gel, penetrating in penetrating barrel via chloroform, until the penetrated liquid has no alkaloid reaction, washing the filter liquid via acid water, extracting via acetic acid ethyl ester, depressurizing, concentrating solvent, to obtain the final product. The inventive compound can be used to treat rheumatic arthritis, atrophic arthritis, Cazenave's lupus or the immunologic rejection after organ transplantation.

Description

technical field [0001] The invention belongs to the field of plant extraction technology and drug research, in particular to a method for extracting alkaloids from Kunming mountain crabapple plants and the application of the extracted alkaloids in pharmacy. Background technique [0002] Rheumatic diseases are a group of common diseases that generally refer to more than 100 diseases that affect bones and joints and their surrounding soft tissues. Among them, the cause of systemic lupus erythematosus is unknown, and the mortality rate is high; rheumatoid arthritis is common and stubborn, which can cause joint swelling, pain and dysfunction throughout the body, and is one of the main disabling diseases. About 5 million patients in our country suffer from these two diseases. Although this disease is not directly life-threatening, if it is not treated in time and reasonably, joint dysfunction, deformity and even disability will appear, which is called "undead cancer". Prelimina...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61P29/00A61K125/00
Inventor 周春香伏春生曹建新
Owner KUNMING FENGSHANJIAN MEDICINE RES
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