188 results about "Isoflavonoid" patented technology

The invention relates to a method for preparing isoflavone metal complexes shown as formulas I and II, and application of the isoflavone metal complexes. The definition of each group is shown in the description. The compounds and pharmaceutically acceptable salts thereof or hydrates thereof or solvate medicinal compositions thereof can be used for treating tumors and tumor angiogenesis or tumor metastasis medicaments. The structural formulas are shown in the attached figure 1 of the abstract.

The invention discloses an isoflavone compound in a tobacco rhizome and a preparation method and application thereof. The preparation method comprises the following steps of: crushing a tobacco rhizome sample, performing ultrasonic extraction for 3 to 5 times by using 95 percent ethanol, combining the extracts, filtering, performing reduced pressure concentration to obtain an extract, primarily separating the extract by using silica gel column chromatography, further separating the extract by adopting high performance liquid chromatography, and thus obtaining the required new compound. Antibacterial activity screening test results show that the compound has strong antibacterial effect on common proteus species, escherichia coli, staphylococcus, bacillus subtilis and the like. The compound used for cigarette tipping paper plays an obvious role in inhibiting microbes for polluting the cigarette tipping paper.

This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention further relates to compounds, compositions, methods and therapeutic uses involving, containing, comprising, including and/or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.

The invention belongs to the medical technical field, in particular relating to an application of isoflavonoids from Belamcanda chinensis in the preparation of anti-hepatitis virus drugs. A Hepatitis B surface antigen (HBsAg) detection reagent test and a hepatitis B core antigen (HBeAg) detection reagent test are performed, and the results indicate that the isoflavonoids from the Belamcanda chinensis can remarkably suppress hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBeAg) and has remarkable effect on preventing and treating hepatitis B viruses. Therefore, the isoflavonoids from the Belamcanda chinensis can be used to prepare medicines or health-care food used to prevent and treat the hepatitis viruses.

The invention relates to an isoflavone compound, its preparation method, and its application in the preparation of antiviral or antitumor drugs, and concretely relates to a compound with a structural formula represented by formula (I). In the formula (I), R1 is hydrogen or C1-6 alkyl; X is -O-, -NH-, -CH=CH-, or ethinyl, or R2 is directly connected with benzopyran; R2 is selected from substituted or unsubstituted phenyl, substituted or unsubstituted heteroaryl, C1-16 alkyl, C1-16 alkyloxy, C1-16 alkyloxycarbonyl, or substituted or unsubstituted benzoyloxy; the heteroaryl is selected from groups derived from a five or six-membered heterocycle or a fused heterocycle containing one or two hetero atoms of N, O or S, and is selected but not limited to pyridyl, benzopyridyl, or groups derived from phenoxathiin, thiophene, oxazole and benzopyridine; and above substituent is selected from halogen, cyan, nitro, hydroxy, amino, C1-6 monosubstituted or disubstituted amino, C1-16 alkyl, halogenated C1-6 alkyl, C2-6 alkenyl, C6-12 arylalkenyl, C1-16 alkyloxy, C1-16 carboxyl, C1-16 alkyloxycarbonyl, C1-16 alkylcarbonyl, and substituted or unsubstituted phenoxyl. The invention also provides the preparation of the compound.

Disclosed is an improved method for preparing the isoflavonoid compound (+/−)-equol, the method comprising reducing an organic diester of the isoflavone daidzein under hydrogen-transfer conditions using palladium hydroxide catalyst.

The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention provides methods and compositions comprising the isoflavone genistein (4′,5,7-trihydroxyflavone) or phytoestrogenic isoflavonoids.

The invention discloses a process for extracting isoflavone substances from trifolium pratense, which relates to the field of extraction of effective substances from plants. The isoflavone substances are valuable medicinal raw materials, but a complete extraction process has not been reported. The invention disclosed a complete extraction process, which comprises the following steps: using ethanol solution to perform hot reflux for primary extraction to obtain an ethanol extract, using sodium hydroxide solution to perform hydrolysis and purification, and then using hydrochloric acid solution to perform aqueous layer treatment, performing extraction through ethyl acetate, and reducing the pressure and distilling the mixed solution to obtain crude products of the isoflavone substances. The process has the advantages of high extraction efficiency, less investment in equipment, quick start of engineering, low cost and easy popularization.

A composite medicine contains soybean isoflavone and lactobacillus, which are obtained by fermenting the juice of germinated soybean by lactobacillus. It can be used for treating menopausal syndrome,osteoporosis and breast cancer with high curative effect.

Soybean and Medicago truncatula CYP93C genes have been isolated which encode a cytochrome P450 that can catalyze the aryl migration of a flavanone to yield an isoflavanone intermediate or an isoflavone. Plants can now be genetically engineered to produce isoflavones that provide potential human health benefits and increase disease resistance in plants. Isoflavones can now be produced in transgenic plants species in which isoflavones do not naturally occur, i.e., in species other than legumes. Alternatively, introducing infection-inducible isoflavonoid biosynthesis into non-legumes qualitatively complements these plants phytoalexin defenses against microbial pathogens, whereas over-expression of the isoflavonoid pathway in legumes quantitatively increases this defense response. Finally, modifying the extend of production of isoflavonoids in legume roots positively impacts nodulation efficiency and therefore plant yield.

The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their hormonal activity and their effects on human health and disease. The types and amounts of these compounds in soy and other plants are controlled by both constitutive expression and stress-induced biosynthesis. The health benefits of soy may therefore be dependent upon the amounts of the various hormonally active phytochemicals present. We have identified increased biosynthesis of the isoflavonoid phytoalexin compounds, Glyceollins I, II and III, in soy plants grown under stressed conditions (elicited soy), which exhibit marked anti-estrogenic effects on ER function. Here we demonstrate that specific glyceollins, isolated from elicited soy, displayed anti-estrogenic activity, suppressing basal and estrogen stimulated colony formation of ER-positive estrogen dependent breast cancer cells and inhibiting ER-dependent gene expression of progesterone receptor (PgR) and stromal derived factor-1 (SDF1/CXCL12). Examining the effects of glyceollin on in vivo tumor formation/growth we demonstrate the ability of glyceollins to significantly suppress basal and estrogen-stimulated tumor growth of ER-positive MCF-7 breast and BG-1 ovarian carcinoma cells in ovariectomized female nude mice. We further demonstrate that the effects of glyceollins on suppression of tumor growth correlate with inhibition of estrogen stimulated PgR expression. In contrast to the uterotropic activity of tamoxifen the glyceollins displayed no uterine agonist activity. The Glyceollin (I-III) compounds may represent an important component of the health effects of soy as well as represent novel anti-estrogens useful in the prevention or treatment of breast and ovarian carcinoma.

Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain isoflavonoid, are disclosed. The anti-restenotic isoflavonoid is phenoxodiol, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the isoflavonoid with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-isoflavonoid blends are disclosed. Additionally, medical devices having a coating comprising at least one isoflavonoid in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.

The invention discloses an isoflavone compound capable of improving comfort of a cigarette suction throat as well as a preparation method for the isoflavone compound and application of the isoflavone compound, and belongs to the technical field of plant chemical technology. The compound is separated from traditional Chinese medicine radix pueraiae, a molecular formula of the compound is C18H14O5, and the compound is named as 7-acetyl-4'-hydroxyl-6-methoxyl-isoflavone; a structural formula of the compound as shown in formula (I): the formula (I) is described in the description. A preparation method for the isoflavone compound comprises the following steps: taking the traditional Chinese medicine radix pueraiae as a raw material, performing extract extraction, performing organic solvent extraction, performing MCI discoloring, performing column chromatography on silica gel and performing efficient liquid-phase chromatographic separation. The compound is added into a cigarette filter tip, so that the comfort of the cigarette suction throat can be improved, and therefore, the compound has the obvious throat clearing effect.

The invention discloses a novel isoflavones compound as shown by a formula I. The results of animal experiments show that the isoflavones compound can significantly inhibit the proliferation of T cells and B cells, and can be used for preparing immunosuppressants or medicaments for treating immunologic diseases. The SI values (IC50/CC50) of the isoflavones compound are high, so the toxic side effects of the isoflavones compound are small, and the treatment interval of the isoflavones compound is wide. The isoflavones compound is obtained by extracting and separating clovershrubs, and the preparation method is simple and convenient.

The invention relates to a gehua isoflavone extract from flower of kudzuvine, the method of the extraction and a drug composition wherein the extract serves as an active component, characterized in that comparing to the present technology, the invention has a high process efficiency with little pollution, suited to the industrial production. Gehua glycoside in the extract is much more soluble than that as a single element, so as to obtain a better bioavailability.

The invention relates to a chickpea germ, effective part of bean sprout, a preparation method and application. The effective part of the total saponin and isoflavone can be obtained from the chickpea germ and bean sprout by adopting an alcohol extraction method or a water extraction method; the initial screening test of the effective part proves that: the effective part has the advantages of playing a role as an inhibitor for protein tyrosine phosphatase (PTP1B). The effective part can be used as a medicine for treating diabetes and as an application of health care product, simultaneously, the effective part or the derivative of which can be applied as a drug combination.

The invention relates to methyltransferase and application thereof and discloses a group of methyltransferase obtained by latest separation and identification. In the case of providing a methyl donor,the enzyme disclosed by the invention can transfer methyl to a flavonoid or isoflavone compound to add one methyl group for the flavonoid or isoflavone compound. Specifically, the methyltransferase disclosed by the invention is capable of specifically and efficiently catalyzing methylation of hydroxyl groups at C-3, C-7, C-3' and C-4' of a flavonoid compound substrate or methylation of hydroxyl groups at C-7 and C-4' of an isoflavone compound substrate. The methyltransferase can be applied to the fields of synthesis, transformation, bioconversion and the like of the flavonoid or isoflavone compounds.

A method is disclosed for increasing blood serum levels of dehydroepiandrosterone by administering the combination of one of a flavonoid, isoflavonoid, coumarin and a flavonolignan; dehydroepiandrosterone; and a plant extract.