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190 results about "Isoflavonoid" patented technology

Isoflavonoids are a class of flavonoid phenolic compounds, many of which are biologically active. Isoflavonoids and their derivatives are sometimes referred to as phytoestrogens, as many isoflavonoid compounds have biological effects via the estrogen receptor.

Method for preparing isoflavone metal complexes and anti-tumor medical application

The invention relates to a method for preparing isoflavone metal complexes shown as formulas I and II, and application of the isoflavone metal complexes. The definition of each group is shown in the description. The compounds and pharmaceutically acceptable salts thereof or hydrates thereof or solvate medicinal compositions thereof can be used for treating tumors and tumor angiogenesis or tumor metastasis medicaments. The structural formulas are shown in the attached figure 1 of the abstract.
Owner:WENZHOU MEDICAL UNIV

Isoflavone compound in tobacco rhizome and preparation method and application thereof

The invention discloses an isoflavone compound in a tobacco rhizome and a preparation method and application thereof. The preparation method comprises the following steps of: crushing a tobacco rhizome sample, performing ultrasonic extraction for 3 to 5 times by using 95 percent ethanol, combining the extracts, filtering, performing reduced pressure concentration to obtain an extract, primarily separating the extract by using silica gel column chromatography, further separating the extract by adopting high performance liquid chromatography, and thus obtaining the required new compound. Antibacterial activity screening test results show that the compound has strong antibacterial effect on common proteus species, escherichia coli, staphylococcus, bacillus subtilis and the like. The compound used for cigarette tipping paper plays an obvious role in inhibiting microbes for polluting the cigarette tipping paper.
Owner:YUNNAN RES INST OF TOBACCO SCI

Method for synthesizing glabridin

The invention relates to a method for synthesizing glabridin. The method comprises the following steps: using acetophenone protected by phenol hydroxy as a raw material, carrying out a Willgerodt-Kindler reaction to obtain aryl phenylacetic acid, and carrying out a Friedel-Crafts reaction to obtain an isoflavones compound; causing the isoflavones compound to carry out Pd / C catalytic hydrogenation to obtain a isoflavanone compound; and causing the isoflavanone compound to carrying out a crclizationreaction, a conyl reduction reaction and a removing phenolic hydroxyl group protection group reaction to obtain the glabridin. The operation and the serparation of the steps of the method are simple, the yield is higher, the used reagents are common reagents, are cheap and are easily obtained, the path is shorter, and the tptal yield is not lower than 20 percent.
Owner:山东济清科技服务有限公司

Combination chemotherapy compositions and methods

This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention further relates to compounds, compositions, methods and therapeutic uses involving, containing, comprising, including and / or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.
Owner:NOVOGEN RES

Use of composition of isoflavonoids from Belamcanda chinensis in preparing anti-hepatitis medicament

InactiveCN101301287ASignificant anti-HBV effectOrganic active ingredientsDigestive systemAntigenBelamcanda chinensis
The invention belongs to the medical technical field, in particular relating to an application of isoflavonoids from Belamcanda chinensis in the preparation of anti-hepatitis virus drugs. A Hepatitis B surface antigen (HBsAg) detection reagent test and a hepatitis B core antigen (HBeAg) detection reagent test are performed, and the results indicate that the isoflavonoids from the Belamcanda chinensis can remarkably suppress hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBeAg) and has remarkable effect on preventing and treating hepatitis B viruses. Therefore, the isoflavonoids from the Belamcanda chinensis can be used to prepare medicines or health-care food used to prevent and treat the hepatitis viruses.
Owner:上海双科医药科技有限公司

Isoflavone compound, its preparation method, and its application in preparation of antiviral or antitumor drugs

The invention relates to an isoflavone compound, its preparation method, and its application in the preparation of antiviral or antitumor drugs, and concretely relates to a compound with a structural formula represented by formula (I). In the formula (I), R1 is hydrogen or C1-6 alkyl; X is -O-, -NH-, -CH=CH-, or ethinyl, or R2 is directly connected with benzopyran; R2 is selected from substituted or unsubstituted phenyl, substituted or unsubstituted heteroaryl, C1-16 alkyl, C1-16 alkyloxy, C1-16 alkyloxycarbonyl, or substituted or unsubstituted benzoyloxy; the heteroaryl is selected from groups derived from a five or six-membered heterocycle or a fused heterocycle containing one or two hetero atoms of N, O or S, and is selected but not limited to pyridyl, benzopyridyl, or groups derived from phenoxathiin, thiophene, oxazole and benzopyridine; and above substituent is selected from halogen, cyan, nitro, hydroxy, amino, C1-6 monosubstituted or disubstituted amino, C1-16 alkyl, halogenated C1-6 alkyl, C2-6 alkenyl, C6-12 arylalkenyl, C1-16 alkyloxy, C1-16 carboxyl, C1-16 alkyloxycarbonyl, C1-16 alkylcarbonyl, and substituted or unsubstituted phenoxyl. The invention also provides the preparation of the compound.
Owner:SHANGHAI RUIGUANG BIOCHEM TECH DEV +1

Preparation of Flavonoid Compounds

Disclosed is an improved method for preparing the isoflavonoid compound (+ / −)-equol, the method comprising reducing an organic diester of the isoflavone daidzein under hydrogen-transfer conditions using palladium hydroxide catalyst.
Owner:YASOO HEALTH

Isoflavone compound and prepration method and application thereof

The invention discloses an isoflavone compound with a novel structure, a preparation method and an application thereof. The compound has the structure as shown in the right formula; the invention uses an MCI column for bleaching a papaya liquid extract, uses the silica gel column chromatography for primary separation, and then adopts the semipreparative high-performance liquid chromatography for further separation, thereby obtaining the new compound which is named as 3',4',5'-trihydroxy-5, 7-dimethoxyisoflavone. An effect test of eliminating free radicals in mainstream cigarette smoke is carried out on the compound, and the test result shows that the compound has good effect of eliminating the free radicals.
Owner:YUNNAN RES INST OF TOBACCO SCI

An isoflavone compound having antibacterial activity and a preparing method and applications thereof

The invention relates to an isoflavone compound having antibacterial activity and a preparing method and applications thereof, and belongs to the technical field of phytochemistry. The structure of the compound is shown as a formula (I). The formula (I) is shown in the specification. The compound is prepared from kudzu vine root that is a traditional medicinal and edible plant and through steps of extractum extraction, column chromatography on silica gel and separation and purification through high performance liquid chromatography. Activity tests prove that the compound has a good bacteriostatic function; when the compound is added into a tobacco material solution, the compound can effectively inhibit microbe growth in the material solution and can prolong the shelf life of the solution; when the compound is used for cigarette tipping paper, the compound can eliminate or reduce the possibility of bacterium breeding and reproduction in the cigarette tipping paper; and the compound has a wide application prospect.
Owner:CHINA TOBACCO YUNNAN IND

Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury

The present invention provides compositions and methods for the prophylactic and therapeutic treatment of animals, including humans from radiation injury. In particular, the present invention provides methods and compositions comprising the isoflavone genistein (4′,5,7-trihydroxyflavone) or phytoestrogenic isoflavonoids.
Owner:US DEPT OF HEALTH & HUMAN SERVICES +2

Fragrant solomonseal rhizome isoflavanone extract as well as preparation method and application thereof

The invention provides a fragrant solomonseal rhizome isoflavanone extract and a preparation method thereof. The fragrant solomonseal rhizome isoflavanone extract contains 3-(4'- hydroxyphenyl)-5,7-dyhydroxy-6-methyl-8-O-methylation-styrene acrylic dihydropyrane-4-ketone, 3-(4'-hydroxyphenyl)-5,7-dyhydroxy-6,8-dimethyl-styrene acrylic dihydropyrane-4-ketone and 3-(4'-methoxyphenyl)-5,7-dyhydroxy-6-methyl-8-O-methylation-styrene acrylic dihydropyrane-4-ketone, and the content sum of all components is larger than or equal to 15 percent. The invention also discloses an application of the fragrantsolomonseal rhizome isoflavanone extract in preparing a product for preventing and / or treating diabetic nephropathy and an application of a fragrant solomonseal rhizome isoflavanone compound containing the 3-(4'- hydroxyphenyl)-5,7-dyhydroxy-6-methyl-8-O-methylation-styrene acrylic dihydropyrane-4-ketone, the 3-(4'-hydroxyphenyl)-5,7-dyhydroxy-6,8-dimethyl-styrene acrylic dihydropyrane-4-ketone and the 3-(4'-methoxyphenyl)-5,7-dyhydroxy-6-methyl-8-O-methylation-styrene acrylic dihydropyrane-4-ketone in preparing an inhibitor product as a protein nonenzyme glycolysis end product.
Owner:吉林亚泰永安堂药业有限公司

Technique for extracting isoflavones materials from red clover

The invention discloses a process for extracting isoflavone substances from trifolium pratense, which relates to the field of extraction of effective substances from plants. The isoflavone substances are valuable medicinal raw materials, but a complete extraction process has not been reported. The invention disclosed a complete extraction process, which comprises the following steps: using ethanol solution to perform hot reflux for primary extraction to obtain an ethanol extract, using sodium hydroxide solution to perform hydrolysis and purification, and then using hydrochloric acid solution to perform aqueous layer treatment, performing extraction through ethyl acetate, and reducing the pressure and distilling the mixed solution to obtain crude products of the isoflavone substances. The process has the advantages of high extraction efficiency, less investment in equipment, quick start of engineering, low cost and easy popularization.
Owner:LANZHOU UNIVERSITY

Synthesis of isoflavone compound through Stille crossed coupling reaction

The invention belongs to heterocyclic compound technical field, concretely relating to a heterocyclic compound in which unhydrogenated six-member heterocyclic ring containing an only ring hetero atom of an oxygen atom fuses with other phenyl rings. The invention provides a synthetic method of an isoflavone compound. The method comprises the steps of adding a reactant (substituted) 3-iodine chromone and tetraarylated tin into a solvent for a chemical reaction, and using column chromatography and recrystallization methods to purify the above resultant to obtain the pure compound of the present invention. By using the method, medicinal isoflavone such as daidzein, genistein, Ipriflavone, puerarin, formononetin and the like is prepared, and a new technical route of industrialization production of the above medicaments is established. Simultaneously, a series of novel isoflavone compounds with potential physiological activity are prepared.
Owner:SHAANXI NORMAL UNIV

Genetic manipulation of isoflavonoids

Soybean and Medicago truncatula CYP93C genes have been isolated which encode a cytochrome P450 that can catalyze the aryl migration of a flavanone to yield an isoflavanone intermediate or an isoflavone. Plants can now be genetically engineered to produce isoflavones that provide potential human health benefits and increase disease resistance in plants. Isoflavones can now be produced in transgenic plants species in which isoflavones do not naturally occur, i.e., in species other than legumes. Alternatively, introducing infection-inducible isoflavonoid biosynthesis into non-legumes qualitatively complements these plants phytoalexin defenses against microbial pathogens, whereas over-expression of the isoflavonoid pathway in legumes quantitatively increases this defense response. Finally, modifying the extend of production of isoflavonoids in legume roots positively impacts nodulation efficiency and therefore plant yield.
Owner:SAMUEL ROBERTS NOBLE FOUND

Isoflavone compound with anti-virus activity as well as preparation method and application thereof

The invention discloses an isoflavone compound shown in a formula (I) in the specification as well as a preparation method and application thereof. The preparation method comprises the following steps: by taking a total tobacco plant as a raw material and taking a mixed solvent of methyl alcohol-water, ethyl alcohol-water or acetone-water as an extracting solvent, performing extraction, combining extracting solutions, filtering, and performing reduced pressure concentration on a filtrate to prepare an extract; performing silica-gel column chromatography on the extract by using silica-gel dry-process column packing; performing gradient elution by using a mixed solvent of trichloromethane-acetone; and further performing high-pressure liquid chromatographic separation and purification on an 8:2 part of an eluent to prepare the required isoflavone compound. Activity tests show that the compound disclosed by the invention has a very good inhibition effect on rotavirus; and the compound disclosed by the invention is simple in structure and good in compound activity, and can be used as an anti-rotavirus lead compound.
Owner:CHINA TOBACCO YUNNAN IND

Antiestrogenic glyceollins suppress human breast and ovarian carcinoma proliferation and tumorigenesis

InactiveUS20060246162A1Preventing minimizing development growthOrganic active ingredientsBiocideStress inducedPhytochemical
The flavonoid family of phytochemicals, particularly those derived from soy, has received attention regarding their hormonal activity and their effects on human health and disease. The types and amounts of these compounds in soy and other plants are controlled by both constitutive expression and stress-induced biosynthesis. The health benefits of soy may therefore be dependent upon the amounts of the various hormonally active phytochemicals present. We have identified increased biosynthesis of the isoflavonoid phytoalexin compounds, Glyceollins I, II and III, in soy plants grown under stressed conditions (elicited soy), which exhibit marked anti-estrogenic effects on ER function. Here we demonstrate that specific glyceollins, isolated from elicited soy, displayed anti-estrogenic activity, suppressing basal and estrogen stimulated colony formation of ER-positive estrogen dependent breast cancer cells and inhibiting ER-dependent gene expression of progesterone receptor (PgR) and stromal derived factor-1 (SDF1 / CXCL12). Examining the effects of glyceollin on in vivo tumor formation / growth we demonstrate the ability of glyceollins to significantly suppress basal and estrogen-stimulated tumor growth of ER-positive MCF-7 breast and BG-1 ovarian carcinoma cells in ovariectomized female nude mice. We further demonstrate that the effects of glyceollins on suppression of tumor growth correlate with inhibition of estrogen stimulated PgR expression. In contrast to the uterotropic activity of tamoxifen the glyceollins displayed no uterine agonist activity. The Glyceollin (I-III) compounds may represent an important component of the health effects of soy as well as represent novel anti-estrogens useful in the prevention or treatment of breast and ovarian carcinoma.
Owner:UNITED STATES OF AMERICA AS REPRESENTED BY THE SEC OF AGRI THE

Medical devices to treat or inhibit restenosis

Implantable medical devices having anti-restenotic coatings are disclosed. Specifically, implantable medical devices having coatings of certain antiproliferative agents, particularly a certain isoflavonoid, are disclosed. The anti-restenotic isoflavonoid is phenoxodiol, and pharmaceutically acceptable derivatives thereof. The anti-restenotic medical devices include stents, catheters, micro-particles, probes and vascular grafts. Intravascular stents are preferred medical devices. The medical devices can be coated using any method known in the art including compounding the isoflavonoid with a biocompatible polymer prior to applying the coating. Moreover, medical devices composed entirely of biocompatible polymer-isoflavonoid blends are disclosed. Additionally, medical devices having a coating comprising at least one isoflavonoid in combination with at least one additional therapeutic agent are also disclosed. Furthermore, related methods of using and making the anti-restenotic implantable devices are also disclosed.
Owner:MEDTRONIC VASCULAR INC

Application of belamcanda chinensis total isoflavone or isoflavone compounds in preparing medicaments and food for preventing and treating women's disease

The invention relates to the technical field of medicaments, in particular to application of 12 isoflavone compound monomers comprising belamcanda chinensis total isoflavone or tecoridin, wild tectoridin, tectorigenin, iridin and the like in preparing medicaments and food for preventing and treating lower women's estrogen level and retarding womb and ovarian failure or climacteric syndrome. Animal experiment results show that the total isoflavone or 12 isoflavone compound monomers in the belamcanda chinensis have remarkable pharmacological effects of improving the estrogen level, promoting the growth of follicle, promoting epitheliosis of womb and vagina, retarding womb and ovarian failure, improving the expression of an epithelial cell estrogen receptor of the vagina and the like, so the total isoflavone or 12 isoflavone compound monomers can be used for preparing the medicaments or food for preventing and treating lower women's estrogen level and retarding womb and ovarian failure or climacteric syndrome. The application provides a new source for seeking a plant estrogen medicament.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Isoflavone compound capable of improving comfort of cigarette suction throat as well as preparation method for isoflavone compound and application of isoflavone compound

The invention discloses an isoflavone compound capable of improving comfort of a cigarette suction throat as well as a preparation method for the isoflavone compound and application of the isoflavone compound, and belongs to the technical field of plant chemical technology. The compound is separated from traditional Chinese medicine radix pueraiae, a molecular formula of the compound is C18H14O5, and the compound is named as 7-acetyl-4'-hydroxyl-6-methoxyl-isoflavone; a structural formula of the compound as shown in formula (I): the formula (I) is described in the description. A preparation method for the isoflavone compound comprises the following steps: taking the traditional Chinese medicine radix pueraiae as a raw material, performing extract extraction, performing organic solvent extraction, performing MCI discoloring, performing column chromatography on silica gel and performing efficient liquid-phase chromatographic separation. The compound is added into a cigarette filter tip, so that the comfort of the cigarette suction throat can be improved, and therefore, the compound has the obvious throat clearing effect.
Owner:CHINA TOBACCO YUNNAN IND

Combination chemotherapy compositions and methods

This invention relates to combination therapies involving anticancer chemotherapeutic agents and isoflavones or analogues thereof. The invention flier relates to compounds, compositions, methods and therapeutic uses involving, containing, comprising, including and / or for preparing platinum-isoflavonoid complexes suitable for use in the combination therapies of the invention.
Owner:MARSHALL EDWARDS INC

Isoflavones compound and preparation and application thereof

The invention discloses a novel isoflavones compound as shown by a formula I. The results of animal experiments show that the isoflavones compound can significantly inhibit the proliferation of T cells and B cells, and can be used for preparing immunosuppressants or medicaments for treating immunologic diseases. The SI values (IC50 / CC50) of the isoflavones compound are high, so the toxic side effects of the isoflavones compound are small, and the treatment interval of the isoflavones compound is wide. The isoflavones compound is obtained by extracting and separating clovershrubs, and the preparation method is simple and convenient.
Owner:BASILEA PHARM CHINA LTD

Method for separating isoflavones monomeric compound in blackberry lily by high speed countercurrent chromatography

The invention relates to the medical technical field, in particular to a method for separating and purifying individual compounds of tectoridin, wild tectoridin, tectorigenin, wild tectorigenin and sub wild tectorigenin from blackberry lily. The column chromatography, recrystallization, and the like, are mostly adopted at home and abroad to separate and purify effective monomers in the blackberry lily. The methods have the problems of high cost, complex operation, serious sample loss, etc. The invention adopts secondary high-speed countercurrent chromatography to separate the individual compounds in the blackberry lily, and particularly the technology of the secondary high-speed countercurrent chromatography with two sets of different solvent systems is adopted to separate target compounds of tectoridin, wild tectoridin, tectorigenin, wild tectorigenin and sub wild tectorigenin from other interference components with similar polarity, thus obtaining target compounds with high purity. The method is simple in operation, high in separation efficiency and good in product purity, and sample can be continuously introduced so that the method is suitable for industrial production.
Owner:SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY

Kudzuvine flower isoflavonoid extraction, its extracting method, medicinal composition and its use in pharmaceutical

The invention relates to a gehua isoflavone extract from flower of kudzuvine, the method of the extraction and a drug composition wherein the extract serves as an active component, characterized in that comparing to the present technology, the invention has a high process efficiency with little pollution, suited to the industrial production. Gehua glycoside in the extract is much more soluble than that as a single element, so as to obtain a better bioavailability.
Owner:INST OF PHARMACY SHANDONG PROV ACAD OF MEDICAL SCI

Method for extracting isoflavonoids compound in all-grass of Twining Rhynchosia with ionic liquid

The invention relates to a method for extracting isoflavonoids compound in all-grass of Twining Rhynchosia with ionic liquid, comprising: obtaining extractum after smashed all-grass of Twining Rhynchosia is extracted with alcohol the concentration of which is 70%; mixing the extractum with water which accounts for 7-12 wt% of extractum to obtain slurry; while stirring at room temperature, adding ionic liquid the volume of which is 1-2 times of slurry; after reacting for 6-10h, obtaining solid-liquid mixture a; and after filtrate obtained by separating the solid-liquid mixture a is dewatered, carrying out chromatographic separation by a silicagel column or a polyamide column, and obtaining isoflavonoids compound. The method of the invention is simple and quick, and utilizes [Bmim] BF4 as extraction and separation solvent to successfully separate and obtain 4'-(1''-methoxy group)-propyl group oxo-5,7-dihydroxyisoflavone and biochanin A from the all-grass of Twining Rhynchosia at room temperature, thus solving the difficulty that the traditional plant chemical means can not effectively separate and purify isoflavonoids compound in all-grass of Twining Rhynchosia.
Owner:HENAN UNIV OF SCI & TECH

Isoflavone compound capable of prolonging quality guarantee period of tobacco absolute oil as well as preparation method for isoflavone compound and application of isoflavone compound

The invention relates to an isoflavone compound capable of prolonging the quality guarantee period of tobacco absolute oil as well as a preparation method for the isoflavone compound and application of the isoflavone compound, and belongs to the technical field of plant chemical technology. The isoflavone compound is separated from traditional Chinese medicine radix pueraiae which is medicinal and edible plant, the compound is named as 4'-hodraxy-7-hydroxymethyl-6-methoxy-isoflavone, a molecular formula of the compound is C17H14O5, and a structural formula of the compound as shown in formula (I): the formula (I) is described in the description. A preparation method for the isoflavone compound comprises the following steps: performing extract extraction, performing column chromatography on silica gel and performing efficient liquid-phase chromatographic separation. Anti-oxidation active screening is performed on the compound, and the experimental results are that the compound displays relatively strong oxidization resistance, and has good effect of prolonging the quality guarantee period of the tobacco absolute oil. According to cigarette sensory evaluation results, the added compound does not affect cigarette suction quality, and is an ideal tobacco absolute oil anti-oxidant.
Owner:CHINA TOBACCO YUNNAN IND

Chick-pea embryo and bean sprout valid part, preparing method and application thereof

The invention relates to a chickpea germ, effective part of bean sprout, a preparation method and application. The effective part of the total saponin and isoflavone can be obtained from the chickpea germ and bean sprout by adopting an alcohol extraction method or a water extraction method; the initial screening test of the effective part proves that: the effective part has the advantages of playing a role as an inhibitor for protein tyrosine phosphatase (PTP1B). The effective part can be used as a medicine for treating diabetes and as an application of health care product, simultaneously, the effective part or the derivative of which can be applied as a drug combination.
Owner:XINJIANG TECHN INST OF PHYSICS & CHEM CHINESE ACAD OF SCI

Methyltransferase and application thereof

The invention relates to methyltransferase and application thereof and discloses a group of methyltransferase obtained by latest separation and identification. In the case of providing a methyl donor,the enzyme disclosed by the invention can transfer methyl to a flavonoid or isoflavone compound to add one methyl group for the flavonoid or isoflavone compound. Specifically, the methyltransferase disclosed by the invention is capable of specifically and efficiently catalyzing methylation of hydroxyl groups at C-3, C-7, C-3' and C-4' of a flavonoid compound substrate or methylation of hydroxyl groups at C-7 and C-4' of an isoflavone compound substrate. The methyltransferase can be applied to the fields of synthesis, transformation, bioconversion and the like of the flavonoid or isoflavone compounds.
Owner:CAS CENT FOR EXCELLENCE IN MOLECULAR PLANT SCI

Homoisoflavonoid compounds and preparation method and use thereof

The invention provides homoisoflavonoid compounds, which are prepared by the following steps: grinding dwarf lilyturf tuber, adding extraction solvent into the ground dwarf lilyturf tuber according to a weight / volume ratio of the medicinal material to the solvent of 1:(6-10), performing normal-temperature extraction or reflux extraction, mixing extract solution, concentrating under reduced pressure, dissolving the extract in water, extracting in an organic solvent, recovering solvent to obtain coarse total homoisoflavonoid, loading onto a macroporous resin for eluting to obtain total homoisoflavonoid active part extract, and obtaining the homoisoflavonoid compounds by separation by normal silica gel, reversed silica gel and aluminum oxide column chromatography. A cell level H9C2 cardiac muscle cell line oxygen-glucose deprivation pharmacological model proves that the homoisoflavonoid compounds have anti-myocardial ischemia activity and can be used for preparing medicines for treating cardiovascular diseases such as ischemic heart diseases, coronary diseases, myocardial ischemia, myocardial infarction, stenocardia, arrhythmia and cardiac insufficiency. The general structural formula of the compound is shown below.
Owner:ZHEJIANG UNIV
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