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Tripterygium hypoglaucum film coated tablets and preparation method thereof

A technology of film-coated tablets and Begonia tablets, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve the problems of non-uniform color of sugar-coated tablets and sugar-coated tablets without Kunming Shanhaitang film-coated tablets. Time-consuming tablet production and other problems, to achieve the effect of improving bioavailability, improving appearance and stable properties of the main drug

Inactive Publication Date: 2010-11-03
昆明梓橦宫全新生物制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although sugar-coated tablets are used by patients and have a better taste, the weight of the embryo tablet is increased by the coating of sugar-coated tablets, which consumes more materials. At the same time, the drying speed is slow during the production process, and the prolonged heating time of the drug will affect the quality of the drug. In addition, sugar-coated tablets Easy to mildew, easy to soften, easy to absorb moisture and disintegrate; at the same time, the color of the sugar-coated tablets is uneven, which is easy to cause unclear labels; moreover, the production of sugar-coated tablets takes a long time and the production cost is relatively high
[0004] In recent years, film-coated tablets have become the development direction of pharmaceuticals, and their use in drug production has attracted the attention of the pharmaceutical industry. Patent applications for inventions related to film coatings have gradually increased, but so far, there has been no patent application for Kunming Shanhaitang film-coated tablets

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Preparation of oblate Kunming Begonia tablets with a diameter of 0.8 to 1.0 cm: (1) crushing and sieving: passing the main drug Kunming Begonia dry extract through a 100-mesh sieve, starch and microcrystalline cellulose through a 100-mesh sieve, stearin Magnesium acid is passed through a 140 mesh sieve; hydroxypropyl methylcellulose is mixed with ethanol; (2) granulation: the components are weighed in the stated weight ratio, and the following groups are weighed in units of grams. Divide: 250 grams of Kunming Begonia dry paste powder, 50 grams of microcrystalline cellulose, 50 grams of starch and mix well, then add 80 grams of 2.5% hydroxypropyl methylcellulose solution; mix to make it meet the requirements of granulation (3) Drying and granulation: put the wet granules in an oven to dry (50-80°C), the total drying time is 2 hours, and granulate. (4) mixing: dry granule is added 4 grams of magnesium stearate, after mixing uniformly, measure content; (5) tabletting: adju...

Embodiment 2

[0028] Preparation of oblate or elliptical Kunming Begonia tablets with a diameter of 1.0 to 1.2 cm: (1) Crushing and sieving: pass the main drug Kunming Begonia dry extract through a 100-mesh sieve, starch and microcrystalline cellulose through a 100-mesh sieve 1. Magnesium stearate is passed through a 140 mesh sieve; hydroxypropyl methylcellulose is mixed with ethanol; (2) granulation: the components are weighed respectively with the stated weight ratio, and in units of grams, weighed respectively The following components: 500 grams of Kunming Begonia dry paste powder, 50 grams of microcrystalline cellulose, 50 grams of starch and after mixing evenly, add 150 grams of 2.5% hydroxypropyl methylcellulose solution; After granulating the soft materials required, granulate; (3) drying and granulation: put the wet granules in an oven to dry (50-80°C), the total drying time is 2 hours, and granulate. (4) mixing: dry granule is added 4 grams of magnesium stearate, after mixing unifo...

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Abstract

The invention discloses film coated tablets of tripterygium hypoglaucum tablets and a preparation method thereof. The film coated tablets are characterized in that: oblate or elliptic tripterygium hypoglaucum tablets with the diameter of 0.8 to 1.2 centimeters are used as tablet bases, and a film coating with the thickness of 0.1 to 0.3 millimeter is sprayed and coated on the tablet surface; and the tripterygium hypoglaucum tablet cores comprise the following components in part by weight: 40 to 80 parts of tripterygium hypoglaucum, 10 to 40 parts of starch, 0 to 30 parts of microcrystalline cellulose, 10 to 30 parts of 1 to 10 percent hydroxypropyl methyl cellulose methanol solution, 0.5 to 5 parts of magnesium stearate and 1 to 5 parts of carboxymethyl starch sodium. The preparation method for the tripterygium hypoglaucum film coated tablets has the advantages of simple preparation, easy operation, easy mastery, low equipment investment and short production period; and the prepared tablets have stable main medicinal property, are favorable for improving the medicinal quality, and ensure the effect of the tablets.

Description

technical field [0001] The invention relates to a film-coated tablet and a preparation method thereof, in particular to a film-coated tablet of Kunming Begonia tablets and a preparation method thereof. Background technique [0002] Kunming Shanhaitang tablet is suitable for rheumatoid arthritis, lupus erythematosus, psoriasis and other autoimmune diseases. [0003] Commercially available Kunming Begonia tablets are mostly sugar-coated tablets. Although sugar-coated tablets are used by patients and have a better taste, the weight of the embryo tablet is increased by the coating of sugar-coated tablets, which consumes more materials. At the same time, the drying speed is slow during the production process, and the prolonged heating time of the drug will affect the quality of the drug. In addition, sugar-coated tablets It is easy to mildew, soften, and absorb moisture and disintegrate; at the same time, the color of sugar-coated tablets is uneven, which may easily cause unclea...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K9/36A61P19/02A61P19/04A61P17/06A61P29/00A61P37/02
Inventor 彭宁张涛董开禄韩进
Owner 昆明梓橦宫全新生物制药有限公司
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