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Pharmaceutical composition of triptolide-containing medicine and bracken and preparation and application thereof

A technology of triptolide and Pteris, which is applied in the field of medicine and can solve the problems of unsafe clinical medicine and limited application

Inactive Publication Date: 2010-05-19
JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Triptolide is not only the most active but also the most toxic ingredient in Tripterygium genus drugs. Its effective dose is very close to the toxic dose, and its clinical use is very unsafe, which greatly limits the use of this type of drug in the treatment of autoimmune system abnormalities. The application in various diseases such as the disease of the human body, malignancy and organ rejection

Method used

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  • Pharmaceutical composition of triptolide-containing medicine and bracken and preparation and application thereof
  • Pharmaceutical composition of triptolide-containing medicine and bracken and preparation and application thereof
  • Pharmaceutical composition of triptolide-containing medicine and bracken and preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Triptolide 1g Pteris 100g

[0026] Preparation methods include:

[0027] 1. Preparation of Pteris vulgaris Extract

[0028] ①Take 100g Pteris vulgaris, add 6 times the amount of water, or 70% ethanol, or pure ethanol, heat and reflux for extraction 3 times, combine the extracts, concentrate, dry, and pulverize to obtain the total water extract of Pteris vulgaris, 70% Ethanol total extract, pure ethanol total extract (expressed as Ea, Eb and Ec, respectively).

[0029] ②The total extracts (Ea, Eb, and Ec) of Pteris chinensis (Ea, Eb, and Ec) were made into suspensions with appropriate amount of water, and then extracted with petroleum ether, ethyl acetate, and n-butanol in turn, and the aqueous phase solution was concentrated under reduced pressure, dried, and pulverized , the water part extract (respectively represented by Ed, Ee and Ef).

[0030] ③Elute the water part extracts (Ed, Ee and Ef) on the macroporous resin (model LSA-40) with water and 95% ethanol aqueous...

Embodiment 2

[0034] Triptolide 1mg Pteris 100g

[0035] Preparation methods include:

[0036] 1. Preparation of Pteris vulgaris Extract

[0037] ①Take 100g Pteris vulgaris, add 7 times the amount of water, or 70% ethanol, or pure ethanol, heat and reflux for extraction 3 times, combine the extracts, concentrate, dry, and pulverize to obtain the total water extract of Pteris vulgaris, 70% Ethanol total extract, pure ethanol total extract (Ea, Eb and Ec).

[0038] ② The total extracts (Ea, Eb and Ec) of Pteris vulgaris were made into suspension with appropriate amount of water, and then extracted with petroleum ether, ethyl acetate and n-butanol in turn, the aqueous phase solution was concentrated under reduced pressure, dried and pulverized , to obtain water part extracts (Ed, Ee and Ef).

[0039] ③Elute the water part extracts (Ed, Ee and Ef) on the macroporous resin (model LSA-40) with water and 95% ethanol aqueous solution in turn, concentrate the 95% ethanol eluate under reduced pres...

Embodiment 3

[0043] Triptolide 1mg Pteris 10kg

[0044] Preparation methods include:

[0045] 1. Preparation of Pteris vulgaris Extract

[0046] ①Take 10kg of Pteris vulgaris, add 8 times the amount of water, or 70% ethanol, or pure ethanol, heat and reflux for extraction 3 times, combine the extracts, concentrate, dry, and pulverize to obtain the total water extract of Pteris vulgaris, 70% Ethanol total extract, pure ethanol total extract (Ea, Eb and Ec).

[0047] ②The total extracts (Ea, Eb, and Ec) of Pteris chinensis (Ea, Eb, and Ec) were made into suspensions with appropriate amount of water, and then extracted with petroleum ether, ethyl acetate, and n-butanol in turn, and the aqueous phase solution was concentrated under reduced pressure, dried, and pulverized , to obtain water part extracts (Ed, Ee and Ef).

[0048] ③Elute the water part extracts (Ed, Ee and Ef) on the macroporous resin (model LSA-40) with water and 95% ethanol aqueous solution in turn, concentrate the 95% ethanol...

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Abstract

The invention belongs to the field of medicines and discloses a pharmaceutical composition of a triptolide-containing medicine and bracken and preparation and application thereof. The triptolide-containing medicine comprises triptolide, tripterygium glycosides, thunder god vine, tripterygium hypoglaucum hutch and tripterygium regelii. The pharmaceutical composition comprises the following raw materials in parts by weight: 1 part of triptolide and 100-107 parts of bracken or 1 part of tripterygium glycosides and 1-105 parts of bracken or 1 part of thunder god vine and 0.01-1000 parts of bracken or 1 part of tripterygium hypoglaucum hutch and 0.01-1000 parts of bracken or 1 part of tripterygium regelii and 0.01-1000 parts of bracken. Compared with the original medicine containing triptolide, the pharmaceutical composition has the advantages of immunological suppression, anti-inflammatory, treatment of rheumatoid arthritis, comparative antineoplastic activity and small toxicity, enhances the medication security and can be used as a medicine for immunological suppression, anti-inflammatory, rheumatoid arthritis and antitumor.

Description

technical field [0001] The invention belongs to the field of medicaments, and in particular relates to a pharmaceutical composition compatible with triptolide-containing medicaments and fern-tail grass, as well as its preparation and application. Background technique [0002] Triptolide is the most active epoxidized diterpene lactone compound isolated from the traditional Chinese medicine Tripterygium wilfordii Hook.f., and is one of the main active ingredients of Tripterygium wilfordii Hook.f. Triptolide is also present in two other plants of the genus Tripterygium, Kunming Mountain Begonia (Tripterygium Hypoglaucum Hutch) and Northeast Tripterygium (Tripterygium regalii Sprague et Take), and is also one of its main active ingredients. Due to the strong physiological activity of triptolide, it has significant immunosuppressive, anti-inflammatory, anti-tumor and anti-fertility effects, and is mainly used clinically to treat rheumatoid arthritis, lupus erythematosus, skin dis...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61K36/37A61P29/00A61P35/00A61P37/06A61K31/365A61K31/7048
Inventor 刘建群张锐洪沁张维吴继梅李青赵元
Owner JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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