The invention relates to a medicinal liquor for treating hyperostosis and a preparation method thereof, the medicinal liquor is prepared by soaking the following raw materials by weight in 1900-2100ml of pure rice wine: 50-70 g of ligusticum wallichii, 40-60g of angelica sinensis, 20-40 g of frankincense, 40-60g of cortex moutan, 40-60g of boea hygrometrica, 40-60g of caesalpiniaceae nom. conserv., 20-40 g of rumex madaio MakinoR. daiwoo Makino, 40-60g of Stem of lycopodium clavatum, 30-50 g of palm root, 20-40 g of pteris multifda poir, 20-40 g of prepared common monkshood daughter root, 40-60g of savia miltiorrhiza, 30-50 g of garter snake, 20-40 g of honeysuckle, 40-60g of eucommia bark, 30-50 g of Cibotium barometz, 30-50 g of turtle shell, 20-40 g of woodlouse, 20-40 g of gynura japonica, 5-15 g of coptis chinensis and 60-80 g of moleplant seed. Compared with the prior art, the medicinal liquor has the beneficial effects that the raw materials are easy to collect, cheap in price, quick in effect and good in curative effect, all the raw materials are purely natural and free of toxic side effects, the medicinal liquor can be taken orally, and can be externally used, by use of a method treating both inside and outside, the medicinal liquor is quick to absorb and strong in penetration ability, and the medicinal liquor aiming at pathogenesis to act can eliminate pains, swell, numbness and other extremity function disturbances caused by the hyperostosis, and is also suitable for lumbar disc herniation, various rheumatic pains and other symptoms. The preparation method is convenient, simple andeasy to operate.