Preparation method of drug eluting microsphere suspension, drug eluting microsphere suspension and application of drug eluting microsphere suspension

By increasing the dilution factor of the drug-eluting microsphere suspension to 30-100 times, and combining it with the mixing of physiological saline and non-ionic contrast agents, and optimizing the dilution according to patient characteristics, the source analgesia after arterial chemoembolization and the synergistic improvement of tumor efficacy were achieved, solving the problem of balancing pain and efficacy in traditional methods.

CN122272869APending Publication Date: 2026-06-26TIANJIN CITY THIRD CENT HOSPITAL
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Patent Information

Application Number
CN202610448999.9
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-04-07
Publication Date
2026-06-26

AI Technical Summary

Technical Problem

Traditional methods for preparing drug-eluting microsphere suspensions have failed to effectively reduce postoperative pain after arterial chemoembolization, and the selection of dilution ratios lacks scientific basis, thus failing to achieve the synergistic effect of source analgesia and optimized efficacy.

Method used

By increasing the dilution factor of the microsphere suspension to 30-100 times, using physiological saline and non-ionic contrast agent mixed at a ratio of 1.5:1, and determining the dilution factor based on individual factors such as tumor anatomical location and liver function grade, uniform dispersion of the drug in the bloodstream can be achieved, thereby reducing the local concentration of chemotherapy drugs.

Benefits of technology

It significantly reduces postoperative severe pain, improves the objective response rate of tumors, provides individualized dilution regimens, is easy to operate, has good safety, and is inexpensive.

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Abstract

The invention relates to the technical field of biological medicine, and provides a preparation method of a drug eluting microsphere suspension, the drug eluting microsphere suspension and application of the drug eluting microsphere suspension, the method comprises the following steps: S1, removing a storage solution of drug eluting microspheres to obtain a microsphere precipitate; s2, adding a chemotherapeutic drug solution into the microsphere precipitate, so that the drug is loaded into the microspheres; s3, normal saline and a nonionic contrast agent are mixed according to the volume ratio of 1.5: 1, and a diluting medium is prepared; s4, adding the diluting medium prepared in the step S3 into the microspheres loaded with the medicine in the step S2, so that the total volume of the suspension reaches a preset multiple of the volume of the microsphere precipitate to obtain a microsphere suspension; and S5, oscillating and uniformly mixing the microsphere suspension obtained in the step S4. By increasing the dilution ratio of the drug eluting microsphere suspension, postoperative chemical stimulation pain is remarkably reduced, meanwhile, tumor response is accidentally improved, and the synergistic effect of relieving pain and improving efficiency is achieved.
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