A jet-characteristic-adjustable drug delivery device adaptable to multiple drugs

Abstract

This invention discloses a jet-characteristic adjustable drug delivery device adaptable to multiple drugs, relating to the field of needle-free drug delivery technology. It includes a needle-free drug delivery body with a drug reservoir at one end. During use, the flexible ring undergoes slight deformation with increasing pressure. A full-bridge strain gauge transmits the pressure signal to a microcontroller for identification and analysis. When the pressure data stabilizes within a set threshold range, a flashing green light indicates that the pressure is stable within the appropriate range. A power system generates instantaneous high pressure, acting on the drug solution in the reservoir, causing the solution to flow rapidly through the jet nozzle under high pressure, forming an extremely fine jet that penetrates the stratum corneum of the skin, completing needle-free drug delivery. A pressure detection component accurately and stably detects the pressure between the injection head and the skin, and adjusts the pressure according to the flashing light's indication.

Description

Technical Field

[0001] This invention relates to the field of needleless drug delivery and injection technology, specifically to a drug delivery device with adjustable jet characteristics that can be adapted to multiple drugs. Background Technology

[0002] Needle-free injection is a drug delivery technology that does not rely on traditional metal needles. It uses high pressure to transform the medication into an extremely fine, high-speed jet. This jet penetrates directly through the epidermis and dermis, precisely injecting into the subcutaneous, intradermal, or muscle tissue to complete the drug delivery. Needle-free injection eliminates the risks associated with needles, avoiding needlestick injuries and cross-infection. It also alleviates the psychological burden on those with a fear of needles. Furthermore, it offers rapid drug delivery, uniform drug diffusion, higher absorption efficiency than traditional injections, and greater bioavailability.

[0003] In existing technologies, when using needle-free injectors, the injection head needs to be pressed against the sterilized skin first. Then, high pressure is used to propel the liquid medication in the reservoir into a jet, completing the injection. However, some people do not control the contact pressure between the injection head and the skin during needle-free injection. This results in some injection heads making only slight contact with the skin, while others press too hard. If the contact between the injection head and the skin is not tight, the jet is prone to dispersion, failing to accurately penetrate the skin to reach the target tissue layer, leading to uneven drug distribution and reduced absorption efficiency. If the injection head presses too hard on the skin, it will compress the subcutaneous tissue and blood vessels at the injection site, changing the local tissue density, increasing the resistance to drug penetration, and causing abnormal injection depth, which is detrimental to the efficacy of needle-free injection.

[0004] Therefore, we propose a jet-characteristic-adjustable drug delivery device that can be adapted to multiple drugs, in order to solve the problems mentioned in the background art. Summary of the Invention

[0005] The purpose of this invention is to provide a jet-characteristic adjustable drug delivery device that can be adapted to multiple drugs, in order to solve the problem mentioned in the background art that some people cannot control the contact force between the injection head and the skin, resulting in insufficient contact between the injection head and the skin or excessive pressure on the skin, causing injection discomfort and affecting the effect of needle-free drug delivery.

[0006] To achieve the above objectives, the present invention provides the following technical solution: a jet characteristic adjustment drug delivery device adaptable to multiple drugs, comprising a needle-free drug delivery body, a drug storage tube provided at one end of the needle-free drug delivery body, a pressure detection component for detecting the contact pressure between the injection head and the skin provided at one end of the drug storage tube, and a jet adjustment component adapted to different drug jet characteristics provided inside the pressure detection component.

[0007] The pressure detection component includes a fixed sleeve with an embedded groove inside. An annular plate is fixedly installed inside the embedded groove. Multiple full-bridge strain gauges are fixedly installed on one outer surface of the annular plate. A flexible ring is movably embedded inside the embedded groove. A battery module is fixedly installed on the inner wall of the embedded groove. A microcontroller is fixedly installed on the inner wall of the embedded groove away from the battery module. When the flexible ring comes into contact with the skin, it undergoes slight deformation with the pressure applied. The full-bridge strain gauges are compressed as the flexible ring deforms, causing a change in the resistance value of the full-bridge strain gauges. This mechanical deformation is converted into a stable electrical signal and transmitted to the microcontroller. The microcontroller converts the electrical signal into a specific pressure value, realizing the quantitative detection of contact pressure.

[0008] Preferably, a flashing light is fixedly installed on the outer surface of the fixed sleeve. When the pressure data received by the microcontroller is lower than the set minimum value, the flashing light is triggered to light up red. When the pressure data exceeds the set maximum value, the microcontroller triggers the flashing light to light up green. When the pressure data is stable within the threshold range, the green light flashes, indicating that the pressure is stable within the appropriate range.

[0009] Preferably, a control switch is provided on the outer surface of the fixing sleeve near the flashing light, a charging socket is provided on the outer surface of the fixing sleeve near the battery module, a plurality of mounting slots are equally spaced on the outer surface of the fixing sleeve, a calibration light is fixedly installed inside each of the plurality of mounting slots, and a control module is provided on the outer surface of the needle-free drug delivery body.

[0010] Preferably, the multiple full-bridge strain gauges are circumferentially distributed to help determine the uniformity of pressure. One outer surface of the flexible ring is in contact with the outer surfaces of the multiple full-bridge strain gauges. One outer surface of the annular plate has multiple through holes. The outer surface and inner wall of the flexible ring each have two annular grooves. Annular clamps are movably embedded in the interior of each of the four annular grooves. The outer surfaces of two of the annular clamps are fixedly installed on one side inside the embedded groove, and the outer surfaces of the other two annular clamps are fixedly installed on the other side inside the embedded groove.

[0011] Preferably, the jet adjustment assembly includes a nozzle component and a connecting component, wherein the nozzle component is used to adjust the jet state of the drug, and the connecting component is used to fix the pressure detection component to the outer surface of the nozzle component.

[0012] Preferably, the nozzle component includes a jet nozzle, the inner wall of which has an L-shaped sealing groove, and an L-shaped sealing ring is fixedly connected to the inner wall of the L-shaped sealing groove. The jet nozzle includes a cylindrical nozzle, a conical nozzle, a fan-shaped nozzle, and a spiral nozzle. The conical nozzle has high dynamic pressure, concentrated jet, and strong penetration, making it suitable for drugs that need to be accurately delivered to a specific depth under the skin. The fan-shaped nozzle has a wide jet beam, which is conducive to large-area spray film formation and is suitable for anti-inflammatory drugs on the superficial skin. The spiral nozzle is not easily clogged and is suitable for suspension drugs containing small particles.

[0013] Preferably, the inner wall of the jet nozzle is threaded to one end of the drug storage tube, the inner wall of the L-shaped sealing ring is in contact with one end of the drug storage tube, and both the fixed sleeve and the flexible ring are movably sleeved on the outer surface of the jet nozzle, with the inner wall of the fixed sleeve in contact with the outer surface of the jet nozzle.

[0014] Preferably, the connecting component includes a connecting sleeve. One outer surface of the connecting sleeve has multiple movable grooves. One side of each of the multiple movable grooves has a hook-shaped slot. A sealing block is movably embedded inside each of the multiple movable grooves. A T-shaped rod is fixedly installed on one outer surface of each of the multiple sealing blocks. A threaded ring is fixedly installed on the other outer surface of the connecting sleeve. A rotating sleeve is threaded onto the outer surface of the threaded ring. An annular groove is formed on one outer surface of the rotating sleeve.

[0015] Preferably, a plurality of hook-shaped clips are fixedly installed on one side of the outer surface of the fixing sleeve, and the outer surfaces of the plurality of hook-shaped clips are respectively movably embedded in the interior of a plurality of hook-shaped clip grooves. The outer surfaces of the plurality of sealing blocks are respectively in contact with one side of the outer surface of the plurality of hook-shaped clips. A plurality of movable holes are opened on the other side of the outer surface of the connecting sleeve, and the outer surfaces of the plurality of T-shaped rods are respectively movably embedded in the interior of the plurality of movable holes.

[0016] Preferably, two limiting blocks are fixedly installed on the inner walls of the plurality of movable holes, two limiting grooves are opened on the outer surfaces of the plurality of T-shaped rods, the outer surfaces of the plurality of limiting blocks are respectively movably embedded in the interior of the plurality of limiting grooves, the cross-section of the annular groove is T-shaped, one end of the plurality of T-shaped rods is movably embedded in the interior of the annular groove, the inner wall of the connecting sleeve is fixedly installed on the outer surface of the jet nozzle, the threaded ring is located on the outer surface of the drug storage tube, and one side of the outer surface of the connecting sleeve is in contact with the outer surface of the fixed sleeve.

[0017] Compared with the prior art, the beneficial effects of the present invention are:

[0018] 1. In use, the flexible ring undergoes slight deformation with increasing pressure. The full-bridge strain gauge transmits the pressure signal to the microcontroller for identification and analysis. Based on the judgment result, it triggers the flashing light to indicate pressure adjustment. When the pressure data stabilizes within the set threshold range, the flashing light flashes green, indicating that the pressure is stable and within the appropriate range, allowing for the next step of injection. A high-pressure system generates instantaneous pressure, acting on the drug solution in the reservoir tube. This causes the drug solution to flow rapidly through the jet nozzle under high pressure, forming an extremely fine jet that penetrates the stratum corneum of the skin, completing needle-free injection. The pressure detection component accurately and stably detects the pressure between the injection head and the skin, and adjusts the pressure according to the flashing light, avoiding dosage deviations and uneven absorption caused by improper pressure, thus preventing adverse drug reactions.

[0019] 2. When using this invention, the circumferentially distributed full-bridge strain gauges can help determine whether the pressure is uniform. The microcontroller and calibration lamp work together to issue adjustment and calibration prompts, readjusting the state so that the jet nozzle is kept perpendicular to the skin, ensuring that the jet penetrates the skin vertically, improving the drug delivery effect, and avoiding local pressure abnormalities caused by the tilting of the jet nozzle.

[0020] 3. When using this invention, the jet nozzle is provided with four different structures, namely cylindrical, conical, fan-shaped and spiral. The structural design of the jet adjustment component allows for the replacement of nozzles with different structures. By changing the jet velocity distribution, diffusion angle and atomization state, it can match the jet requirements of multiple drugs. There is no need to equip different drugs with special needleless injectors, reducing medical costs and solving the adaptation problem of fixed structure nozzles. Attached Figure Description

[0021] Figure 1 This is a frontal perspective view of a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention;

[0022] Figure 2 This is a schematic diagram of the pressure detection component in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention.

[0023] Figure 3 This is a cross-sectional schematic diagram of the fixed sleeve in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention;

[0024] Figure 4 This is a cross-sectional schematic diagram of the nozzle component in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention;

[0025] Figure 5 This is a schematic diagram showing the structure of the connecting component in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention.

[0026] Figure 6This is a cross-sectional schematic diagram of the T-shaped rod in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention;

[0027] Figure 7 This is a schematic diagram of the hook-shaped card block in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention;

[0028] Figure 8 This is a cross-sectional view of the flexible ring structure in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention.

[0029] Figure 9 This is a schematic diagram showing the unfolded structure of the annular plate in a jet characteristic adjustment drug delivery device adaptable to multiple drugs according to the present invention.

[0030] Figure 10 This is a schematic diagram of the different nozzle structures in a drug delivery device with adjustable jet characteristics that can be adapted to multiple drugs, according to the present invention.

[0031] In the picture:

[0032] 1. Needle-free drug delivery body; 2. Drug reservoir; 3. Pressure detection assembly; 301. Fixing sleeve; 302. Annular plate; 303. Full-bridge strain gauge; 304. Wire hole; 305. Flexible ring; 306. Annular slot; 307. Annular clamp; 308. Battery module; 309. Microcontroller; 310. Flashing light; 311. Control switch; 312. Charging socket; 313. Mounting slot; 314. Calibration light; 315. Hook-shaped locking block; 316. 4. Embedded groove; 4. Jet adjustment assembly; 41. Nozzle component; 411. Jet nozzle; 412. L-shaped sealing groove; 413. L-shaped sealing ring; 42. Connecting component; 421. Connecting sleeve; 422. Movable groove; 423. Hook-shaped slot; 424. Sealing block; 425. T-shaped rod; 426. Moving hole; 427. Limiting block; 428. Limiting groove; 429. Threaded ring; 4210. Rotating sleeve; 4211. Annular groove; 5. Control module. Detailed Implementation

[0033] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0034] Example 1: Please refer to Figures 1-10As shown, the present invention provides a technical solution: a jet characteristic adjustment drug delivery device adaptable to multiple drugs, including a needle-free drug delivery body 1, a drug storage tube 2 at one end of the needle-free drug delivery body 1, a pressure detection component 3 for detecting the contact pressure between the injection head and the skin at one end of the drug storage tube 2, and a jet adjustment component 4 adapted to different drug jet characteristics inside the pressure detection component 3; the pressure detection component 3 includes a fixing sleeve 301, an embedded groove 316 is formed inside the fixing sleeve 301, an annular plate 302 is fixedly installed inside the embedded groove 316, and multiple full-bridge strain gauges are fixedly installed on one outer surface of the annular plate 302. 303. A flexible ring 305 is movably embedded inside the recessed groove 316. A battery module 308 is fixedly installed on the inner wall of the recessed groove 316. A microcontroller 309 is fixedly installed on the inner wall of the recessed groove 316 away from the battery module 308. When the flexible ring 305 comes into contact with the skin, it will undergo slight deformation with the pressure. The full-bridge strain gauge 303 will be compressed with the deformation of the flexible ring 305, causing the resistance value of the full-bridge strain gauge 303 to change. The mechanical deformation is converted into a stable electrical signal and sent to the microcontroller 309. The microcontroller 309 converts the electrical signal into a specific pressure value to realize the quantitative detection of contact pressure. A flashing light 310 is fixedly installed on the outer surface of the fixing sleeve 301. When the pressure data received by the microcontroller 309 is lower than the set minimum value, the flashing light 310 is triggered to light up red. When the pressure data exceeds the set maximum value, the microcontroller 309 triggers the flashing light 310 to light up green. When the pressure data stabilizes within the threshold range, the green light flashes, indicating that the pressure is stable within the appropriate range, and the next step of injection drug delivery can be performed. A control switch 311 is provided on the outer surface of the fixing sleeve 301 near the flashing light 310, and a charging socket 312 is provided on the outer surface of the fixing sleeve 301 near the battery module 308. Multiple mounting slots 313 are equidistantly opened on the outer surface of the fixing sleeve 301, and calibration lights 314 are fixedly installed inside each of the multiple mounting slots 313. A control module 5 is provided on the outer surface of the needle-free drug delivery body 1. Multiple full-bridge strain gauges 303 are circumferentially distributed to aid in judging the uniformity of pressure. One outer surface of the flexible ring 305 is in contact with the outer surfaces of the multiple full-bridge strain gauges 303. Multiple wire holes 304 are provided on one outer surface of the annular plate 302. Two annular grooves 306 are provided on both the outer surface and the inner wall of the flexible ring 305. Annular clamps 307 are movably embedded in the four annular grooves 306. The outer surfaces of two annular clamps 307 are fixedly installed on one side inside the embedded groove 316, and the outer surfaces of the other two annular clamps 307 are fixedly installed on the other side inside the embedded groove 316. The jet adjustment assembly 4 includes a nozzle component 41 and a connecting component 42. The nozzle component 41 is used to adjust the jet state of the drug, and the connecting component 42 is used to fix the pressure detection assembly 3 to the outer surface of the nozzle component 41.The connecting component 42 includes a connecting sleeve 421. A plurality of movable grooves 422 are formed on one outer surface of the connecting sleeve 421. A hook-shaped slot 423 is formed on one side of each movable groove 422. A sealing block 424 is movably embedded in the interior of each movable groove 422. A T-shaped rod 425 is fixedly installed on one outer surface of each sealing block 424. A threaded ring 429 is fixedly installed on the other outer surface of the connecting sleeve 421. A rotating sleeve 4210 is threadedly fitted on the outer surface of the threaded ring 429. An annular groove 4211 is formed on one outer surface of the rotating sleeve 4210. A plurality of hook-shaped blocks 315 are fixedly installed on one outer surface of the fixed sleeve 301. The outer surfaces of the plurality of hook-shaped blocks 315 are movably embedded in the interior of the plurality of hook-shaped slots 423.

[0035] In this embodiment, during use, the pressure detection component 3 is mounted on the outer surface of the jet nozzle 411 via the connecting component 42, such as... Figure 3As shown, the bottom of the flexible ring 305 is flush with the bottom of the jet nozzle 411. The jet nozzle 411 is aimed at the sterilized skin and slowly pressed against it. Simultaneously, the flexible ring 305 contacts the skin. As the pressure gradually increases, the flexible ring 305 undergoes slight deformation. At the same time, the full-bridge strain gauge 303 compresses due to the deformation of the flexible ring 305, causing a change in its resistance value. The circuit characteristics of the full-bridge strain gauge 303 amplify the resistance change signal, reduce interference such as temperature drift, and convert the mechanical deformation into a stable electrical signal, which is then transmitted to the microcontroller 309. After receiving the electrical signal, the microcontroller 309 converts the signal into a specific pressure value using a preset calibration algorithm, and performs identification and analysis to achieve quantitative detection of the contact pressure. When the microcontroller 309 receives a pressure signal, it triggers the flashing light 310 to illuminate red, indicating that the pressure value is below the set minimum value and needs to be increased gradually. When the received pressure data exceeds the set maximum value, the microcontroller 309 triggers the flashing light 310 to illuminate green, indicating that the pressure is too high and needs to be reduced gradually. When the received pressure data stabilizes within the set threshold range, the flashing light 310 flashes green, indicating that the pressure has stabilized within the appropriate range and the next step of injection can proceed. The needle-free drug delivery unit 1 is equipped with a power system to provide high-pressure power. The power system generates instantaneous high pressure, which acts on the drug solution in the drug reservoir 2, causing the drug solution to flow rapidly through the jet nozzle 411 under high pressure, forming a rapid, ultra-fine jet. This high-speed jet has sufficient kinetic energy to penetrate the stratum corneum of the skin and diffuse in the subcutaneous tissue, completing the needle-free injection drug delivery. With the help of the pressure detection component 3, the pressure between the injection head and the skin is accurately and stably detected, and the pressure is adjusted according to the prompts of the flashing light 310. This avoids dosage deviation and uneven absorption caused by improper pressure, which affects the drug administration effect. It solves the problem that some people cannot control the contact force between the injection head and the skin, resulting in insufficient contact between the injection head and the skin or excessive pressure on the skin, causing injection discomfort and affecting the drug administration effect of needle-free injection.

[0036] Furthermore, multiple full-bridge strain gauges 303 are arranged in a circular pattern on the outer surface of the flexible ring 305, and calibration lamps 314 are installed at corresponding positions of the multiple full-bridge strain gauges 303. When the jet nozzle 411 is tilted, the flexible ring 305 is deformed to different degrees. The side with higher pressure deforms significantly more than the side with lower pressure, resulting in a greater degree of compression of the full-bridge strain gauge 303 corresponding to the side with higher pressure than the side with lower pressure. The microcontroller 309 compares multiple pressure signals to determine the tilt state and triggers the calibration lamp 314 corresponding to the side with higher pressure to light up red, issuing an adjustment calibration prompt to readjust the state so that the jet nozzle 411 remains perpendicular to the skin, ensuring that the jet penetrates the skin vertically, improving the drug delivery effect, and avoiding local pressure abnormalities caused by the tilt of the jet nozzle 411.

[0037] Furthermore, by twisting the rotating sleeve 4210, it spirals upward on the outer surface of the threaded ring 429. Through the movable connection between the annular groove 4211 and the T-shaped rod 425, when the rotating sleeve 4210 moves upward, it drives the T-shaped rod 425 to move upward in the moving hole 426, thereby removing multiple sealing blocks 424 from the hook-shaped locking block 315. At this point, the hook-shaped locking block 315 loses its limiting position. Next, rotating the fixed sleeve 301 causes multiple hook-shaped locking blocks 315 to rotate together, moving them from the hook-shaped locking groove 423 to the movable groove 422. Finally, pulling out the fixed sleeve 301 separates the pressure detection component 3 from the jet adjustment component 4, without affecting the subsequent individual replacement of the jet adjustment component 4. The flexible ring 305 is embedded in the inner groove 316. By pulling the flexible ring 305 outward, the annular groove 306 and the annular clamp 307 are misaligned. Through the deformation and contraction of the flexible ring 305, the flexible ring 305 can be removed separately for replacement or cleaning, reducing the cost of component replacement.

[0038] Example 2: Figures 2-6 and Figure 10As shown, the jet adjustment assembly 4 includes a nozzle component 41 and a connecting component 42. The nozzle component 41 is used to adjust the jet state of the drug, and the connecting component 42 is used to fix the pressure detection component 3 to the outer surface of the nozzle component 41. The nozzle component 41 includes a jet nozzle 411, and an L-shaped sealing groove 412 is formed on the inner wall of the jet nozzle 411. An L-shaped sealing ring 413 is fixedly connected to the inner wall of the L-shaped sealing groove 412. The jet nozzle 411 includes cylindrical nozzles, conical nozzles, fan-shaped nozzles, and spiral nozzles. Conical nozzles have high dynamic pressure, concentrated jets, and strong penetration, making them suitable for drugs that need to be accurately delivered to a specific depth under the skin. Fan-shaped nozzles have a large jet beam width, which is beneficial for large-area spraying. The membrane is suitable for superficial anti-inflammatory drugs. The spiral nozzle is not easily clogged and is suitable for suspensions containing small particles. The inner wall of the jet nozzle 411 is threaded to one end of the drug reservoir 2. The inner wall of the L-shaped sealing ring 413 fits against one end of the drug reservoir 2. The fixing sleeve 301 and the flexible ring 305 are both movably sleeved on the outer surface of the jet nozzle 411. The inner wall of the fixing sleeve 301 is in contact with the outer surface of the jet nozzle 411. The connecting component 42 includes a connecting sleeve 421. Multiple movable grooves 422 are opened on one side of the outer surface of the connecting sleeve 421. A hook-shaped slot 423 is opened on one side of each of the multiple movable grooves 422. A sealing block 4 is movably embedded in the interior of each of the multiple movable grooves 422. 24. T-shaped rods 425 are fixedly installed on one side of the outer surface of multiple sealing blocks 424. A threaded ring 429 is fixedly installed on the other side of the outer surface of the connecting sleeve 421. A rotating sleeve 4210 is threaded onto the outer surface of the threaded ring 429. An annular groove 4211 is formed on one side of the outer surface of the rotating sleeve 4210. Multiple hook-shaped locking blocks 315 are fixedly installed on one side of the outer surface of the fixing sleeve 301. The outer surfaces of the multiple hook-shaped locking blocks 315 are movably embedded in the interiors of multiple hook-shaped locking grooves 423. The outer surfaces of the multiple sealing blocks 424 are in contact with one side of the outer surface of the multiple hook-shaped locking blocks 315. Multiple moving holes 426 are formed on the other side of the outer surface of the connecting sleeve 421. Multiple T-shaped rods 425 are threaded onto the outer surface of the connecting sleeve 421. The outer surfaces of the T-shaped rods 425 are movably embedded in the interiors of multiple moving holes 426. Two limiting blocks 427 are fixedly installed on the inner walls of the multiple moving holes 426. Two limiting grooves 428 are opened on the outer surfaces of the multiple T-shaped rods 425. The outer surfaces of the multiple limiting blocks 427 are movably embedded in the interiors of the multiple limiting grooves 428. The cross-section of the annular groove 4211 is T-shaped. One end of the multiple T-shaped rods 425 is movably embedded in the interior of the annular groove 4211. The inner wall of the connecting sleeve 421 is fixedly installed on the outer surface of the jet nozzle 411. The threaded ring 429 is located on the outer surface of the drug storage tube 2. One side of the outer surface of the connecting sleeve 421 is in contact with the outer surface of the fixed sleeve 301.

[0039] In this embodiment, the jet nozzle 411 has four different structures during use: cylindrical, spiral, fan-shaped, and conical, as shown below. Figure 10As shown, connecting parts 42 are installed on the outer surfaces of the four nozzle components 41 with different structures. After separating the pressure detection component 3 from the jet adjustment component 4 through the connecting parts 42, the nozzle component 41 can be rotated and removed from one end of the drug storage tube 2 to replace the nozzle with a different structure. When a drug solution flows through a nozzle under high pressure, the shape of the nozzle's inner cavity directly alters the flow trajectory and energy conversion method of the drug solution. Cylindrical jet nozzles 411 are suitable for most drug injections without special requirements; conical jet nozzles 411 gradually increase the drug solution flow rate through a constricted flow channel, forming a concentrated high-speed jet with high dynamic pressure, high static pressure energy conversion efficiency, concentrated jet, and strong penetration, making them suitable for drugs such as insulin and growth hormone that require precise delivery to a specific depth under the skin; fan-shaped jet nozzles 411 change the direction of drug solution flow through a flat outlet, causing the jet to diffuse along a plane, resulting in a large beam width, which is beneficial for large-area spraying and film formation, making them suitable for superficial anti-inflammatory drugs and local anesthetics; spiral jet nozzles 411 guide the drug solution to rotate and flow through a spiral inner cavity, forming a uniform atomized state after ejection, which is less prone to clogging, making them suitable for suspensions containing small particles or vaccines that require atomized absorption. The structural design of the jet adjustment component 4 allows for the replacement of nozzles with different structures. By changing the jet velocity distribution, diffusion angle, and atomization state, it can match the jet requirements of multiple drugs without the need for dedicated needleless injectors for different drugs, thus reducing medical costs and solving the adaptation problem of fixed structure nozzles.

[0040] The overall mechanism works as follows: the jet nozzle 411 is slowly applied to the skin, while the flexible ring 305 contacts the skin. The flexible ring 305 undergoes slight deformation with the pressure applied, and the full-bridge strain gauge 303 compresses along with the deformation of the flexible ring 305, causing a change in its resistance value. The microcontroller 309 receives the electrical signal, identifies and analyzes it, and achieves quantitative detection of the contact pressure. When the microcontroller 309 receives a pressure signal, it triggers the flashing light 310 to illuminate red, indicating that the pressure is below the set minimum value and needs to be gradually increased. When the received pressure data exceeds the set maximum value, the microcontroller 309 triggers the flashing light 310 to illuminate green, indicating that the pressure is too high and needs to be gradually reduced. When the received pressure data stabilizes within the set threshold range, the flashing light 310 flashes green, indicating that the pressure is stable within the appropriate range and the next step of injection can proceed. When the jet nozzle 411 tilts, the flexible ring 305 experiences varying degrees of deformation. The side with higher pressure deforms significantly more than the side with lower pressure, resulting in greater compression of the full-bridge strain gauge 303 corresponding to the side with higher pressure compared to the side with lower pressure. The microcontroller 309 compares multiple pressure signals to determine the tilt state and triggers the calibration light 314 corresponding to the side with higher pressure to illuminate red, issuing an adjustment calibration prompt to readjust the state so that the jet nozzle 411 remains perpendicular to the skin. The internal power system of the needle-free drug delivery unit 1 generates instantaneous high pressure, which acts on the drug solution in the drug reservoir 2, causing the drug solution to flow rapidly through the jet nozzle 411 under high pressure, forming a rapid, extremely fine jet that penetrates the stratum corneum of the skin and diffuses in the subcutaneous tissue, completing the needle-free injection drug delivery. Rotate the rotating sleeve 4210 upwards to remove the sealing block 424 from the hook-shaped locking block 315 via the T-shaped rod 425. Then rotate the fixing sleeve 301 to rotate the hook-shaped locking block 315 from the hook-shaped locking groove 423 into the movable groove 422. Finally, pull the fixing sleeve 301 outwards. Rotate the nozzle component 41 to remove it from one end of the drug storage tube 2, allowing you to replace nozzles with different structures to match the jetting requirements of multiple drugs.

[0041] Among them, the needle-free drug delivery body 1, the full-bridge strain gauge 303, the battery module 308, the microcontroller 309, the flashing light 310, the control switch 311, the charging socket 312, the calibration light 314, and the control module 5 are all existing technologies, and their components and operating principles are all publicly available technologies, which will not be explained in detail here.

[0042] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. An adaptable multi-drug jet characteristic adjusting drug delivery device, comprising a needle-free drug delivery main body (1), one end of the needle-free drug delivery main body (1) is provided with a drug storage tube (2), characterized in that: One end of the drug storage tube (2) is provided with a pressure detection component (3) for detecting the pressure of the injection head in contact with the skin. The pressure detection component (3) is provided with a jet adjustment component (4) adapted to different drug jet characteristics. The pressure detection component (3) includes a fixed sleeve (301), an embedded groove (316) is provided inside the fixed sleeve (301), an annular plate (302) is fixedly installed inside the embedded groove (316), a plurality of full-bridge strain gauges (303) are fixedly installed on one outer surface of the annular plate (302), a flexible ring (305) is movably embedded inside the embedded groove (316), and a battery module (308) is fixedly installed on the inner wall of the embedded groove (316). A microcontroller (309) is fixedly installed on the inner wall away from the battery module (308). When the flexible ring (305) comes into contact with the skin, it will undergo slight deformation with the pressure. The full-bridge strain gauge (303) will be compressed with the deformation of the flexible ring (305), causing the resistance value of the full-bridge strain gauge (303) to change. The mechanical deformation is converted into a stable electrical signal and sent to the microcontroller (309). The microcontroller (309) converts the electrical signal into a specific pressure value to realize the quantitative detection of contact pressure.

2. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 1, characterized in that: A flashing light (310) is fixedly installed on the outer surface of the fixed sleeve (301). When the pressure data received by the microcontroller (309) is lower than the set minimum value, the flashing light (310) is triggered to light up red. When the pressure data exceeds the set maximum value, the microcontroller (309) triggers the flashing light (310) to light up green. When the pressure data is stable within the threshold range, the green light flashes, indicating that the pressure is stable within the appropriate range.

3. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 2, characterized in that: A control switch (311) is provided on the outer surface of the fixing sleeve (301) near the flashing lamp (310), a charging socket (312) is provided on the outer surface of the fixing sleeve (301) near the battery module (308), a plurality of mounting slots (313) are provided at equal intervals on the outer surface of the fixing sleeve (301), a calibration lamp (314) is fixedly installed inside the plurality of mounting slots (313), and a control module (5) is provided on the outer surface of the needleless drug delivery body (1).

4. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 3, characterized in that: Multiple full-bridge strain gauges (303) are circumferentially distributed to help determine the uniformity of pressure. One outer surface of the flexible ring (305) is in contact with the outer surfaces of the multiple full-bridge strain gauges (303). Multiple wire holes (304) are provided on one outer surface of the annular plate (302). Two annular grooves (306) are provided on both the outer surface and the inner wall of the flexible ring (305). Annular clamps (307) are movably embedded in the interior of each of the four annular grooves (306). The outer surfaces of two annular clamps (307) are fixedly installed on one side inside the embedded groove (316), and the outer surfaces of the other two annular clamps (307) are fixedly installed on the other side inside the embedded groove (316).

5. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 3, characterized in that: The jet adjustment assembly (4) includes a nozzle component (41) and a connecting component (42). The nozzle component (41) is used to adjust the jet state of the drug, and the connecting component (42) is used to fix the pressure detection component (3) to the outer surface of the nozzle component (41).

6. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 5, characterized in that: The nozzle component (41) includes a jet nozzle (411), the inner wall of which is provided with an L-shaped sealing groove (412), and an L-shaped sealing ring (413) is fixedly connected to the inner wall of the L-shaped sealing groove (412). The jet nozzle (411) includes a cylindrical nozzle, a conical nozzle, a fan-shaped nozzle and a spiral nozzle. The conical nozzle has high dynamic pressure, concentrated jet and strong penetration, and is suitable for drugs that need to be accurately delivered to a specific depth under the skin. The fan-shaped nozzle has a large jet beam width, which is conducive to large-area spray film formation and is suitable for anti-inflammatory drugs on the superficial skin. The spiral nozzle is not easy to clog and is suitable for suspension drugs containing small particles.

7. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 6, characterized in that: The inner wall of the jet nozzle (411) is threaded to one end of the drug storage tube (2), the inner wall of the L-shaped sealing ring (413) is in contact with one end of the drug storage tube (2), the fixed sleeve (301) and the flexible ring (305) are both movably sleeved on the outer surface of the jet nozzle (411), and the inner wall of the fixed sleeve (301) is in contact with the outer surface of the jet nozzle (411).

8. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 7, characterized in that: The connecting component (42) includes a connecting sleeve (421). A plurality of movable grooves (422) are provided on one side of the outer surface of the connecting sleeve (421). A hook-shaped slot (423) is provided on one side of each of the movable grooves (422). A sealing block (424) is movably embedded in the interior of each of the movable grooves (422). A T-shaped rod (425) is fixedly installed on one side of the outer surface of each of the sealing blocks (424). A threaded ring (429) is fixedly installed on the other side of the outer surface of the connecting sleeve (421). A rotating sleeve (4210) is threaded on the outer surface of the threaded ring (429). An annular groove (4211) is provided on one side of the outer surface of the rotating sleeve (4210).

9. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 8, characterized in that: A plurality of hook-shaped blocks (315) are fixedly installed on one side of the outer surface of the fixed sleeve (301). The outer surfaces of the plurality of hook-shaped blocks (315) are respectively movably embedded in the interior of a plurality of hook-shaped slots (423). The outer surfaces of the plurality of sealing blocks (424) are respectively in contact with one side of the outer surface of the plurality of hook-shaped blocks (315). A plurality of moving holes (426) are opened on the other side of the outer surface of the connecting sleeve (421). The outer surfaces of the plurality of T-shaped rods (425) are respectively movably embedded in the interior of the plurality of moving holes (426).

10. The jet characteristic adjustment drug delivery device adaptable to multiple drugs according to claim 9, characterized in that: Two limiting blocks (427) are fixedly installed on the inner walls of the multiple moving holes (426). Two limiting grooves (428) are opened on the outer surfaces of the multiple T-shaped rods (425). The outer surfaces of the multiple limiting blocks (427) are respectively movably embedded in the interior of the multiple limiting grooves (428). The cross-section of the annular groove (4211) is T-shaped. One end of the multiple T-shaped rods (425) is movably embedded in the interior of the annular groove (4211). The inner wall of the connecting sleeve (421) is fixedly installed on the outer surface of the jet nozzle (411). The threaded ring (429) is located on the outer surface of the drug storage tube (2). One side of the outer surface of the connecting sleeve (421) is in contact with the outer surface of the fixed sleeve (301).

Images