Novel drug delivery method for ocular administration and apparatus therefor

Abstract

Provided is a novel drug delivery method for ocular administration, which specifically comprises the following steps: S1, filling a dedicated solution bottle with a drug solution; S2, during use of the solution bottle for spraying, aiming the solution bottle at an eye so that drug droplets enter the eye, wherein the solution bottle is used in combination with an atomization apparatus, fine misty droplets are sprayed out by means of the atomization apparatus, the particle size of the misty droplets is 0.1-60 μm, and the misty droplets reach the eyeball and a periocular area; and S3, during use, carrying out drug administration in a drug-instrument combination mode, wherein the drug solution and the atomization apparatus can be produced and prepared separately and are used in combination during use.

Description

A novel drug delivery method and device for ocular drug delivery

[0001] Priority information

[0002] This application claims priority and benefit to patent application No. 202411845364.X, filed with the China National Intellectual Property Administration on December 16, 2024, the entire contents of which are incorporated herein by reference. Technical Field

[0003] This application relates to the field of ocular drug delivery technology, specifically a novel drug delivery method and device for ocular drug delivery. Background Technology

[0004] With changes in people's lifestyles and living environment, the incidence of eye diseases is increasing. Eye drops are one of the most common treatment methods for eye diseases.

[0005] Traditional eye drop administration requires precise application techniques and involves complex steps. Incorrect application can not only fail to treat the condition but also cause further damage to the eyes. Typically, people apply eye drops by pulling down the eyelid and directly into the eyeball, then close their eyes and blink frequently, allowing the drops to swirl around in the eye. This method is ineffective and can easily irritate the cornea. Forceful eyelid closure and increased blinking can cause the drops to overflow, reducing their effectiveness. Applying the drops by pulling down the lower eyelid without prior hand washing and disinfection can easily lead to eye infections. During application, the bottle opening can come into contact with eyelashes and the ocular surface, causing bacterial growth and contamination of the drops. After application, the drops coat the surface of the eyeball, causing temporary blurred vision and discomfort. Additionally, some drops can flow from the corner of the eye through the nasolacrimal duct into the nasal cavity and throat, causing discomfort and irritation.

[0006] In addition, some special groups, such as patients with cervical spondylosis, Parkinson's disease, and ataxia, also have difficulty using traditional eye drops, as they find it difficult to put the drops into their eyes. Summary of the Invention

[0007] To address the shortcomings of existing technologies, this application provides a novel ocular drug delivery method and apparatus, which solves the problems mentioned in the background section.

[0008] To achieve the above objectives, this application provides the following technical solution: a novel ocular drug delivery method, specifically comprising the following steps:

[0009] S1. Fill the drug solution into a special solution bottle;

[0010] S2. When using the solution bottle spray, aim it at the eyes to allow the drug droplets to enter the eyes. The solution bottle is used in conjunction with the nebulizer to spray out fine mist droplets with a droplet size of 0.1-30μm, which reach the eyeball and the area around the eyes.

[0011] S3. When using it, the drug is administered in combination with the device. The drug solution and the nebulizer can be produced and prepared separately, and the two are used together. Attached Figure Description

[0012] Figure 1 is a schematic diagram of the atomizing device of this application. Detailed Implementation

[0013] The technical solutions of the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments of this application, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this application.

[0014] Please refer to Figure 1. This application provides a technical solution: a novel method for ocular drug delivery, specifically including the following steps:

[0015] S1. Fill the drug solution into a special solution bottle;

[0016] S2. When using the solution bottle spray, aim it at the eyes to allow the drug droplets to enter the eyes. The solution bottle is used in conjunction with the nebulizer to spray out fine mist droplets with a droplet size of 0.1-60μm, which reach the eyeball and the area around the eyes.

[0017] S3. When using it, the drug is administered in combination with the device. The drug solution and the nebulizer can be produced and prepared separately, and the two are used together.

[0018] S4. During the administration process, control the distance between the mist outlet and the eye to be 2-15cm, the nebulization rate to be 0.1-2ml / min, the dose of drug delivered to the eye each time to be 20-300mg, and the number of times of administration per day to be 1-10.

[0019] Furthermore, any content not described in detail in this specification is existing technology known to those skilled in the art.

[0020] Specifically, in S1, the solution bottle is made of any one of glass, polyethylene, polypropylene, polyethylene terephthalate, and metal.

[0021] Specifically, in S1, the drug solution is eye drops for treating eye diseases.

[0022] This application also discloses a novel drug delivery device for ocular drug delivery, which includes an nebulizer. The nebulizer consists of a main body and an nebulizer unit. The main body has a cavity for housing the nebulizer unit. The main body contains a circuit board and a battery connected to the circuit board. A switch is provided on the circuit board, and the switch cap is located outside the main body. A nebulizer port is provided outside the main body and communicates with the cavity. The nebulizer unit has a liquid inlet, and a liquid container is detachably mounted on the liquid inlet. A nebulizer plate is assembled on the nebulizer unit. One end face of the nebulizer plate communicates with the inner cavity of the liquid inlet, and the other end face of the nebulizer plate is located outside the nebulizer unit.

[0023] Specifically, after the atomizing unit is aligned and installed in the mounting cavity, the atomizing port is directly opposite the outer end face of the atomizing plate; the atomizing unit and the circuit board are connected by conductive components to form a circuit connection; both the mounting cavity and the atomizing unit of the atomizing device are equipped with magnetic components, the mounting cavity is equipped with conductive contacts, and the atomizing unit has conductive pins, which together constitute conductive components; after the atomizing unit is aligned and installed in the mounting cavity, the conductive pins and conductive contacts contact each other.

[0024] When the switch cap is flipped, the atomizing nozzle is exposed, the atomizing unit is powered on and works; when the switch cap is flipped, the power is disconnected, the atomizing unit stops working, and the switch cap covers the atomizing nozzle.

[0025] Specifically, the atomizing body has a built-in rechargeable battery and circuit board. The circuit board is equipped with a charging interface, and the charging port is located on the outside of the body. The circuit board also has an indicator light. A light guide block is provided on the outside of the body relative to the indicator light, and the inner end of the light guide block is directly opposite the indicator light.

[0026] Specifically, the atomizing unit includes a base and a bottom plate. The liquid inlet is located on the base and is connected to the liquid container by a thread. The inner cavity of the base is provided with a slot for inserting an atomizing plate, the size of which is adapted to the atomizing plate. The slot is provided with an inlet and an outlet. After the atomizing plate is inserted into the slot, the inlet and outlet of the slot meet the requirements for liquid entry and atomization discharge of the atomizing plate. The bottom plate is detachably closed to the inner cavity of the base. The atomizing plate inserted into the atomizing unit is a lead-free pressure-sensitive ceramic atomizing plate.

[0027] Specifically, the atomizing device is a mesh atomizing device.

[0028] Working principle of the mesh atomizing device: Sliding the button switch downwards triggers a Hall effect switch on the main board. The Hall effect switch sends an electrical signal to the control IC, which then powers on. The control IC controls the battery power supply, generating a high-frequency voltage signal through a resonant circuit on the main board. This signal drives the lead-free varistor ceramic atomizing plate assembly to vibrate at high frequency. The high-frequency vibration of the lead-free varistor ceramic drives the atomizing plate to vibrate at high frequency. This high-frequency vibration of the atomizing plate propels the liquid on one side of the atomizing plate through the micropores on the plate, creating a high-speed mist-like diffusion of liquid particles with a median diameter of 3μm-20μm.

[0029] It should be noted that, in this document, relational terms such as "first" and "second" are used only to distinguish one entity or operation from another, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Furthermore, the terms "comprising," "including," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such process, method, article, or apparatus.

[0030] Although embodiments of this application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of this application, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A novel method of drug delivery to the eye, wherein: Specifically, the following steps are included: S1. Fill the drug solution into a special solution bottle; S2. When using the solution bottle spray, aim it at the eyes to allow the drug droplets to enter the eyes. The solution bottle is used in conjunction with the nebulizer to spray out fine mist droplets with a droplet size of 0.1-60μm, which reach the eyeball and the area around the eyes. S3. When using it, the drug is administered in combination with the device. The drug solution and the nebulizer can be produced and prepared separately, and the two are used together.

2. The novel ocular drug delivery method according to claim 1, wherein: In S1, the solution bottle is made of any one of glass, polyethylene, polypropylene, polyethylene terephthalate, and metal.

3. A novel method for administering medication to the eye according to claim 1, wherein: In S1, the drug solution is eye drops for treating eye diseases.

4. A novel method for ocular drug delivery according to claim 3, wherein: The eye diseases mentioned include refractive system diseases (myopia, hyperopia, astigmatism), ocular surface diseases (dry eye, conjunctivitis, keratitis), fundus diseases (retinal detachment, macular degeneration, retinal diseases), lens diseases (glaucoma, cataracts), and optic nerve conduction diseases (optic nerve atrophy, optic neuritis, anterior ischemic optic neuropathy).

5. A novel method for administering medication to the eye according to claim 1, wherein: In S2, the distance between the mist outlet and the eye is 2-15cm, the atomization rate is 0.1-2ml / min, the dose of drug delivered to the eye each time is 20-300mg, and the number of times the drug is administered per day is 1-10.

6. A novel ocular drug delivery device, applied to a novel ocular drug delivery method as described in any one of claims 1-5, wherein: The novel ocular drug delivery device includes a nebulizer, which consists of a main body and a nebulizer unit. The main body has a cavity for housing the nebulizer unit. The main body contains a circuit board and a battery connected to the circuit board. A switch is provided on the circuit board, and the switch cap is located outside the main body. A nebulizer port is provided outside the main body and communicates with the cavity. The nebulizer unit has a liquid inlet, and a liquid container is detachably mounted on the liquid inlet. A nebulizer plate is assembled on the nebulizer unit. One end of the nebulizer plate communicates with the inner cavity of the liquid inlet, and the other end of the nebulizer plate is located outside the nebulizer unit.

7. A novel drug delivery device for ocular drug delivery according to claim 6, wherein: After the atomizing unit is aligned and installed in the mounting cavity, the atomizing port is directly opposite the outer end face of the atomizing plate. The atomizing unit and the circuit board are connected by conductive components to form a circuit. The main body of the atomizing device and the mounting cavity and the atomizing unit are both equipped with magnetic components. The mounting cavity is equipped with conductive contacts, and the atomizing unit has conductive pins, which together form conductive components. After the atomizing unit is aligned and installed in the mounting cavity, the conductive pins and conductive contacts touch each other.

8. A novel drug delivery device for ocular drug delivery according to claim 6, wherein: The atomizing body has a built-in rechargeable battery and circuit board. The circuit board is equipped with a charging interface, and the charging port is located on the outside of the body. The circuit board also has an indicator light. A light guide block is set on the outside of the body relative to the indicator light, and the inner end of the light guide block is directly opposite the indicator light.

9. A novel drug delivery device for ocular drug delivery according to claim 6, wherein: The atomizing unit includes a base and a bottom plate. The liquid inlet is located on the base and is connected to the liquid container by a thread. The inner cavity of the base is provided with a slot for inserting an atomizing plate, and the slot is provided with an inlet and an outlet. After the atomizing plate is inserted into the slot, the inlet and outlet of the slot meet the requirements for liquid entry and atomization discharge of the atomizing plate. The bottom plate is detachably closed to the inner cavity of the base. The atomizing plate inserted into the atomizing unit is a lead-free pressure-sensitive ceramic atomizing plate.

10. A novel drug delivery device for ocular drug delivery according to claim 6, wherein: The atomizing device is a mesh atomizing device.

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