62results about How to "Solve the side effects" patented technology

The invention discloses a sustained-release soluble microneedle, a preparation method and application. The microneedle comprises a base body, a needle body and a carrier which is distributed in the needle body and coated with a drug to be sustained-released, wherein the carrier comprises a degradable high polymer material or inorganic nanoparticles modified by a polymer. The method comprises the following steps of: preparing the carrier coated with the drug to be sustained-released by adopting one of an emulsion method, a dialysis method, a solvent evaporation method, a spray drying method anda polyelectrolyte protection method, wherein the carrier comprises the degradable high polymer material or the inorganic nanoparticles; and dissolving or dispersing the carrier coated with the drug to be sustained-released into a matrix solution, casting the matrix solution into a mold by utilizing a vacuumizing method, drying and demolding to obtain the sustained-release soluble microneedle. According to the sustained-release soluble microneedle, the degradable high polymer material or the inorganic nanoparticles modified by the polymer are used as the carrier of the drug, so that the release speed of the drug is slowed down.

The invention relates to a 10-deacetylbaccatin-9(R)-hydrogenation-1-deoxidized paclitaxel analog and a preparation method thereof. The structural formula of the analog is as the right; in the method of the invention, 1-deoxidized baccatin VI is taken as a material for synthesizing the 1-deoxidized paclitaxel analog. The method of the invention maintains the ring skeleton and the necessary functional group of taxanes and selects the taxanes as a semi-synthetic precursor or carries out structure decoration on the taxanes; the obtained output 10-deacetylbaccatin-9(R)-hydrogenation-1-deoxidized paclitaxel analog has the biological activity of antitumor of the natural paclitaxel and has a certain application prospect in the aspects of reducing the multidrug resistance and the side effects of the natural paclitaxel. The method has the advantages of easily obtained materials, simple and convenient operation, good selectivity and high yield.

The invention discloses a blue-light luminous capsule capable of being used for killing helicobacter pylori, which comprises a sealed shell. A control circuit board is arranged in the shell and is successively serially connected with a power source, a switch and an LED bulb emitting blue light, at least one portion in the shell is transparent, and accordingly the light emitted from the LED bulb is transmitted outwards. A blue-light bactericidal principle is adopted to realize the purpose of killing the helicobacter pylori of the gastrointestinal tract of a patient. The blue-light luminous capsule has the advantages of small volume, light weight, independent structure and the like, is applicable to realizing blue-light illumination in severe special environments such as gastrointestinal tracts and the like, can be integrally swallowed by the patient in a medicine taking manner, is used for realizing blue-light illumination for the inner wall of the gastrointestinal tract of the patient, kills the helicobacter pylori, is a pollution-free disposable miniature medical instrument, does not cause any wounds on gastrointestinal tissues and other organs of the patient, is fine in sterilization effect and free of poison and side effects, and excellently resolves problems that traditionally orally administrated medicine is poor in helicobacter pylori killing effect and high in side effects.

Disclosed is an interferon-α (IFN-α) fused protein having IFN-α fused to a cytoplasmic transduction peptide (CTP). The disclosure relates to a fused protein wherein a CTP, which binds well to cell-membrane barriers and enables translocation into the liver, is genetically fused to a human IFN-α, thereby enhancing the conjugation capacity of cell membranes and antiviral activity, inhibiting CTP transport into the cell nucleus, and enhancing the translocation and settlement of the fused protein into the liver and of transduction to the liver tissue. Accordingly, it is possible to develop protein-based medicines effective for preventing or treating various liver diseases associated with viral infection at low doses.

The invention discloses a traditional Chinese medicine for harmonizing liver and spleen, dispelling wind and eliminating dampness and nourishing blood and stopping throat pains. The traditional Chinese medicine is prepared from the following raw materials by weight: primary materials including 10g-30g of caulis sinomenii, 15g-30g of sarcandra glabra, 15g-30g of white paeony root, 15g-25g of Chinese angelica, 9g-20g of rhizoma atractylodis, 6g-15g of divaricate saposhnikovia root, 15g-20g of roasted rhizoma atractylodis macrocephaiae and 6g-15g of ligusticum wallichii, and auxiliary materials including 6g-15g of raw liquorice. The traditional Chinese medicine disclosed by the invention has the whole set of treatment effects of regulating the function of the liver and spleen, dispelling wind and eliminating dampness, nourishing blood and relieving throat pains, and the like, is especially suitable for patients with rheumatic disease (rheumatoid arthritis, and the like) symptoms such as muscular soreness, arthrocele, pain, inconvenient flexing and stretching, numb and stiffness, weakness, and the like. Moreover, the traditional Chinese medicine is integrated with treating and healthy qi-supporting, can be used for effectively improving the immunity of the body while treating the diseases, and effectively solving the problems such as great drug side effect, great injuries on body and poor treatment effect, of the existing bi-syndrome treatment.

The invention provides a targeting responsive release system. The targeting responsive release system comprises a chimeric apoptotic corpuscle, the chimeric apoptotic corpuscle comprises an apoptoticcorpuscle membrane and mesoporous nanoparticles wrapped in the apoptotic corpuscle membrane, the apoptotic corpuscle membrane is an apoptotic corpuscle membrane derived from immune cells, and the mesoporous nanoparticles are loaded with active substances. The system provides an effective means for constructing a specific treatment product with a targeted delivery function and an accurate drug release function.

The invention relates to a traditional Chinese medicine composition for treating skin diseases of a pet dog and a preparation method of the decocted fluid of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 10-30 parts of gardenia, 30-50 parts of cortex phellodendri, 30-50 parts of fructus kochiae, 30-50 parts of common carpesium fruit, 10-30 parts of cortex dictamni, 10-30 parts of mint, 10-30 parts of radix stemonae, 1-20 parts of honeysuckle flower, 10-30 parts of semen cassia, 1-20 parts of folium artemisiae argyi and 1-20 parts of angelica sinensis. The components of the traditional Chinese medicine composition are natural Chinese herbal medicines, have a good treatment effect on skin diseases of the pet dog by medicated bath, and does not affect the health of the pets; the pain when the pets are medicated is reduced; and economic pressure is reduced for owners of the pets.

The invention discloses a preparation method for alleviating or treating acnes by utilizing Chinese herbal medicines, aiming at solving the problem that the conventional medicine for treating acnes is large in side effects. The medicine comprises the following materials: 10g of salvia miltiorrhiza, 15g of scutellaria baicalensis, 15g of gardenia, 15g of honeysuckle flower and a proper amount of honey. The preparation method comprises the following steps: soaking the salvia miltiorrhiza, scutellaria baicalensis, gardenia and honeysuckle flower for 2 hours by using clear water, boiling the medicinal materials and the soaking water in an earthenware pot, boiling for half an hour by using soft fire, filtering the decoction dregs, and removing the filtrate; heating and concentrating while shaking, and blending the honey into thin paste; cleansing by using warm water, removing the facial oil and dirt, coating the salvia miltiorrhiza and gardenia mask, and washing the mask by using clear water within 30 minutes, wherein the mask is dressed once per day in the morning and evening. The mask has good curative effects on the festered acnes and the formed cystic acnes.

The invention relates to medicinal granules containing ginseng powder. The medicinal granules contain ginseng powder and cocoa powder. Not only can the taste be adjusted by combination of the ginseng powder and the cocoa powder, but also active components in the ginseng powder and the cocoa powder can be in supplement each other after being combined. Thus, the problem of a side effect generated by eating a single material can be solved, and the curative effect also can be improved.

The invention relates to traditional Chinese medicine ointment for preventing and treating fungal skin diseases of livestock and poultry. By the aid of the traditional Chinese medicine ointment, problems that fungal skin diseases cannot be thoroughly radically treated, medicine-resistant strains can be generated and toxic and side effects can be realized in the prior art can be effectively solved. The technical scheme includes that the traditional Chinese medicine ointment comprises, by weight, 15-30 g of traditional Chinese medicine extract, 8-15 g of stearic acid, 2-5 g of glyceryl monostearate, 2-5 g of liquid paraffin, 2-4 g of Vaseline, 2-5 g of lanolin, 0.5-1 g of triethanolamine, 0.2 g of ethylparaben, 10-20 g of urea and 30-60 mL of distilled water; the traditional Chinese medicine extract comprises, by weight, 50-100 parts of fructus cnidii, 50-100 parts of radix sophorae flavescentis, 10-50 parts of Szechwan chinaberry fruits, 10-50 parts of cortex dictamni, 10-50 parts of ligusticum wallichii, 10-50 parts of rhizoma smilacis glabrae, 10-50 parts of angelica dahurica, 5-15 parts of borneol and 2-10 parts of cantharides. The traditional Chinese medicine ointment has the advantages that effects of killing parasites to relieve itching, clearing away heat and drying dampness can be realized by the traditional Chinese medicine ointment, the traditional Chinese medicine ointment is free of toxic and side effects and is innovation in the aspect of medicines for the fungal skin diseases of the livestock and poultry, medicine resistance can be prevented, and the troublesome problems of medicine resistance and toxic and side effects when western medicines are used for treating fungal infection can be effectively solved.

The invention relates to a traditional Chinese medicine pill for treating psoriasis. The prescription comprises the following components: 30g of mother chrysanthemum, 15g of raw flos sophorae, 12g of cortex dictamni, 10g of fructus kochiae, 10g of fried rhizoma atractylodis macrocephalae, 15g of tuckahoe, 30g of fried coix seed, 10g of Chinese angelica, 15g of dried rhizome of rehmannia, 10g of red-rooted salvia root, 15g of radices lithospermi, 10g of tree peony bark, 15g of honeysuckle, 6g of raw liquorice, 10g of folium mori, 15g of roasted zaocys dhumnade, 8g of common cnidium fruit and 6g of semen armeniacae amarae. The invention mainly solves the technical problems of large side effect and high recurrence rate of conventional medicaments for treating the psoriasis and provides the traditional Chinese medicine pill which treats the psoriasis and has no toxic or side effects, short course of treatment, good curative effect, low price and easy and convenient carrying. The preparation method of the traditional Chinese medicine pill is carried out according to the preparation procedure of a conventional honeyed pill. The traditional Chinese medicine pill has the effects of dispelling wind, clearing heat, removing dampness, nourishing the blood to expel wind and moistening dryness and also has the advantages of good curative effect, high cure rate, no toxic or side effects, short course of treatment and low price.

The invention discloses an application of disulfiram to preparation of a drug for treating systemic lupus erythematosus. For the systemic lupus erythematosus, a lupus mouse model induced by pristane is taken as an experiment object. According to the application, the disulfiram can effectively improve the disease condition of a lupus mouse, and specific performances are as follows: (1) the urine protein level of the lupus mouse after being treated with the disulfiram is significantly reduced; (2) the disulfiram can reduce the level of a peripheral blood anti-dsDNA and the level of an inflammatory factor IL-1beta of the lupus mouse; and (3) after intervention is carried out by using the disulfiram, pathological damage to kidney of the lupus mouse is significantly reduced, and immune complexIgG and C3 deposits are also reduced.

The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis. The composition adopts the following 18 components for compatibility: largehead atractylodes rhizome, orange fruit, nutgrass galingale rhizome, dangshen, coptis root, medicinal evodia fruit, almonds, sharpleaf galangal fruit, radix astragali, turmeric root tuber, medicated leaven, raw hawthorn, morinda root, weeping forsythia capsule, radix bupleuri, honeysuckle, akebia stem and white paeony root. The composition has obvious treatment effects on chronic gastritis, intestinal metaplasia accompanied by atrophic gastritis and atypical hyperplasia. The composition has the following pharmacological characteristics that the composition invigorates the spleen and supplements qi, harmonizes the liver and spleen, regulates qi and dissipates dampness, removes stasis to stop pains, softens hardness to break stones, nourishes and relaxes the liver, nourishes yin with sour and sweet herbs and can adjust the functions of pylorus, prevent backflow of bile and promote damaged tissue healing and gastric mucosa regeneration. The composition makes up for the deficiency of single traditional Chinese medicine preparations, solves the problems that the Western medicines fail to solve and toxic and side effects and has short course of treatment and low side effects.

The present invention discloses a pharmaceutical formula for treating liver cirrhosis. The pharmaceutical formula for treating liver cirrhosis comprises the following components in weight ratios: 9-10g of radix bupleuri, 9 g of rhizoma pinelliae preparata, 9-12 g of radix scutellariae, 9-12 g of coptidis rhizoma, 12 g of radix codonopsis, 10-12 g of angelica sinensis, 10-12 g of radix paeoniae alba, 10-12 g of carapax trionycis preparata, 6-9 g of cortex magnoliae officinalis, 8-10 g of fructus psoraleae, 10-12 g of rhizoma atractylodis macrocephalae, 10-12 g of poria cocos, 9 g of honey-fried licorice root, 6 g of fresh ginger, 6 g of Chinese dates and 8-10 g of radix ophiopogonis. The pharmaceutical formula is suitable for treating liver cirrhosis and also solves a problem of large sideeffects of the existing drugs for treating liver cirrhosis. After years of clinical applications, symptoms of patients with liver cirrhosis are significantly improved and the quality of life is significantly improved.

The invention relates to the field of health care products, and particularly discloses a uric acid-reducing composition and a preparation method thereof, an oral medical agent and an application thereof, and the uric acid-reducing composition comprises the following raw materials: honeysuckle, chrysanthemum, lalang grass rhizome, reed rhizome, kudzuvine root, mulberry leaf, lotus leaf, lophatherumgracile, dandelion, corn stigma, liquorice, camellia nitidissima and red date. The uric acid-reducing composition provided by the invention can achieve the good uric acid reducing effect, can be usedfor reducing uric acid and preventing and treating gout through reasonable compatibility of various raw materials, is cheap, convenient and free of side effects, and can adjust purine metabolic disorder, promote uric acid excretion, reduce uric acid to a normal level and achieve the effect of treating gout by replacing medicines with tea without orally taking western medicines. The preparation method of the composition for reducing uric acid provided by the embodiment of the invention is simple, low in price and easy to implement, and solves the problem that most of the existing medicines forreducing uric acid are western medicines and have great side effects.

The invention discloses a polypeptide for killing tumor cells and application thereof, and belongs to the technical field of molecular biology. The invention aims to provide a polypeptide with strong concentration-dependent targeting property and strong stability. The sequence structure of the polypeptide is a + n (b) + a, a is any one amino acid or multiple amino acids in KKLL, b is KKLL, and n is an integer of 1-10. The larger the molecular weight of the polypeptide drug for killing tumor cells is, the stronger the drug effect is, and the smaller the molecular weight of the drug is, the smaller the drug effect is. In tumor treatment, the compound can be applied to drugs for killing tumor cells in a special administration mode or treatment schemes of special administration equipment.

The present invention combines the traditional theory of Chinese medicine compatibility with the modern pharmacology and the vegetable chemistry. The present invention provides a novel compound Chinese herbal recipe technology, as well as a formulation and a preparation method produced according to the technology for treating or assistantly treating tumor. The non-water-soluble active part of a manyflower tylophora root is used as the main drug or the principal drug; the non-water-soluble active part of a paris chinensis is used as the supplementary drug or the adjuvant drug; according to needs, the non-water-soluble active part of hairyflower actinidia root, ford nervilia leaf, sunplant, Herba Hedyotis, bittersweet root and or liquorice is used as the supplementary drug or the adjuvant drug for medicine compatibility. The present invention can decrease the toxic side effects caused by the large dosage of main drug in the process of treating tumor while increasing the main curative effect. The anti-tumor preparation provided by the present invention can effectively eliminate and inhibit tumor cells, protect and increase the hematopoietic cell function, and improve the immune system of human body.

The invention discloses a traditional Chinese medicine formula for treating child nephritis. According to the formula, the traditional Chinese medicine is prepared from 19g to 21g of corn stigma, 19g to 21g of rhizoma imperatae, 14g to 16g of folium callicarpae macrophyllae, 11g to 13g of honeysuckle flower, 11g to 13g of fructus forsythiae, 11g to 13g of plantain herb, 5g to 7g of cicada slough, 11g to 13g of herba cirsii, 14g to 16g of herba taraxaci, 14g to 16g of spica prunellae, 8g to 10g of radix isatidis, 14g to 16g of herba agrimoniae and 2g to 4g of safflower. The traditional Chinese medicine formula disclosed by the invention has a low price, is effective and has an accurate curative effect; the components have a synergistic effect and have the effects of promoting diuresis, eliminating swelling, lowering pressure, stopping bleeding and resisting bacteria; the traditional Chinese medicine formula is a traditional Chinese medicine formula which is used for treating the child nephritis and accords with the modern medicine; the problems that the side effect is great and an illness state is easy to recur when western medicines are used for treating the child nephritis; the traditional Chinese medicine formula is very suitable for being popularized in grass-roots units and is especially suitable for patients who live in villages which are far away from towns and are relatively remote; the problems of local low-income families of high expense in medical care and shortage of medical services and medicines are solved .

The invention provides a traditional Chinese medicine composition for treating oral ulcer. The traditional Chinese medicine composition is prepared from 10-18 parts by weight of licorice root, 20-26 parts by weight of bamboo leaf, 6-12 parts by weight of Chinese angelica, 3-7 parts by weight of rhizoma cimicifugae, 2-5 parts by weight of borneol, 8-15 parts by weight of coptis root, 5-7 parts by weight of cassia seed and 1-3 parts by weight of cinnabar. The traditional Chinese medicine composition has the advantages of fast action, short treatment course, difficult relapse and no side effect.

The invention discloses a field plate, a manufacturing method of a semiconductor device and the semiconductor device. The manufacturing method of the semiconductor device comprises the manufacturing method of the field plate. The manufacturing method of the field plate comprises the step of manufacturing field plate oxide layers with different thicknesses by adopting TEOS deposition and high-temperature thermal annealing methods, so that the thickness of the field plate oxide layers can be increased under the condition of not causing surface silicon damage, and the voltage endurance capabilityof the device can be improved; the preparation of the field plate is completed by two steps of etching: firstly, performing dry etching and wet rinsing to obtain a middle-stage field plate structure,and then performing dry etching on the end part of the middle-stage field plate structure to obtain a final-stage field plate structure, so that the edge defect of the middle-stage field plate structure caused by wet rinsing is eliminated, and the voltage-withstanding reliability of a device is improved. The manufacturing method of the semiconductor device and the semiconductor device comprise the manufacturing method of the field plate, and a field plate oxide layer with a large thickness can be obtained, and the voltage withstanding is reliable.

The invention provides a method for treating acne through dandelion masks. Acne is relieved or treated through pure natural Chinese herbal medicines to solve the problem that existing medicines have many side effects when used for treating acne. The raw materials are 120 g of dandelions, 50 g of mung beans and 10 g of honey. The method comprises the steps that 120 g of the collected whole dandelions are decocted in water; 500 ml of clean juice is taken; 50 g of the mung beans are added into the dandelion juice and boiled till the mung beans explode; 10 g of the honey is mixed with the dandelion juice; the mung beans and soup are eaten up in several times in one day; meanwhile, the residual soup is smeared on the face and washed off 30 minutes later; and eating of the mung beans and the soup and smearing of the residual soup are continuously conducted for more than a week. The dandelion is also called the diluteyellow crotalaria herb and has heat clearing, toxicity removing and broad-spectrum antibacterial effects; the mung beans are matched with the dandelions to strengthen the curative effects of heat clearing and toxicity removing; and the honey is matched with the dandelions for seasoning, antibacterial and anti-inflammation effects of the dandelions are strengthened, and the soup has direct decontamination and antibacterial effects when smeared on the face and nutritious and caring efficacies.

The invention relates to the field of medicines, and particularly discloses a traditional Chinese medicine composition, a preparation method thereof, an external medicine and application. The traditional Chinese medicine composition comprises oldenlandia diffusa, wild chrysanthemum flower, sea clam shell, seaweed, bryozoatum, spina gleditsiae, prunella vulgaris, ricepaperplant pith, forsythia, herba violae, dandelion, patrinia herb, houttuynia cordata, ampelopsis japonica, rhizoma smilacis glabrae, barberry root, humulus japonicus, astragalus membranaceus, toad, radix paeoniae rubra, loofah sponge, fructus gardeniae, radix trichosanthis, peach kernels, bletilla striata, pseudo-ginseng, safflower carthamus, angelica sinensis, cowherb seeds, verbena officinalis, eupolyphaga, solanum lyratum,cottonrose hibiscus leaves, paris polyphylla, pangolin scales, dragon's blood, olibanum, myrrh and other raw materials. The traditional Chinese medicine composition provided by the invention is a pure traditional Chinese medicine for external use and has the advantages of no toxic or side effects, the preparation method provided by the invention is simple, black and bright plaster is formed through a chemical reaction generated at high temperature, the effects of removing stasis, diminishing swelling, dispersing blood stasis, diminishing inflammation, relieving pain and the like are achievedthrough application, and the problem that most of existing medicines for removing stasis and diminishing swelling are western medicines and have toxic and side effects is solved.

The invention discloses a traditional Chinese medicine formula for treating angina pectoris in coronary heart disease, wherein the traditional Chinese medicine formula includes the following traditional Chinese medicine components in parts by weight: 16 g of raw radix astragalis, 10-16 g of raw basked ginseng, 16 g of salvia miltiorrhiza, 13 g of full radix angelica sinensis, 13 g of rhizoma corydalis, 13 g of ligustici wallichii, 12-18 g of pogostemon cablin, 10-16 g of herba eupatorii, 13 g of dried tangerine or orange peel, 13 g of pinellia ternata, and 6-13 g of raw rheum officinale. A preparation and using method of the traditional Chinese medicine composition comprises the steps: in first decoction, adding water with the amount 10-15 times of the total weight of the medicinal materials, decocting and extracting, and decocting for 1-2 h; in a second time, adding water with the amount 8-12 times of the total weight of the medicinal materials, decocting for 1-1. 2 h, and filtering out to obtain a drug liquid for standby application; in a third time, adding water with the amount of 8-12 times of the total weight of the medicinal materials, decocting for 0. 8-1. 2 h, and filteringout a drug liquid for standby application; merging the three-time decoction liquids, and filtering; and taking one dose a day, and warmly taking for 3 times respectively in the morning, at noon and in the evening, wherein one treatment course comprises 6 doses, and the medicine is needed to be taken for 3-5 treatment courses.