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Application of disulfiram to preparation of drug for treating systemic lupus erythematosus

A systemic technology for lupus erythematosus, applied in the field of medicine, can solve the problems of high price, large side effects of treatment methods, etc., and achieve the effects of low price, easy availability, and reduced deposition

Inactive Publication Date: 2020-09-15
南方医科大学第三附属医院(广东省骨科研究院)
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] The purpose of the present invention is to provide the application of disulfiram in the preparation of drugs for the treatment of systemic lupus erythematosus, so as to solve the problems of large side effects and high price of existing systemic lupus erythematosus treatment means

Method used

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  • Application of disulfiram to preparation of drug for treating systemic lupus erythematosus
  • Application of disulfiram to preparation of drug for treating systemic lupus erythematosus
  • Application of disulfiram to preparation of drug for treating systemic lupus erythematosus

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Embodiment

[0027] The experimental animals were 6-8 weeks old, female BALB / c mice, which were purchased from Guangdong Experimental Animal Center. All animals were raised under specific non-pathogenic conditions in the Experimental Animal Center of Southern Medical University. All experimental operations and feeding methods were reviewed and approved by the Experimental Animal Ethics Review Committee of Southern Medical University.

[0028] method:

[0029] (1) Establishment of Pristane-induced lupus mouse model

[0030] Female BALB / c mice of 6-8 weeks were selected, and 500 μl of pristane (pristane) was injected intraperitoneally once to establish the model. Starting from the 6th week after the injection, the urinary protein level was detected every two weeks until two consecutive occurrences When the urinary protein score is greater than 1 +, it is judged that the mouse has developed the disease and the model is successfully established. For the urinary protein score, see method (3)....

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Abstract

The invention discloses an application of disulfiram to preparation of a drug for treating systemic lupus erythematosus. For the systemic lupus erythematosus, a lupus mouse model induced by pristane is taken as an experiment object. According to the application, the disulfiram can effectively improve the disease condition of a lupus mouse, and specific performances are as follows: (1) the urine protein level of the lupus mouse after being treated with the disulfiram is significantly reduced; (2) the disulfiram can reduce the level of a peripheral blood anti-dsDNA and the level of an inflammatory factor IL-1beta of the lupus mouse; and (3) after intervention is carried out by using the disulfiram, pathological damage to kidney of the lupus mouse is significantly reduced, and immune complexIgG and C3 deposits are also reduced.

Description

technical field [0001] The invention belongs to the field of medicines, and in particular relates to the application of disulfiram in the preparation of medicines for treating systemic lupus erythematosus. Background technique [0002] Systemic lupus erythematosus (SLE) is an autoimmune disease that accumulates in multiple organs throughout the body. It is typically characterized by a large number of antibodies against its own extracellular components and the formation of antigen-antibody complexes. SLE mainly affects women of childbearing age, with complex conditions and a high incidence rate. The disease course is repeated and protracted, and the disability rate is high. [0003] However, the current treatment measures for SLE are still based on glucocorticoids and cytotoxic drugs. However, this clinical treatment method has side effects such as opportunistic infection, fracture, and gonad suppression, and is expensive, requiring long-term or even life-long administration...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/145A61P37/02
CPCA61K31/145A61P37/02
Inventor 孙尔维庄丽丽何懿罗晓青庄坚吴舒帆李业豪杨方圆张亚楠翟泽清梁建亨
Owner 南方医科大学第三附属医院(广东省骨科研究院)
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