87results about How to "Reduce treatment risk" patented technology

The invention discloses a microwave ablation needle and a microwave ablation therapeutic apparatus thereof, and relates to a structure of the microwave ablation needle and the microwave ablation therapeutic apparatus using the microwave ablation needle. The microwave ablation needle mainly comprises an ablation needle, an ablation needle tube, a microwave coaxial cable, a capillary, a handle with a crank, a temperature sensor, a fixed frame, a high-frequency joint and a water cavity, wherein the fixed frame comprises the high-frequency joint, a water inlet joint, a water outlet joint and the temperature sensor and is connected with a terminal external socket; the high-frequency joint comprises a lock card reed; and the water cavity used for circulating cold water is arranged in the handle. The circulating water enters the capillary from the water inlet joint, then enters the water cavity from the ablation needle tube, and finally flows out from the water outlet joint. The microwave energy enters the microwave coaxial cable from the high-frequency joint, and radiates through the ablation needle. The microwave ablation needle, a microwave power source and a computer control unit form the microwave ablation therapeutic apparatus. The microwave ablation needle and the microwave ablation therapeutic apparatus are mainly used for treating tumor through microwave ablation.

The invention relates to 3D navigation equipment for non-invasive real-time operation positioning, which is characterized by comprising a laser positioning system and a space positioning device, wherein the laser positioning system is composed of a laser driving device, a work server, a digital signal shunt and a display, the laser driving device is in Bluetooth communication with the work server, and the work server, the digital signal shunt and the display are electrically connected; and the space positioning device is composed of a fixing slide rail, a two-way slide rail, a two-degree-of-freedom fixing slide block, a two-degree-of-freedom two-way slide block, a laser positioning rod and an operation channel which are mutually matched. According to the invention, path planning before an operation is realized through a computer, and an operation path can be spatially positioned accurately by visualized real-time registering of a focus point in the operation by the laser positioning system as well as the angle and depth control of the space positioning device; and the system is suitable for minimally-invasive orthopedic operations of any parts of patients.

The invention relates to the field of medical instruments, in particular to a vein continuous infusion intelligent controller and an application method thereof. The technical scheme is as follows: a single machine can realize uninterrupted continuous infusion of multiple bags; according to different types of drug in each bag, the dropping speed and drug amount can be regulated; the intelligent controller can automatically rinse an infusion tube, automatically gives an alarm and closes for abnormal infusion, automatically closes after infusion is finished and notifies a central display monitor system to process. The invention changes the current situation of gravity infusion, artificial care, manual bag change and manual dropping speed control, greatly lightens the labor intensity and psychological nervousness of hospitals and patient family members, causes infusion treatment to become relaxed, safe, ordered, precise and controllable and can greatly save manpower, so that nurses have time to observe the treatment situation of patients. In addition, the invention can improve clinic drug administration efficiency, lowers treatment risk, improves vein drug administration treatment level, and improves hospital treatment level and nursing images; and furthermore, the invention has low manufacture cost and strong practicality and is favorable for popularizing and applying.

The invention provides a method and a kit for detecting BRCA1 and BRCA2 gene mutation. The method and the kit utilize two sets of PCR (polymerase chain reaction) primers, wherein a first set of PCR primers comprises 189 pairs of PCR primers and is divided into two groups, a first group comprises 95 pairs of primers with sequences represented as SEQ ID NO.5-SEQ ID NO.194, a second group comprises 94 pairs of primers with sequences represented as SEQ ID NO.195-SEQ ID NO.382, a sequence represented as SEQ ID NO.1 is added to the 5' end of each upstream primer, and a sequence represented as SEQ ID NO.2 is added to the 5' end of each downstream primer; sequences of upstream and downstream primers of a second set of PCR primers are represented as SEQ ID NO.3 and SEQ ID NO.4.

The invention discloses a method and system for realizing artificial intelligence medical system based on VR model. The method comprise: S1 Import CT image file, S2 reconstruct an image according to that CT image file, S3, after image reconstruction, inputting into a CNN convolutional neural network to obtain image segmentation of the affected area and S4 generates a surface model according to thespatial information, S5 imports the surface model into a virtual reality environment, and S6 renders the result in real time in the virtual reality environment. The invention can further simulate theoperation of various treatment means on the model, thereby changing the medical image reading mode in the prior art and carrying out operation planning, thereby greatly reducing the treatment risk. The invention adopts artificial intelligence algorithm based on neural convolution network, which can accurately, more effectively and more separably screen and segment the image of the affected part.

The invention relates to an anti-cancer composition with synergistic effect, specifically a composition comprising an effective amount of at least one VEGF / VEGFR inhibitor and dopamine. The composition provided by the invention can obviously inhibit the growth of tumor cells, substantially reduce the use of anticancer drugs, and reduce the treatment risk and cost, and has broad application prospects.

The invention provides a dyskinesia non-intrusive rehabilitative closed-loop brain-computer integrated system based on an FPGA. The FPGA is used as a control core of the system, nuclei basales and thalamic-cortical prosthesis hardware model is set up, data obtained through calculation of a self-adaptation control algorithm based on the FPGA is used as input to control model parameter setting and force feedback and adjustment until an expected control result is achieved, the self-adaptation control algorithm based on the dynamic causal model is realized, force feedback signals are output, and therefore rehabilitation of patients with the dyskinesia nervous system diseases is achieved. Rehabilitation of the patients with dyskinesia nervous system diseases is achieved, and the complex nuclei basales and thalamic-cortical neuron network and the self-adaptation control algorithm of the dynamic causal model are modeled. The platform provides the effective theoretical basis and technical support for rehabilitation of the dyskinesia nervous system diseases and has important practical value in research on control and treatment on nerve diseases such as Parkinson's disease, epilepsia and alzheimer's disease.

The invention discloses an image guide method implemented by the aid of two-dimensional images. The image guide method includes steps of selecting and screening reference feature regions; searching real-time feature regions; performing positioning and computing on the basis of the reference feature regions and the real-time feature regions; estimating deformation and errors, and the like. The image guide method has the advantages that two-dimensional DRRs (digitally reconstructed radiographs) need to be generated according to three-dimensional images of lesions of patients when image guide is carried out by the aid of two-dimensional images, and then the feature regions in real-time images which are acquired in real time are compared to feature regions in the two-dimensional DRRs, so that deviation among current locations and preset locations can be determined; markers do not need to be implanted in the patients when the patients are examined by the aid of the image guide method, accordingly, suffering can be relieved for the patients, and treatment risks and the treatment cost can be reduced for the patients.

The invention provides gRNA, a gene editing system, an expression vector and a gene editing kit for repairing HBB1 gene point mutation. Two common mutation sites of HBB genes can be repaired through one-time gene editing aiming at fixed-point repair of beta 17 (A ->T) and beta 41-42 (-TCTT), and thus treatment methods of thalassemia and sickle-shaped anemia are expanded; and in addition, the editing is directly preformed in hematopoietic stem cells (HSC), and compared with gene editing of iPS cells in the prior art, the safety risks of cell carcinogenesis and mutation are avoided, and the clinical use is safer.

The invention discloses a choking device of atrium and ventricular septal defects and patent foramen ovale, which is safe and convenient for operation release, comprising a front tray 1 and a rear tray 2 which are approximate mushroom-shaped and composed of a plurality of metal wires, the front tray 1 and the rear tray 2 can hold the opening of atrium and ventricular septal defects and patent foramen ovale, especially, the metal wire extended by the front tray 1 and the metal wire extended by the rear tray 2 are all fixed by a rear chucking appliance on the outer surface of the rear tray 2, the rear chucking appliance 3 has screw threads connected with a conveyor, the structure of the invention is reasonable, especially a lumbar part formed by being braided with the front tray and the rear tray together recorded in the existing technology is not provided between the front tray and the rear tray, and the front tray and the rear tray are all composed of separate a set of metal wires, so the interactive pull force of the existing technology is not provided between the front tray and the rear tray. Accordingly, after the front tray is released from the tube of the conveyor, the maximum size state can be reached rapidly.

The invention relates to a detection method for BRAF gene mutation, comprising the following steps: a) extracting DNA of tumor tissue; b) with the extracted DNA in step a) as the template, carrying out PCR amplification by using a primer pair comprising SEQ (1) and SEQ (2) in a sequence table and Taqman-MGB probes of SEQ (3) and SEQ (4); c) carrying out BRAF allele identification and analysis on products of the amplification in step b). The detection method provided in the invention can assist clinicians in detecting BRAF gene mutation of patients and provide guidance and basis for clinicians to use medicines, and therefore risk in treatment for clinicians and economic burden for patients are reduced. According to the invention, high flux detection is realized and up to 96 samples can be detected at a time; the detection method has a simple process, thereby substantially raising detection accuracy; detection time is short; wild type and mutant alleles can be detected simultaneously; and high sensitivity and good specificity are obtained.

The invention relates to a radiofrequency ablation micro-catheter. The radiofrequency ablation micro-catheter comprises a catheter body, a heating resistor winding the catheter body and fiber gratingwinding the catheter body, wherein the heating resistor is a single-loop flaky heating resistor with an inner layer and an outer layer; the fiber grating comprises an inner layer and an outer layer; the front end of the catheter body is provided with an ultrasonic probe. The radiofrequency ablation micro-catheter has the advantages that the miniature ultrasonic probe is used for imaging to observethe state of blood vessels or cavities during thermal ablation treatment in real time; the fiber grating winding the catheter body is used to detect temperature and stress strain during the thermal ablation treatment; by the flaky heating resistor, the detection and control function of the thermal ablation micro-catheter can be increased greatly, and the structural size of the radiofrequency ablation micro-catheter can be effectively controlled; the control ability and treatment effect during the thermal ablation treatment can be evidently increased, and treatment risks can be lowered.

The invention provides a gRNA and gene editing system for repairing HBB1 gene site mutation, an expression vector and a gene editing kit. The gRNA aims at site-directed repair of [beta]17 (A->T) and [beta]41-42 (-TCTT), two common mutation sites of an HBB gene are repaired through one-time gene editing, and treatment methods of thalassemia and sickle anemia are expanded; in addition, the gene editing system is used for editing directly in hematopoietic stem cells (HSC); compared with gene editing on iPS cells in the prior art, the safe risks of cell carcinogenesis and mutation are avoided, andthe clinical use is safer.

The invention provides a sealing connection method of a vacuum sealing drainage device and an orthopedic external fixator and a vacuum sealing drainage system. The system comprises the vacuum sealing drainage device and sealing rubber rings for connecting and sealing puncture needles on the orthopedic external fixator and the vacuum sealing drainage device, wherein the sealing rubber rings comprise elastic sealing sleeves and sealing bases which are positioned on the lower parts of the elastic sealing sleeves and extend outwards; and the elastic sealing sleeves and the sealing bases are mutually communicated. When the method is used, the sealing rubber rings are sleeved on the lower parts of the puncture needles of the orthopedic external fixator; after the puncture needles of the orthopedic external fixator are located, notches are cut on the positions, corresponding to the puncture needles of the orthopedic external fixator, of a porous foam cushion and a sealing film, the puncture needles penetrate through the notches, and the sealing film of the vacuum sealing drainage device and the porous foam cushion completely cover the surroundings of the puncture needles of the orthopedic external fixator; and then the sealing rubber rings are adjusted downward so that the bases of the sealing rubber rings are fit with the sealing film of the vacuum sealing drainage device, thus the sealing rubber rings completely cover and seal the notches of the sealing film in the positions of the puncture needles.

The invention discloses a portable circulation therapeutic instrument. The portable circulation therapeutic instrument comprises a lower base and a machine body, the machine body is fixed to the upperend of the lower base, the machine body comprises an air compressor, and a central processing unit is arranged at the front end of the machine body. Air is transmitted to airbag cavities through theair compressor, the central processing unit is used for controlling the air to be conveyed and sucked into the airbag cavities repeatedly, a pressure sensor is used for detecting the pressure on the human body, the flow of an air conveying device in unit time is adjusted according to a feedback signal of a detection device in order to change the pressure of the airbag acting on the treatment partof the human body, by controlling the inflation time of all the air bag cavities, unequal-pressure inflation of all the airbag cavities can be achieved, a directional and progressive extrusion mode can be achieved when the pressure acts on the human body, backflow of deposited venous blood and lymph can be further promoted, and a better use prospect is brought.

The invention discloses a balloon catheter with balloons with two asymmetric ends. The balloon catheter comprises a fixed catheter, wherein one end of the fixed catheter is fixedly connected with a catheter end; a clamping groove is formed in one end of the catheter end; a puncture needle is clamped in the clamping groove; one side of the outer surface of the fixed catheter is fixedly connected with first balloons and the other side of the outer surface of the fixed catheter is fixedly connected with first drug layers; a movable catheter sleeves the outer surface of the fixed catheter; and oneside of the outer surface of the movable catheter is fixedly connected with second balloons. According to the balloon catheter with the balloons with two asymmetric ends, through the arrangement of the clamping groove and the puncture needle, the target that the puncture needle can be properly disposed after use to reduce the risk is achieved; and through the arrangement of a first ventilation pipe, a second ventilation pipe, a third ventilation pipe and a fourth ventilation pipe, the target that the size of each balloon can be conveniently adjusted to reduce the pain of a patient is achieved.

The invention relates to application of epigallocatechin gallate (EGCG) combined with a tyrosine kinase inhibitor in the preparation of a cancer treatment medicament, and belongs to the technical field of biological medicines. The invention provides a drug administration method combining epigallocatechin gallate (EGCG) as a lead compound with a tyrosine kinase inhibitor, and the combined use can obviously inhibit the growth of EGFR wild-type tumors, and reduce the treatment risk and toxic or side effects caused by anti-cancer drugs in larger doses. The invention improves the sensitivity of theinhibitor and widens the application range of the inhibitor. The invention provides an effective treatment strategy for EGFR wild-type cancer patients.

The invention discloses a medical laser thermal therapy target head based on a graphite-based composite thermal conductive material. The medical laser thermal therapy target head comprises a protective jacket, an inner heat insulating layer, heat conductive bands and an outer heat insulating layer. The front end of the protective jacket is provided with an end head, and the back end is provided with a connecting body. A side part of the connecting body and the center of the back end part of the connecting body are respectively provided with openings which communicate through a channel. A fiberextends into the opening of the center of the back end part of the connecting body and reaches the opening of the side part of the end head. The inner heat insulating layer coats the outer peripheryof the fiber at the back end of the connecting body. The multiple layers of heat conductive bands are spaced apart at the outer periphery of the heat insulating layer, and each layer of heat conductive bands is spaced. The outer heat insulating layer coats the outer periphery of the heat conductive bands which are formed by multiple long curved pieces. The heat conductive bands are made of graphite-based heat-conducting materials. The problem of burning due to thermal deposition and the flexibility of the target head during the use of the target head are solved, the improvement of the power ofthe medical laser thermal therapy target head is facilitated, and the mass of the target head is reduced.