34 results about "Cortical neuron" patented technology

The present invention relates to the effect of Radix Pseudostellariae water extract, Radix Pseudostellariae cyclic peptide extract, and Radix Pseudostellariae cyclic peptide B on memory enhancement in normal mice and the improvement of learning and memory impairment in dementia mice induced by Aβ1-42 injection into the contralateral ventricle, and explores the mechanism of action thereof. The results clearly indicate that Radix Pseudostellariae water extract, Radix Pseudostellariae cyclic peptide extract, and Radix Pseudostellariae cyclic peptide B can significantly enhance the cognitive and memory ability of normal mice and improve the memory impairment of dementia model mice, promote the regeneration of neuronal processes in the cerebral cortex, and protect against the loss and protrusion atrophy of cortical neurons induced by Aβ; the results suggest that Radix Pseudostellariae cyclic peptide B and Radix Pseudostellariae water and cyclic peptide extracts may improve memory by promoting the regeneration of nerve processes and rebuilding the neural circuit network, and can be used for preparing medicines or health foods for preventing and treating Alzheimer's disease.

The invention discloses tissue engineering neural tissue and a constructing method thereof, and belongs to the technical field of tissue engineering. Silk fibroin and collagen composite materials areadopted, primary cortical neurons are adopted as seed cells for three-dimensional culture, and tissue engineering neural tissue is formed. The operation steps are simple, and can be easily executed repeatedly, and no special technology or equipment requirement is met. The neural tissue constructed under the system generates a neural network with abundant network connection. The mechanical performance of the adopted silk fibroin is suitable for neural cell inoculation and culture, and the elasticity modulus of the neural tissue is close to that of rat brain tissue.

The invention discloses the application of an exogenous recombinant protein Reelin in the preparation of a drug for treating cerebral hemorrhage, belonging to the technical field of biomedicine. The invention discloses the time course change process of pyroptosis in striatum and cortex tissue after cerebral hemorrhage; the distribution of pyroptosis in different cell types in striatum and cortex tissue after cerebral hemorrhage; proves that Reelin improves striatum after cerebral hemorrhage It is proved that Reelin can reduce the pyroptosis of striatum and cortical neurons after cerebral hemorrhage; the present invention provides a basis for using Reelin as a new type of drug for the treatment of cerebral hemorrhage.

The invention belongs to the field of life science / medical technology, and discloses a non-therapeutic perceptual training method for inducing the plasticity of the auditory cortex, which includes a training device, which is located in a sound-proof shielding box, including a controller, a sound generator, Loudspeaker, food feeder, infrared nose detector and lighting lamp. The invention also discloses the application of the training device in induction of auditory cortical plasticity and perception training. The invention has the characteristics of non-invasiveness and broad spectrum, improves the frequency selectivity of auditory cortex neurons, and has wide application prospects.

The invention provides the application of extracellular vesicles derived from mesenchymal stem cells in cerebral ischemia-reperfusion injury. The present invention discovers and confirms that extracellular vesicles (MSCs-EVs) derived from mesenchymal stem cells can treat brain dysfunction and neuroprotection through neurogenesis and angiogenesis after stroke. The results of the study showed that MSCs-EVs could significantly alleviate the neurological deficit at 24h and 48h after MCAO in rats, reduce the volume of cerebral infarction and brain water content, improve the pathological damage of the cortex of the brain tissue, and attenuate the apoptosis of cortical neurons and significantly up-regulate p‑AMPK, while p‑JAK2, p‑STAT3 and p‑NF‑κB were downregulated. The present invention provides essential support for the use of MSCs‑EVs as a potential therapeutic strategy for MCAO treatment.

A method is disclosed for predicting the stimulation effect of cortical neurons in response to extracellular electrical stimulation. The method comprising the steps of defining an electrode configuration, defining a reconstructed neuronal cell type, wherein the reconstructed neuronal cell is characteristic of the physical and electrical properties of a neuronal cell, computing an electric field potential at the reconstructed neuronal cell, computing an effective transmembrane current of an arborization of the reconstructed neuronal cell, and determining a probability of activation of the reconstructed neuronal cell. A method for inducing an electrical stimulation effect on a cortical column is also disclosed. In an embodiment, the predicted network response of a cortical column is used to configure one or more electrodes to induce cortical stimulation.