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Application of heterophyllin b in improving memory and/or preventing and treating senile dementia

A technology for Alzheimer's disease and memory improvement, applied in the field of biomedicine, can solve problems such as brain neurodegeneration, damage to neuronal microtubule structure, loss of function of cell vascular system, etc., and achieve the effect of promoting protrusion regeneration and improving memory

Active Publication Date: 2020-09-01
GUANGDONG OCEAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Tau protein is the microtubule-associated protein with the highest content. After hyperphosphorylation, it will cause the loss of function of the cell vascular system, destroy the microtubule structure of neurons, cause brain neurodegeneration, and lead to Alzheimer's disease
Pseudostellariae peptides can play an immunomodulatory role by activating Ca2+ / CaN / NFATc1 / IFN-γ signaling pathway in splenic lymphocytes, and Pseudostellaria cyclic peptide B can improve LPS-induced macrophage RAW264 by inhibiting PI3K / Akt signaling pathway. 7 The role of inflammation and oxidative stress; but there is no report about the effect of Pseudostellaria Pseudostellariae extract, especially Pseudostellaria cyclic peptide extract on the nervous system

Method used

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  • Application of heterophyllin b in improving memory and/or preventing and treating senile dementia
  • Application of heterophyllin b in improving memory and/or preventing and treating senile dementia
  • Application of heterophyllin b in improving memory and/or preventing and treating senile dementia

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Effect test

Embodiment 1

[0033] The preparation of embodiment 1 Radix Pseudostellariae water extract

[0034] Pseudostellaria Pseudostellariae (produced in Fujian Province) dried root tuber 30g, add 3L water to extract once, keep slightly boiling state for 1 hour, filter, the filtrate is freeze-dried to obtain water extract 7.2g, the yield is 24%.

Embodiment 2

[0035] Example 2 Preparation of Pseudostellaria cyclic peptide extract by organic solvent extraction

[0036] Pseudostellaria Pseudostellariae (produced in Fujian Province) dried root tuber 30g, add 3L 95% ethanol to extract once, keep slightly boiling state for 1 hour, filter, the filtrate is dried under reduced pressure to obtain alcohol extract. Resuspend the alcohol extract in 400mL petroleum ether, stir and dissolve twice at room temperature, discard the petroleum ether solution, add 400mL ethyl acetate to dissolve and extract twice, combine the filtrates, and dry under reduced pressure to obtain 200mg of total cyclic peptide extract, containing Pseudostellaria cyclic peptide B about 10mg.

Embodiment 3

[0037] Example 3 Preparation of Pseudostellaria cyclic peptide extract by macroporous resin method

[0038] Pseudostellaria Pseudostellariae (produced in Fujian Province) dried root tuber 30g, add 3L 95% ethanol to extract once, keep slightly boiling state for 1 hour, filter, the filtrate is dried under reduced pressure to obtain alcohol extract. Enriched with a macroporous adsorption resin column, gradient eluted with water, 40% ethanol, 65% ethanol, and 90% ethanol respectively, collected the 65% ethanol eluate, recovered ethanol under reduced pressure, and obtained 235 mg of total cyclic peptide extract, containing Prince Edward Circadin B is about 12mg.

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Abstract

The present invention relates to the effect of Radix Pseudostellariae water extract, Radix Pseudostellariae cyclic peptide extract, and Radix Pseudostellariae cyclic peptide B on memory enhancement in normal mice and the improvement of learning and memory impairment in dementia mice induced by Aβ1-42 injection into the contralateral ventricle, and explores the mechanism of action thereof. The results clearly indicate that Radix Pseudostellariae water extract, Radix Pseudostellariae cyclic peptide extract, and Radix Pseudostellariae cyclic peptide B can significantly enhance the cognitive and memory ability of normal mice and improve the memory impairment of dementia model mice, promote the regeneration of neuronal processes in the cerebral cortex, and protect against the loss and protrusion atrophy of cortical neurons induced by Aβ; the results suggest that Radix Pseudostellariae cyclic peptide B and Radix Pseudostellariae water and cyclic peptide extracts may improve memory by promoting the regeneration of nerve processes and rebuilding the neural circuit network, and can be used for preparing medicines or health foods for preventing and treating Alzheimer's disease.

Description

technical field [0001] The present invention relates to the technical field of biomedicine, and more specifically, relates to the application of heterophyllin B in improving memory and / or preventing and treating senile dementia. Background technique [0002] Alzheimer's disease (AD) is a long-term progressive neurodegenerative disease, accounting for about 60% to 70% of the total number of dementia patients. The inhibitor rivastigmine and the NMDA receptor inhibitor memantine belong to symptomatic therapy, which are not enough to improve the memory function of patients and are accompanied by serious side effects. The number of dementia patients in China ranks first in the world. According to reports, the number of dementia patients in China is expected to reach 14.1 million in 2020 and 23.3 million in 2030, bringing huge economic and nursing burdens to families and society. [0003] The pathogenesis of Alzheimer's disease has not yet been clarified. However, there are many...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/12A61K36/36A61P25/28A23L33/105A23L33/18
CPCA23V2002/00A61K36/36A61K38/12A23L33/105A23L33/18A61P25/28A23V2200/322A23V2250/21A23V2250/55A23V2300/14A23V2300/10
Inventor 杨志友胡雪琼杨隆恩张才刘白平
Owner GUANGDONG OCEAN UNIVERSITY
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