Active salt of dipeptide compound of ornithine and aspartic acid as well as application thereof

A peptide compound, aspartic acid technology, applied in the field of medicine, can solve the problems of undisclosed ornithine and aspartic acid dipeptide compound active salts, undisclosed uses, etc.
CN107573404AActive Publication Date: 2018-01-12NANJING YOUKE BIOLOGICAL MEDICAL RES +3
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
NANJING YOUKE BIOLOGICAL MEDICAL RES
Publication Date
2018-01-12

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Abstract

The invention provides active salt of a dipeptide compound of ornithine and an aspartic acid, a preparation method of the active salt, a pharmaceutical composition including the active salt, and application of the dipeptide compound or the active salt thereof in preparation of medicine for preventing or treating hyperammonemia or liver diseases, in particular to hepatic encephalopathy. A test result clearly indicates that after the dipeptide compound of the ornithine and the aspartic acid and the active salt of the dipeptide compound are administered, the concentration of blood ammonia can beobviously reduced, and secondary memory disorder after TAA(tumor-associated antigen)-induced liver injury in rats can be obviously improved, indicating that the dipeptide compound and the active saltof the dipeptide compound have a certain treatment effect on hyperammonemia or liver diseases, in particular to the hepatic encephalopathy.
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Description

technical field

[0001] The present invention belongs to the field of medicine, and in particular relates to an active salt of an ornithine and aspartic acid dipeptide compound, a preparation method thereof, a pharmaceutical composition containing the active salt, and the dipeptide compound or its active salt in Use in the preparation of medicines for preventing or treating hyperammonemia or liver disease, especially hepatic encephalopathy. Background technique

[0002] Hepatic encephalopathy (HE) is a complex neuropsychiatric disorder that occurs in a variety of clinical conditions such as acute or chronic liver disease and spontaneous portosystemic shunts. In the early stages of hepatic encephalopathy, subtle mental changes such as difficulty concentrating, confusion, and disorientation occur. In severe cases, hepatic encephalopathy can lead to stupor, coma, swelling of the brain (cerebral edema), and death. Accumulation of ammonia is thought to play an important role in ...

Claims

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