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505 results about "Medication taking" patented technology

Medication adherence, or taking medications correctly, is generally defined as the extent to which patients take medication as prescribed by their doctors. This involves factors such as getting prescriptions filled, remembering to take medication on time, and understanding the directions.

Meloabalin besylate double-release preparation and preparation method thereof

PendingCN119970683ANervous disorderPeptide/protein ingredientsSustained release pelletsImmediate release
The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a meloabalin besylate double-release preparation and a preparation method thereof. Comprising a quick-release pellet and a sustained-release pellet, and the quick-release pellet and the sustained-release pellet are wrapped in a hollow capsule; the quick-release pellet comprises a quick-release blank pellet core, a quick-release drug layer and a quick-release film coating layer; the sustained-release pellet comprises a sustained-release blank pellet core, a sustained-release drug layer, a sustained-release layer and a sustained-release film coating layer. According to the invention, the stable blood concentration is obtained while the medicine effect takes effect quickly, the medicine taking frequency is reduced, convenience is brought to patients, and the compliance is improved. The invention also provides a preparation method thereof.
Owner:OCEAN UNIV OF CHINA +1

Pharmaceutical composition, preparation containing pharmaceutical composition, suite containing pharmaceutical composition, and preparation method and application of pharmaceutical composition

The invention discloses a pharmaceutical composition, a preparation containing the pharmaceutical composition, a kit containing the pharmaceutical composition, and a preparation method and application of the pharmaceutical composition. The pharmaceutical composition comprises an active pharmaceutical ingredient and a hot melt adhesive, wherein the active pharmaceutical ingredient is voriconazole, and the hot-melt adhesive is selected from an A-type hot-melt adhesive, namely poloxamer P188 and / or poloxamer P407, and a B-type hot-melt adhesive, namely poloxamer P188 and / or poloxamer P407; or the B-type hot melt adhesive is polyethylene glycol 6000; the mass percent of the B-type hot melt adhesive in the pharmaceutical composition is 12%-25%; the pharmaceutical composition is a pharmaceutical composition in the form of hot-melt granulated particles. According to the pharmaceutical composition and the preparation and the kit containing the pharmaceutical composition, the stability of active pharmaceutical ingredients can be improved, swallowing of a patient can be further improved, and the medicine taking compliance of the patient during actual taking can be improved.
Owner:SHANGHAI WD PHARM CO LTD

Traditional Chinese medicine prescription data analysis method and device based on OCR (Optical Character Recognition) and large model

The invention discloses a traditional Chinese medicine prescription data analysis method and device based on OCR and a large model, and relates to the field of data processing. In the method, a traditional Chinese medicine prescription image of a handwritten traditional Chinese medicine prescription is acquired; performing OCR identification on the traditional Chinese medicine prescription image, and extracting prescription data, patient data and physician data; constructing a first cue word, a second cue word and a third cue word for model input based on the prescription data, the patient data and the doctor data; splicing the first cue word, the second cue word and the third cue word to obtain a target cue word; inputting the target cue word into a preset large model to obtain a medicinal material category congruent result, a medicinal material dosage result and a medicine taking suggestion judgment result; and generating a comprehensive judgment result based on the medicinal material category comparison result, the medicinal material dosage result and the medicine taking suggestion judgment result. By implementing the technical scheme provided by the invention, the accuracy of traditional Chinese medicine prescription evaluation is improved.
Owner:CONITECH (BEIJING) MANAGEMENT SOFTWARE CO LTD

Antidepressant drug compliance management system and method based on biological feature recognition

The invention discloses an antidepressant drug compliance management system based on biological feature recognition and a method thereof, and belongs to the field of medical health systems. The system comprises a biological characteristic acquisition module for acquiring multi-modal biological characteristic data of a drug user in real time; the identity authentication module is used for verifying the identity of a medicine user to prevent illegal use or cheating behaviors; the medicine taking behavior management module is responsible for analyzing the behavior sequence of the medicine taking person in real time, identifying the appearance characteristics of the medicine and verifying the accuracy of the medicine taking action; the data analysis module performs cleaning, feature extraction and pattern analysis on the collected data, constructs a personalized medication behavior model and predicts a medication trend; the abnormity monitoring and early warning module is used for carrying out real-time monitoring and risk assessment on medication behaviors through a comprehensive risk assessment mechanism and generating early warning information and intervention suggestions of corresponding levels; and the interaction management module provides a self-adaptive user interface and is responsible for information display, medication reminding pushing and data visual presentation.
Owner:广州市从化区鳌头镇龙潭卫生院(广州市从化区鳌头镇龙潭疾病预防控制中心广州市从化区鳌头镇龙潭妇幼保健计划生育服务站)

Computer-aided drug dosage optimization method

The invention discloses a computer-aided drug dosage optimization method. The method comprises the following steps: constructing and optimizing a QSP model of a drug and a patient; defining a state space and an action space, and initializing a bidirectional model; performing bidirectional deduction on the trained bidirectional model to obtain a virtual track; forming integrated data based on the real data, the output of the QSP model and the virtual track; constructing a learning relationship between the hierarchies; a learner and a guider are trained based on the integrated data and a PPO algorithm. According to the application, PBPK / PD modeling of the medicine in bodies of different crowds is carried out through a quantitative systematic pharmacology (QSP) model, and the physiological status of the patient after taking the medicine is calculated and predicted through a formula. According to the method, the PPO algorithm is used for strategy optimization, the amplitude of strategy updating is limited, the problem that strategy updating is too large in a traditional strategy gradient method is avoided, and the efficiency of the algorithm is improved while the strategy updating stability is guaranteed.
Owner:NANTONG UNIV

Tracking management method and system for long-term medication of endocrine patient

The invention relates to the technical field of medical information, in particular to an endocrine patient long-term medication tracking management method and system, and the method comprises the following steps: extracting multiple pieces of key information in a prescription based on the electronic prescription information of a patient, recognizing the taking time and dosage information of multiple medicines, and sending medication reminding information to the patient, by monitoring the opening and closing state of the medicine box, the medicine taking time and quantity are recorded, and reminding and medicine taking monitoring information is generated. According to the method, the opening and closing state of the medicine box is monitored in real time, the taking time and quantity of medicine are recorded, the transparency of medicine treatment and the compliance of a patient are improved, physiological parameters of the patient are collected regularly, time sequence analysis and doctor feedback are matched, the change trend and periodic fluctuation of the illness state of the patient are accurately recognized, and the patient compliance is improved. By analyzing drug use logs of patients and doctors, effects of various drugs are identified, side effects are detected, drug doses and types are helped to be adjusted in time, the risk of adverse drug reactions is effectively reduced, and the treatment effect is improved.
Owner:中国人民解放军总医院第八医学中心

Optimized management method and device for hypertension medication, medium and equipment

PendingCN120048415AMedical data miningDrug and medicationsHypertension medicationsEmergency medicine
The invention discloses an optimal management method and device for hypertension medication, a medium and equipment. The method comprises the following steps: acquiring initial medication data of a target object for a target blood pressure drug; collecting and analyzing physiological data of the target object in a preset time range, and generating a physiological cycle curve of the target object; adjusting a blood pressure reference curve based on the physiological cycle curve to generate a blood pressure change target curve of the target object; and optimizing the initial medication data according to a blood pressure change target curve to generate a medication optimization scheme. According to the method, the actual blood pressure state of regular change of the patient is measured according to the physiological data change condition of the patient within a certain time range, so that the actual blood pressure state serves as supplement of sphygmomanometer measurement data, when 24-hour sphygmomanometer monitoring data of the patient is difficult to obtain, targeted medicine taking suggestions can be provided for the patient, the medicine taking accuracy of the patient is improved, and the patient experience is improved. And the hypertension management individuation level of the patient is improved.
Owner:HUBEI DONGYAN HEALTH CONSULTING CO LTD

Multifunctional medicine chest control method, system and equipment and storage medium

The invention relates to the technical field of computer software, and particularly provides a multifunctional medicine chest control method, system and device and a storage medium, and the method comprises the steps: collecting an image of a medicine put into a medicine chest, and recognizing medicine information based on the image of the medicine; acquiring demand data through a sound pickup or an image acquisition device, and converting the demand data into structured data; collecting physical sign data through a sensor, and generating temporary demand data based on the physical sign data; generating a medicine taking scheme based on the medicine information, the structured data and the temporary demand data; and disassembling the medicine taking scheme into a timed task, wherein the timed task comprises playing a voice prompt at a target moment and sending an unlocking instruction to a medicine box lock. The intelligent level of medicine management and the medicine taking compliance of a patient are improved.
Owner:SHANDONG ARTAPLAY INTELLIGENT TECH CO LTD

Intelligent oral medicine box system for hospitalized patients

The invention discloses an intelligent oral medicine box system for hospitalized patients, and relates to the technical field of intelligent oral medicine boxes, and the system comprises an equipment distribution module which is used for distributing intelligent medicine boxes for patients; the medicine distribution and reminding module is used for automatically distributing medicine according to the medicine information of the patient and reminding the patient to take medicine through sound and visual signals; the medicine taking education module is used for providing medicine information for the patient by using the intelligent medicine box; the real-time monitoring and adjusting module is used for the intelligent medicine box to collect health data of a patient through health monitoring equipment, a multiple regression model is constructed to analyze the health data, and a support vector machine (SVM) model is constructed based on the analyzed data to adjust medicine use; and the storage module is used for storing the used data. According to the method, health data are analyzed and predicted through the multiple regression model and the SVM model of the intelligent medicine box system, and personalized medication guidance and dynamic adjustment strategies are provided.
Owner:CARDIOVASCULAR HOSPITAL AFFILIATED TO XIAMEN UNIV

Traditional Chinese medicine composition for treating constipation and preparation method thereof

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating constipation and a preparation method thereof. The traditional Chinese medicine composition for treating constipation comprises the following raw material components in parts by weight: 2-4 parts of fructus mali, 2-4 parts of desmodium caudatum, 1-3 parts of rhizoma atractylodis macrocephalae, 1-3 parts of poria cocos, 1-2 parts of malt and 1-2 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition for treating constipation is developed and researched according to the traditional Chinese medicine theory, the usage and dosage of the prescription medicines are scientific and clear, the curative effect is guaranteed, clinical effectiveness is guaranteed, and the medicine taking compliance is improved. Experiments prove that the traditional Chinese medicine composition for treating constipation can improve the defecation quantity of mice with constipation, enhance the small intestine propulsion function of the mice, improve the water content of excrement and relieve intestinal injury caused by constipation, and has a treatment effect on the constipation of the mice.
Owner:JIUHUA HUAYUAN PHARMACEUTICAL CO LTD

Penicillamine sustained release preparation and preparation method thereof

The invention provides a penicillamine sustained-release preparation. The release rate of the penicillamine sustained-release preparation is adjusted through a specific sustained-release coating. Unexpectedly, the release rate can be obviously improved by adding a small amount of lactose. More unexpectedly, in the prescription system provided by the invention, under the condition that the weight gain of the sustained-release coating is the same, the penicillamine sustained-release preparation which can be released for 12 hours or 24 hours can be respectively obtained only by adjusting the content of lactose, that is, the release rate of the penicillamine sustained-release preparation in 12 hours or 24 hours can reach 85% respectively. According to the penicillamine sustained release preparation provided by the invention, the medication compliance can be improved, and the blood concentration fluctuation can be reduced.
Owner:PEKING UNION MEDICAL COLLEGE HOSPITAL +1

Slow-release oral soluble film and preparation method thereof

The invention belongs to the field of pharmaceutical preparations, and particularly relates to a sustained-release oral soluble film and a preparation method thereof, and the sustained-release oral soluble film comprises a sustained-release pellet core, a film forming material, a plasticizer and a flavoring agent. According to the invention, a multi-unit drug delivery system is provided, a small-particle-size film-controlled sustained-release pellet core is firstly prepared as an intermediate and then added into a film-forming material to form the oral-soluble film preparation, so that the limitation that the oral-soluble film is only applied as a quick-release preparation generally is broken through; the invention provides a slow-release oral soluble film preparation which is convenient for accurately dividing dosage, has better taste, can improve the medicine taking convenience and compliance of patients and has stable and lasting blood concentration.
Owner:HUNAN PEGLAN PHARMACEUTICAL CO LTD

Intelligent accompanying robot used by old people

The invention relates to the technical field of intelligent robots, in particular to an intelligent accompanying robot used by old people. The intelligent accompanying robot comprises a robot body and a protection plate, the protection plate is connected to the front side of the robot body, the intelligent accompanying robot further comprises supporting shafts, a frame body, a protection shell, a rotating disc, a medicine storage disc and a discharging assembly, the supporting shafts are connected to the left side and the right side in the protection plate correspondingly, the frame body is rotatably connected between the supporting shafts, and the protection shell is connected to the frame body. A protective shell is arranged on the front side of the frame body and fixed in a clamping mode. The inside of the medicine storage tray is divided into a plurality of compartments by partition plates, medicines needed by the old in daily life can be stored in order, when the robot reminds the old to take medicine and take medicine according to preset time, the rotating handle is pushed to enable the baffle to move, discharging of one part of medicine is achieved, the medicine storage tray is automatically rotated after medicine taking, and the next compartment containing the medicine is aligned with the notch, so that medicine taking is achieved. And the accuracy and orderliness of medicine taking are ensured.
Owner:赣州职业技术学院

Intelligent management system for medicine taking of old people

The invention belongs to the technical field of intelligent medicine taking, and particularly relates to an intelligent management system for medicine taking of old people, which comprises a medicine box, a system server and a mobile terminal, by means of the structural design of the medicine box, the functions of intelligent arrangement and reminding of medicine taking plans of old people are achieved, the problems of wrong medicine taking and missing medicine taking possibly occurring when the old people take medicine are solved, it is ensured that the old people take the medicine on time according to the quantity through intelligent arrangement and reminding of the medicine taking plans of the old people, and the problems of wrong medicine taking, missing medicine taking and the like are avoided; the safety and the standardization of medicine taking of the old people are improved; through the structural design of each module contained in the mobile terminal, the functions of medicine taking compliance monitoring and excitation are realized, the enthusiasm and compliance of the old in medicine taking can be effectively improved, the medicine box records the medicine taking time and the medicine dosage through the cooperative use of the timer and the detection module, accurate monitoring is realized, and the use experience of the old is improved. Meanwhile, a certain reward is given to the old with good compliance in cooperation with the excitation module, and the enthusiasm of the old to medicine taking is improved.
Owner:GUANGXI KINGON SOFTWARE

Intracavity anchor, preparation method thereof and blood vessel occlusion device

The invention discloses an intracavity anchor, a preparation method thereof and a blood vessel occlusion device. Relates to the technical field of medical instruments, in particular to an intracavity anchor which comprises an anchor body and a medicine carrying coating, the surface of the anchor body is coated with the medicine carrying coating, and the medicine carrying coating comprises at least one of anti-platelet adhesion medicine, anti-coagulation medicine, anti-proliferation medicine and anti-infection medicine. The intracavitary anchor provided by the invention has excellent anticoagulation, anti-proliferation and anti-infection capabilities, can effectively reduce the generation of clinical complications, avoids the need of long-term medicine taking of patients, reduces the pain and risk of the patients during treatment, and further enables the vascular structure and function to recover to a healthy state as soon as possible.
Owner:SEALMED

Preparation method of isavuconazole sulfate capsule

The invention relates to a preparation method of an isavuconazole sulfate capsule, which comprises the following steps: drying a filled capsule under reduced pressure, pre-treating a hollow capsule, controlling a production environment, packaging in a damp-proof manner and the like to quickly reduce the moisture of a product to a lower level, so that the moisture of the product is effectively controlled, the control requirement on the humidity of the production environment is reduced, and the production cost is reduced. The relative humidity is controlled to be not more than 40% RH. The product produced by the invention can also meet the requirement of product stability by adopting conventional packaging modes such as bottling and the like, large-scale production is easy to realize, and the cost is reduced. The patient can be prevented from mistakenly eating the drying agent, and the medicine taking safety of the patient is improved.
Owner:CHONGQING XIWEI MEDICAL TECH CO LTD

Medicine box subpackaging device with reminding function

ActiveCN222467552UTake it accuratelyImprove dustproofLavatory sanitoryOral administration deviceComputer hardwareTablet computer
The utility model discloses a medicine box subpackaging device with a reminding function, which comprises a medicine box main body, a display screen is embedded at the front end of the medicine box main body, and a control key is arranged on one side of the display screen. By arranging the control key, the display screen, the prompt lamp, the loudspeaker, the storage groove, the control module and the wireless module, the medicine taking reminding function is achieved, the control key can control the control module, the display screen is matched to record medicine information in the storage groove and set the medicine taking number and time, and the medicine taking reminding function is achieved. Or a wireless module is connected with a mobile phone, a tablet computer and other equipment to set the medicine box subpackaging device, and when the medicine taking time is up, the control module issues an instruction according to a system program, controls the prompt lamp at the position of the corresponding storage groove to be normally turned on and controls the loudspeaker to give out a prompt tone, so that the medicine needing to be taken can be quickly and accurately taken, and the medicine box subpackaging device is convenient to use. Meanwhile, the display screen can display the medicine information and the medicine taking quantity, so that wrong medicine taking is avoided.
Owner:FOURTH MILITARY MEDICAL UNIVERSITY

Briracetam oral soluble film pharmaceutical composition and preparation method thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a briracetam oral soluble film pharmaceutical composition and a preparation method thereof. The oral soluble film pharmaceutical composition comprises the following components: briracetam, a film-forming material, a plasticizer, ion exchange resin, a pigment and a flavoring agent. The Briracetam oral soluble film pharmaceutical composition is good in appearance, moderate in flexibility, good in taste, short in dissolution time limit, rapid in effect taking and convenient to carry, and the medication compliance and safety of patients with dysphagia are improved.
Owner:BEIJING XINLINGXIAN MEDICAL TECH DEV CO LTD +1

Dialect intelligent medicine dispensing box

The invention relates to the technical field of medical instruments, and discloses a dialect intelligent medicine dispensing box which comprises a box body, a base is fixedly installed at the bottom of the box body, and six sub-packaging boxes are arranged in the box body. A storage battery, a main control module, a LoRa communication module, a voice chip, a GPS positioning module, an environment adaptation module and an intelligent management module are fixedly installed in the base, an LED lamp and an SOS button are fixedly installed at the top of the box body, and a sound outlet hole is formed in the side face of the base; and six mounting cavities are formed in the box body. According to the dialect intelligent medicine distribution box, medicine weight changes are accurately monitored in real time through the pressure sensor, intelligent analysis and judgment are conducted in cooperation with the microcontroller according to a medicine use plan, and early warning information is sent to a preset contact person in time in combination with multi-mode reminding of the LED lamp and the vibration motor and the LoRa communication module, so that it is ensured that old people take medicine correctly on time; the medication accuracy is effectively improved, and the health of old people is guaranteed.
Owner:QINGTIAN COUNTY PEOPLES HOSPITAL

Intelligent medicine box for old people and medicine taking reminding system thereof

According to the intelligent medicine box for the old people and the medicine taking reminding system of the intelligent medicine box, a controller medicine taking reminding signal is triggered, a braking assembly is started, one guide roller is repelled through the braking assembly, so that the guide roller is pushed towards a linkage assembly and clamped, then a driving motor is started, and the driving motor drives the linkage assembly to rotate; the corresponding rotating guide roller drives the conveying roller to rotate, so that the medicine placed on the conveying roller is pushed towards the medicine outlet cover cylinder along with rotation of the conveying roller, the medicine located at the tail end of the conveying roller is finally output from an outlet of the medicine outlet cover cylinder after multiple times of rotation, and then old people can take the medicine according to the output medicine without recognizing the medicine. The household treatment effect is improved.
Owner:HAINAN SEISMIC CONTROL INTELLIGENT TECHNOLOGY CO LTD +2

Intelligent medicine taking management method and related equipment

The invention discloses an intelligent medicine taking management method and related equipment. The method comprises the following steps: acquiring medicine information of a to-be-taken medicine through an intelligent mobile communication terminal under the jurisdiction of a medicine taking user; under the condition that medicine taking information input by a medicine taking user is received, a medicine specification of a medicine to be taken is inquired based on the medicine information obtained through intelligent movement, so that an information input correction prompt message is generated when the medicine taking information input by the medicine taking user cannot be matched with the medicine specification, the medicine taking information comprises medicine taking time, medicine taking frequency, medicine taking treatment course and single-time medicine taking dosage; and sending a medicine taking reminding message to an intelligent mobile communication terminal under the administration of the medicine taking user at each medicine taking time based on the medicine taking treatment course and the medicine taking frequency. The problems that according to a traditional medicine taking mode, a patient takes medicine according to the advice of a doctor, the patient is prone to missing taking, no reminding exists, or the patient forgets to take or purchase a box of medicine after taking up, and consequently treatment is interrupted, the treatment effect is affected, or disease relapse occurs can be solved.
Owner:TONGJI HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI TECH

Intelligent robot system integrating health monitoring and cleaning functions for old people and control method

The invention discloses an intelligent robot system integrating health monitoring and cleaning functions for old people, and belongs to the technical field of intelligent old people nursing auxiliary equipment. According to the system, through cooperative work of the health monitoring module, the cleaning module, the interaction module, the control module and the communication module, health monitoring, intelligent cleaning and convenient interaction of old people in a family scene are achieved. The health monitoring module integrates the functions of blood pressure detection, medicine taking reminding and fall detection, and supports multi-dimensional health data acquisition and cloud transmission; the cleaning module realizes an efficient cleaning task through dual-mode control and intelligent path planning; the interaction module adopts a voice recognition mode and a touch control operation mode and adapts to the use habits of the old. And the control module dynamically coordinates health monitoring and cleaning functions through a multi-modal data fusion algorithm and a priority scheduling strategy, and preferentially processes emergency health requirements. The communication module supports dual-network encryption transmission, and collaborative management of local equipment and a cloud is realized. The system breaks through the bottleneck of function isolation of traditional equipment, improves the life safety and convenience of old people through an intelligent algorithm and an aging-suitable design, and has the advantages of high integration level, high adaptability and remote management capability.
Owner:HUNAN LANTIE TECH CO LTD

Tiopronin-containing composition as well as preparation method and application thereof

The invention belongs to the technical field of pharmaceutical preparations, and particularly relates to a tiopronin-containing composition as well as a preparation method and application thereof. The preparation method comprises the following steps: granulating by adopting isopropanol as a granulating solution, drying and tabletting to obtain a tablet core with extremely low water content, and meanwhile, dissolving a mixture of an amine alkyl methacrylate copolymer and hydroxypropylcellulose in isopropanol as an isolating layer solution to coat the tablet core, so that the stability of the tablet core is improved; and finally, calcium carbonate, cane sugar and the like are adopted for sugar coating, so that unpleasant odor is effectively covered, the compliance of a patient is improved, the preparation is suitable for large-scale production, the medicine taking convenience and the medicine administration safety of the patient are improved, and therefore, the preparation has a good practical application value.
Owner:BEIJING YUANFANG TONGDA PHARM TECH CO LTD

Intelligent image monitoring and intervention system and method for AIDS treatment compliance

The invention discloses an AIDS treatment compliance intelligent image monitoring and intervention system and method, and belongs to the technical field of artificial intelligence and image processing, and the system comprises an image collection module, an image preprocessing module, a feature extraction module, an image sequence modeling module, a compliance evaluation module, a reminding strategy module and a notification execution module. The core innovation of the system lies in the image sequence modeling module, the module maps continuously collected medicine images to Riemannian manifold to form a medicine taking behavior track, accurate judgment of the medicine taking behavior is achieved through geodesic distance calculation and curvature tensor analysis, and the system particularly has outstanding advantages in the aspect of identifying false medicine taking behaviors, and has good application prospects. The medicine taking behavior recognition accuracy is improved to 93.1%, the false medicine taking behavior detection rate reaches 95.4%, and clinical application proves that the treatment compliance of AIDS patients can be improved to 91.6% from 72.3% by using the system, the treatment effect is remarkably improved, and the development of drug resistance is reduced.
Owner:何惠惠

Rebamipide TBPH ion pair compound freeze-dried flash release tablet and preparation method thereof

The invention relates to a rebamipide TBPH ion pair compound freeze-dried flash release tablet and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations. Comprising the following components in parts by weight: 80-90 parts of a rebamipide TBPH ion pair compound, 60-100 parts of a proppant, 8-20 parts of a stabilizer, 8-15 parts of an acidulant, 1-5 parts of a sweetening agent and 3-8 parts of a flavoring agent. The rebamipide TBPH ion pair compound has the advantages that in order to improve the solubility and bioavailability of rebamipide, the rebamipide is firstly prepared into the rebamipide TBPH ion pair compound, so that the hydrophilicity and lipophilicity of the rebamipide TBPH ion pair compound are effectively improved, the solubility of the rebamipide TBPH ion pair compound in water or lipid can be remarkably improved, and then quick release and dissolution are realized through a freeze-drying technology; the tablet can be rapidly disintegrated and dissolved in a short time, is good in molding, free of cracking and collapse phenomena, free of water during taking, convenient to take, instant to dissolve in the mouth, good in taste, free of grit feeling, free of peculiar smell, convenient to take by a patient, rapid in effect taking, capable of reducing waiting time after taking, and capable of improving the bioavailability of the tablet.
Owner:JILIN UNIVERSITY

Production and preparation method of compound double-flower oral liquid for enhancing palatability

The invention discloses a production and preparation method of palatability-enhanced compound double-flower oral liquid, and relates to the technical field of traditional Chinese medicine preparations. The production and preparation method of the oral liquid comprises the following steps: pretreatment of medicinal materials: taking herba andrographitis, honeysuckle, radix isatidis, fructus forsythiae, honey and dark plum, washing, denucleating and slicing the dark plum (the honey is in a liquid state and does not need to be pretreated), ultrasonic extraction, integrated purification, filtrate collection, dynamic taste modification, sterilization and filling; the method has the advantages that bitter components are accurately neutralized by an innovative gradient inclusion process, qualitative leap of a bitter masking effect is realized, sensory evaluation is verified according to international standards, children acceptance score reaches an excellent level (full score of 10 scores), the core problem that children refer to take medicines due to bitter taste is thoroughly solved, the treatment compliance of patients is remarkably improved, and the treatment cost is reduced. The continuity of medication is ensured, a breakthrough solution is provided for the field of medication for children, and meanwhile, a technical normal form is provided for improvement of medicines similar to bitter taste.
Owner:YUANSHENG SUYUANG BIOLOGICAL SCI TECH BEIJING

Topiromilast osmotic pump controlled release tablet and preparation method thereof

The invention discloses a topiromilast osmotic pump tablet and a preparation method thereof. The topiromilast osmotic pump tablet comprises a tablet core composed of a drug layer and a pushing layer, a semipermeable membrane coating outside the tablet core, and a single drug release small hole and an isolation coating on the surface of a controlled release tablet on one side of the drug layer. Compared with topiromilast tablets on the market at present, the topiromilast osmotic pump controlled release tablet prepared by the invention can realize continuous and stable constant-speed release of drugs. After a patient takes the medicine, the medicine in the medicine release layer cannot be released immediately, and the tablet can rhythmically release the medicine, maintain the steady-state blood concentration, delay the peak time and prolong the half-life period of the medicine within more than ten subsequent hours under the action of the pushing layer, so that the bioavailability is improved, and the slow release effect of more than 12 hours is achieved. Due to the adoption of a double-layer osmotic pump controlled release technology, compared with a single-layer tablet, the double-layer osmotic pump controlled release tablet has the advantages of stronger controllability, more complete release and higher availability.
Owner:NANJING HUAWE MEDICINE TECH DEV

Tumor nursing service management system based on artificial intelligence

The invention relates to the technical field of tumor nursing, in particular to a tumor nursing service management system based on artificial intelligence, and the system comprises a medication detection module, a combined medication module, a physical sign recognition module, an action pushing module and a resource scheduling module. And comparing the actual dose with the standard dose. According to the invention, by automatically analyzing a continuous medication mode of a patient, physical sign changes and real-time laboratory monitoring data and fusing multi-source health parameters, dynamic collection and linkage judgment are completed, risk factor high-frequency identification and sensitive physical sign fluctuation monitoring are realized, intervention measure pushing information is generated in time, and a nursing task response process is optimized; by means of multi-dimensional data fusion and intelligent task sorting, accurate matching of patient risk management and nursing resource scheduling is achieved, so that a data closed loop and an intervention closed loop in the whole tumor nursing process are promoted, and the initiative and adaptability of nursing decisions are enhanced.
Owner:SICHUAN CANCER HOSPITAL

Loxoprofen sodium double-release capsule microtablet and preparation method thereof

The invention provides a loxoprofen sodium double-release capsule micro-tablet and a preparation method of the loxoprofen sodium double-release capsule micro-tablet. Through the synergistic effect of the quick-release micro-tablet and the sustained-release micro-tablet, the quick-release micro-tablet can realize quick release and absorption, and the sustained-release micro-tablet can maintain relatively stable blood concentration for a long time. The administration frequency is reduced, the coordination of the postprandial administration requirement and the dietary habit is ensured, and the occurrence of gastrointestinal tract adverse reactions is reduced. The preparation provided by the invention conforms to the dosage form design of the hour pharmacology, can quickly take effect through administration twice every day, can maintain the blood concentration in the high-incidence time period of night diseases, avoids the disadvantage of taking medicine after meal when the night diseases attack, guarantees the sleep quality, and improves the overall treatment effect. The micro tablet is small in size and easy to swallow, and the medication compliance of patients with dysphagia is obviously improved. Through dosage form design and improvement, unmet clinical requirements are expected to be met by virtue of obvious advantages of the traditional Chinese medicine composition.
Owner:BEIJING ZHONGKELIHUA PHARM RES INST CO LTD

An intelligent companion robot for the elderly

The present invention relates to the technical field of intelligent robots, and particularly relates to an intelligent companion robot for the use of the elderly. The present invention provides such an intelligent companion robot for the use of the elderly, which includes a robot main body and a guard plate. The guard plate is connected to the front side of the robot main body. It also includes a support shaft, a frame body, a protective shell, a turntable, a medicine storage tray and a discharging assembly. Support shafts are respectively connected to the left and right sides inside the guard plate, and a frame body is rotatably connected between the support shafts. A protective shell is provided on the front side of the frame body and is fixed by a clamping method. The interior of the medicine storage tray is divided into multiple compartments by partitions, and can orderly store the daily medicines required by the elderly. The robot will remind the elderly to take medicine at a preset time. When taking medicine, by pushing the turning handle, the baffle plate is moved to achieve the discharging of one portion of the medicine. After taking the medicine, the medicine storage tray automatically rotates to align the next compartment filled with medicine with the notch, ensuring the accuracy and orderliness of medicine taking.
Owner:赣州职业技术学院