Traditional Chinese medicine composition for treating constipation and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating constipation and a preparation method thereof. The traditional Chinese medicine composition for treating constipation comprises the following raw material components in parts by weight: 2-4 parts of fructus mali, 2-4 parts of desmodium caudatum, 1-3 parts of rhizoma atractylodis macrocephalae, 1-3 parts of poria cocos, 1-2 parts of malt and 1-2 parts of pericarpium citri reticulatae. The traditional Chinese medicine composition for treating constipation is developed and researched according to the traditional Chinese medicine theory, the usage and dosage of the prescription medicines are scientific and clear, the curative effect is guaranteed, clinical effectiveness is guaranteed, and the medicine taking compliance is improved. Experiments prove that the traditional Chinese medicine composition for treating constipation can improve the defecation quantity of mice with constipation, enhance the small intestine propulsion function of the mice, improve the water content of excrement and relieve intestinal injury caused by constipation, and has a treatment effect on the constipation of the mice.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating constipation and a preparation method thereof. Background Art

[0002] Constipation is a common functional gastrointestinal disease of the digestive system in clinical practice. It is a functional intestinal disease of the digestive system without structural abnormalities and metabolic disorders. It does not belong to organic lesions. Clinically, it manifests as reduced bowel movements, reduced stool volume, dry stool, and labored defecation, accompanied by abdominal distension, abdominal discomfort, and loss of appetite. At present, Western medicine mainly uses two means of treatment for constipation patients: general treatment and drug treatment. General treatment covers psychological intervention, adjustment of dietary structure and other methods. Drug treatment generally uses laxatives to promote gastrointestinal motility. Although it relieves constipation in patients, it also brings more adverse reactions at the same time, which can cause patients to have symptoms such as diarrhea and abdominal pain. In severe cases, it can even cause colon melanosis. In addition, long-term use of Western medicine can form a certain degree of dependence, and once the drug is stopped, it will easily cause repeated attacks of the disease.

[0003] Traditional Chinese medicine has been used to treat constipation for thousands of years, but there are few traditional Chinese medicine strategies for effectively treating constipation in the prior art. Therefore, it is urgent to develop a traditional Chinese medicine composition that can effectively treat constipation. Summary of the invention

[0004] The purpose of the present application is to provide a Chinese medicine composition for treating constipation and a preparation method thereof, aiming to solve the problem that there are few existing Chinese medicine strategies for treating constipation and their poor effects to a certain extent.

[0005] In order to achieve the above application purpose, the technical solution adopted in this application is as follows:

[0006] In a first aspect, the present application provides a Chinese medicine composition for treating constipation, comprising the following raw material components in parts by weight:

[0007] 2-4 parts of Crataegus pinnatifida, 2-4 parts of Sophora japonica flowers, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Poria cocos, 1-2 parts of malt and 1-2 parts of dried tangerine peel.

[0008] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight:

[0009] 2.5-3.6 parts of Crataegus pinnatifida, 2-3 parts of Sophora japonica flowers, 1.5-2.2 parts of Atractylodes macrocephala, 1.5-2.2 parts of Poria cocos, 1.5-2 parts of malt and 1-1.5 parts of dried tangerine peel.

[0010] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight:

[0011] 2.5 parts of Crataegus pinnatifida, 2 parts of Sophora japonica, 1.5 parts of Atractylodes macrocephala, 1.5 parts of Poria cocos, 1.5 parts of Malt and 1 part of Tangerine peel;

[0012] Alternatively, 3 parts of Crataegus pinnatifida, 2.5 parts of Sophora japonica, 2 parts of Atractylodes macrocephala, 2 parts of Poria cocos, 1.8 parts of malt, and 1.3 parts of dried orange peel;

[0013] Alternatively, 3.6 parts of Crataegus pinnatifida, 3 parts of Flos Sophorae Fructus, 2.2 parts of Atractylodes macrocephala, 2.2 parts of Poria cocos, 2 parts of malt and 1.5 parts of dried tangerine peel.

[0014] In some possible implementations, the Chinese medicine composition is a granule that passes through a 14-mesh sieve.

[0015] In some possible implementations, the Chinese medicine composition is taken directly.

[0016] In some possible implementations, the daily dosage of the Chinese medicine composition for a patient is 0.5 g / kg to 2 g / kg.

[0017] In some possible implementations, the traditional Chinese medicine composition further comprises at least one auxiliary material selected from the group consisting of citric acid, sucrose, steviol glycoside, acesulfame potassium, DL-malic acid, orange flavor, strawberry flavor, and apple flavor.

[0018] In a second aspect, the present application provides a method for preparing a Chinese medicine composition for treating constipation, comprising the following steps:

[0019] 2-4 parts of Crataegus pinnatifida, 2-4 parts of Sophora japonica flowers, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Poria cocos, 1-2 parts of malt and 1-2 parts of dried tangerine peel are extracted to prepare a Chinese medicine composition for treating constipation.

[0020] In some possible implementations, the extraction process includes:

[0021] Distill and extract the Atractylodes macrocephala and the dried orange peel, and collect volatile oil and the distilled aqueous solution respectively;

[0022] The hawthorn fruit, the small sophora flower, the poria and the malt are decocted in water, and the filtrate is combined with the distilled aqueous solution to prepare an ointment;

[0023] The ointment is mixed with the volatile oil to prepare granules, thereby obtaining the traditional Chinese medicine composition.

[0024] In some possible implementations, the preparation of the filtrate includes the steps of: decocting the Crataegus pinnatifida, the Sophora japonica flower, the Poria cocos and the malt with water for 2 to 3 times, each decocting for 2 to 3 hours, combining the decoctions and filtering to obtain the filtrate.

[0025] In some possible implementations, the preparation of the ointment includes the steps of: combining the filtrate with the distilled aqueous solution, concentrating the mixture into a clear paste, cooling the mixture, adding an alcohol solvent to precipitate impurities, recovering the supernatant filtrate, and concentrating the mixture into a thick paste to obtain the ointment.

[0026] In some possible implementations, the mass ratio of the total mass of the Crataegus pinnatifida, the flos Sophorae flavescentis, the Poria cocos and the malt to the water is 1:(8-12).

[0027] In some possible implementations, the combined decoction is filtered using a 200-mesh filter cloth.

[0028] In some possible implementations, the relative density of the clear paste is 1.17-1.23 (70° C.).

[0029] In some possible implementations, the relative density of the thick paste is 1.32-1.37 (60° C.).

[0030] In some possible implementations, the step of precipitating impurities with an alcohol solvent includes: adding an ethanol solvent so that the alcohol content in the clear paste is 60% to 70%, standing for 24 to 48 hours, filtering the supernatant to obtain the supernatant filtrate.

[0031] In some possible implementations, the preparation of the granules includes the steps of: adding auxiliary materials to the ointment, drying, spraying the volatile oil for mixing, and granulating to obtain the granules of the traditional Chinese medicine composition.

[0032] In some possible implementations, the auxiliary material includes at least one of citric acid, sucrose, steviol glycoside, acesulfame potassium, DL-malic acid, orange flavor, strawberry flavor, and apple flavor.

[0033] In some possible implementations, in the granules of the traditional Chinese medicine composition, the mass percentage of the auxiliary material is 65% to 95.5%.

[0034] In some possible implementations, the granulated particles are sieved through a 14-mesh screen.

[0035] In the Chinese medicine composition formula for treating constipation provided by the first aspect of the present application, guangzha shanzi and xiaosophora japonica are used as the main medicines, wherein guangzha shanzi is sweet, sour and astringent, slightly warm in nature, has the functions of regulating qi and strengthening the spleen, and promoting digestion and removing stagnation, and is commonly used for food stagnation and abdominal distension. xiaosophora japonica is sweet and bitter in taste, flat in nature, has the functions of appetizing and strengthening the spleen, eliminating stagnation and relieving pain, and is commonly used for diseases such as infantile malnutrition. The two medicines are used together to form the functions of harmonizing the spleen and promoting transportation, promoting appetite and promoting digestion, and having the spleen and stomach to restore normal reception, digestion, absorption and transportation functions, so that food will not be stagnant, and the spleen can be healthy and transported, and is used for constipation. Atractylodes macrocephala, Poria cocos, malt and dried orange peel are used as the ministerial medicines, wherein Atractylodes macrocephala is sweet and bitter in taste, warm in nature, and can strengthen the spleen and replenish qi to help transportation. Poria cocos is tasted and light in nature, and can strengthen the spleen and harmonize the middle. Malt is sweet in taste, slightly warm in nature, and can promote digestion and promote digestion. The three medicines are used together to add the main medicine to harmonize the spleen and help digestion, and they are the minister medicines in the prescription. Tangerine peel, which is pungent, bitter and warm in nature, can regulate qi and strengthen the spleen and resolve stagnation, and can assist the functions of the main and minister medicines, and is sufficient to be the best medicine in the prescription. The above medicines are used in combination, and they can harmonize the spleen and help digestion, and they can stimulate the appetite and digestion, and are used for constipation. The Chinese medicine composition for treating constipation in this application is developed and researched according to the theory of traditional Chinese medicine. The usage and dosage of the prescription medicine flavors are scientific and clear, which not only guarantees the efficacy and clinical effectiveness, but also improves the compliance of taking the medicine. It has been confirmed through experiments that the Chinese medicine composition for treating constipation in this application can increase the number of defecation in constipated mice, enhance the propulsion function of the small intestine of mice, increase the water content of feces, reduce the intestinal damage caused by constipation, and has a therapeutic effect on constipation in mice.

[0036] The preparation method of the Chinese medicine composition of the present application uses 2 to 4 parts of Crataegus pinnatifida, 2 to 4 parts of Sophora japonica, 1 to 3 parts of Atractylodes macrocephala, 1 to 3 parts of Poria cocos, 1 to 2 parts of malt and 1 to 2 parts of dried tangerine peel as raw materials, and extracts the active substances in each component to prepare a Chinese medicine composition for treating constipation. The preparation process is simple and suitable for industrial large-scale production and application. The prepared Chinese medicine composition can increase the number of bowel movements in patients with constipation, enhance the propulsion function of the patient's small intestine, increase the water content of feces, reduce intestinal damage caused by constipation, and has a significant therapeutic effect on patients with constipation. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0038] Figure 1 The process diagram of the preparation method of the Chinese medicine composition for treating constipation provided in the embodiment of the present application is as follows Figure 1 ;

[0039] Figure 2 The process diagram of the preparation method of the Chinese medicine composition for treating constipation provided in the embodiment of the present application is as follows Figure 2 . DETAILED DESCRIPTION

[0040] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present application more clearly understood, the present application is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present application and are not used to limit the present application.

[0041] In this application, the term "and / or" describes the association relationship of associated objects, indicating that there may be three relationships. For example, A and / or B can mean: A exists alone, A and B exist at the same time, and B exists alone. A and B can be singular or plural. The character " / " generally indicates that the associated objects are in an "or" relationship.

[0042] In this application, "at least one" means one or more, and "plurality" means two or more. "At least one of the following" or similar expressions refers to any combination of these items, including any combination of single items or plural items. For example, "at least one of a, b or c", or "at least one of a, b and c", can all represent: a, b, c, ab (i.e. a and b), ac, bc, or abc, where a, b, c can be single or multiple, respectively.

[0043] It should be understood that in the various embodiments of the present application, the size of the serial numbers of the above-mentioned processes does not mean the order of execution, some or all of the steps can be executed in parallel or sequentially, and the execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0044] The terms used in the embodiments of the present application are only for the purpose of describing specific embodiments, and are not intended to limit the present application. The singular forms "a", "an" and "the" used in the embodiments of the present application and the appended claims are also intended to include plural forms, unless the context clearly indicates other meanings.

[0045] The weight of the relevant components mentioned in the embodiments of the present specification can not only refer to the specific content of each component, but also represent the proportional relationship between the weights of the components. Therefore, as long as the content of the relevant components in the embodiments of the present specification is proportionally enlarged or reduced, it is within the scope disclosed in the embodiments of the present specification. Specifically, the mass described in the embodiments of the present specification can be μg, mg, g, kg and other mass units known in the chemical industry.

[0046] The terms "first" and "second" are used only for descriptive purposes to distinguish objects such as substances from each other, and should not be understood as indicating or implying relative importance or implicitly indicating the number of indicated technical features. For example, without departing from the scope of the embodiments of the present application, the first XX may also be referred to as the second XX, and similarly, the second XX may also be referred to as the first XX. Thus, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features.

[0047] The first aspect of the embodiment of the present application provides a Chinese medicine composition for treating constipation, comprising the following raw material components in parts by weight:

[0048] 2-4 parts of Crataegus pinnatifida, 2-4 parts of Sophora japonica flowers, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Poria cocos, 1-2 parts of malt and 1-2 parts of dried tangerine peel.

[0049] In the formula of the Chinese medicine composition for treating constipation provided in the first aspect of the embodiment of the present application, guangzha shanzhai and xiaosophora japonica are the main medicines, wherein guangzha shanzhai has a sweet, sour and astringent taste, is slightly warm in nature, has the functions of regulating qi and strengthening the spleen, and promoting digestion and removing stagnation, and is commonly used for the symptoms of food stagnation and abdominal distension. xiaosophora japonica has a sweet and bitter taste, is flat in nature, has the functions of appetizing and strengthening the spleen, eliminating stagnation and relieving pain, and is commonly used for the symptoms of infantile malnutrition. The two medicines are used together to form the functions of harmonizing the spleen and promoting transportation, stimulating appetite and promoting digestion, and have the spleen and stomach to restore the normal reception, digestion, absorption and transportation functions, so that food will not be stagnant, and the spleen can be healthy and transported, which is used for constipation. Atractylodes macrocephala, Poria cocos, malt and tangerine peel are the ministerial medicines, wherein Atractylodes macrocephala has a sweet and bitter taste, is warm in nature, and can strengthen the spleen and replenish qi to help transportation. Poria cocos has a taste and is light in nature, and can strengthen the spleen and harmonize the middle. Malt has a sweet taste, is slightly warm in nature, and can promote digestion and promote digestion. The three medicines are used together to add the main medicine to harmonize the spleen and help digestion, and they are the minister medicines in the prescription. Tangerine peel is pungent, bitter and warm in nature, and can regulate qi and strengthen the spleen and resolve stagnation. It can assist the functions of the main and minister medicines and is sufficient to be the best medicine in the prescription. The above medicines are used together, and they can harmonize the spleen and help digestion, and they can stimulate the appetite and digestion, and are used for constipation. The Chinese medicine composition for treating constipation in the embodiment of the present application is developed and researched according to the theory of traditional Chinese medicine. The usage and dosage of the prescription medicine are scientific and clear, which not only guarantees the efficacy and clinical effectiveness, but also improves the compliance of taking the medicine. It has been confirmed by experiments that the Chinese medicine composition for treating constipation in the embodiment of the present application can increase the number of defecations in constipated mice, enhance the propulsion function of the small intestine of mice, increase the water content of feces, reduce the intestinal damage caused by constipation, and has a therapeutic effect on constipation in mice.

[0050] In some possible implementations, the Chinese medicine composition for treating constipation in the embodiment of the present application can be used as Anshikang granules, which can not only effectively improve the constipation situation, but also play the conventional therapeutic effects of Anshikang granules such as strengthening the spleen, appetizing, and digesting food, and can be used for anorexia in children caused by spleen and stomach qi deficiency. Studies have found that the Anshikang granules made from the Chinese medicine composition in the embodiment of the present application have a significant improvement effect on gastrointestinal dysfunction, can significantly improve appetite, increase food intake, improve symptoms such as pale complexion, belching and nausea, irregular bowel movements, and increase body weight. No adverse reactions of Anshikang granules were found in the experiment, and they have high safety, and have a sweet and sour hawthorn taste, which is more suitable for children to take.

[0051] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight: 2.5-3.6 parts of guangzha shanzi, 2-3 parts of xiaozhuhua, 1.5-2.2 parts of atractylodes macrocephala, 1.5-2.2 parts of tuckahoe, 1.5-2.2 parts of malt and 1-1.5 parts of dried orange peel. In the Chinese medicine composition for treating constipation in the embodiment of the present application, guangzha shanzi, also known as awn hawthorn and big fruit hawthorn, guangzha shanzi is the mature fruit of Taiwan apple (Malus doumeri (Bois.) Chev.) or light calyx apple (M.leiocalyx SZ Huang). Guangzha shanzi itself has a certain digestive effect, and its rich variety of organic acids can stimulate gastric juice secretion, thereby improving gastrointestinal motility and contributing to the digestion and absorption of food. In addition, the dietary fiber contained in Guangzha shanzi can promote intestinal peristalsis, shorten the residence time of food residues in the intestine, reduce the chance of excessive absorption of water, make the stool more moist and easy to discharge, thereby achieving the effect of preventing and improving constipation. Increasing the dosage of Hawthorn Root in an appropriate amount can enhance its digestion-promoting and bowel-moistening effects. Too low a content will not be effective in preventing and improving constipation, and too high a content may cause excessive gastric acid or discomfort. Sophora japonica has the effects of cooling blood and stopping bleeding and clearing away heat and purging fire, and has a certain helpful effect on constipation symptoms such as dry stool and difficulty in defecation. An appropriate amount of Sophora japonica can assist in improving constipation. Too low a content will not be effective in improving constipation, and too high a content may cause the coldness to be too strong, affecting the spleen and stomach function. Atractylodes macrocephala has the effects of invigorating qi, drying dampness, digesting food, and promoting diuresis. It can moisturize the intestines and relieve constipation symptoms, especially those caused by spleen dampness. At the same time, Atractylodes macrocephala also has the effect of strengthening the spleen, and can treat constipation caused by weak spleen and stomach. Increasing the dosage of Atractylodes macrocephala in an appropriate amount can enhance its bowel-moistening and bowel-moistening effects. Too low a content will not be effective, and too high a content may cause the drug effect to be too strong, causing discomfort. Poria can play a role in strengthening the spleen, thereby enhancing the body's transportation and transformation function, allowing stool to be discharged normally, and achieving the effect of relieving constipation. An appropriate amount of Poria cocos can assist in improving constipation. Too low a content has a poor effect, but an excessive amount may affect the absorption and metabolism of other drugs. Malt contains particularly rich dietary fiber, which can promote gastrointestinal motility to a certain extent and play a role in moistening the intestines and promoting bowel movements. At the same time, malt also has the effect of promoting qi and promoting digestion, which can relieve the phenomenon of food accumulation after constipation. An appropriate amount of malt can promote gastrointestinal motility and improve constipation. Too low a content has a poor effect, and too high a content may cause gastrointestinal discomfort. Tangerine peel has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm, and can indirectly promote digestion and defecation by strengthening the spleen and regulating qi. An appropriate amount of tangerine peel can assist in improving constipation. Too low a content has a poor effect, and too high a content may cause getting angry or gastrointestinal discomfort. The components in the composition work together to act on the spleen, stomach and large intestine, achieving the effects of moistening the intestines and promoting bowel movements, strengthening the spleen and promoting digestion. Among them, Atractylodes macrocephala and Poria cocos both have the effect of strengthening the spleen, which can promote digestion and absorption of the gastrointestinal tract. The synergistic effect of Hawthorn frutescens and the two not only enhances the spleen-strengthening effect, but also promotes the digestion and excretion of food, thereby helping to relieve constipation.Malt is rich in dietary fiber and can promote intestinal peristalsis; tangerine peel has the effect of regulating qi and strengthening the spleen. The synergistic effect of Guangshan and the two further enhances the effect of moistening the intestines and relieving constipation. Sophora japonica flowers can remove liver and stomach heat, while Atractylodes macrocephala and Poria cocos can strengthen the spleen and replenish qi. The synergistic effect of the three helps to improve the spleen and stomach function, promote the digestion and absorption of food, and thus relieve constipation. The appetizing and digestive effects of malt and tangerine peel complement the digestive effect of Sophora japonica flowers, and jointly promote the digestion and excretion of food. Atractylodes macrocephala and Poria cocos are both good medicines for strengthening the spleen and replenishing qi. The synergistic effect of the two significantly enhances the spleen-strengthening effect, which helps to improve constipation caused by weak spleen and stomach. The appetizing and digestive effects of malt and tangerine peel cooperate with the spleen-strengthening effect of Atractylodes macrocephala to promote the digestion and excretion of food, which helps to relieve constipation. The diuretic and dampness-infiltrating effect of Poria cocos combined with the appetizing and digestive effects of malt and tangerine peel can help improve constipation caused by excessive moisture in the body and indigestion. Malt is rich in dietary fiber and can promote intestinal peristalsis, while tangerine peel has the effect of regulating qi and strengthening the spleen. The synergistic effect of the two further enhances the effect of moistening the intestines and relieving constipation.

[0052] In some possible implementations, among the raw material components of the Chinese medicine composition, the weight proportion of Crataegus pinnatifida can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 3.6 parts, 4 parts, etc., the weight proportion of Sophora japonica flos can be 2 parts, 2.5 parts, 3 parts, 3.5 parts, 3.6 parts, 4 parts, etc., the weight proportion of Atractylodes macrocephala can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc., the weight proportion of Poria cocos can be 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, etc., the weight proportion of malt can be 1 part, 1.5 parts, 2 parts, etc., the weight proportion of dried tangerine peel can be 1 part, 1.5 parts, 2 parts, etc., which are typical but non-limiting arbitrary point values ​​or interval values ​​between any two point values.

[0053] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight: 2 parts of Crataegus pinnatifida, 2 parts of Sophora japonica flos, 1 part of Atractylodes macrocephala, 1 part of Poria cocos, 1 part of malt and 1 part of dried tangerine peel.

[0054] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight: 2.5 parts of Crataegus pinnatifida, 2 parts of Sophora japonica, 1.5 parts of Atractylodes macrocephala, 1.5 parts of Poria cocos, 1.5 parts of malt and 1 part of dried tangerine peel;

[0055] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight: 3 parts of Crataegus pinnatifida, 2.5 parts of Sophora japonica, 2 parts of Atractylodes macrocephala, 2 parts of Poria cocos, 1.8 parts of malt and 1.3 parts of dried tangerine peel;

[0056] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight: 3.6 parts of Crataegus pinnatifida, 3 parts of Sophora japonica flos, 2.2 parts of Atractylodes macrocephala, 2.2 parts of Poria cocos, 2 parts of malt and 1.5 parts of dried tangerine peel.

[0057] In some possible implementations, the Chinese medicine composition includes the following raw material components in parts by weight: 4 parts of Crataegus pinnatifida, 4 parts of Sophora japonica floret, 3 parts of Atractylodes macrocephala, 3 parts of Poria cocos, 2 parts of malt and 2 parts of dried tangerine peel.

[0058] In some possible implementations, the Chinese medicine composition is in the form of granules that pass through a 14-mesh sieve. In this case, the particle size of the granules of the Chinese medicine composition is no greater than 1.18 mm, and the particles are small, making them convenient for patients to take.

[0059] In some possible implementations, the Chinese medicine composition is taken directly, which is convenient for patients to use.

[0060] In some possible implementations, the daily dosage of the Chinese medicine composition for patients is 0.5g / kg to 2g / kg; wherein g / kg refers to how many grams of the Chinese medicine composition are taken for each kg of the patient's body weight. Exemplarily, the daily dosage of the patient can be 2g / kg, 1.8g / kg, 1.5g / kg, 1.2g / kg, 1.0g / kg, 0.8g / kg, 0.5g / kg, and other typical but non-restrictive arbitrary point values ​​or interval values ​​between any two point values. In this case, the dosage can be flexibly adjusted according to the patient's condition. If the patient has a high degree of constipation, the daily dosage is increased. If the patient has a mild degree of constipation, the daily dosage is reduced.

[0061] In some possible implementations, the Chinese medicine composition also contains at least one auxiliary material selected from citric acid, sucrose, stevioside, acesulfame potassium, DL-malic acid, orange flavor, strawberry flavor, and apple flavor. In this case, by adding auxiliary materials such as citric acid and sucrose to the Chinese medicine composition, the taste of the Chinese medicine composition can be adjusted, which is convenient for molding and stability. Among them, citric acid is an organic acid that can be used as a pH regulator to help adjust the pH of the Chinese medicine composition, thereby making it more stable. In addition, citric acid can also be used as a stabilizer to improve the bioavailability and stability of the drug. Citric acid has antioxidant and anti-inflammatory physiological activities, which can protect the effective ingredients in Chinese medicine from oxidative damage and may enhance the anti-inflammatory effect of the drug. Citric acid can interact with other ingredients in the Chinese medicine composition to produce a synergistic effect, thereby improving the efficacy of the drug. Sucrose is sweet and can significantly improve the taste of the Chinese medicine composition, making it more acceptable. For Chinese medicines with a bitter taste, adding sucrose can play a good masking role. It has the effect of moistening the lungs and harmonizing the middle, and can also nourish the spleen and soothe the liver. It has a certain alleviating effect on symptoms such as weak spleen and stomach, and liver qi disharmony.

[0062] The Chinese medicine composition in the above examples of the present application can be prepared by the following example method.

[0063] In a second aspect, the present application provides a method for preparing a Chinese medicine composition for treating constipation, as shown in the attached Figure 1As shown, the following steps are included:

[0064] S10. Extract 2-4 parts of Crataegus pinnatifida, 2-4 parts of Sophora japonica flos, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Poria cocos, 1-2 parts of malt and 1-2 parts of dried tangerine peel to prepare a traditional Chinese medicine composition for treating constipation.

[0065] The preparation method of the Chinese medicine composition in the embodiment of the present application uses 2 to 4 parts of Crataegus pinnatifida, 2 to 4 parts of Sophora japonica, 1 to 3 parts of Atractylodes macrocephala, 1 to 3 parts of Poria cocos, 1 to 2 parts of malt and 1 to 2 parts of dried tangerine peel as raw materials, and extracts the active substances in each component to prepare a Chinese medicine composition for treating constipation. The preparation process is simple and suitable for industrial large-scale production and application. The prepared Chinese medicine composition can increase the number of bowel movements in patients with constipation, enhance the propulsion function of the patient's small intestine, increase the water content of feces, reduce intestinal damage caused by constipation, and has a significant therapeutic effect on patients with constipation.

[0066] In some possible implementations, such as the attached Figure 2 As shown, the steps of the extraction process include:

[0067] S11. Distill and extract Atractylodes macrocephala and dried orange peel, and collect the volatile oil and the aqueous solution after distillation respectively.

[0068] In this case, the volatile oil of Atractylodes macrocephala is its main effective part, and its content in the rhizome of Atractylodes macrocephala is about 1.4% to 2.5%. The chemical composition of volatile oil of Atractylodes macrocephala is complex, with a total of about 78 terpenes, 5 aliphatic, 3 aromatic, 1 steroid and 1 alkaloid, mainly composed of atractylodes ketone, β-eudesmol, γ-elemene, atractylodes lactone I and III, etc. Tangerine peel volatile oil is one of the important active ingredients in tangerine peel, mainly containing limonene, pinene, sabinene and other ingredients. These volatile oils give tangerine peel a unique aroma and taste, making it unique in cooking and medicinal use.

[0069] S12. Decoct Crataegus pinnatifida, Sophora japonica flower, Poria cocos and malt with water, and combine the filtrate obtained with the distilled aqueous solution to prepare an ointment.

[0070] In the examples of the present application, Atractylodes macrocephala and dried tangerine peel are selected for distillation to extract volatile oils and other components; the other four medicinal materials, namely Crataegus pinnatifida, Sophora japonica flos, Poria cocos and malt, are decocted using aqueous solutions using traditional techniques; different extraction methods are used according to the different properties of the effective chemical components of the prescription drugs to ensure the therapeutic effect.

[0071] In some possible implementations, the preparation of the filtrate includes the steps of: boiling hawthorn, Sophora japonica, Poria cocos and malt with water for 2 to 3 times, boiling for 2 to 3 hours each time, combining the decoctions, filtering and obtaining the filtrate. In this case, by boiling hawthorn, Sophora japonica, Poria cocos and malt for 2 to 3 times and combining the decoctions, the active substances in the medicinal materials are fully extracted.

[0072] In some possible implementations, the mass ratio of the total mass of Crataegus pinnatifida, Sophora japonica, Poria cocos and malt to water is 1:(8-12). In this case, the mass ratio of the medicinal materials to water can fully ensure the extraction of the effective ingredients of Crataegus pinnatifida, Sophora japonica, Poria cocos and malt. Exemplarily, the mass ratio of the total mass of Crataegus pinnatifida, Sophora japonica, Poria cocos and malt to water can be 1:8, 1:9, 1:10, 1:11, 1:12, etc., typical but non-limiting arbitrary point values ​​or interval values ​​between any two point values.

[0073] In some possible implementations, the preparation of the ointment includes the steps of: combining the filtrate with the distilled aqueous solution, concentrating to a clear paste, cooling, adding an alcohol solvent to precipitate impurities, recovering the supernatant filtrate, concentrating to a thick paste, and obtaining the ointment. The ointment is obtained by combining the filtrate with the distilled aqueous solution of Atractylodes macrocephala and dried orange peel, concentrating and removing impurities.

[0074] In some possible implementations, the relative density of the clear paste is 1.17-1.23 (70°C). For example, the relative density of the clear paste can be 1.17 (70°C), 1.18 (70°C), 1.19 (70°C), 1.20 (70°C), 1.21 (70°C), 1.22 (70°C), 1.23 (70°C), and other typical but non-limiting arbitrary point values ​​or interval values ​​between any two point values. The relative density refers to the density relative to water, that is, the density of the clear paste relative to water is 1.17-1.23 (70°C).

[0075] In some possible implementations, the relative density of the thick paste is 1.32-1.37 (60°C). For example, the relative density of the thick paste can be 1.32 (60°C), 1.33 (60°C), 1.34 (60°C), 1.35 (60°C), 1.36 (60°C), 1.37 (60°C), and other typical but non-limiting arbitrary point values ​​or interval values ​​between any two point values. The relative density refers to the density relative to water, that is, the density of the thick paste relative to water is 1.32-1.37 (60°C).

[0076] In some possible implementations, the step of precipitating impurities with an alcohol solvent includes: adding an ethanol solvent so that the alcohol content in the clear paste is 60% to 70%, standing for 24 to 48 hours, filtering the supernatant to obtain a supernatant filtrate. Different alcohol contents have different degrees of impurity removal, and the dose-effect relationship may be affected. In this case, the added ethanol solvent can fully precipitate the impurity components to obtain the target supernatant filtrate.

[0077] Exemplarily, the alcohol content in the clear paste can be 60%, 62%, 65%, 68%, 70%, or any other typical but non-limiting value or an interval value between any two values ​​by adding ethanol solvent.

[0078] S13. After mixing the ointment with volatile oil, the mixture is made into granules to obtain a Chinese medicine composition.

[0079] In some possible implementations, the preparation of granules includes the steps of: adding auxiliary materials to the ointment, drying, spraying volatile oil for mixing, and granulating to obtain granules of the traditional Chinese medicine composition.

[0080] In some possible implementations, the excipients include at least one of citric acid, sucrose, steviol glycosides, acesulfame potassium, DL-malic acid, orange flavor, strawberry flavor, and apple flavor; these excipients can adjust the taste of the Chinese medicine composition, facilitate molding, stability, etc.

[0081] In some possible implementations, the mass percentage of the auxiliary material in the granules of the Chinese medicine composition is 65% to 95.5%. In this case, the granules in the Chinese medicine composition can effectively improve its taste, molding effect, stability and other properties. Exemplarily, in the granules of the Chinese medicine composition, the mass percentage of the auxiliary material can be 65%, 70%, 75%, 80%, 85%, 90%, 95%, 95.5% and other typical but non-limiting arbitrary point values ​​or interval values ​​between any two point values.

[0082] In some embodiments, the granules of the Chinese medicine composition include 65wt% to 95wt% sucrose and 0.1wt% to 0.5wt% citric acid as auxiliary materials. In other embodiments, the granules of the Chinese medicine composition include 65wt% to 95wt% acesulfame potassium and 0.1wt% to 0.5wt% DL-malic acid as auxiliary materials. In this case, the granules in the Chinese medicine composition have better taste, molding effect, stability and other characteristics.

[0083] In some possible implementations, the granules after granulation are sieved through a 14-mesh sieve, so that the particle size of the granules of the Chinese medicine composition is not greater than 1.18 mm, and the particles are small and convenient for patients to take.

[0084] In order to enable the above-mentioned implementation details and operations of the present application to be clearly understood by those skilled in the art, as well as to demonstrate the significant improvement in the performance of the Chinese medicine composition for treating constipation and the preparation method thereof in the embodiments of the present application, the above-mentioned technical scheme is illustrated by means of multiple embodiments below.

[0085] Example 1

[0086] A traditional Chinese medicine composition for treating constipation comprises raw material components: 2 parts of Crataegus pinnatifida, 2 parts of Sophora japonica flowers, 1 part of Atractylodes macrocephala, 1 part of Poria cocos, 1 part of malt and 1 part of dried tangerine peel.

[0087] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica flower, poria and malt, boiling twice, each time for 2 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 65%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.35 (60°C), adding 85% sucrose and 0.5% citric acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0088] Example 2

[0089] A traditional Chinese medicine composition for treating constipation comprises raw material components: 2.5 parts of Crataegus pinnatifida, 2 parts of Sophora japonica flowers, 1.5 parts of Atractylodes macrocephala, 1.5 parts of Poria cocos, 1.5 parts of malt and 1 part of dried tangerine peel.

[0090] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica flower, poria and malt, boiling twice, each time for 2 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 65%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.35 (60°C), adding 85% sucrose and 0.5% citric acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0091] Example 3

[0092] A traditional Chinese medicine composition for treating constipation comprises raw material components: 3 parts of Crataegus pinnatifida, 2.5 parts of Sophora japonica flowers, 2 parts of Atractylodes macrocephala, 2 parts of Poria cocos, 1.8 parts of malt and 1.3 parts of dried tangerine peel.

[0093] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica, tuckahoe and malt, decocting twice, each time for 2 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 65%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.35 (60°C), adding 85% sucrose and 0.5% citric acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0094] Example 4

[0095] A traditional Chinese medicine composition for treating constipation comprises raw material components: 3.6 parts of Crataegus pinnatifida, 3 parts of Sophora japonica flowers, 2.2 parts of Atractylodes macrocephala, 2.2 parts of Poria cocos, 2 parts of malt and 1.5 parts of dried tangerine peel.

[0096] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica flower, poria and malt, boiling twice, each time for 2 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 65%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.35 (60°C), adding 85% sucrose and 0.5% citric acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0097] Example 5

[0098] A traditional Chinese medicine composition for treating constipation comprises raw material components: 4 parts of Crataegus pinnatifida, 4 parts of Sophora japonica flowers, 3 parts of Atractylodes macrocephala, 3 parts of Poria cocos, 2 parts of malt and 2 parts of dried tangerine peel.

[0099] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica flower, poria and malt, boiling twice, each time for 2 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 65%, standing for 24 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.35 (60°C), adding 85% sucrose and 0.5% citric acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0100] Example 6

[0101] A traditional Chinese medicine composition for treating constipation comprises raw material components: 2 parts of Crataegus pinnatifida, 2 parts of Sophora japonica flowers, 1 part of Atractylodes macrocephala, 1 part of Poria cocos, 1 part of malt and 1 part of dried tangerine peel.

[0102] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica flower, poria and malt, boiling twice, each time for 2 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 70%, standing for 48 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.32 (60°C), adding 85% sucrose and 0.5% citric acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0103] Example 7

[0104] A traditional Chinese medicine composition for treating constipation comprises raw material components: 2 parts of Crataegus pinnatifida, 2 parts of Sophora japonica flowers, 1 part of Atractylodes macrocephala, 1 part of Poria cocos, 1 part of malt and 1 part of dried tangerine peel.

[0105] The preparation method comprises the following steps: steam distilling the above six medicinal materials, two medicinal materials of white atractylodes and dried tangerine peel water, extracting volatile oil, collecting the distilled aqueous solution in another container and setting aside; adding water to the remaining four medicinal materials of hawthorn, small sophora japonica flower, poria and malt, boiling for 3 times, each time for 3 hours, combining the decoctions, filtering through a 200-mesh filter cloth, combining the filtrate with the distilled aqueous solution, concentrating under reduced pressure to a clear paste with a relative density of 1.20 (70°C), cooling, adding ethanol to make the alcohol content reach 70%, standing for 48 hours, taking the supernatant, filtering, recovering ethanol from the filtrate, concentrating to a thick paste with a relative density of 1.32 (60°C), adding 85% acesulfame potassium and 0.5% DL-malic acid, drying, spraying the volatile oil extracted from the white atractylodes and dried tangerine peel, mixing evenly, preparing granules, and obtaining a Chinese medicine composition granule.

[0106] Comparative Example 1

[0107] A Chinese medicine composition for treating constipation comprises raw material components: 1 part of Crataegus pinnatifida, 1 part of Sophora japonica flower, 4 parts of Atractylodes macrocephala, 4 parts of Poria cocos, 3 parts of malt and 3 parts of dried orange peel. The preparation steps and conditions thereof refer to Example 1.

[0108] Comparative Example 2

[0109] A Chinese medicine composition for treating constipation comprises raw material components: 1.5 parts of Crataegus pinnatifida, 1.5 parts of Sophora japonica, 3.5 parts of Atractylodes macrocephala, 3.5 parts of Poria cocos, 2.5 parts of malt and 2.5 parts of dried tangerine peel. The preparation steps and conditions thereof refer to Example 1.

[0110] Comparative Example 3

[0111] A Chinese medicine composition for treating constipation comprises raw material components: 1.5 parts of Crataegus pinnatifida, 1.5 parts of Sophora japonica, 4 parts of Atractylodes macrocephala, 4 parts of Poria cocos, 3 parts of malt and 3 parts of dried orange peel. The preparation steps and conditions thereof refer to Example 1.

[0112] In order to verify the progress of the examples of the present application, the following performance tests were performed on the Chinese medicine compositions prepared in the above examples and comparative examples:

[0113] To investigate the effect of Chinese herbal medicine combination on loperamide-induced constipation in mice:

[0114] 1. Grouping and modeling: After 1 week of adaptive feeding, 60 ICR (Institute of Cancer Research) mice aged 4-6 weeks were randomly divided into a normal group (normal animals), a model group (constipated animals), a positive control group (mosapride group, 0.003 g / kg), a low-dose group of Chinese medicine composition (2.0 g granules / kg), a medium-dose group of Chinese medicine composition (4.0 g granules / kg), and a high-dose group of Chinese medicine composition (8.0 g granules / kg), with 10 mice in each group. At 9:00 am every day, the normal group was gavaged with normal saline (0.2 ml), and the other groups were gavaged with loperamide (10 mg / kg, 0.2 ml) for 21 consecutive days. The loperamide is a constipation modeling agent to induce constipation in animals. Starting from the eighth day, the normal group and the model group were gavaged with normal saline at 3:00 pm every day, the positive control group was gavaged with mosapride, 0.003 g / kg, and the Chinese medicine composition test group was gavaged with different doses of Anshikang granules (2.0 g granules / kg for the low-dose group of the Chinese medicine composition, 4.0 g granules / kg for the medium-dose group of the Chinese medicine composition, and 8.0 g granules / kg for the high-dose group of the Chinese medicine composition) for 2 consecutive weeks.

[0115] 2. On the 20th day, each mouse was placed in a separate cage to collect feces within 24 hours, the amount of mouse feces, the weight of feces before and after drying, and the feces moisture content was calculated (feces moisture content = (feces wet weight - feces dry weight) / feces wet weight * 100%).

[0116] 3. On the 21st day, an appropriate amount of ink was gavaged 30 minutes after administration, and the mice were killed by cervical dislocation 20 minutes later. The length of ink in the small intestine and the total length of the small intestine were measured with a ruler, and the ink propulsion rate of the small intestine was calculated (ink propulsion rate = ink length of small intestine / total length of small intestine*100%).

[0117] 4. After the mice were killed, part of the small intestine was taken for pathological examination. The steps of intestinal pathology detection include: the small intestine of the mouse was fixed in 4% formaldehyde solution, and then dehydrated with ethanol gradient. Subsequently, it was made transparent and immersed in xylene, and paraffin embedding technology was used to make paraffin sections with a thickness of 6μm. Next, the sections were placed in an oven at a temperature of 65°C and baked for about 20 minutes, and conventional H&E staining was performed. Finally, neutral resin was used to seal the sections, and after complete solidification, the pathological changes in the intestinal barrier of the small intestinal tissue were observed under an optical microscope.

[0118] The above test results are shown in Table 1 below:

[0119] Table 1

[0120]

[0121]

[0122] The above test results show that, firstly, compared with the normal group, the model group mice had less defecation and lower fecal water content, and the constipation model was successful. Compared with the model group, the mice in each administration group of the Chinese medicine composition in the embodiment of the present application had more defecation and higher fecal water content.

[0123] Second, compared with the normal group, the ink propagation rate of mice in the model group was reduced. Compared with the model group, the ink propagation rate of mice in each administration group of the Chinese medicine composition in the embodiment of the present application was increased.

[0124] Third, the normal group mice had more microvilli in the small intestinal mucosal epithelial cells, which were arranged neatly, with tight intercellular spaces, no obvious epithelial cell shedding, normal cell morphology and clear structure. The small intestinal mucosal epithelial cells of the model group mice were wrinkled, smaller in size, sparsely arranged, and the intestinal villi were truncated and most of them disappeared. This shows that after treatment with the Chinese medicine composition in the embodiment of the present application, the damage to the small intestinal mucosal epithelial cells of the mice in each administration group showed different degrees of repair.

[0125] Fourthly, in the Chinese medicine compositions provided in Comparative Examples 1-3, the contents of Crataegus pinnatifida and Sophora japonica are too low, and the contents of Atractylodes macrocephala, Poria cocos and Tangerine peel are too high; the number of defecation of mice is reduced, the water content of feces is reduced, and the ink propulsion rate is reduced, indicating that the improvement effect on constipation in mice is lower than that in Examples 1 to 7 of the present application. Under the formula conditions of 2 to 4 parts of Crataegus pinnatifida, 2 to 4 parts of Sophora japonica, 1 to 3 parts of Atractylodes macrocephala, 1 to 3 parts of Poria cocos, 1 to 2 parts of malt and 1 to 2 parts of Tangerine peel in the Chinese medicine compositions of the present application embodiments, the number of defecation of constipated mice can be better increased, the propulsion function of the small intestine of mice can be enhanced, the water content of feces can be increased, the intestinal damage caused by constipation can be reduced, and the constipation of mice can be better treated.

[0126] The above description is only a preferred embodiment of the present application and is not intended to limit the present application. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present application should be included in the protection scope of the present application.

Claims

1. A Chinese medicine composition for treating constipation, characterized in that: The raw material components include the following parts by weight: 2-4 parts of Crataegus pinnatifida, 2-4 parts of Sophora japonica flowers, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Poria cocos, 1-2 parts of malt and 1-2 parts of dried tangerine peel.

2. The Chinese medicine composition for treating constipation according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw material components in parts by weight: 2.5-3.6 parts of Crataegus pinnatifida, 2-3 parts of Sophora japonica flowers, 1.5-2.2 parts of Atractylodes macrocephala, 1.5-2.2 parts of Poria cocos, 1.5-2 parts of malt and 1-1.5 parts of dried tangerine peel.

3. The Chinese medicine composition for treating constipation according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw material components in parts by weight: 2.5 parts of Crataegus pinnatifida, 2 parts of Sophora japonica, 1.5 parts of Atractylodes macrocephala, 1.5 parts of Poria cocos, 1.5 parts of Malt and 1 part of Tangerine peel; Alternatively, 3 parts of Crataegus pinnatifida, 2.5 parts of Sophora japonica, 2 parts of Atractylodes macrocephala, 2 parts of Poria cocos, 1.8 parts of malt, and 1.3 parts of dried orange peel; Alternatively, 3.6 parts of Crataegus pinnatifida, 3 parts of Flos Sophorae Fructus, 2.2 parts of Atractylodes macrocephala, 2.2 parts of Poria cocos, 2 parts of malt and 1.5 parts of dried tangerine peel.

4. The Chinese medicine composition for treating constipation according to claim 1, characterized in that: The Chinese medicine composition is a granule that passes through a 14-mesh sieve; And / or, the Chinese medicine composition is taken directly; And / or, the daily dosage of the Chinese medicine composition for a patient is 0.5 g / kg to 2 g / kg; And / or, the Chinese medicine composition further comprises at least one auxiliary material selected from the group consisting of citric acid, sucrose, steviol glycoside, acesulfame potassium, DL-malic acid, orange flavor, strawberry flavor, and apple flavor.

5. A method for preparing a Chinese medicine composition for treating constipation, characterized in that: The following steps are involved: 2-4 parts of Crataegus pinnatifida, 2-4 parts of Sophora japonica flowers, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Poria cocos, 1-2 parts of malt and 1-2 parts of dried tangerine peel are extracted to prepare a Chinese medicine composition for treating constipation.

6. The method for preparing the Chinese medicine composition for treating constipation according to claim 5, characterized in that: The steps of the extraction process include: Distill and extract the Atractylodes macrocephala and the dried orange peel, and collect volatile oil and the distilled aqueous solution respectively; The hawthorn fruit, the small sophora flower, the poria and the malt are decocted in water, and the filtrate is combined with the distilled aqueous solution to prepare an ointment; The ointment is mixed with the volatile oil to prepare granules, thereby obtaining the traditional Chinese medicine composition.

7. The method for preparing the Chinese medicine composition for treating constipation according to claim 6, characterized in that: The preparation of the filtrate comprises the following steps: adding water to the hawthorn fruit, the small sophora flower, the poria and the malt and boiling them for 2 to 3 times, boiling them for 2 to 3 hours each time, combining the decoctions and filtering them to obtain the filtrate; And / or, the preparation of the ointment comprises the steps of: combining the filtrate with the distilled aqueous solution, concentrating the mixture into a clear paste, cooling the mixture, adding an alcohol solvent to precipitate impurities, recovering the supernatant filtrate, and concentrating the mixture into a thick paste to obtain the ointment.

8. The method for preparing the Chinese medicine composition for treating constipation according to claim 7, characterized in that: The mass ratio of the total mass of the hawthorn, the small sophora flower, the poria and the malt to water is 1: (8-12); and / or, filtering the combined decoction liquid using a 200-mesh filter cloth; And / or, the relative density of the clear paste is 1.17 to 1.23 (70°C); and / or, the relative density of the thick paste is 1.32 to 1.37 (60° C.); And / or, the step of precipitating impurities with an alcohol solvent comprises: adding an ethanol solvent so that the alcohol content in the clear paste is 60% to 70%, leaving it to stand for 24 to 48 hours, filtering the supernatant to obtain the supernatant filtrate.

9. The method for preparing the Chinese medicinal composition for treating constipation according to any one of claims 6 to 8, characterized in that: The preparation of the granules comprises the following steps: adding auxiliary materials to the ointment, drying, spraying the volatile oil for mixing, and granulating to obtain the granules of the traditional Chinese medicine composition.

10. The method for preparing the Chinese medicine composition for treating constipation according to claim 9, characterized in that: The auxiliary materials include at least one of citric acid, sucrose, steviol glycoside, acesulfame potassium, DL-malic acid, orange flavor, strawberry flavor, and apple flavor; And / or, in the granules of the traditional Chinese medicine composition, the mass percentage of the auxiliary material is 65% to 95.5%; And / or, the granulated particles are sieved through a 14-mesh sieve.

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