4 results about "Clinical effectiveness" patented technology

A system may model, in a computer system, a first model representing a plurality of decision-options. A system may model, in the computer system, a second model representing an effectiveness of the plurality of decision-options. A system evaluates sensitivities, uncertainties, and alternative scenarios related to the plurality of decision-options of the first model and the effectiveness of the plurality of decision-options of the second model. A system provides an output indicating recommendations and tradeoffs among the set of design options selected from the plurality of decision-options. A system and method for decision-making support in medical technology strategy integrates Multi-Attribute Tradespace Exploration (MATE) and Clinical Cost-Effectiveness Analysis (CEA) models. The system models a plurality of decision-options, and evaluates their effectiveness using clinical effectiveness metrics such as quality-adjusted life years (QALYs). The system optimizes these decision-options by performing probabilistic analyses, including Monte Carlo simulations, to account for uncertainties.

A System and method enhance clinical effectiveness for monitoring for a change in a level of fluid in tissue by using a device attached to a body portion that wirelessly reports to a remote apparatus or receiver power level for indications of extravasation or infiltration. Adjusting an activation rate of fluid detection, reporting or both extends service life of the device.

This invention discloses a Markov chain Monte Carlo sampling method based on a dual-constraint set projection mechanism, which solves the problems of poor target distribution adaptability, slow convergence, and sensitivity to initial values ​​in traditional MCMC sampling in personalized drug delivery scenarios. The method includes: sampling initialization, using the ppk+MAPB algorithm to construct a four-layer nested target probability distribution model; determining a multivariate normal distribution as the proposed distribution; introducing a dual-constraint mechanism of Euclidean distance constraint set and orientation constraint set during iterative sampling, mapping candidate samples to the intersection of the two sets through a projection operator, and sampling numerical parameters θ and covariance matrix Σ in stages using the MH criterion; and performing convergence judgment. This invention improves the clinical effectiveness and accuracy of the sampled samples, achieves faster convergence, and can be widely applied to parameter estimation and protocol optimization scenarios in personalized drug delivery.

A system may model, in a computer system, a first model representing a plurality of decision-options. A system may model, in the computer system, a second model representing an effectiveness of the plurality of decision-options. A system evaluates sensitivities, uncertainties, and alternative scenarios related to the plurality of decision-options of the first model and the effectiveness of the plurality of decision-options of the second model. A system provides an output indicating recommendations and tradeoffs among the set of design options selected from the plurality of decision-options. A system and method for decision-making support in medical technology strategy integrates Multi-Attribute Tradespace Exploration (MATE) and Clinical Cost-Effectiveness Analysis (CEA) models. The system models a plurality of decision-options, and evaluates their effectiveness using clinical effectiveness metrics such as quality-adjusted life years (QALYs). The system optimizes these decision¬ options by performing probabilistic analyses, including Monte Carlo simulations, to account for uncertainties.