Pharmaceutical composition comprising a proton pump inhibitor and a prebiotic for the treatment of ulcerous lesions of the stomach and duodenum

Abstract

A pharmaceutical composition comprising proton pump inhibitors and prebiotics is proposed for the treatment of gastric and duodenal ulcer, this allowing effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum antibiotics. The comprehensive treatment of ulcer disease associated with a helicobaterial infection using a pharmaceutical composition of a PPI and a prebiotic makes it possible, in conditions of an elevated pH of the stomach contents, actively to stimulate the growth of lactobacilli in the upper sections of the gastrointestinal tract, including the duodenum, and substantially to increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment.; The high clinical effectiveness and safety resulting from the synergistic action of the proton pump inhibitor and the prebiotic in the upper sections of the gastrointestinal tract, the absence of side effects and recurrences, and also the level of compliance to the combined treatment provided by the claimed pharmaceutical composition indicate that the proposed formulation is a promising new means for the treatment of gastric and duodenal ulcer. Use of the claimed composition dramatically reduces the number of recurrences of the illness.

Description

technical field [0001] The invention relates to the fields of medicine and pharmacy, and more to a pharmaceutical composition for treating gastric ulcer and duodenal ulcer. Background technique [0002] Gastric ulcer and duodenal ulcer are chronic diseases that are prone to relapse, and the main feature is the formation of ulcers on the gastric and duodenal mucosa. Such diseases are the most common lesions of the organs of the digestive tract. According to epidemiological data, 8-10% of adults in the world suffer from ulcer disease. 1% of children suffer from this disease. Ulcer disease is most common in young and middle-aged people. The ratio of gastric ulcer to duodenal ulcer incidence is 1:4. Among them, young people mainly suffer from duodenal ulcers, while the rate of gastric ulcers among middle-aged and elderly people gradually increases. Men are more likely than women to develop duodenal ulcers. [0003] The discovery of the role of Helicobacter pylori in the de...

AI Technical Summary

Problems solved by technology

[0012] The disadvantages of the above drugs are the toxic effects of antibacterial drugs and the dysbiosis of the digestive tract due to the inhibition of normal flora by antibacterial drugs

[0014] The disadvantages of the above drugs are the toxic effect of large doses of

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