A pharmaceutical composition comprising 
proton pump inhibitors and prebiotics is proposed for the treatment of gastric and 
duodenal ulcer, this allowing effective ulcer treatment and eradication of H. pylori from the gastric and duodenal mucosa to be carried out without using wide-spectrum 
antibiotics. The comprehensive treatment of 
ulcer disease associated with a helicobaterial infection using a pharmaceutical composition of a PPI and a 
prebiotic makes it possible, in conditions of an 
elevated pH of the 
stomach contents, actively to stimulate the growth of lactobacilli in the upper sections of the 
gastrointestinal tract, including the 
duodenum, and substantially to increase the titre of lactobacilli, which are antagonists of H. pylori, which greatly improves the effectiveness of the ulcer treatment.; The high 
clinical effectiveness and safety resulting from the synergistic action of the 
proton pump inhibitor and the 
prebiotic in the upper sections of the 
gastrointestinal tract, the absence of side effects and recurrences, and also the level of compliance to the 
combined treatment provided by the claimed pharmaceutical composition indicate that the proposed formulation is a promising new means for the treatment of gastric and 
duodenal ulcer. Use of the claimed composition dramatically reduces the number of recurrences of the illness.