14 results about "Growth plates" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention provides a developmental growth plate layered stent as well as a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered stent provided by the invention is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is an ossification layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite stent is stable in structure and not easy to break; the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are free of cells. Under the condition of in-vitro chondrogenesis induction culture, the BMSCs on the upper layer can penetrate through the middle layer and be colonized on the lower layer, and in the process, part of the BMSCs can be differentiated into cartilage cells. The middle layer containing the platelet reaction protein 1 (TSP1) has a specific intervention effect on cell migration, which is expressed by inhibiting the migration of vascular endothelial cells, but has no influence on the migration of the BMSCs.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

Methods and devices for applying a compressive force to a growth plate in a long bone of a pediatric patient. A dynamically compressive bone plate is provided for applying the compressive force to the growth plate of the long bone. By applying compressive force to the growth plate in the long bone, the activity of the growth plate is suppressed, inactivated, or otherwise shut down.

The present disclosure relates to a stackable growth module comprising a vertically arranged growth plate, the growth plate having a vertical surface for supporting a plant. The growth plate includes: a porous growth medium; a water supply tank arranged along the upper edge of the growth plate and including water distribution holes; a header tank disposed along a lower edge of the growth plate and including a valve; the drainage device comprises a liquid channel which bypasses the porous growth medium from the water supply tank and leads to the water collection tank. An inlet of the drainage device is located in the water supply tank.

The invention relates to the technical field of medical treatment, and discloses an intelligent growth plate activated child height promotion system and a personalized control method, and the system comprises the following modules: an evaluation parameter input module which collects parameters and standardizes the parameters; the AI prescription engine module is used for calculating a comprehensive growth score based on the standardized parameters and generating a personalized vibration prescription; the waveform generation engine module is used for converting the personalized vibration prescription into an execution instruction of vibration equipment; the training feedback module is used for collecting the somatosensory comfort score of the child and the thickness change of the growth plate; and the AI prescription training engine module is used for iteratively optimizing a model of the AI prescription training engine module based on the data of the training feedback module and generating an updated personalized vibration prescription. According to the system, multi-dimensional development parameters of children are collected through the evaluation parameter input module and standardized, comprehensive growth scores are calculated in combination with the AI prescription engine module, personalized vibration prescriptions are generated, and it is ensured that vibration stimulation adapts to individual development characteristics of the children.

The invention discloses a milk protein peptide for promoting bone growth as well as a preparation method and application thereof, and belongs to the technical field of bioactive peptides. The preparation method specifically comprises the following steps: (1) adding milk protein into a sodium hydroxide aqueous solution, and homogenizing through a colloid mill; (2) adjusting the pH value to 7.8, carrying out enzymolysis, carrying out enzyme inactivation, and cooling; (3) ultrafiltration and collection; (4) centrifugally filtering, taking supernate, and concentrating; and (5) carrying out spray drying. The milk protein peptide can significantly promote proliferation and differentiation of osteoblasts MC3T3-E1, up-regulate expression of osteogenesis-related genes ALP, promote mineralization of extracellular matrixes, promote proliferation of chondrocytes C28 / I2, and contribute to thickening of cartilage growth plates so as to promote bone growth. The compound can be used for preparing medicines and foods for promoting bone growth, preventing or assisting in treating osteoporosis and promoting bone health, and has the advantages of simple preparation process, low cost and definite components and activity.

This application discloses an automatic analysis method for CT images of long bones in mice and rats, relating to the field of image processing technology. The method includes: acquiring a CT image sequence of the target long bone, extracting the three-dimensional spatial distribution of bone tissue, and performing pose alignment and three-dimensional cropping to obtain a standardized bone image sequence; then constructing candidate depth intervals based on butterfly-shaped anatomical features and key points of growth plate strip-shaped gaps, respectively, and obtaining a fine search range through intersection operation; subsequently identifying candidate slices of triangular fractures and determining the anatomical zero point; finally, mapping the target analysis region based on the anatomical zero point, completing cortical bone segmentation, medullary cavity segmentation, and trabecular bone extraction under closed mask constraints, and outputting quantitative parameters of bone tissue. This application achieves accurate positioning of the growth plate and unified analysis region mapping in long bone CT images, improving the accuracy of trabecular bone extraction and the consistency of bone tissue quantification results.

The application provides a developmental growth plate layered scaffold and a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered scaffold provided by the application is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is a bone formation layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite scaffold structure is stable and is not easy to break; and the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are cell-free. Under the in-vitro chondrogenic induction culture condition, the BMSCs in the upper layer can pass through the middle layer and colonize in the lower layer, and in the process, part of the BMSCs can differentiate into cartilage cells. The middle layer containing thrombospondin 1 (TSP1) has specific intervention effect on cell migration, which is manifested as inhibition of the migration of vascular endothelial cells, but has no effect on the migration of BMSCs.

An embodiment relates to a composition for promoting height growth comprising an Artemisia dubia Wall. extract as an active ingredient, and may provide a composition for promoting height growth comprising an Artemisia dubia Wall. extract as an active ingredient, which has excellent effects of increasing body weight, increasing the tibial growth plate, increasing the femoral growth plate, and increasing the expression of a blood growth factor.

The invention discloses a composition for improving functions of cartilage cells of a growth plate and promoting body growth and application of the composition, the composition comprises a first component, a second component and a third component, and the first component comprises rose acid; the second component is prepared from 3-(4-hydroxy-3-methoxyphenyl) propionic acid; the third component comprises ursolic acid and / or chitosan oligosaccharide. The components of the composition are high in safety to human bodies, the advantages of all the components can be fully combined and exerted through accurate adjustment, the functions of cartilage cells of a growth plate are better improved, and the growth of body length (height) is promoted.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

The invention provides ultra-stable nano amorphous calcium phosphate and a preparation method thereof. A phosphate radical source of the amorphous calcium phosphate is adenosine triphosphate or pyrophosphate. The amorphous calcium phosphate contains alkaline phosphatase capable of hydrolyzing adenosine triphosphate, extracellular nucleotide pyrophosphatase 1 and alpha2-HS glycoprotein or secretory phosphoprotein 1 capable of stably adsorbing calcium ions. Researches prove that a mineralization raw material adenosine triphosphate involved in the mineralization process of a human body growth plate is used as a source of phosphate radicals, and protein capable of hydrolyzing adenosine triphosphate and pyrophosphate is sequentially added and combined with protein capable of adsorbing calcium ions, so that a spherical amorphous calcium phosphate cluster structure can be formed; and the formed amorphous calcium phosphate can stably exist for more than 35 days under the conditions that the pH is 7.0-7.3 and the temperature is 37 DEG C, and can stably exist for more than 120 days under the condition of 4 DEG C, so that the stabilization time of the nanoscale amorphous calcium phosphate under the mild condition is remarkably prolonged, and the method has a wide application prospect in the field of bone tissue engineering.