29 results about "Growth plates" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention relates to the technical field of training effect evaluation, and provides an effect evaluation system for rehabilitation training of lower limbs of children, which comprises a processor, and a multi-modal sensor module, a data processing module, a training effect evaluation module and a prediction module which are connected with the processor. The multi-mode sensor module monitors and collects physiological data in the rehabilitation process of the child femoral distal closed fracture. The data processing module receives and processes sensor data and extracts features; the training effect evaluation module comprises a growth plate state feature evaluation unit, a skeleton growth feature evaluation unit, a physiological feature evaluation unit and a training effect evaluation unit, and evaluation is performed through a preset feature evaluation formula; and the prediction module uses a random forest model, inputs real-time feature data and predicts a training effect, including data collection, data cleaning and preprocessing, model initialization and training, model evaluation and optimization and evaluation value prediction, so as to evaluate and predict the training effect of the child patient with the distal closed femoral fracture.

The invention discloses a box-type glutinous yam cultivation device with clamping grooves, and relates to the technical field of yam cultivation. By arranging the clamping groove assemblies and the fixing clamping grooves, the number of the directional growth plate units can be increased or decreased according to different varieties of Chinese yams, gaps between the directional growth plate units can be adjusted at the same time, and therefore the width of the directional growth groove can be changed, and the directional growth groove with the corresponding width is provided for planting of different varieties of waxy Chinese yams; in each directional growth plate unit, the longitudinal height of the directional growth plate can be increased through a heightening plate, the height requirement for growth of the glutinous Chinese yam is met, the height and width of the directional growth groove in the clamping groove assembly are adjusted, and the application range of the directional growth plate is widened; by arranging the root system growth expansion assembly, a space for growth of the waxy yam root system can be additionally arranged at the bottom of the cultivation box, the path for the waxy yam root system to obtain nutrients is increased, the growth speed of waxy yam can be increased, and the yield of yam planting is increased.

The invention provides a developmental growth plate layered stent as well as a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered stent provided by the invention is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is an ossification layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite stent is stable in structure and not easy to break; the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are free of cells. Under the condition of in-vitro chondrogenesis induction culture, the BMSCs on the upper layer can penetrate through the middle layer and be colonized on the lower layer, and in the process, part of the BMSCs can be differentiated into cartilage cells. The middle layer containing the platelet reaction protein 1 (TSP1) has a specific intervention effect on cell migration, which is expressed by inhibiting the migration of vascular endothelial cells, but has no influence on the migration of the BMSCs.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

Compositions and peptides for enhancing formation of cartilage in a site of a cartilage injury or defect, or joint condition, and methods of the use of the compositions and peptides in such treatments. Examples of the sites may include a knee, ankle, wrist, shoulder, elbow, patella, hip, vertebrae, femoral head, temporomandibular joint, glenoid of the scapula, jaw, and growth plate.

Methods and devices for applying a compressive force to a growth plate in a long bone of a pediatric patient. A dynamically compressive bone plate is provided for applying the compressive force to the growth plate of the long bone. By applying compressive force to the growth plate in the long bone, the activity of the growth plate is suppressed, inactivated, or otherwise shut down.

Methods for affixing soft tissue to an implant. The implant has a soft tissue attachment structure that includes a surface defining one or more troughs, and either at least one ingrowth plate spanning a portion of the trough and defining a suture tunnel between the ingrowth plate and trough for receiving a suture, or fixation bridges spanning a portion of the one or more troughs, each fixation bridge and respective trough defining a suture tunnel for receiving suture. Systems for performing the method are also disclosed.

An orthopedic implant that can be used to control the growth rate of bones. An opening of the implant for inserting a fixing screw is provided with at least two supporting parts in the longitudinal direction of the opening. After the screw is screwed into the bone through the opening, different sides of the screw are supported respectively to prevent the screw from shifting in the opening in the growth direction of the bone away from the growth plate. The implant can function immediately after implantation, thereby reducing the implant's in-place time, improving the efficiency of epiphyseal blocking, and avoiding the occurrence of secondary joint deformities.

The present disclosure relates to a stackable growth module comprising a vertically arranged growth plate, the growth plate having a vertical surface for supporting a plant. The growth plate includes: a porous growth medium; a water supply tank arranged along the upper edge of the growth plate and including water distribution holes; a header tank disposed along a lower edge of the growth plate and including a valve; the drainage device comprises a liquid channel which bypasses the porous growth medium from the water supply tank and leads to the water collection tank. An inlet of the drainage device is located in the water supply tank.

A method of tagging an object, particularly, an object in the form of a horn of a rhinoceros. The method comprises inserting or embedding at least one radioactive isotope insert comprising 60Co into a horn of the rhinoceros at a minimum distance of approximately 10 cm to 15 cm from a growth plate of the horn. The method comprises subsequently detecting the horn by detecting radiation emitted from the horn as a result of decay of the at least one radioactive isotope insert embedded within the horn.

The invention relates to the technical field of medical treatment, and discloses an intelligent growth plate activated child height promotion system and a personalized control method, and the system comprises the following modules: an evaluation parameter input module which collects parameters and standardizes the parameters; the AI prescription engine module is used for calculating a comprehensive growth score based on the standardized parameters and generating a personalized vibration prescription; the waveform generation engine module is used for converting the personalized vibration prescription into an execution instruction of vibration equipment; the training feedback module is used for collecting the somatosensory comfort score of the child and the thickness change of the growth plate; and the AI prescription training engine module is used for iteratively optimizing a model of the AI prescription training engine module based on the data of the training feedback module and generating an updated personalized vibration prescription. According to the system, multi-dimensional development parameters of children are collected through the evaluation parameter input module and standardized, comprehensive growth scores are calculated in combination with the AI prescription engine module, personalized vibration prescriptions are generated, and it is ensured that vibration stimulation adapts to individual development characteristics of the children.

A light source unit not only applies red light and infrared light to promote immediate cellular activity, but also applies the light to a femoral epiphysis area (first area) and a tibial epiphysis area (second area) together so that a stimulating device for a growth plate includes a light source unit that directly emits light of 600 to 1100 nm to a femoral epiphysis area (first area) and a tibial epiphysis area (second area) where the growth plates are distributed.

The invention discloses a milk protein peptide for promoting bone growth as well as a preparation method and application thereof, and belongs to the technical field of bioactive peptides. The preparation method specifically comprises the following steps: (1) adding milk protein into a sodium hydroxide aqueous solution, and homogenizing through a colloid mill; (2) adjusting the pH value to 7.8, carrying out enzymolysis, carrying out enzyme inactivation, and cooling; (3) ultrafiltration and collection; (4) centrifugally filtering, taking supernate, and concentrating; and (5) carrying out spray drying. The milk protein peptide can significantly promote proliferation and differentiation of osteoblasts MC3T3-E1, up-regulate expression of osteogenesis-related genes ALP, promote mineralization of extracellular matrixes, promote proliferation of chondrocytes C28 / I2, and contribute to thickening of cartilage growth plates so as to promote bone growth. The compound can be used for preparing medicines and foods for promoting bone growth, preventing or assisting in treating osteoporosis and promoting bone health, and has the advantages of simple preparation process, low cost and definite components and activity.

This application discloses an automatic analysis method for CT images of long bones in mice and rats, relating to the field of image processing technology. The method includes: acquiring a CT image sequence of the target long bone, extracting the three-dimensional spatial distribution of bone tissue, and performing pose alignment and three-dimensional cropping to obtain a standardized bone image sequence; then constructing candidate depth intervals based on butterfly-shaped anatomical features and key points of growth plate strip-shaped gaps, respectively, and obtaining a fine search range through intersection operation; subsequently identifying candidate slices of triangular fractures and determining the anatomical zero point; finally, mapping the target analysis region based on the anatomical zero point, completing cortical bone segmentation, medullary cavity segmentation, and trabecular bone extraction under closed mask constraints, and outputting quantitative parameters of bone tissue. This application achieves accurate positioning of the growth plate and unified analysis region mapping in long bone CT images, improving the accuracy of trabecular bone extraction and the consistency of bone tissue quantification results.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

The application provides a developmental growth plate layered scaffold and a preparation method and application thereof, and belongs to the technical field of bone tissue engineering materials. The developmental growth plate layered scaffold provided by the application is divided into three layers, the upper layer is a cartilage cell layer, the middle layer is a blood vessel barrier layer, and the lower layer is a bone formation layer. The blood vessel barrier layer can be used as biological glue to bond the upper layer and the lower layer, so that the composite scaffold structure is stable and is not easy to break; and the upper layer contains bone marrow mesenchymal stem cells (BMSCs), and the middle layer and the lower layer are cell-free. Under the in-vitro chondrogenic induction culture condition, the BMSCs in the upper layer can pass through the middle layer and colonize in the lower layer, and in the process, part of the BMSCs can differentiate into cartilage cells. The middle layer containing thrombospondin 1 (TSP1) has specific intervention effect on cell migration, which is manifested as inhibition of the migration of vascular endothelial cells, but has no effect on the migration of BMSCs.

A method is proposed to increase the proliferation of growth plate chondrocytes in children from early childhood to adolescence or in subjects where the growth plates are not closed by administering an agonist to activate G protein-coupled estrogen receptor 1 (GPER-1), thereby promoting children to grow taller or enhancing bone growth.

An embodiment relates to a composition for promoting height growth comprising an Artemisia dubia Wall. extract as an active ingredient, and may provide a composition for promoting height growth comprising an Artemisia dubia Wall. extract as an active ingredient, which has excellent effects of increasing body weight, increasing the tibial growth plate, increasing the femoral growth plate, and increasing the expression of a blood growth factor.

The invention discloses application of an RFLNA gene in regulating and controlling proliferation and development of pig thoracic vertebra growth plate cartilage cells, and belongs to the technical field of pig breeding. The invention finds that the proliferation and development of the pig thoracic vertebra growth plate cartilage cells can be regulated and controlled by regulating and controlling the expression of the RFLNA gene. The RFLNA gene can be applied to genetic breeding of pig body characters, acceleration of breeding progress, improvement of meat production rate or manufacturing of small pig experimental animal models, and has great economic value and scientific research value.

Reader and plate methods, operations, and systems for observing a biological sample are shown and described. In one embodiment, a device for observing biological growth, when present, on a growth plate, includes an imaging device and a variable positioning nest. The nest may include a first sunken frame to receive a first growth plate, and an offset second sunken frame to receive a distinct second growth plate in an operating position offset about the first operating position.

A tether assembly may be attached to a bone to correct a rotational deformity. The bone may have a growth plate that separates a first section of the bone from a second section of the bone. The tether assembly may have a tether member with a first end, a second end, and a central portion extending between the first end and the second end. The first end may have a closed outer wall that defines and fully bounds a first aperture. The second end may have an open outer wall that defines and partially bounds a second aperture. The open outer wall may define a slot in communication with the second aperture. The first and second ends may be securable to the first and second sections of the bone via coupling members inserted through the first and second apertures and anchored in the first and second sections, respectively.

The invention discloses a composition for improving functions of cartilage cells of a growth plate and promoting body growth and application of the composition, the composition comprises a first component, a second component and a third component, and the first component comprises rose acid; the second component is prepared from 3-(4-hydroxy-3-methoxyphenyl) propionic acid; the third component comprises ursolic acid and / or chitosan oligosaccharide. The components of the composition are high in safety to human bodies, the advantages of all the components can be fully combined and exerted through accurate adjustment, the functions of cartilage cells of a growth plate are better improved, and the growth of body length (height) is promoted.

A spiral growth tether system may be securable to a bone having a growth plate that separates a first portion of the bone from a second portion of the bone. The spiral growth tether system may include a tether including a first end configured to be secured to the first portion, a second end configured to be secured to the second portion, and a central portion between the first end and the second end. The first end and the second end may be configured to separate at the central portion in response to the first end being urged away from the second end as a result of growth of the bone urging the first portion away from the second portion.

The peptide of the present invention has activity for promoting the production of growth hormone (GH) and promoting the growth of the growth plate. Accordingly, the peptide of the present invention can be used for promoting growth and can be effectively used as an active ingredient for the treatment, prevention, or alleviation of growth delay disorders such as short stature.

The invention provides ultra-stable nano amorphous calcium phosphate and a preparation method thereof. A phosphate radical source of the amorphous calcium phosphate is adenosine triphosphate or pyrophosphate. The amorphous calcium phosphate contains alkaline phosphatase capable of hydrolyzing adenosine triphosphate, extracellular nucleotide pyrophosphatase 1 and alpha2-HS glycoprotein or secretory phosphoprotein 1 capable of stably adsorbing calcium ions. Researches prove that a mineralization raw material adenosine triphosphate involved in the mineralization process of a human body growth plate is used as a source of phosphate radicals, and protein capable of hydrolyzing adenosine triphosphate and pyrophosphate is sequentially added and combined with protein capable of adsorbing calcium ions, so that a spherical amorphous calcium phosphate cluster structure can be formed; and the formed amorphous calcium phosphate can stably exist for more than 35 days under the conditions that the pH is 7.0-7.3 and the temperature is 37 DEG C, and can stably exist for more than 120 days under the condition of 4 DEG C, so that the stabilization time of the nanoscale amorphous calcium phosphate under the mild condition is remarkably prolonged, and the method has a wide application prospect in the field of bone tissue engineering.

The present invention relates to the unexpected discovery of compositions and methods for the treatment of growth plate defects. In certain embodiments, the methods prevent the growth of “bony bars” at the site of growth plate injury, thereby preventing growth arrest and / or deformity. In certain embodiments, the compositions comprise hydrogels comprising at least one biological factor capable of preventing bony bar formation.