61 results about "Epiphysis" patented technology

Systems and methods for shaping and filling offset bone voids during revision procedures of total knee replacements are disclosed. The systems disclosed herein generally include an intramedullary reamer, an offset driver, a cylindrical reaming tool, an offset reaming guide, and a conical reamer. An alternate embodiment of the system may also generally include an IM reamer, an offset driver, an offset broaching tool, and a second stage broaching tool. Yet another embodiment may generally include an elongate IM reamer, a cone reamer, a reamer guide shaft, a cone trial, a sizing template, a template guide, an offset lobe reamer, and offset lobe reamer retainer. Metaphyseal reconstruction devices and void filling cones can be used to fill the bone voids in conjunction with the systems and methods disclosed herein.

A support for vertebral fusion prevents subsidence and eliminates the need for posterior surgery and instrumentation. The support is constructed of an implantable man-made material. One embodiment is generally a U-shaped metal support that rests on the apophyseal ring of a patient's vertebrae, with the open portion of the U facing the patient's posterior. The metal support is connected to a previously placed threaded cage or bone dowel such as that used in anterior lumbar interbody fusion (ALIF). The U-shaped support is preferably comprised of a trabecular metal such as tantalum.

A fixation device for treating an epiphyseal fracture, comprises a shaft extending longitudinally along a central axis from a first end to a second end configured to slidably engage a bone implant opening and a having a maximum radius r and a spherical head element attached to the first end of the shaft and having a radius R>r, the spherical head element configured to be inserted into a fragmented portion of bone such that the fragmented portion rotates about the spherical head element relative to the central axis of the shaft.

Disclosed herein are systems and methods for shaping bone voids during revision procedures of total knee replacements. The systems disclosed herein generally include a cannulated reamer assembly, a reaming guide assembly, a guide tube assembly, a trial stem assembly, and an optional insertion/removal tool. Metaphyseal reconstruction devices can be used to fill the bone voids in conjunction with the systems and methods disclosed herein.

The invention discloses a bone age prediction method and device based on a deep regression network. The method comprises the following steps: inputting a to-be-processed bone age slice image; according to the multi-level key point detection deep convolutional network, obtaining a epiphyseal area image; and inputting the epiphysis region image into a preset deep learning regression network to obtain an epiphysis grade prediction result, and calculating the corresponding bone age. The technical problem that a bone age prediction method is poor in effect is solved. According to the method and thedevice, the epiphysis grade prediction result can be directly output without linking the epiphysis grade labeling database, and the bone age can be accurately predicted. According to the method, theepiphysis area obtained based on multi-level key point detection serves as input, the epiphysis level prediction result is output through the multi-branch deep regression network after the epiphysis area passes through the convolutional network, and the obtained prediction effect is good.

Embodiments of the present application provide a method and a device for detecting bone age, which relate to the technical field of machine learning. The method comprises the following steps: acquiring a bone age sheet of a user to be detected; and determining the position of each target epiphysis in the bone age sheet by using a positioning model. For each target epiphysis, the bone age score ofthe target epiphysis is determined according to the characteristics of the target epiphysis and the position of the target epiphysis, and finally, the bone age of the user to be detected is determinedaccording to the bone age score of each target epiphysis. Because the different forms of epiphysis represent different stages of bone age, there are also some differences in the shape of the epiphyses at different locations, as such, embodiment of that present application employ a positioning model to automatically determine the position of the target epiphysis, then, the bone age score is determined based on the characteristics of target epiphysis and the position of target epiphysis, and the bone age of the user to be detected is determined based on the bone age score, without artificial subjective judgment of bone age according to bone age slices, so that on the one hand, the precision of detecting bone age is improved, and on the other hand, the efficiency of detecting bone age is improved.

The invention relates to a surgical guide (1, 1′) for implanting a knee prosthesis, advantageously capable of allowing the intraoperative balancing of the knee ligaments, comprising: a first component (G1, G1′) intended for uniquely coupling with the distal epiphyseal end (Ed) of a femur (Fe); a template (Gr, Gr′) rotatably mounted with respect to said first component (G1, G1′) and intended for guiding a marking operation of said distal epiphyseal end (Ed) aimed to determine the position of a knee prosthesis to be implanted; and a second component (G2) intended for solidly coupling said template (Gr, Gr′) with a proximal epiphyseal end (Ep) of a tibia (Ti) corresponding to said femur (Fe).

A humeral component of a reverse shoulder prosthesis (2) comprises an elongate stem part (4) for location within the intramedullary cavity of the humerus, and an epiphyseal part having a concave bearing surface (12) for articulation with the convex bearing surface (12) of a glenoid component (8). The elongate stem part (4) defines a stem axis and the concave bearing surface of the epiphyseal part defines an epiphyseal axis. The epiphyseal axis is offset posteriorly relative to the stem axis.

The invention discloses a method for isolating dendritic cells, which comprises the following steps: (1) preparation of bone marrow mononuclear cell suspension: taking bone, cutting the epiphysis, washing the middle bone to obtain bone marrow fluid, and cutting the epiphysis until it becomes viscous mixed with the aforementioned bone marrow fluid, placed on a strainer, washed 3 to 4 times to obtain a cell suspension, centrifuged, collected the precipitate, added red blood cell lysate, left standing, centrifuged, washed, and obtained bone marrow mononuclear cells; (2) imDC Cell culture: the bone marrow mononuclear cells obtained in step (1) were resuspended in medium 1, inoculated and cultured, centrifuged, cultured in medium 2 added with growth factors, and cultured continuously for 7 days to obtain imDC cells; (3) mDC Cell culture: Add cell culture medium 3 containing maturation-promoting factors to imDC cells to continue induction culture. The method for isolating dendritic cells of the present invention can effectively separate dendritic cells from mouse bone marrow, and has excellent clinical application prospects.

The invention provides a bone age evaluation method and system based on a graph convolutional neural network, a terminal and a storage medium. The method comprises the steps: obtaining N target epiphysis of a wrist bone image; adopting a feature extraction network model to extract initial features X of N target epiphysis and nearby areas of the wrist bone image; adopting a context feature fusion network model based on a graph convolution network, adding the initial feature X and the context feature subjected to multilayer graph convolution to obtain a final fusion feature, inputting the fusionfeature into a prediction distribution network model, and predicting to obtain development level distribution of N target epiphysis, correspondingly calculating development grade expectation and variance, development score expectation and bone maturity total score; and performing calculating to obtain a final bone age prediction value according to a bone age standard by utilizing the predicted development grade and the calculated bone maturity total score. Context feature fusion is realized through the graph convolution network to promote information communication among different local bone regions, accumulated bone age errors are avoided through a bone maturity total score loss function, and bone age evaluation accuracy and robustness are realized.

The invention discloses a hand epiphysis development grade determination method and related equipment. The method comprises the steps of obtaining a feature map of a first hand skeleton image; inputting the feature map into a preset hand epiphysis development grade determination model to obtain a position probability map of hand epiphysis points and a development grade probability map of the handepiphysis points output by the hand epiphysis development grade determination model; and determining the development level of the hand epiphysis point according to the position probability graph of the hand epiphysis point and the development level probability graph of the hand epiphysis point. According to the invention, the probability that each position in the hand bone image is an epiphysis point position and the probability that the development level of each position is determined are determined through the hand epiphysis development level determination model, and the development level ofeach hand epiphysis point in the hand skeleton image is determined; according to the technical means, the technical problem that an existing bone age prediction method is low in reliability is solved, and then the technical effect of scientifically determining the bone age is achieved.

The invention provides a separation and culture method of mouse mesenchymal stem cells. The separation and culture method comprises the following steps: (1) an ICR mouse is anesthetized and killed; (2) thighbones and tibiae are taken and placed in ethyl alcohol of 75% to be soaked and disinfected; (3) washing is conducted for three times through PBS, and the epiphysis ends of the thighbones and the tibiae are cut off; (4) a culture medium containing double resistants is sucked through a needle tube of 10 ml to rush out bone marrow; (5) a percoll separating medium is used for centrifuging through a density gradient method, and a middle white layer is taken; (6) washing is conducted for two times through the PBS; (7) the cell activity is detected; (8) the cells are counted; (9) the cell morphology is identified; (10) detecting is conducted through an ELISA method; and (11) RT-PCR detection is conducted. The separation and culture method of the mouse mesenchymal stem cells is easy to operate, large in number of the obtained cells, high in survival rate and ideal, and provides the reliable cell resource for experiments.

The embodiment of the invention provides a bone age evaluation method and device, and solves the problems that an existing bone age evaluation method cannot automatically identify difficult bone/epiphysis and cannot effectively intervene in uncertainty of bone age evaluation. The bone age evaluation method comprises the following steps: inputting a bone X-ray image into a bone age evaluation network model to obtain probability distribution data, the probability distribution data comprising a plurality of matching probability values corresponding to a plurality of standard bone age maps, and the plurality of standard bone age maps corresponding to a plurality of bone age standard values; inputting the bone X-ray image into an uncertainty estimation network model to obtain an uncertainty prediction value used for representing the uncertainty of the bone age evaluation value of the bone X-ray image; and when the uncertainty prediction value is greater than a preset threshold, sending keyauditing prompt information. According to the invention, bone/epiphysis with high uncertainty (easy to diverge) can be evaluated according to automatic identification of bone age, and doctors are recommended to focus on auditing.

Concepts for measuring and monitoring characteristics of osseous tissue are presented. In various embodiments, a monitoring probe may be inserted through a hollow passageway within a cannulated screw during an operation in order to measure characteristics of the osseous tissue in which the cannulated screw is inserted. In various embodiments, the cannulated screw may be inserted into a femoral head, through a physis, and into an epiphysis for stabilization of Slipped Capital Femoral Epiphysis. During surgical treatment thereof, a pressure transducer may be inserted into the osseous tissue through the cannulated screw in order to monitor epiphysis perfusion through the femoral head.

The present invention relates to an internal bone plate fixation device (1) for use as a means of synthesis in anatomical regions or epiphysis/metaphysis with poor coating of soft tissues, of the type comprising a bone plate (2) that is bilobate or having eight-like shape, comprising a pair of portions (23, 24) adapted to be respectively associated to the epiphysis and to the metaphysis of a bone and joined by a central portion (15) and in each of which is formed at least one through hole (3, 4) to receive a corresponding screw (5) for fixing to the bone. Advantageously, the bone plate (2) is flat with almost constant thickness and is delimited by opposite surfaces (6, 7) parallel with a single recess (8) or notch that is transversal to the longitudinal axis of bone plate (2) formed on only one (6) of said surfaces (6, 7), with the thickness (s) of the plate being less than a ninth of its maximum longitudinal extension (L).

The invention discloses a minimally invasive intramedullary plate system comprising an integrally formed intramedullary plate body. The intramedullary plate body is composed of an intramedullary part,an extramedullary part and a transition part connecting the two parts. The intramedullary part is in the long tube type, and the extramedullary part is attached to the epiphysis end and the articularsurface. A main body of the intramedullary part is provided with a locking nail hole, and a main body of the extramedullary part is provided with a locking threaded hole. The system combines the advantages of distal humeral plates, interlocking intramedullary nails and minimally invasive surgery techniques. The intramedullary part can provide static or dynamic fixation for the bone fracture, andsubstantially has no stress shielding effect. At the same time, the closed nailing operation mode is adopted to avoid exposure to the fracture end, protect the fractured part from hematoma, reduce damage and improve the fracture healing rate. The extramedullary part can provide a good supporting effect, and achieve the purpose of restoring the length of the fractured part, correcting the rotational displacement and correcting the force line at the same time to ensure early activities of a patient.

The invention relates to the technical field of medical apparatus and instruments, and provides a thighbone far-end prosthesis capable of preserving epiphysis. The thighbone far-end prosthesis comprises a thighbone far-end prosthesis body and a myeloid needle sleeve, wherein the thighbone far-end prosthesis body and the myeloid needle sleeve are in taper fit. The thighbone far-end prosthesis bodyis provided with a lower end face; a lower end protrusion is arranged on the lower end face, and a third bone trabecula structure is arranged on the surface of the lower end protrusion; and the myeloid needle sleeve is provided with a solid inner wall, and a second bone trabecula structure is arranged on the surface of the solid inner wall. The beneficial effects lie in that the lower end protrusion is customized in size according to the medullary cavity of a patient and matched with the medullary cavity of the patient, rapid intraoperative positioning can be achieved, the postoperative prosthesis is prevented from deviating front and back, and the prosthesis is prevented from damaging the bone of the patient. The third bone trabecula structure is arranged on the surface of the lower end protrusion, so that the contact area between the prosthesis body and human bones is increased, the bone ingrowth places can be increased, and the prosthesis body is more stable and firmer and is not easy to dislocate.

The invention discloses a manufacturing method of an inductive artificial periosteum. The method comprises the steps that: animal bone epiphysis is adopted, and is cut into bone slices with thicknesses of 0.5-1mm; the bone slices are decalcified in a hydrochloric acid solution, until the bone slices turn soft; the softened bone slices are cleaned by washing, and are placed in an oxidation liquid; under a baking environment, foreign protein antigen is extracted; the bone slices with the foreign protein antigen extracted are cleaned by washing, and are defatted in a chloroform-methanol liquid; the defatted bone slices are cleaned by washing, sufficiently volatilized, and cleaned by using clear water; the cleaned bone slices are extracted again in the oxidation liquid; the extracted bone slices are cleaned by using clear water, and are cleaned by rinsing by using purified water; the bone slices are trimmed, and residual soft tissues on periosteum are removed; the periosteum is shaped, and periosteum slices are manufactured. The invention also discloses an application of the inductive artificial periosteum. The periosteum slice provided by the invention can be directly applied on a fracture line for achieving a fracture healing promoting purpose.