Manufacturing method and application of inductive artificial periosteum

A manufacturing method, artificial bone technology, applied in medical science, prosthesis, etc., to achieve the effect of improving the manufacturing process and promoting fracture healing

Active Publication Date: 2012-10-17
SHANGHAI XIAOBO TECH DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In the prior art, in the field of artificial bone substitute materials and bone grafts to promote fracture healing, materials made from inorganic or animal bones are all in the form of strips, grains or powders

Method used

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  • Manufacturing method and application of inductive artificial periosteum

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Experimental program
Comparison scheme
Effect test

Embodiment

[0030] Such as figure 1 Shown, a kind of manufacture method of inductive artificial periosteum comprises the following steps:

[0031] Step S101, taking the animal bone epiphysis, removing the remaining muscle, periosteum, articular cartilage and bone cortex around the epiphysis, cutting the epiphysis into square cancellous bone blocks, and then cutting them into 0.5mm-1mm thick bone slices, bone slices The thickness is preferably 1mm.

[0032] Step S102, put the bone slice into 0.6 mol hydrochloric acid liquid for decalcification until the bone slice becomes completely soft.

[0033] Step S103, wash the softened bone slices, put into H20 containing 20% ​​by weight 2 0 2 In the oxidizing liquid, extracting the heterologous protein antigen in an oven at a temperature of 35°C for 7 hours can ensure that the heterologous protein antigen can be fully extracted.

[0034] Step S104, washing the bone slices from which the heterologous protein antigens have been extracted, and put...

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Abstract

The invention discloses a manufacturing method of an inductive artificial periosteum. The method comprises the steps that: animal bone epiphysis is adopted, and is cut into bone slices with thicknesses of 0.5-1mm; the bone slices are decalcified in a hydrochloric acid solution, until the bone slices turn soft; the softened bone slices are cleaned by washing, and are placed in an oxidation liquid; under a baking environment, foreign protein antigen is extracted; the bone slices with the foreign protein antigen extracted are cleaned by washing, and are defatted in a chloroform-methanol liquid; the defatted bone slices are cleaned by washing, sufficiently volatilized, and cleaned by using clear water; the cleaned bone slices are extracted again in the oxidation liquid; the extracted bone slices are cleaned by using clear water, and are cleaned by rinsing by using purified water; the bone slices are trimmed, and residual soft tissues on periosteum are removed; the periosteum is shaped, and periosteum slices are manufactured. The invention also discloses an application of the inductive artificial periosteum. The periosteum slice provided by the invention can be directly applied on a fracture line for achieving a fracture healing promoting purpose.

Description

technical field [0001] The invention relates to artificial periosteum technology, in particular to a manufacturing method and application of inductive artificial periosteum. Background technique [0002] In the prior art, in the field of artificial bone substitute materials and bone grafts to promote fracture healing, materials made from inorganic or animal bones are all in the form of strips, grains or powders, and the application methods are implantation or filling of bony defects. , there is no form of a diaphragm, and there is no application method that is directly attached to the fracture line to promote fracture healing. Contents of the invention [0003] Based on this, in view of the above problems, it is necessary to propose a method for manufacturing an inductive artificial periosteum and its application. [0004] The technical scheme of the present invention is: a kind of manufacture method of inductive artificial periosteum, comprises the following steps: [0...

Claims

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Application Information

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IPC IPC(8): A61L27/36
Inventor 胡晓波
Owner SHANGHAI XIAOBO TECH DEV
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