The invention discloses a wrist part scaphoid bone replacement prosthesis, which is characterized by comprising a replacement part scaphoid bone, a residual healthy scaphoid bone, an anti-rotation forcing screw and a transplantation prosthesis, the replacement part navicular bone is a part of the carpal navicular bone, the transplantation prosthesis is fixedly connected with the residual healthy navicular bone, one end of the anti-rotation forcing screw is fixedly connected to the transplantation prosthesis, and the other end of the anti-rotation forcing screw is fixedly connected to the residual healthy navicular bone; according to the prosthesis, a three-dimensional scaphoid model of a patient is constructed through three-dimensional CT scanning of the scaphoid of the carpal bone at the intact position of the patient, and a three-dimensional model of a scaphoid replacement part is obtained by mirroring the three-dimensional model. Therefore, the scaphoid fracture healing process is directly simplified, the conditions of slow healing, non-healing and ischemic death of the two scaphoids after scaphoid fracture are avoided, the scaphoid fracture rehabilitation speed of the carpal bone is increased, the inconvenience of wrist movement caused by scaphoid fracture healing disorder in the later period is avoided, the later-period hidden danger is eliminated, and the postoperative rehabilitation quality of a patient is guaranteed.