This invention relates to the field of
vancomycin pharmacokinetic technology, specifically to the design of a
vancomycin clearance prediction scheme based on a VPB ensemble model. This method, based on an
ensemble learning strategy, constructs a blending ensemble model to predict
vancomycin clearance in adult Chinese patients. First, a variational
autoencoder is used to amplify the original sample data to increase
data diversity. Then, a
particle swarm optimization algorithm is introduced to optimize the parameters of multiple base learners, and the prediction results of the optimized base learners are used as new feature inputs. Finally, a
support vector regression machine is used as a meta-learner to integrate and model the above features, forming the final vancomycin clearance prediction model. The VPB model constructed in this invention achieves a determination coefficient R² exceeding 0.9 on both the test and training sets, demonstrating superior prediction accuracy compared to
population pharmacokinetic models.