33 results about "Bone Trabeculae" patented technology

The invention discloses a titanium-magnesium intramedullary nail and a designing and manufacturing method thereof, and the designing and manufacturing method comprises the steps that multiple working modes of the titanium-magnesium intramedullary nail are defined according to use requirements, a mode specification table is generated, and the mode specification table comprises main structure parameters, simulated bone trabecula structure parameters and a magnesium alloy filling scheme corresponding to each working mode; based on the mode specification table, optimization design of parameter mapping is conducted, a customized parameter combination of the titanium-magnesium intramedullary nail is determined, and the customized parameter combination comprises pore distribution and magnesium alloy gradient degradation configuration; a 3D digital model of the titanium-magnesium intramedullary nail is generated through modeling of the mode specification table, a titanium-magnesium intramedullary nail prototype is manufactured through a low-temperature 3D printing process, and magnesium alloy filling and micropore channel integration are completed through customized parameter combination in the period; the process of designing, optimizing, forming and compositing is achieved; according to the method, a mode specification table and parameterization mapping serve as links, the titanium-magnesium intramedullary nail integrated design and manufacturing process is constructed, and therefore multi-mode parameter customization is achieved while the manufacturing stability is guaranteed.

The present application relates to femoral stem prosthesis, specifically provides a femoral stem prosthesis with twisted trabecular structure, aims to solve the problem that although the existing femoral stem prosthesis has trabecular porous structure to promote bone growth, but still due to the high material elastic modulus and stress concentration inside the pore, leading to stress shielding effect and trabecular fracture, so it is difficult to effectively prevent long-term loosening of the prosthesis. For this purpose, a femoral stem prosthesis with twisted trabecular structure of the present application comprises a trabecular structure unit arranged on the surface layer of the prosthesis, the shape of the trabecular structure unit is a space net structure, the space net structure is provided with pores, the pores can accommodate new bone, and the space net structure is twisted from the inside of the prosthesis to the surface layer of the prosthesis. The present application introduces the mechanical regulation effect brought by structure twisting by arranging the space net trabecular structure which is twisted continuously from inside to outside on the surface layer of the prosthesis, on the basis of ensuring that the pores can be used for new bone growth and realizing bone-prosthesis biological fixation.

The application relates to an image-based marrow component segmentation method and system, comprising the following steps: acquiring an original marrow biopsy digital image and preprocessing, obtaining a hematopoietic cell tissue and bone trabecula Mask mask image based on the preprocessed image; based on the original marrow biopsy digital image, sequentially performing color channel conversion, morphological open operation, isolated point elimination and hole filling to obtain a bone trabecula Mask mask image; based on the preprocessed image, obtaining a fat cell tissue Mask mask image according to the morphological characteristics of fat cells; and according to the obtained bone trabecula Mask mask image, the bone trabecula and hematopoietic cell tissue Mask mask image and the fat cell tissue Mask mask image, obtaining the area proportion of the bone trabecula, the hematopoietic cell tissue and the fat cell tissue in the original marrow biopsy digital image in each image.

The application discloses an X-ray scanning imaging method based on an X-ray flat panel array, relates to the technical field of scanning imaging, and breaks through the traditional dose constraint by simulating high dose noise characteristics in a projection domain based on virtual dose enhancement; based on dynamic registration of bone probability weighting, the method eliminates the blurred edge of a vertebral body caused by respiratory displacement without the need of external sensors or patient cooperation; by means of an iterative weight shrinkage mechanism, a weighted total variation model can inhibit soft tissue noise while preserving micron-level features such as bone trabeculae, and over-smoothing distortion is avoided; frame frequency control in a respiratory phase is self-adaptive, compatible with existing flat hardware, and can directly upgrade existing equipment, thereby reducing hospital procurement costs.

The invention provides an individualized tibia defect repairing type knee joint prosthesis, and belongs to the technical field of orthopedic implants. The device is formed by assembling a femoral condyle, a femoral bone marrow needle, a plateau pad, a tibia plateau, a restoration body and a tibia bone marrow needle. Wherein the tibia platform and the restoration body are matched through metal-metal threads and are assisted by bone cement to achieve anti-rotation locking, the restoration body adopts a 3D printing individualized bone trabecula structure and is compounded with an HA coating to promote bone ingrowth, the tibia bone marrow needle and the platform are connected through a standard taper connector, inventory and individualization compatibility is achieved, and the bone marrow needle and the platform are connected through a standard taper connector. The defects that an existing prosthesis is large in bone mass loss, unattractive in reconstruction, free of bone ingrowth function, high in processing cost and the like are overcome, and the postoperative function of a tibia defect patient and the long-term stability of the prosthesis can be remarkably improved.

The invention discloses a titanium-magnesium nail plate system capable of promoting fracture healing and a manufacturing and forming method. The manufacturing and forming method comprises the steps that a bone fracture plate digital model containing a bone trabecula simulation porous area and a partition filling cavity is established according to a bone anatomical structure, and a titanium-based workpiece of a porous structure is manufactured through selective laser melting forming; a titanium-zinc-calcium component gradient transition layer is constructed layer by layer on the surface of the porous inner wall of the titanium-based workpiece through a directional deposition process, interface bonding is strengthened through low-temperature heat treatment, and the titanium-based workpiece with a gradient interface is obtained; the titanium-based workpiece with the gradient interface is placed in an inert atmosphere, after heating is conducted, molten magnesium or magnesium alloy is injected into all the cavities through a partitioned vacuum pressure injection technology, and after cooling is conducted, a titanium-magnesium composite workpiece is formed; through a customized and interface-controllable manufacturing method, a high-strength titanium skeleton and a degradable healing-promoting magnesium material are firmly combined, and integrated design and manufacturing of mechanical support and biological activity of the internal fixation device are achieved.

The invention discloses a model construction method of a gradient random porous structure of a simulated bone trabecula, a white calendite piezoelectric bone scaffold and a preparation method of the white calendite piezoelectric bone scaffold, and the model construction method provided by the invention is a design method based on a Thiessen polygon porous structure with seed point release gradient change and volume scaling coefficient linear gradient change. In the body center scaling process, interpolation calculation is conducted on scaling coefficients from the axis to the outermost end in the cylindrical domain in the radial direction, and therefore the model of the stochastic gradient porous structure with the pore diameter decreasing from inside to outside in the radial direction and the pore edge diameter increasing from inside to outside in the radial direction is finally formed, by designing the formula and process parameters of the white calcium stone ceramic slurry, the possible problems of over-curing, cracking and the like are avoided, and the white calcium stone piezoelectric ceramic bone scaffold with excellent bonding performance is prepared by adopting a 3D printing photocuring printing technology.

The invention relates to the technical field of medical image detection, and discloses a medical image quality control report generation method which comprises the following steps: firstly, performing soft tissue background field correction on a near-end femur scanning image to remove low-frequency interference, and determining a stress conduction direction of a main pressure-bearing bone trabecula based on an anatomical geometric position; converting the image into a spatial frequency domain, respectively extracting a structure frequency spectrum and a full-angle average structure frequency spectrum along the stress conduction direction, and calculating effective texture cut-off frequencies of the structure frequency spectrum and the full-angle average structure frequency spectrum by using a breakpoint regression model; calculating the logarithmic ratio of the two cut-off frequencies to obtain a quantitative index reflecting the anisotropy retention degree of the structure, and comparing the quantitative index with an adaptive threshold constructed based on the number of frequency points to generate a quality control report indicating whether the image quality is qualified or not; according to the method, an anatomical mechanical path is used as a physical reference, and the homomorphism and heterogeneity problem that image quality degradation and pathological change are similar in performance is solved.

The application provides a parameter design method of a acetabular revision guiding support based on image modeling, and belongs to the field of medical instruments, and comprises the following steps: establishing an acetabular coordinate system, and extracting geometric parameters of medical images of a bone defect area; defining a plurality of bone trabecula metal acetabular cup outer cup abduction angle, anteversion angle and vertical upward height, and coupling to obtain a limited parameter combination; respectively calculating the contact volume ratio η of the bone trabecula metal acetabular cup and the bone defect area and the distance Doffse from the rotation center of the outer cup to the healthy rotation center; screening a group of optimal parameters according to the numerical values of η and Doffse; and designing a guiding support for the outer cup according to the optimal parameters. The application provides a simple, efficient and accurate digital solution for Paprosky III type acetabular defect revision, and the core geometric quantification method and guiding support design can be expanded to other complex bone defect repair, and has significant clinical application value and technical foresight.

The application belongs to the field of simulation, and provides a filling modified screw mechanical analysis method based on a finite element analysis model, which comprises the following steps: obtaining three-dimensional medical image data of a target bone tissue region, and constructing a finite element analysis model of a micro bone trabecula structure and a macro pelvis structure based on the three-dimensional medical image data; introducing a filling modified screw structure into the finite element analysis model; constructing a response control factor field for representing the local adaptation capability of each position in the filling structure, and automatically updating the distribution of the factor field according to the stress state change; iteratively optimizing the distribution of the factor field based on a global error minimization principle, so that the overall stress distribution of the filling modified screw in the bone tissue tends to a target state; and outputting the stress response distribution, strain distribution and mechanical adaptation region of the filling modified screw in the bone tissue, which are used for evaluating the fixing performance of the filling modified screw under the condition of osteoporosis.

The application discloses a preparation method and system of a tendon / ligament-bone junction special trabecular zone biomechanical bidirectional biomimetic bone biological structure, and belongs to the technical field of bone biological material preparation, and comprises the following steps: extracting morphological information of trabeculae and mechanical parameters of a tendon / ligament-bone junction based on a target region of a human specimen slice; determining a biomimetic structure based on the morphological information of the trabeculae; determining a biological material for preparing the biomimetic structure based on the mechanical parameters of the tendon / ligament-bone junction; preparing the biomimetic bone biological structure based on the biomimetic structure and the bone biological material; and performing modification treatment on a surface of the biomimetic bone biological structure to obtain a final biomimetic bone biological structure. The application combines the construction information of the trabeculae of the tendon / ligament-bone junction with 3D printing technology, realizes the structure and material collaborative biomimetic of an implant when the tendon / ligament-bone junction is reconstructed, and provides important technical support for researching and developing a bone biological structure with better biocompatibility for the tendon / ligament-bone junction.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

This invention discloses a lightweight biomimetic skeleton structure for aircraft and its fabrication and design methods, belonging to the field of biomimetic aircraft technology. The lightweight biomimetic skeleton structure includes: a biomimetic skeleton structure composed of three periodic minimal curved surfaces; and a panel layer integrally connected to both sides of the biomimetic skeleton structure, the panel layer being a dense structure or a microporous structure. The biomimetic skeleton structure is constructed based on the topological features of the three-dimensional structure of human trabeculae, and a trabeculae-like microtopological structure is introduced into the local high-stress areas of the biomimetic skeleton structure. By mimicking the porous structure of human trabeculae, a highly efficient load-bearing lattice structure is used for the lightweight design and manufacturing of key load-bearing components of aircraft equipment. This achieves both structural lightweighting and high strength and toughness in the lightweight biomimetic skeleton structure for aircraft. It solves the problem that existing technologies lack in-depth reference to the efficient load-bearing mechanism of trabeculae, and fail to achieve structural self-adaptation and functional integration under extreme environments.

The utility model discloses a personalized root type implant. Comprising an implant body, a central screw hole is formed in the upper end of the implant body, a Morse taper hole is formed in the upper portion of the central screw hole, and an inner hexagonal base hole is formed in the upper end of the Morse taper hole; the implant made of Ti-Ta alloy is close to a bone tissue of a human body, so that the stress shielding effect is effectively reduced; meanwhile, due to the introduction of tantalum, the corrosion resistance and bone combining capacity of the material are improved; a 3D printing technology is adopted to realize that the implant is completely matched with a tooth extraction socket in shape, and bone holes and convex blocks of a bionic bone trabecula porous structure are constructed on the surface of the interior part of a bone, so that the implant is convenient to mount in a tooth socket; the central screw hole and the Morse taper hole are designed at the upper end of the implant, so that the false tooth is conveniently mounted and connected, and the inner hexagonal base hole is formed at the upper end of the implant, so that the connection stability of the false tooth is conveniently improved, and the false tooth is prevented from rotating and falling off.

The invention discloses a bone biological structure preparation method and system for mechanical biology bidirectional bionic of a special bone trabecula area at a tendon / ligament bone joint, and belongs to the technical field of bone biological material preparation, and the method comprises the following steps: extracting morphological information of a bone trabecula and mechanical parameters of the tendon / ligament bone joint based on a human body specimen slice of a target area; determining a bionic structure based on the morphological information of the bone trabecula; determining a biological material for preparing a bionic structure based on mechanical parameters of the tendon / ligament bone joint; preparing a bionic bone biological structure based on the bionic structure and the bone biological material; and carrying out modification treatment on the surface of the bionic bone biological structure to obtain the final bionic bone biological structure. The construction information of the bone trabecula at the tendon / ligament bone joint is combined with the 3D printing technology, so that when the tendon / ligament bone joint is reconstructed, the structure and material of the implant are synergistically bionic, and important technical support is provided for research and development of a bone biological structure with better biocompatibility at the tendon / ligament bone joint.

The present application belongs to the technical field of natural active peptides, and particularly relates to a crab shell polypeptide as well as a preparation method and application thereof. The preparation method provided by the present application takes crab shells as raw materials, extracts crab shell polypeptides by using a hydrolysis, enzymolysis and alcohol precipitation method, controls the hydrolysis, enzymolysis and alcohol precipitation conditions in the extraction process, and makes the prepared crab shell polypeptides mainly composed of low-molecular-weight peptides and rich in glutamic acid, aspartic acid and lysine. Experiments prove that the crab shell polypeptide provided by the present application can enhance calcium deposition, improve OB activity, improve bone density, restore trabecular bone structure, maintain the integrity of bone tissue, inhibit OC function, has no obvious systemic toxicity, and can reestablish the osteoblast / osteoclast balance at the molecular level and restore calcium-phosphorus homeostasis, and therefore can be used for preparing medicines for preventing and treating osteoporosis or health-care foods for improving bone density, and has a good application prospect.

To provide an X-ray imaging device that has resolution characteristics capable of sufficiently visualizing bone trabeculae, respiratory bronchioles, alveolar ducts, etc., and also has excellent signal-to-noise ratio (SNR). [Solution] The X-ray imaging apparatus of the present invention includes an X-ray irradiation unit including an X-ray tube for irradiating a subject with X-rays, an X-ray detection unit including an X-ray detector positioned opposite the X-ray tube with the subject in between for detecting transmitted X-rays from the subject, a pedestal on which the subject is placed, a rotation mechanism having a ring-shaped frame configured to rotate around the pedestal, and a control unit that controls the rotation of the ring-shaped frame and the irradiation of X-rays from the X-ray tube. The X-ray irradiation unit and the X-ray detection unit are attached to the ring-shaped frame, and the X-ray tube is positioned outside the ring-shaped frame.

The embodiment of the invention provides a bone microstructure parameter extraction method, computing equipment, a computer readable storage medium and a computer program product. The bone microstructure parameter extraction method comprises the following steps: firstly, carrying out super-resolution reconstruction on a CT (Computed Tomography) image to enhance the image quality; then, a first bone mask is generated through a global threshold value, a local adaptive threshold value is constructed in combination with local gray statistical characteristics, and a mask edge and a low-contrast region are subjected to reclassification to obtain a more accurate second bone mask; and then, noise connected domain elimination under volume constraint is performed on the second bone mask, and a fracture or a pseudo joint of the bone trabecula network is repaired based on morphological characteristics to obtain a high-fidelity bone tissue structure segmentation result. And finally, cortical bones are removed from the result to separate out cancellous bones, and bone microstructure parameters are extracted from the cancellous bones. According to the technical scheme provided by the embodiment of the invention, the accuracy of bone microstructure parameter extraction is improved.

The present application relates to the technical field of patient bone X-ray image recognition, and particularly relates to a hidden fracture auxiliary recognition method based on image processing. A bone region and its connected soft tissue region are located in an X-ray image. A reference bone region is selected, and the fracture manifestation degree is evaluated by analyzing the similar gray pixel distribution and edge position of the reference bone region. For the soft tissue region, the soft tissue enhancement necessity degree is calculated according to the gray difference between the soft tissue region and the surrounding tissue, the gray difference between the two internal regions of the soft tissue region, and the distance between the soft tissue region and the bone. The bone enhancement necessity degree is determined by comprehensively considering the number of soft tissues connected to the bone, the soft tissue enhancement necessity degree of each soft tissue, and the fracture manifestation degree. The to-be-enhanced region is selected for image enhancement according to the bone enhancement necessity degree, and finally the accurate recognition of hidden fracture is realized. The present application can detect extremely small trabecular structure disorder or density change, thereby improving the recognition accuracy of related personnel on patients.

This application discloses an automatic analysis method for CT images of long bones in mice and rats, relating to the field of image processing technology. The method includes: acquiring a CT image sequence of the target long bone, extracting the three-dimensional spatial distribution of bone tissue, and performing pose alignment and three-dimensional cropping to obtain a standardized bone image sequence; then constructing candidate depth intervals based on butterfly-shaped anatomical features and key points of growth plate strip-shaped gaps, respectively, and obtaining a fine search range through intersection operation; subsequently identifying candidate slices of triangular fractures and determining the anatomical zero point; finally, mapping the target analysis region based on the anatomical zero point, completing cortical bone segmentation, medullary cavity segmentation, and trabecular bone extraction under closed mask constraints, and outputting quantitative parameters of bone tissue. This application achieves accurate positioning of the growth plate and unified analysis region mapping in long bone CT images, improving the accuracy of trabecular bone extraction and the consistency of bone tissue quantification results.

This application provides a self-adaptive trabecular bone knee joint prosthesis and its design and fabrication method. The electronic device acquires a bone-cut model of the knee joint and a prosthesis model that adapts to the osteotomy surface of the bone-cut model; assembles the bone-cut model and the current prosthesis model into an assembly; performs mechanical simulation using the assembly to obtain the stress and strain distribution at the contact surface between the prosthesis model and the bone-cut model; if the strain distribution does not meet the ideal strain range requirement, the structure of the contact interface is adjusted according to the strain distribution to obtain a new prosthesis model; this process continues until the strain distribution at the contact interface meets the ideal strain range requirement. Thus, instead of relying on experience or a uniform template, a fitting scheme is dynamically generated based on each patient's actual anatomy and mechanical response, thereby solving the current problem of not being able to adapt to individual patient differences, improving the long-term bonding stability of the prosthesis and bone, and extending the prosthesis's lifespan.

The application relates to the technical field of orthopedic artificial joint, in particular to an integrated unicompartmental prosthesis system and a preparation method of the integrated unicompartmental prosthesis system. The integrated unicompartmental prosthesis system comprises a femoral condyle prosthesis, a tibial plateau prosthesis and a tibial plateau pad prosthesis; the femoral condyle prosthesis and the tibial plateau prosthesis are both made of a zirconium niobium alloy 3D printing; the tibial plateau pad prosthesis is made of a zirconium niobium alloy 3D printing or a zirconium niobium alloy forging; the upper surface of the femoral condyle prosthesis is in contact with the tibial plateau pad prosthesis, and the upper surface of the tibial plateau prosthesis is in contact with the lower surface of the tibial plateau pad prosthesis. The bone integration interfaces of the integrated unicompartmental prosthesis system are all formed by zirconium niobium alloy trabecular structures, and the friction contact surfaces between the prostheses are all metal ceramic interfaces formed by zirconium niobium surface oxidation, so that the bone resection amount of the tibial plateau can be reduced, the wear resistance of the friction interface can be improved, the wear debris of the friction interface can be greatly reduced, and the stability of the prosthesis in the later period is improved.

The embodiment of the invention discloses a peptide calcium chelate as well as a preparation method and application thereof. The preparation method of the peptide calcium chelate comprises the following steps: mixing a calcium solution with a wolfberry glycopeptide liquid, adjusting the pH value of the system, carrying out a chelation reaction, cooling with ice water, adding ethanol, centrifuging, and freeze-drying the obtained precipitate to obtain the peptide calcium chelate. The peptide calcium chelate provided by the invention has remarkable calcium supplement advantage and biological activity, calcium extracted from bovine bones and wolfberry peptides are chelated to form a stable compound, the stability of calcium is remarkably improved, the peptide calcium chelate is more convenient to carry and take, and the solubility and absorptivity of calcium ions are increased. Meanwhile, limitation of traditional calcium ion absorption can be avoided through an intestinal peptide transfer channel (such as PepT1), and interference of antagonists in diet is reduced. Scanning electron microscope results prove that the fructus lycii peptide calcium is successfully prepared, and animal experiments show that the fructus lycii peptide calcium can effectively improve the serum calcium level, improve the bone microstructure, increase the bone mineral density and the number of bone trabecula and regulate bone metabolism indexes, and shows a calcium supplement effect and a bone protection effect superior to those of a traditional calcium agent (such as calcium gluconate); the calcium supplement is a novel calcium supplement with high bioavailability and a bone health promoting function.

The invention discloses a digital modeling method and device for a bone microstructure, computing equipment and a medium. The method comprises the steps that CT or MRI three-dimensional image data of the bone tissue microstructure are obtained based on high-resolution imaging equipment; a bone tissue area is segmented from the three-dimensional image data, bone microstructure features are extracted from the bone tissue area, and the bone microstructure features comprise the number of bone trabecula nodes, the number of connecting rods corresponding to the bone trabecula nodes, the porosity, the thickness of the bone trabecula and the distance between the bone trabecula; and according to the bone microstructure characteristics, representing nodes of the bone trabecula by using balls, representing connecting rods between the bone trabecula by using sticks, and constructing a ball-stick model of the bone microstructure. According to the scheme, the biological characteristics and mechanical characteristics of bones are better understood by constructing the bone microstructure model, and a more scientific and effective basis is provided for prevention, diagnosis and treatment of orthopedic diseases.

The invention relates to the technical field of image analysis, and discloses a multi-modal image fusion cylindrical skeleton repair detection method and system, and the method comprises the steps: collecting the multi-modal image data of a cylindrical skeleton, recognizing the bone trabecula structure feature points of each modal in the multi-modal image data, carrying out the modal space registration of the multi-modal image data, and carrying out the recognition of the feature points of the bone trabecula structure. A spatial registration image is obtained; using the spatial registration image to identify a multi-dimensional cylindrical skeleton feature of the cylindrical skeleton; performing feature level fusion on the multi-dimensional cylindrical skeleton features to obtain a fusion feature map of the cylindrical skeleton, and constructing a skeleton three-dimensional model of the cylindrical skeleton by using the fusion feature map; and utilizing the three-dimensional skeleton model to identify the callus volume and the bone cortex continuous state of a repair area corresponding to the cylindrical skeleton, analyzing the skeleton integrity and the adjacent bone fusion degree of the repair area, and constructing a repair detection report of the cylindrical skeleton. According to the invention, the precision of cylindrical skeleton repair detection can be improved.

The application provides a near-infrared response magnesium-releasing and antioxidant double-layer microneedle and a preparation method and application thereof. The double-layer microneedle comprises a needle tip layer and a backing layer, the needle tip layer contains MoS2@PDA@Mg 2+ The application discloses a composite particle, which is composed of molybdenum disulfide nanosheets, surface-coated polydopamine and coordination-loaded magnesium ions. The preparation method comprises the following steps: one-step reaction of molybdenum disulfide, dopamine and magnesium salt to obtain the composite particle, and then preparation of the composite particle into a needle tip layer precursor solution together with GelMA, PVA and the like, and two-step light cross-linking molding with a backing layer precursor solution. The double-layer microneedle can rapidly release magnesium ions under near-infrared irradiation, the release amount is 4.6 times that of a non-irradiation group, can significantly scavenge DPPH, ABTS and other free radicals, can relieve cell oxidative stress induced by lipopolysaccharide, and can effectively promote new bone formation and trabecular reconstruction in a rat tooth socket model. The application realizes the synergistic effect of light-controlled magnesium release and antioxidant, and is suitable for the fields of neural microenvironment reconstruction and bone regeneration.

The invention belongs to the field of bone tissue engineering scaffold materials, and particularly relates to an in-vivo degradable polycaprolactone porous scaffold capable of efficiently promoting osteogenesis as well as preparation and application of the in-vivo degradable polycaprolactone porous scaffold. According to the invention, polycaprolactone (PCL), polyethyleneimine (PEI) and cellulose (CL) are used as raw materials, and steam induced phase separation is carried out to form the polycaprolactone porous scaffold with a through hole structure similar to a bone trabecula network and multilevel porous structural characteristics. The stent has an excellent through hole structure, excellent plasticity, excellent elasticity, efficient osteogenesis promoting capability, excellent biological safety, excellent degradability, excellent osseointegration and osteoconductivity and certain toughness, so that the surgical operation process is simpler. The whole stent shows excellent bone induction, bone conduction and osseointegration capabilities.

The application relates to the technical field of medical devices, in particular to a novel metal ceramic reverse type shoulder joint prosthesis system and a preparation method thereof. The system comprises a humeral stem, a humeral holder, a humeral pad, a reverse type glenoid head, a taper adapter and a glenoid holder which are sequentially assembled together. The humeral holder, the humeral pad, the reverse type glenoid head and the taper adapter are all formed by 3D zirconium niobium metal printing or forging; the humeral stem and the glenoid holder are integrally formed by 3D printing zirconium niobium alloy, and the bone combining surface is a trabecular structure; an active contact friction interface is formed between the humeral pad and the reverse type glenoid head, and the interface is a zirconium niobium surface oxidized metal ceramic interface. It can be seen that, by replacing the high polymer material component with the zirconium niobium metal ceramic component, the prosthesis system can reduce the bone cutting amount of the proximal humerus, increase the wear resistance of the friction interface, and manufacture a micro-texture structure on the friction interface to realize the super strong wear resistance and low wear of the friction interface, which is beneficial to the long-term stability after the prosthesis is implanted.

This application relates to the field of medical device technology, and in particular to a method for manufacturing a unicompartmental prosthesis system and the unicompartmental prosthesis system itself. The method for manufacturing the unicompartmental prosthesis system includes using zirconium-niobium alloy powder as raw material to sequentially print a first body and a first trabecular bone structure layer to form a first intermediate product of the femoral condyle prosthesis, and sequentially printing a second body and a second trabecular bone structure layer to form a first intermediate product of the tibial plateau prosthesis; when printing to the first trabecular bone structure layer of the femoral condyle prosthesis and when printing to the second trabecular bone structure layer of the tibial plateau prosthesis, magnesium metal particles are added to the zirconium-niobium alloy powder; heat treatment; machining and shaping; and surface oxidation treatment. According to the manufacturing method and unicompartmental prosthesis system provided in this application, the bone formation rate of elderly patients is effectively improved, and the incidence of aseptic loosening is reduced.

The application discloses an artificial intelligence driven jaw bone defect bionic reconstruction system and method. A three-dimensional segmentation model is used to segment the facial CBCT image of a healthy person to construct a jaw bone dentition database; the segmentation model is used to segment the healthy side and the diseased side of the jaw bone of a patient, and intelligent matching is performed in the database based on the segmented healthy side jaw bone data as a reference to obtain the most similar target jaw bone; then the opposite jaw bone of the target jaw bone is taken as a to-be-applied template, three-dimensional integration is performed with the diseased side defect of the patient to generate a basic virtual jaw bone support; then a planting scheme is generated according to the matched healthy dentition data to obtain a segmented virtual support; trabecular bone structure filling is performed in the segmented virtual support to output a bionic reconstruction customized body; finally, the overhanging structure of the trabecular bone is detected according to the complex topological structure of the trabecular bone, and corresponding printing support is generated. The above can improve the bionic adaptation degree of the reconstructed defect jaw bone, and support entity production such as 3D printing.