72 results about "Bone Trabeculae" patented technology

The invention relates to the technical field of osteoporosis diagnosis, and discloses an osteoporosis diagnosis method based on image recognition. The method comprises the following steps: acquiring bone density image data of a target object and bone structure image data of a target area based on medical imaging equipment, and determining a bone trabecula distribution condition of the target area according to the bone structure image data; constructing a three-dimensional bone mineral density model of the target object according to the bone mineral density image data, and determining an image analysis strategy by combining the three-dimensional bone mineral density model and the bone trabecula distribution condition; and an image analysis module acquires bone structure feature data of the target area according to the strategy, and identifies the bone density grade and the osteoporosis degree of the target area according to the feature data to obtain diagnosis data. According to the method, related data of the bone mineral density and the bone structure are integrated, comprehensive analysis is carried out in combination with the image recognition technology, an efficient and reliable new mode is provided for clinical diagnosis, the accuracy and objectivity of osteoporosis diagnosis are improved, and misdiagnosis and missed diagnosis are reduced.

The invention provides an osteoporosis automatic diagnosis method and system based on position specific attention, and the method comprises the steps: carrying out the dual-channel enhancement preprocessing of a lumbar CT image, and generating an enhanced image taking the bone mineral density and the bone trabecula structure characteristics into consideration; inputting the enhanced image into a deep convolutional neural network for multi-scale feature extraction to obtain a feature map containing spatial semantic information; on the basis of the anatomical position index information, generating attention weighted features which highlight the key diagnosis area of the vertebral body; global pooling is carried out on the attention weighted features, and then comprehensive diagnosis features containing anatomical priori knowledge are constructed; and inputting the comprehensive diagnosis features into a classifier to realize centrum-level accurate diagnosis. According to the invention, the workload of radiologists can be effectively relieved, and the efficiency and coverage of osteoporosis screening can be improved. Especially under the condition that primary medical institutions are lack of experienced radiologists, the primary medical service level can be improved.

The invention discloses a self-adaptive bionic cancellous bone defect prosthesis and a design method thereof, and belongs to the technical field of medical prostheses, the prosthesis is composed of biological interface gradient microporous structure parts and a main body bionic truss supporting structure part, the biological interface gradient microporous structure parts are arranged at the two ends of the main body bionic truss supporting structure part, and the main body bionic truss supporting structure part is arranged on the main body bionic truss supporting structure part. The method is mainly used for reconstructing bone defects, bionically designing a truss part of a main body with consistent arrangement direction and form of human body bone trabecula through an established linear relation between CT gray value and bone density-elasticity modulus, adaptively matching mechanical conduction of a bone structure, reducing stress shielding effect, and improving bone defect reconstruction efficiency. Meanwhile, various complex mechanical working condition requirements of the prosthesis are met, the prosthesis failure risk is reduced, and the service life of the prosthesis is prolonged.

The invention discloses a titanium-magnesium intramedullary nail and a designing and manufacturing method thereof, and the designing and manufacturing method comprises the steps that multiple working modes of the titanium-magnesium intramedullary nail are defined according to use requirements, a mode specification table is generated, and the mode specification table comprises main structure parameters, simulated bone trabecula structure parameters and a magnesium alloy filling scheme corresponding to each working mode; based on the mode specification table, optimization design of parameter mapping is conducted, a customized parameter combination of the titanium-magnesium intramedullary nail is determined, and the customized parameter combination comprises pore distribution and magnesium alloy gradient degradation configuration; a 3D digital model of the titanium-magnesium intramedullary nail is generated through modeling of the mode specification table, a titanium-magnesium intramedullary nail prototype is manufactured through a low-temperature 3D printing process, and magnesium alloy filling and micropore channel integration are completed through customized parameter combination in the period; the process of designing, optimizing, forming and compositing is achieved; according to the method, a mode specification table and parameterization mapping serve as links, the titanium-magnesium intramedullary nail integrated design and manufacturing process is constructed, and therefore multi-mode parameter customization is achieved while the manufacturing stability is guaranteed.

Knee arthroplasty implants, instruments, systems, and methods of implanting the same. The knee arthroplasty implants may include a femoral implant and a tibial tray implant, each with trabecular surfaces configured to contact bone to provide a scaffold for bone healing and interdigitation. The implants may also include fixation pegs with bulleted profiles to increase the surface area for bone ingrowth. An inserter instrument may include a sliding rack, which is incrementally extended with a rotatable shaft, thereby allowing for quick lock and release of various tibia trays.

The present application relates to femoral stem prosthesis, specifically provides a femoral stem prosthesis with twisted trabecular structure, aims to solve the problem that although the existing femoral stem prosthesis has trabecular porous structure to promote bone growth, but still due to the high material elastic modulus and stress concentration inside the pore, leading to stress shielding effect and trabecular fracture, so it is difficult to effectively prevent long-term loosening of the prosthesis. For this purpose, a femoral stem prosthesis with twisted trabecular structure of the present application comprises a trabecular structure unit arranged on the surface layer of the prosthesis, the shape of the trabecular structure unit is a space net structure, the space net structure is provided with pores, the pores can accommodate new bone, and the space net structure is twisted from the inside of the prosthesis to the surface layer of the prosthesis. The present application introduces the mechanical regulation effect brought by structure twisting by arranging the space net trabecular structure which is twisted continuously from inside to outside on the surface layer of the prosthesis, on the basis of ensuring that the pores can be used for new bone growth and realizing bone-prosthesis biological fixation.

The invention relates to the technical field of joint prostheses, in particular to an interchangeable joint prosthesis which comprises a thighbone prosthesis, a tibia platform and a tibia liner. The femoral prosthesis comprises a half-shell prosthesis, a first stand column, a second stand column and a bone trabecula structure. The first stand column and the second stand column are fixedly arranged on the inner wall of the half-shell prosthesis. A dismounting table is arranged on the surface of the tibia platform, a clamping groove matched with the tibia liner is formed in the surface of the tibia platform, a press-fit edge matched with the clamping groove is fixedly arranged on the surface of the tibia liner, and the tibia liner is used for supporting a thighbone prosthesis to move; a fixing wing and a fixing stand column are arranged on the surface of the other side of the tibial plateau. By arranging the thighbone prosthesis, the tibia platform and the tibia liner, the size of the joint prosthesis can be freely changed in the actual operation process, operation prosthesis selection can be conveniently adjusted in the operation, finally, the joint prosthesis is used for biological fixation, and the long-term stability of the prosthesis after implantation is guaranteed.

The application relates to an image-based marrow component segmentation method and system, comprising the following steps: acquiring an original marrow biopsy digital image and preprocessing, obtaining a hematopoietic cell tissue and bone trabecula Mask mask image based on the preprocessed image; based on the original marrow biopsy digital image, sequentially performing color channel conversion, morphological open operation, isolated point elimination and hole filling to obtain a bone trabecula Mask mask image; based on the preprocessed image, obtaining a fat cell tissue Mask mask image according to the morphological characteristics of fat cells; and according to the obtained bone trabecula Mask mask image, the bone trabecula and hematopoietic cell tissue Mask mask image and the fat cell tissue Mask mask image, obtaining the area proportion of the bone trabecula, the hematopoietic cell tissue and the fat cell tissue in the original marrow biopsy digital image in each image.

The application discloses an X-ray scanning imaging method based on an X-ray flat panel array, relates to the technical field of scanning imaging, and breaks through the traditional dose constraint by simulating high dose noise characteristics in a projection domain based on virtual dose enhancement; based on dynamic registration of bone probability weighting, the method eliminates the blurred edge of a vertebral body caused by respiratory displacement without the need of external sensors or patient cooperation; by means of an iterative weight shrinkage mechanism, a weighted total variation model can inhibit soft tissue noise while preserving micron-level features such as bone trabeculae, and over-smoothing distortion is avoided; frame frequency control in a respiratory phase is self-adaptive, compatible with existing flat hardware, and can directly upgrade existing equipment, thereby reducing hospital procurement costs.

The present invention discloses a preparation method and application of fermented milk rich in osteogenic growth peptide FPPQSVL, and belongs to the technical field of dairy product processing. The present invention prepares Lactobacillus helveticus fermented milk rich in osteogenic growth peptide FPPQSVL by inoculating Lactobacillus helveticus CCFM1263 into skimmed milk for fermentation. The fermented milk has the functions of significantly enhancing bone density, significantly increasing the number and thickness of trabeculae, significantly increasing bone volume fraction, significantly enhancing the bone biomechanics of rats, and significantly reducing the content of bone turnover biomarkers TRAP, CTX-1, and DPD in serum, while significantly increasing the content of BALP. The Lactobacillus helveticus fermented milk rich in osteogenic growth peptide FPPQSVL provided by the present invention can effectively prevent or treat osteoporosis, promote bone health, and is of great significance to the development of health products and medicines that promote bone health.

The invention provides an individualized tibia defect repairing type knee joint prosthesis, and belongs to the technical field of orthopedic implants. The device is formed by assembling a femoral condyle, a femoral bone marrow needle, a plateau pad, a tibia plateau, a restoration body and a tibia bone marrow needle. Wherein the tibia platform and the restoration body are matched through metal-metal threads and are assisted by bone cement to achieve anti-rotation locking, the restoration body adopts a 3D printing individualized bone trabecula structure and is compounded with an HA coating to promote bone ingrowth, the tibia bone marrow needle and the platform are connected through a standard taper connector, inventory and individualization compatibility is achieved, and the bone marrow needle and the platform are connected through a standard taper connector. The defects that an existing prosthesis is large in bone mass loss, unattractive in reconstruction, free of bone ingrowth function, high in processing cost and the like are overcome, and the postoperative function of a tibia defect patient and the long-term stability of the prosthesis can be remarkably improved.

The invention discloses a titanium-magnesium nail plate system capable of promoting fracture healing and a manufacturing and forming method. The manufacturing and forming method comprises the steps that a bone fracture plate digital model containing a bone trabecula simulation porous area and a partition filling cavity is established according to a bone anatomical structure, and a titanium-based workpiece of a porous structure is manufactured through selective laser melting forming; a titanium-zinc-calcium component gradient transition layer is constructed layer by layer on the surface of the porous inner wall of the titanium-based workpiece through a directional deposition process, interface bonding is strengthened through low-temperature heat treatment, and the titanium-based workpiece with a gradient interface is obtained; the titanium-based workpiece with the gradient interface is placed in an inert atmosphere, after heating is conducted, molten magnesium or magnesium alloy is injected into all the cavities through a partitioned vacuum pressure injection technology, and after cooling is conducted, a titanium-magnesium composite workpiece is formed; through a customized and interface-controllable manufacturing method, a high-strength titanium skeleton and a degradable healing-promoting magnesium material are firmly combined, and integrated design and manufacturing of mechanical support and biological activity of the internal fixation device are achieved.

The invention provides a cereal dietary fiber, a composite dietary fiber and a preparation method and application thereof, and the cereal dietary fiber comprises the following components based on the total weight of the cereal dietary fiber: less than or equal to 2% of oil content, less than or equal to 5% of starch content, more than or equal to 50% of total dietary fiber content, and more than or equal to 2% of soluble pentosan content. According to the cereal dietary fiber provided by the invention, osteoblasts can be remarkably increased, and the sparse degree of bone trabecula can be improved, so that the cereal dietary fiber has the effect of improving bone metabolism, and is particularly suitable for improving bone metabolism of old people. Furthermore, by compounding the cereal dietary fiber and the inulin provided by the invention, the cereal dietary fiber and the inulin have a synergistic effect, and as a food raw material, the food texture can be improved, and the nutrition can be improved; and one or more effects of improving the anti-aging and anti-oxidation effects of the body, regulating intestinal flora, relieving chronic inflammation, improving the athletic ability and cognitive ability, improving the immunity and the like are also facilitated.

A method and system for analysis of medical images is presented in the field of analysis of medical images. The method and systems is provided to determine one or more parameters of bones in medical images. The method and system may be characterized as an advancement in analysis of medical images to ascertain bone health and discern pathologies in bone. Specifically, a system and method is disclosed for analysing medical images showing at least a portion of a bone to determine one or more bone parameters for the at least one portion of a bone. Steps taken by the system and method include: determining a region of interest of the medical image; identifying a boundary of at least one of an inner edge and an outer edge of cortical bone of the at least one portion of the bone within the region of interest; identifying at least one boundary of trabecular bone of the at least one portion of the bone within the region of interest; utilising the identified boundaries to determine at least one of the following bone parameters: orientation, bone mineral density, length, width of trabecular structure, for the at least one portion of bone within the region of interest.

The invention relates to the technical field of patient skeleton X-ray image recognition, in particular to an image processing-based latent fracture auxiliary recognition method. And positioning a skeleton region and a soft tissue region connected with the skeleton region in the X-ray image. Selecting a reference skeleton area, and evaluating the fracture expression degree by analyzing similar gray pixel distribution and edge positions of the reference skeleton area; and for the soft tissue region, calculating the necessary degree of soft tissue enhancement according to the gray difference between the soft tissue region and the peripheral tissue, the gray difference between the two internal regions and the distance between the soft tissue region and the skeleton. And determining the necessary degree of bone enhancement according to the number of the soft tissues connected with the bone, the necessary degree of enhancement of each soft tissue and the fracture expression degree. And screening a to-be-enhanced area to perform image enhancement, and finally realizing accurate identification of the occult fracture. According to the invention, extremely small bone trabecula structure disorder or density change can be detected, so that the patient identification accuracy of related personnel is improved.

The invention discloses a model construction method of a gradient random porous structure of a simulated bone trabecula, a white calendite piezoelectric bone scaffold and a preparation method of the white calendite piezoelectric bone scaffold, and the model construction method provided by the invention is a design method based on a Thiessen polygon porous structure with seed point release gradient change and volume scaling coefficient linear gradient change. In the body center scaling process, interpolation calculation is conducted on scaling coefficients from the axis to the outermost end in the cylindrical domain in the radial direction, and therefore the model of the stochastic gradient porous structure with the pore diameter decreasing from inside to outside in the radial direction and the pore edge diameter increasing from inside to outside in the radial direction is finally formed, by designing the formula and process parameters of the white calcium stone ceramic slurry, the possible problems of over-curing, cracking and the like are avoided, and the white calcium stone piezoelectric ceramic bone scaffold with excellent bonding performance is prepared by adopting a 3D printing photocuring printing technology.

The invention relates to the technical field of medical image detection, and discloses a medical image quality control report generation method which comprises the following steps: firstly, performing soft tissue background field correction on a near-end femur scanning image to remove low-frequency interference, and determining a stress conduction direction of a main pressure-bearing bone trabecula based on an anatomical geometric position; converting the image into a spatial frequency domain, respectively extracting a structure frequency spectrum and a full-angle average structure frequency spectrum along the stress conduction direction, and calculating effective texture cut-off frequencies of the structure frequency spectrum and the full-angle average structure frequency spectrum by using a breakpoint regression model; calculating the logarithmic ratio of the two cut-off frequencies to obtain a quantitative index reflecting the anisotropy retention degree of the structure, and comparing the quantitative index with an adaptive threshold constructed based on the number of frequency points to generate a quality control report indicating whether the image quality is qualified or not; according to the method, an anatomical mechanical path is used as a physical reference, and the homomorphism and heterogeneity problem that image quality degradation and pathological change are similar in performance is solved.

The application provides a parameter design method of a acetabular revision guiding support based on image modeling, and belongs to the field of medical instruments, and comprises the following steps: establishing an acetabular coordinate system, and extracting geometric parameters of medical images of a bone defect area; defining a plurality of bone trabecula metal acetabular cup outer cup abduction angle, anteversion angle and vertical upward height, and coupling to obtain a limited parameter combination; respectively calculating the contact volume ratio η of the bone trabecula metal acetabular cup and the bone defect area and the distance Doffse from the rotation center of the outer cup to the healthy rotation center; screening a group of optimal parameters according to the numerical values of η and Doffse; and designing a guiding support for the outer cup according to the optimal parameters. The application provides a simple, efficient and accurate digital solution for Paprosky III type acetabular defect revision, and the core geometric quantification method and guiding support design can be expanded to other complex bone defect repair, and has significant clinical application value and technical foresight.

The present invention provides a calculation method for the morphological metrology parameters of trabecular bone in polymer-embedded sectional specimens, which relates to the field of biomedical engineering technology. The aim is to solve the problems in the existing trabecular bone morphology measurement, such as the inability to quickly reflect the true situation in vivo and the repeated sampling, which increases the labor intensity. The adopted technical solution is that at the macro-micro level, the precise morphological metrology parameters of trabecular bone at multiple positions are intelligently identified in a large range, which is of great significance for understanding the biomechanical information of the trabecular bone gradient change in situ bone and further developing biomaterials with better biocompatibility; in programming software, the division of the region of interest of bone sections is realized, and the operator can repeatedly extract the trabecular bone information of the region of interest in a large range and at multiple sites according to his own situation, without the need for manual cutting and grinding of bone tissue, reducing the human error and simplifying the work process.

The application belongs to the field of simulation, and provides a filling modified screw mechanical analysis method based on a finite element analysis model, which comprises the following steps: obtaining three-dimensional medical image data of a target bone tissue region, and constructing a finite element analysis model of a micro bone trabecula structure and a macro pelvis structure based on the three-dimensional medical image data; introducing a filling modified screw structure into the finite element analysis model; constructing a response control factor field for representing the local adaptation capability of each position in the filling structure, and automatically updating the distribution of the factor field according to the stress state change; iteratively optimizing the distribution of the factor field based on a global error minimization principle, so that the overall stress distribution of the filling modified screw in the bone tissue tends to a target state; and outputting the stress response distribution, strain distribution and mechanical adaptation region of the filling modified screw in the bone tissue, which are used for evaluating the fixing performance of the filling modified screw under the condition of osteoporosis.

A self-adaptive bionic cancellous bone defect prosthesis and a design method thereof belong to the technical field of medical prostheses. The prosthesis consists of a bio-interface gradient microporous structure portion and a main bionic truss support structure portion. The bio-interface gradient microporous structure portion is arranged at both ends of the main bionic truss support structure portion and is mainly used to reconstruct bone defects. Through the established linear relationship between CT grayscale value and bone density-elastic modulus, the main truss portion is bionicly designed with the same arrangement direction and morphology as human trabeculae, adaptively matching the mechanical conduction of the bone structure, reducing the stress shielding effect, and simultaneously matching the prosthesis's various complex mechanical working conditions, reducing the risk of prosthesis failure, and extending the prosthesis's service life.

The application discloses a preparation method and system of a tendon / ligament-bone junction special trabecular zone biomechanical bidirectional biomimetic bone biological structure, and belongs to the technical field of bone biological material preparation, and comprises the following steps: extracting morphological information of trabeculae and mechanical parameters of a tendon / ligament-bone junction based on a target region of a human specimen slice; determining a biomimetic structure based on the morphological information of the trabeculae; determining a biological material for preparing the biomimetic structure based on the mechanical parameters of the tendon / ligament-bone junction; preparing the biomimetic bone biological structure based on the biomimetic structure and the bone biological material; and performing modification treatment on a surface of the biomimetic bone biological structure to obtain a final biomimetic bone biological structure. The application combines the construction information of the trabeculae of the tendon / ligament-bone junction with 3D printing technology, realizes the structure and material collaborative biomimetic of an implant when the tendon / ligament-bone junction is reconstructed, and provides important technical support for researching and developing a bone biological structure with better biocompatibility for the tendon / ligament-bone junction.

The present invention relates to the technical field of orthopedic artificial joints, and in particular, to a metal total knee artificial joint and a method for preparing a metal total knee artificial joint. The metal total knee artificial joint comprises a femoral condyle prosthesis and a tibial plateau prosthesis. Both the femoral condyle prosthesis and the tibial plateau prosthesis are made of 3D printing of zirconium-niobium alloy. The two can be slidably matched, and the sliding contact surface of the femoral condyle prosthesis and the tibial plateau prosthesis is provided with a metal-ceramic interface; the integration interface of the femoral condyle prosthesis and the tibial plateau prosthesis with the external bone body is a 3D-printed trabecular integration interface. The metal total knee artificial joint eliminates the tibial plateau pad prosthesis, and through the metal-ceramic interface, it can reduce the amount of osteotomy of the tibial plateau and optimize the wear of the friction interface, thereby avoiding the risk of osteolysis caused by debris generated by wear, which in turn causes the prosthesis to loosen. It can also improve the bone integration efficiency of the interface between the prosthesis and the bone tissue, which is beneficial to the stability of the prosthesis in the later stage of implantation.

This invention discloses a biomimetic helical chiral porous bone repair and bone augmentation scaffold, comprising: a scaffold body composed of an array of multiple lattice units, each lattice unit being a biomimetic trabecular bone cell; the lattice units follow the natural helical arrangement of human bone trabeculae, forming a continuous and interconnected helical channel network within the scaffold body; the lattice units are distributed in a helical gradient along the radial direction of the scaffold body, and the outer wall of the scaffold body has a protruding structure integrally formed with the lattice units. This invention, through the deep coupling of the biomimetic helical chiral structure and cellular fluid dynamics, overcomes the limitations of traditional scaffolds with "static channels," forming a composite flow field of "high-speed guidance - low-speed vortex," effectively solving the problem of "nutrient islands," and significantly improving the survival rate and quality of osteoblasts in the central region.

The present invention relates to a method for interactively designing via an implant design platform an artificial joint implant for hip arthroplasty and corresponding broaching and osteotomy guide apparatuses. The proposed implant design platform reconstructs the anatomy of the patient's pelvic and femoral bones in a 3D digital environment, and accordingly develops a patient-specific femoral implant stem as well as patient-specific surgical tools broach / rasp, osteotomy guide) used in total 10 hip arthroplasty. The patient-specific femoral implant stem developed may be optimized to ensure optimum mechanical performance for the patient, employing complex internal lattices that minimize stress shielding and advanced trabecular surfaces to promote osseointegration.

This invention discloses a lightweight biomimetic skeleton structure for aircraft and its fabrication and design methods, belonging to the field of biomimetic aircraft technology. The lightweight biomimetic skeleton structure includes: a biomimetic skeleton structure composed of three periodic minimal curved surfaces; and a panel layer integrally connected to both sides of the biomimetic skeleton structure, the panel layer being a dense structure or a microporous structure. The biomimetic skeleton structure is constructed based on the topological features of the three-dimensional structure of human trabeculae, and a trabeculae-like microtopological structure is introduced into the local high-stress areas of the biomimetic skeleton structure. By mimicking the porous structure of human trabeculae, a highly efficient load-bearing lattice structure is used for the lightweight design and manufacturing of key load-bearing components of aircraft equipment. This achieves both structural lightweighting and high strength and toughness in the lightweight biomimetic skeleton structure for aircraft. It solves the problem that existing technologies lack in-depth reference to the efficient load-bearing mechanism of trabeculae, and fail to achieve structural self-adaptation and functional integration under extreme environments.

The utility model discloses a personalized root type implant. Comprising an implant body, a central screw hole is formed in the upper end of the implant body, a Morse taper hole is formed in the upper portion of the central screw hole, and an inner hexagonal base hole is formed in the upper end of the Morse taper hole; the implant made of Ti-Ta alloy is close to a bone tissue of a human body, so that the stress shielding effect is effectively reduced; meanwhile, due to the introduction of tantalum, the corrosion resistance and bone combining capacity of the material are improved; a 3D printing technology is adopted to realize that the implant is completely matched with a tooth extraction socket in shape, and bone holes and convex blocks of a bionic bone trabecula porous structure are constructed on the surface of the interior part of a bone, so that the implant is convenient to mount in a tooth socket; the central screw hole and the Morse taper hole are designed at the upper end of the implant, so that the false tooth is conveniently mounted and connected, and the inner hexagonal base hole is formed at the upper end of the implant, so that the connection stability of the false tooth is conveniently improved, and the false tooth is prevented from rotating and falling off.

The present disclosure discloses a shoulder joint prosthesis containing zirconium-niobium alloy on oxidation layer and a preparation method thereof, the preparation method comprises: using zirconium-niobium alloy powder as a raw material, conducting a 3D printing for one-piece molding to obtain an intermediate products of the humeral handle with articular surface and the scapular glenoid plate, and performing Sinter-HIP, cryogenic cooling and surface oxidation to obtain humeral handle with articular surface and scapular glenoid plate. The prosthesis comprises a humeral handle, an articular surface, a humeral head and a scapular glenoid plate, a bone trabeculae is arranged on the outer surface of the upper part of the humeral handle, the upper surface of the scapular glenoid plate and the outer surface of the circular pipe with internal thread.

The invention discloses a bone biological structure preparation method and system for mechanical biology bidirectional bionic of a special bone trabecula area at a tendon / ligament bone joint, and belongs to the technical field of bone biological material preparation, and the method comprises the following steps: extracting morphological information of a bone trabecula and mechanical parameters of the tendon / ligament bone joint based on a human body specimen slice of a target area; determining a bionic structure based on the morphological information of the bone trabecula; determining a biological material for preparing a bionic structure based on mechanical parameters of the tendon / ligament bone joint; preparing a bionic bone biological structure based on the bionic structure and the bone biological material; and carrying out modification treatment on the surface of the bionic bone biological structure to obtain the final bionic bone biological structure. The construction information of the bone trabecula at the tendon / ligament bone joint is combined with the 3D printing technology, so that when the tendon / ligament bone joint is reconstructed, the structure and material of the implant are synergistically bionic, and important technical support is provided for research and development of a bone biological structure with better biocompatibility at the tendon / ligament bone joint.

The present application belongs to the technical field of natural active peptides, and particularly relates to a crab shell polypeptide as well as a preparation method and application thereof. The preparation method provided by the present application takes crab shells as raw materials, extracts crab shell polypeptides by using a hydrolysis, enzymolysis and alcohol precipitation method, controls the hydrolysis, enzymolysis and alcohol precipitation conditions in the extraction process, and makes the prepared crab shell polypeptides mainly composed of low-molecular-weight peptides and rich in glutamic acid, aspartic acid and lysine. Experiments prove that the crab shell polypeptide provided by the present application can enhance calcium deposition, improve OB activity, improve bone density, restore trabecular bone structure, maintain the integrity of bone tissue, inhibit OC function, has no obvious systemic toxicity, and can reestablish the osteoblast / osteoclast balance at the molecular level and restore calcium-phosphorus homeostasis, and therefore can be used for preparing medicines for preventing and treating osteoporosis or health-care foods for improving bone density, and has a good application prospect.