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Prunus humilis procyanidine as well as preparation method, application and medicine thereof

A technology of the original flower of Prunus oleifera and anthocyanin, applied in the field of medicine, can solve the problems of poor patient compliance, gastrointestinal intolerance, etc., and achieve the effects of food safety, convenient storage and transportation, and maintenance of bone structure

Pending Publication Date: 2020-11-03
青岛得高健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, the gastrointestinal intolerance caused by these drugs, poor patient compliance, and safety issues in long-term treatment have been controversial

Method used

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  • Prunus humilis procyanidine as well as preparation method, application and medicine thereof
  • Prunus humilis procyanidine as well as preparation method, application and medicine thereof
  • Prunus humilis procyanidine as well as preparation method, application and medicine thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] This embodiment provides a kind of preparation method of prunus proanthocyanidins, it comprises the following steps:

[0036] S1. Take fresh parsley, remove the core and cut into pieces to obtain the pitted parsnip.

[0037] S2. After mixing 10 g of the above-mentioned denucleated Plum and 30 mL of an aqueous ethanol solution with a volume concentration of 60%, ultrasonic extraction was carried out at a temperature of 30° C. for 3 times, and the extract was obtained by combining. Wherein, the ultrasonic power of ultrasonic extraction is 400W, the ultrasonic frequency is 30KHz, and the time of each extraction is 20min.

[0038] S3. Suction filter the above extract with a 400-mesh nylon filter cloth, take the filtrate, place it at a temperature of 35° C. for vacuum concentration, and then freeze-dry to obtain Prunus proanthocyanidins (lyophilized powder).

[0039] This embodiment also provides a medicine for treating and / or preventing osteoporosis, which includes a medic...

Embodiment 2

[0041] This embodiment provides a kind of preparation method of prunus proanthocyanidins, it comprises the following steps:

[0042] S1. Take fresh parsley, remove the core and cut into pieces to obtain the pitted parsnip.

[0043] S2. After mixing 10 g of the above-mentioned denucleated Prunus annuli and 70 mL of an aqueous ethanol solution with a volume concentration of 80%, ultrasonic extraction was carried out at a temperature of 50° C. for 3 times, and the extract was obtained by combining. Wherein, the ultrasonic power of ultrasonic extraction is 800W, the ultrasonic frequency is 50KHz, and the time of each extraction is 40min.

[0044] S3. Suction filter the above extract with a 600-mesh nylon filter cloth, take the filtrate, and place it at a temperature of 35-55°C for vacuum concentration, and then freeze-dry to obtain Prunus proanthocyanidins (freeze-dried powder ).

Embodiment 3

[0046] This embodiment provides a kind of preparation method of prunus proanthocyanidins, it comprises the following steps:

[0047] S1. Take fresh parsley, remove the core and cut into pieces to obtain the pitted parsnip.

[0048] S2. After mixing 10 g of the above-mentioned denucleated Prunus annuli and 40 mL of an aqueous ethanol solution with a volume concentration of 65%, ultrasonic extraction was carried out at a temperature of 35° C. for 3 times, and the combined extract was obtained. Wherein, the ultrasonic power of ultrasonic extraction is 500W, the ultrasonic frequency is 35KHz, and the time of each extraction is 35min.

[0049] S3. Suction filter the above extract with a 450-mesh nylon filter cloth, take the filtrate, place it at 40°C for vacuum concentration, and then freeze-dry to obtain Prunus proanthocyanidins (lyophilized powder).

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Abstract

The invention is applicable to the technical field of medicines, and provides prunus humilis procyanidins, a preparation method and application thereof, and a medicine; the preparation method of the prunus humilis procyanidins comprises the following steps: preparing and depitting prunus humilis to obtain depitted prunus humilis; carrying out ultrasonic extraction on the prunus humilis and an ethanol aqueous solution at the temperature of 30-50 DEG C to obtain an extracting solution; and carrying out suction filtration on the extracting solution, and then carrying out vacuum concentration andfreeze-drying treatment to obtain the prunus humilis procyanidine. The active ingredients in the prunus humilis bunge are extracted and prepared into the freeze-dried powder, so that the biological activity of the prunus humilis bunge can be maintained, the prunus humilis is convenient to store and transport, and the prunus humilis freeze-dried powder has important significance in development of the prunus humilis industry and meeting of increasing large health requirements of people. In addition, the prunus humilis procyanidine has the effects of preventing osteoporosis, maintaining a bone structure, protecting the integrity of a bone trabecula microstructure, improving estrogen disorder caused by menopause, regulating and controlling intestinal flora metabolites of organisms and the like.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a prunus proanthocyanidin, its preparation method, its application and medicine. Background technique [0002] Osteoporosis is the most common skeletal disease. It is a systemic bone disease characterized by low bone mass and damage to the microstructure of bone tissue, resulting in increased bone fragility and susceptibility to fracture. It has no specific clinical symptoms in the early stage, so Also known as the "silent disease". With the advent of an aging society, the incidence of osteoporosis is increasing year by year, and more and more attention has been paid to it. [0003] At present, the main method for the treatment of osteoporosis is drug therapy. Anti-osteoporosis drugs are mainly based on two ideas: inhibit bone resorption or induce bone formation. Commonly used bone resorption inhibitors mainly include bisphosphonates, calcitonin, estrogen and sele...

Claims

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Application Information

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IPC IPC(8): C07D311/62C09B61/00C09B67/54A61K31/353A61P19/10A61P3/00A61P5/00A61P1/00A61P15/12
CPCC07D311/62C09B61/00C09B67/0096A61P19/10A61P3/00A61P5/00A61P1/00A61P15/12
Inventor 李卫东崔清宇李宗朔
Owner 青岛得高健康科技有限公司
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